Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mitochondrial fission 1 protein

Gene

Fis1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. May be not essential for the assembly of functional fission complexes and the subsequent membrane scission event. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial fission 1 protein
Alternative name(s):
FIS1 homolog
Tetratricopeptide repeat protein 11
Short name:
TPR repeat protein 11
Gene namesi
Name:Fis1
Synonyms:Ttc11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1913687. Fis1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 122CytoplasmicSequence analysisAdd BLAST122
Transmembranei123 – 143HelicalSequence analysisAdd BLAST21
Topological domaini144 – 152Mitochondrial intermembraneSequence analysis9

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001063941 – 152Mitochondrial fission 1 proteinAdd BLAST152

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei10PhosphoserineBy similarity1

Post-translational modificationi

Ubiquitinated by MARCH5.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9CQ92.
MaxQBiQ9CQ92.
PaxDbiQ9CQ92.
PeptideAtlasiQ9CQ92.
PRIDEiQ9CQ92.
TopDownProteomicsiQ9CQ92.

PTM databases

iPTMnetiQ9CQ92.
PhosphoSitePlusiQ9CQ92.
SwissPalmiQ9CQ92.

Expressioni

Gene expression databases

BgeeiENSMUSG00000019054.
ExpressionAtlasiQ9CQ92. baseline and differential.
GenevisibleiQ9CQ92. MM.

Interactioni

Subunit structurei

Interacts with DNM1L/DLP1 through the TPR region. Interacts with MARCH5. Interacts with MIEF1. Interacts with PEX11A, PEX11B and PEX11G.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211472. 1 interactor.
IntActiQ9CQ92. 1 interactor.
MINTiMINT-1859640.
STRINGi10090.ENSMUSP00000019198.

Structurei

Secondary structure

1152
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 6Combined sources5
Helixi11 – 27Combined sources17
Helixi32 – 44Combined sources13
Beta strandi45 – 47Combined sources3
Helixi48 – 61Combined sources14
Helixi68 – 83Combined sources16
Helixi87 – 100Combined sources14
Helixi105 – 120Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IYGNMR-A1-120[»]
ProteinModelPortaliQ9CQ92.
SMRiQ9CQ92.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9CQ92.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati71 – 104TPRAdd BLAST34

Domaini

The C-terminus is required for mitochondrial or peroxisomal localization, while the N-terminus is necessary for mitochondrial or peroxisomal fission, localization and regulation of the interaction with DNM1L.By similarity

Sequence similaritiesi

Belongs to the FIS1 family.Curated
Contains 1 TPR repeat.Curated

Keywords - Domaini

TPR repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3364. Eukaryota.
ENOG4111PPH. LUCA.
GeneTreeiENSGT00390000000592.
HOGENOMiHOG000165386.
HOVERGENiHBG081530.
InParanoidiQ9CQ92.
KOiK17969.
OMAiEGYIGMA.
OrthoDBiEOG091G0YFW.
PhylomeDBiQ9CQ92.
TreeFamiTF315180.

Family and domain databases

CDDicd12212. Fis1. 1 hit.
Gene3Di1.25.40.10. 1 hit.
InterProiIPR016543. Fis1.
IPR033745. Fis1_cytosol.
IPR028061. Fis1_TPR_C.
IPR028058. Fis1_TPR_N.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PANTHERiPTHR13247. PTHR13247. 1 hit.
PfamiPF14853. Fis1_TPR_C. 1 hit.
PF14852. Fis1_TPR_N. 1 hit.
[Graphical view]
PIRSFiPIRSF008835. TPR_repeat_11_Fis1. 1 hit.
SUPFAMiSSF48452. SSF48452. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CQ92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAVLNELVS VEDLKNFERK FQSEQAAGSV SKSTQFEYAW CLVRSKYNED
60 70 80 90 100
IRRGIVLLEE LLPKGSKEEQ RDYVFYLAVG NYRLKEYEKA LKYVRGLLQT
110 120 130 140 150
EPQNNQAKEL ERLIDKAMKK DGLVGMAIVG GMALGVAGLA GLIGLAVSKS

