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Q9CQ92

- FIS1_MOUSE

UniProt

Q9CQ92 - FIS1_MOUSE

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Protein

Mitochondrial fission 1 protein

Gene
Fis1, Ttc11
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. May be not essential for the assembly of functional fission complexes and the subsequent membrane scission event. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission.1 Publication

GO - Biological processi

  1. calcium-mediated signaling using intracellular calcium source Source: Ensembl
  2. mitochondrial fission Source: UniProtKB
  3. mitochondrial fragmentation involved in apoptotic process Source: UniProtKB
  4. mitochondrial fusion Source: UniProtKB
  5. mitochondrion degradation Source: Ensembl
  6. mitochondrion morphogenesis Source: MGI
  7. negative regulation of endoplasmic reticulum calcium ion concentration Source: Ensembl
  8. peroxisome fission Source: UniProtKB
  9. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  10. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  11. positive regulation of intrinsic apoptotic signaling pathway Source: Ensembl
  12. positive regulation of mitochondrial calcium ion concentration Source: Ensembl
  13. positive regulation of mitochondrial fission Source: UniProtKB
  14. positive regulation of protein targeting to membrane Source: UniProtKB
  15. protein homooligomerization Source: Ensembl
  16. protein targeting to mitochondrion Source: Ensembl
  17. release of cytochrome c from mitochondria Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial fission 1 protein
Alternative name(s):
FIS1 homolog
Tetratricopeptide repeat protein 11
Short name:
TPR repeat protein 11
Gene namesi
Name:Fis1
Synonyms:Ttc11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1913687. Fis1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 122122Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei123 – 14321Helical; Reviewed predictionAdd
BLAST
Topological domaini144 – 1529Mitochondrial intermembrane Reviewed prediction

GO - Cellular componenti

  1. integral component of mitochondrial outer membrane Source: UniProtKB
  2. integral component of peroxisomal membrane Source: UniProtKB
  3. mitochondrion Source: MGI
  4. peroxisome Source: UniProtKB
  5. protein complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 152152Mitochondrial fission 1 proteinPRO_0000106394Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity

Post-translational modificationi

Ubiquitinated by MARCH5 By similarity.

Keywords - PTMi

Acetylation, Ubl conjugation

Proteomic databases

MaxQBiQ9CQ92.
PaxDbiQ9CQ92.
PRIDEiQ9CQ92.

PTM databases

PhosphoSiteiQ9CQ92.

Expressioni

Gene expression databases

BgeeiQ9CQ92.
GenevestigatoriQ9CQ92.

Interactioni

Subunit structurei

Interacts with DNM1L/DLP1 through the TPR region. Interacts with MARCH5 By similarity. Interacts with MIEF1 By similarity.

Protein-protein interaction databases

BioGridi211472. 1 interaction.
IntActiQ9CQ92. 1 interaction.
MINTiMINT-1859640.
STRINGi10090.ENSMUSP00000019198.

Structurei

Secondary structure

1
152
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi2 – 65
Helixi11 – 2717
Helixi32 – 4413
Beta strandi45 – 473
Helixi48 – 6114
Helixi68 – 8316
Helixi87 – 10014
Helixi105 – 12016

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1IYGNMR-A1-120[»]
ProteinModelPortaliQ9CQ92.
SMRiQ9CQ92. Positions 1-122.

Miscellaneous databases

EvolutionaryTraceiQ9CQ92.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati71 – 10434TPRAdd
BLAST

Domaini

The C-terminus is required for mitochondrial or peroxisomal localization, while the N-terminus is necessary for mitochondrial or peroxisomal fission, localization and regulation of the interaction with DNM1L By similarity.

Sequence similaritiesi

Belongs to the FIS1 family.
Contains 1 TPR repeat.

Keywords - Domaini

TPR repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG235677.
GeneTreeiENSGT00390000000592.
HOGENOMiHOG000165386.
HOVERGENiHBG081530.
InParanoidiQ9CQ92.
KOiK17969.
OMAiEIFRTSP.
PhylomeDBiQ9CQ92.
TreeFamiTF315180.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR016543. Fis1.
IPR028061. Fis1_TPR_C.
IPR028058. Fis1_TPR_N.
IPR011990. TPR-like_helical.
[Graphical view]
PANTHERiPTHR13247. PTHR13247. 1 hit.
PfamiPF14853. Fis1_TPR_C. 1 hit.
PF14852. Fis1_TPR_N. 1 hit.
[Graphical view]
PIRSFiPIRSF008835. TPR_repeat_11_Fis1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CQ92-1 [UniParc]FASTAAdd to Basket

