Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mitochondrial fission 1 protein

Gene

Fis1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. May be not essential for the assembly of functional fission complexes and the subsequent membrane scission event. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial fission 1 protein
Alternative name(s):
FIS1 homolog
Tetratricopeptide repeat protein 11
Short name:
TPR repeat protein 11
Gene namesi
Name:Fis1
Synonyms:Ttc11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1913687 Fis1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 122CytoplasmicSequence analysisAdd BLAST122
Transmembranei123 – 143HelicalSequence analysisAdd BLAST21
Topological domaini144 – 152Mitochondrial intermembraneSequence analysis9

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001063941 – 152Mitochondrial fission 1 proteinAdd BLAST152

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei10PhosphoserineBy similarity1

Post-translational modificationi

Ubiquitinated by MARCH5.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9CQ92
MaxQBiQ9CQ92
PaxDbiQ9CQ92
PeptideAtlasiQ9CQ92
PRIDEiQ9CQ92
TopDownProteomicsiQ9CQ92

PTM databases

iPTMnetiQ9CQ92
PhosphoSitePlusiQ9CQ92
SwissPalmiQ9CQ92

Expressioni

Gene expression databases

BgeeiENSMUSG00000019054
ExpressionAtlasiQ9CQ92 baseline and differential
GenevisibleiQ9CQ92 MM

Interactioni

Subunit structurei

Interacts with DNM1L/DLP1 through the TPR region. Interacts with MARCH5. Interacts with MIEF1. Interacts with PEX11A, PEX11B and PEX11G.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211472, 2 interactors
IntActiQ9CQ92, 1 interactor
MINTiQ9CQ92
STRINGi10090.ENSMUSP00000019198

Structurei

Secondary structure

1152
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 6Combined sources5
Helixi11 – 27Combined sources17
Helixi32 – 44Combined sources13
Beta strandi45 – 47Combined sources3
Helixi48 – 61Combined sources14
Helixi68 – 83Combined sources16
Helixi87 – 100Combined sources14
Helixi105 – 120Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IYGNMR-A1-120[»]
ProteinModelPortaliQ9CQ92
SMRiQ9CQ92
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9CQ92

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati71 – 104TPRAdd BLAST34

Domaini

The C-terminus is required for mitochondrial or peroxisomal localization, while the N-terminus is necessary for mitochondrial or peroxisomal fission, localization and regulation of the interaction with DNM1L.By similarity

Sequence similaritiesi

Belongs to the FIS1 family.Curated

Keywords - Domaini

TPR repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3364 Eukaryota
ENOG4111PPH LUCA
GeneTreeiENSGT00390000000592
HOGENOMiHOG000165386
HOVERGENiHBG081530
InParanoidiQ9CQ92
KOiK17969
OMAiEMVGVQT
OrthoDBiEOG091G0YFW
PhylomeDBiQ9CQ92
TreeFamiTF315180

Family and domain databases

CDDicd12212 Fis1, 1 hit
Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR016543 Fis1
IPR033745 Fis1_cytosol
IPR028061 Fis1_TPR_C
IPR028058 Fis1_TPR_N
IPR011990 TPR-like_helical_dom_sf
PANTHERiPTHR13247 PTHR13247, 1 hit
PfamiView protein in Pfam
PF14853 Fis1_TPR_C, 1 hit
PF14852 Fis1_TPR_N, 1 hit
PIRSFiPIRSF008835 TPR_repeat_11_Fis1, 1 hit
SUPFAMiSSF48452 SSF48452, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CQ92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAVLNELVS VEDLKNFERK FQSEQAAGSV SKSTQFEYAW CLVRSKYNED
60 70 80 90 100
IRRGIVLLEE LLPKGSKEEQ RDYVFYLAVG NYRLKEYEKA LKYVRGLLQT
110 120 130 140 150
EPQNNQAKEL ERLIDKAMKK DGLVGMAIVG GMALGVAGLA GLIGLAVSKS

KS
Length:152
Mass (Da):17,009
Last modified:June 1, 2001 - v1
Checksum:iB012DF491518A4B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004479 mRNA Translation: BAB23324.1
AK004917 mRNA Translation: BAB23668.1
AK008078 mRNA Translation: BAB25445.1
AK008323 mRNA Translation: BAB25601.1
AK008916 mRNA Translation: BAB25966.1
BC010783 mRNA Translation: AAH10783.1
CCDSiCCDS19757.1
RefSeqiNP_001156715.1, NM_001163243.1
NP_079838.1, NM_025562.3
UniGeneiMm.25849

Genome annotation databases

EnsembliENSMUST00000019198; ENSMUSP00000019198; ENSMUSG00000019054
GeneIDi66437
KEGGimmu:66437
UCSCiuc009abf.2 mouse

Similar proteinsi

Entry informationi

Entry nameiFIS1_MOUSE
AccessioniPrimary (citable) accession number: Q9CQ92
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health