KS
Length:152
Mass (Da):17,009
Last modified:June 1, 2001 - v1
Checksum:iB012DF491518A4B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004479 mRNA. Translation: BAB23324.1.
AK004917 mRNA. Translation: BAB23668.1.
AK008078 mRNA. Translation: BAB25445.1.
AK008323 mRNA. Translation: BAB25601.1.
AK008916 mRNA. Translation: BAB25966.1.
BC010783 mRNA. Translation: AAH10783.1.
CCDSiCCDS19757.1.
RefSeqiNP_001156715.1. NM_001163243.1.
NP_079838.1. NM_025562.3.
UniGeneiMm.25849.

Genome annotation databases

EnsembliENSMUST00000019198; ENSMUSP00000019198; ENSMUSG00000019054.
GeneIDi66437.
KEGGimmu:66437.
UCSCiuc009abf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004479 mRNA. Translation: BAB23324.1.
AK004917 mRNA. Translation: BAB23668.1.
AK008078 mRNA. Translation: BAB25445.1.
AK008323 mRNA. Translation: BAB25601.1.
AK008916 mRNA. Translation: BAB25966.1.
BC010783 mRNA. Translation: AAH10783.1.
CCDSiCCDS19757.1.
RefSeqiNP_001156715.1. NM_001163243.1.
NP_079838.1. NM_025562.3.
UniGeneiMm.25849.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IYGNMR-A1-120[»]
ProteinModelPortaliQ9CQ92.
SMRiQ9CQ92.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211472. 1 interactor.
IntActiQ9CQ92. 1 interactor.
MINTiMINT-1859640.
STRINGi10090.ENSMUSP00000019198.

PTM databases

iPTMnetiQ9CQ92.
PhosphoSitePlusiQ9CQ92.
SwissPalmiQ9CQ92.

Proteomic databases

EPDiQ9CQ92.
MaxQBiQ9CQ92.
PaxDbiQ9CQ92.
PeptideAtlasiQ9CQ92.
PRIDEiQ9CQ92.
TopDownProteomicsiQ9CQ92.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019198; ENSMUSP00000019198; ENSMUSG00000019054.
GeneIDi66437.
KEGGimmu:66437.
UCSCiuc009abf.2. mouse.

Organism-specific databases

CTDi51024.
MGIiMGI:1913687. Fis1.

Phylogenomic databases

eggNOGiKOG3364. Eukaryota.
ENOG4111PPH. LUCA.
GeneTreeiENSGT00390000000592.
HOGENOMiHOG000165386.
HOVERGENiHBG081530.
InParanoidiQ9CQ92.
KOiK17969.
OMAiEGYIGMA.
OrthoDBiEOG091G0YFW.
PhylomeDBiQ9CQ92.
TreeFamiTF315180.

Miscellaneous databases

EvolutionaryTraceiQ9CQ92.
PROiQ9CQ92.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019054.
ExpressionAtlasiQ9CQ92. baseline and differential.
GenevisibleiQ9CQ92. MM.

Family and domain databases

CDDicd12212. Fis1. 1 hit.
Gene3Di1.25.40.10. 1 hit.
InterProiIPR016543. Fis1.
IPR033745. Fis1_cytosol.
IPR028061. Fis1_TPR_C.
IPR028058. Fis1_TPR_N.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PANTHERiPTHR13247. PTHR13247. 1 hit.
PfamiPF14853. Fis1_TPR_C. 1 hit.
PF14852. Fis1_TPR_N. 1 hit.
[Graphical view]
PIRSFiPIRSF008835. TPR_repeat_11_Fis1. 1 hit.
SUPFAMiSSF48452. SSF48452. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFIS1_MOUSE
AccessioniPrimary (citable) accession number: Q9CQ92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.