« Hide

MEAVLNELVS VEDLKNFERK FQSEQAAGSV SKSTQFEYAW CLVRSKYNED    50
IRRGIVLLEE LLPKGSKEEQ RDYVFYLAVG NYRLKEYEKA LKYVRGLLQT 100
EPQNNQAKEL ERLIDKAMKK DGLVGMAIVG GMALGVAGLA GLIGLAVSKS 150
KS 152
Length:152
Mass (Da):17,009
Last modified:June 1, 2001 - v1
Checksum:iB012DF491518A4B1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK004479 mRNA. Translation: BAB23324.1.
AK004917 mRNA. Translation: BAB23668.1.
AK008078 mRNA. Translation: BAB25445.1.
AK008323 mRNA. Translation: BAB25601.1.
AK008916 mRNA. Translation: BAB25966.1.
BC010783 mRNA. Translation: AAH10783.1.
CCDSiCCDS19757.1.
RefSeqiNP_001156715.1. NM_001163243.1.
NP_079838.1. NM_025562.3.
UniGeneiMm.25849.

Genome annotation databases

EnsembliENSMUST00000019198; ENSMUSP00000019198; ENSMUSG00000019054.
GeneIDi66437.
KEGGimmu:66437.
UCSCiuc009abf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK004479 mRNA. Translation: BAB23324.1 .
AK004917 mRNA. Translation: BAB23668.1 .
AK008078 mRNA. Translation: BAB25445.1 .
AK008323 mRNA. Translation: BAB25601.1 .
AK008916 mRNA. Translation: BAB25966.1 .
BC010783 mRNA. Translation: AAH10783.1 .
CCDSi CCDS19757.1.
RefSeqi NP_001156715.1. NM_001163243.1.
NP_079838.1. NM_025562.3.
UniGenei Mm.25849.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1IYG NMR - A 1-120 [» ]
ProteinModelPortali Q9CQ92.
SMRi Q9CQ92. Positions 1-122.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 211472. 1 interaction.
IntActi Q9CQ92. 1 interaction.
MINTi MINT-1859640.
STRINGi 10090.ENSMUSP00000019198.

PTM databases

PhosphoSitei Q9CQ92.

Proteomic databases

MaxQBi Q9CQ92.
PaxDbi Q9CQ92.
PRIDEi Q9CQ92.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000019198 ; ENSMUSP00000019198 ; ENSMUSG00000019054 .
GeneIDi 66437.
KEGGi mmu:66437.
UCSCi uc009abf.2. mouse.

Organism-specific databases

CTDi 51024.
MGIi MGI:1913687. Fis1.

Phylogenomic databases

eggNOGi NOG235677.
GeneTreei ENSGT00390000000592.
HOGENOMi HOG000165386.
HOVERGENi HBG081530.
InParanoidi Q9CQ92.
KOi K17969.
OMAi EIFRTSP.
PhylomeDBi Q9CQ92.
TreeFami TF315180.

Miscellaneous databases

ChiTaRSi FIS1. mouse.
EvolutionaryTracei Q9CQ92.
NextBioi 321685.
PROi Q9CQ92.
SOURCEi Search...

Gene expression databases

Bgeei Q9CQ92.
Genevestigatori Q9CQ92.

Family and domain databases

Gene3Di 1.25.40.10. 1 hit.
InterProi IPR016543. Fis1.
IPR028061. Fis1_TPR_C.
IPR028058. Fis1_TPR_N.
IPR011990. TPR-like_helical.
[Graphical view ]
PANTHERi PTHR13247. PTHR13247. 1 hit.
Pfami PF14853. Fis1_TPR_C. 1 hit.
PF14852. Fis1_TPR_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF008835. TPR_repeat_11_Fis1. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo, Liver, Small intestine and Stomach.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  3. Lubec G., Klug S., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 20-32; 54-64; 72-83 AND 96-108, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain and Hippocampus.
  4. "Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission."
    Loson O.C., Song Z., Chen H., Chan D.C.
    Mol. Biol. Cell 24:659-667(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "Solution structure of RSGI RUH-001, a FIS1p-like and CGI-135 homologous domain from a mouse cDNA."
    RIKEN structural genomics initiative (RSGI)
    Submitted (AUG-2002) to the PDB data bank
    Cited for: STRUCTURE BY NMR.

Entry informationi

Entry nameiFIS1_MOUSE
AccessioniPrimary (citable) accession number: Q9CQ92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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