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Q9CQ92

- FIS1_MOUSE

UniProt

Q9CQ92 - FIS1_MOUSE

Protein

Mitochondrial fission 1 protein

Gene

Fis1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. May be not essential for the assembly of functional fission complexes and the subsequent membrane scission event. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission.1 Publication

    GO - Biological processi

    1. calcium-mediated signaling using intracellular calcium source Source: Ensembl
    2. mitochondrial fission Source: UniProtKB
    3. mitochondrial fragmentation involved in apoptotic process Source: UniProtKB
    4. mitochondrial fusion Source: UniProtKB
    5. mitochondrion degradation Source: Ensembl
    6. mitochondrion morphogenesis Source: MGI
    7. negative regulation of endoplasmic reticulum calcium ion concentration Source: Ensembl
    8. peroxisome fission Source: UniProtKB
    9. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
    10. positive regulation of cytosolic calcium ion concentration Source: Ensembl
    11. positive regulation of intrinsic apoptotic signaling pathway Source: Ensembl
    12. positive regulation of mitochondrial calcium ion concentration Source: Ensembl
    13. positive regulation of mitochondrial fission Source: UniProtKB
    14. positive regulation of protein targeting to membrane Source: UniProtKB
    15. protein homooligomerization Source: Ensembl
    16. protein targeting to mitochondrion Source: Ensembl
    17. release of cytochrome c from mitochondria Source: Ensembl

    Keywords - Biological processi

    Apoptosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial fission 1 protein
    Alternative name(s):
    FIS1 homolog
    Tetratricopeptide repeat protein 11
    Short name:
    TPR repeat protein 11
    Gene namesi
    Name:Fis1
    Synonyms:Ttc11
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1913687. Fis1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of mitochondrial outer membrane Source: UniProtKB
    2. integral component of peroxisomal membrane Source: UniProtKB
    3. mitochondrion Source: MGI
    4. peroxisome Source: UniProtKB
    5. protein complex Source: Ensembl

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion outer membrane, Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 152152Mitochondrial fission 1 proteinPRO_0000106394Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity

    Post-translational modificationi

    Ubiquitinated by MARCH5.By similarity

    Keywords - PTMi

    Acetylation, Ubl conjugation

    Proteomic databases

    MaxQBiQ9CQ92.
    PaxDbiQ9CQ92.
    PRIDEiQ9CQ92.

    PTM databases

    PhosphoSiteiQ9CQ92.

    Expressioni

    Gene expression databases

    BgeeiQ9CQ92.
    GenevestigatoriQ9CQ92.

    Interactioni

    Subunit structurei

    Interacts with DNM1L/DLP1 through the TPR region. Interacts with MARCH5 By similarity. Interacts with MIEF1 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi211472. 1 interaction.
    IntActiQ9CQ92. 1 interaction.
    MINTiMINT-1859640.
    STRINGi10090.ENSMUSP00000019198.

    Structurei

    Secondary structure

    1
    152
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi2 – 65
    Helixi11 – 2717
    Helixi32 – 4413
    Beta strandi45 – 473
    Helixi48 – 6114
    Helixi68 – 8316
    Helixi87 – 10014
    Helixi105 – 12016

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1IYGNMR-A1-120[»]
    ProteinModelPortaliQ9CQ92.
    SMRiQ9CQ92. Positions 1-122.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9CQ92.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 122122CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini144 – 1529Mitochondrial intermembraneSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei123 – 14321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati71 – 10434TPRAdd
    BLAST

    Domaini

    The C-terminus is required for mitochondrial or peroxisomal localization, while the N-terminus is necessary for mitochondrial or peroxisomal fission, localization and regulation of the interaction with DNM1L.By similarity

    Sequence similaritiesi

    Belongs to the FIS1 family.Curated
    Contains 1 TPR repeat.Curated

    Keywords - Domaini

    TPR repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG235677.
    GeneTreeiENSGT00390000000592.
    HOGENOMiHOG000165386.
    HOVERGENiHBG081530.
    InParanoidiQ9CQ92.
    KOiK17969.
    OMAiEIFRTSP.
    PhylomeDBiQ9CQ92.
    TreeFamiTF315180.

    Family and domain databases

    Gene3Di1.25.40.10. 1 hit.
    InterProiIPR016543. Fis1.
    IPR028061. Fis1_TPR_C.
    IPR028058. Fis1_TPR_N.
    IPR011990. TPR-like_helical.
    [Graphical view]
    PANTHERiPTHR13247. PTHR13247. 1 hit.
    PfamiPF14853. Fis1_TPR_C. 1 hit.
    PF14852. Fis1_TPR_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF008835. TPR_repeat_11_Fis1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9CQ92-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEAVLNELVS VEDLKNFERK FQSEQAAGSV SKSTQFEYAW CLVRSKYNED    50
    IRRGIVLLEE LLPKGSKEEQ RDYVFYLAVG NYRLKEYEKA LKYVRGLLQT 100
    EPQNNQAKEL ERLIDKAMKK DGLVGMAIVG GMALGVAGLA GLIGLAVSKS 150
    KS 152
    Length:152
    Mass (Da):17,009
    Last modified:June 1, 2001 - v1
    Checksum:iB012DF491518A4B1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK004479 mRNA. Translation: BAB23324.1.
    AK004917 mRNA. Translation: BAB23668.1.
    AK008078 mRNA. Translation: BAB25445.1.
    AK008323 mRNA. Translation: BAB25601.1.
    AK008916 mRNA. Translation: BAB25966.1.
    BC010783 mRNA. Translation: AAH10783.1.
    CCDSiCCDS19757.1.
    RefSeqiNP_001156715.1. NM_001163243.1.
    NP_079838.1. NM_025562.3.
    UniGeneiMm.25849.

    Genome annotation databases

    EnsembliENSMUST00000019198; ENSMUSP00000019198; ENSMUSG00000019054.
    GeneIDi66437.
    KEGGimmu:66437.
    UCSCiuc009abf.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK004479 mRNA. Translation: BAB23324.1 .
    AK004917 mRNA. Translation: BAB23668.1 .
    AK008078 mRNA. Translation: BAB25445.1 .
    AK008323 mRNA. Translation: BAB25601.1 .
    AK008916 mRNA. Translation: BAB25966.1 .
    BC010783 mRNA. Translation: AAH10783.1 .
    CCDSi CCDS19757.1.
    RefSeqi NP_001156715.1. NM_001163243.1.
    NP_079838.1. NM_025562.3.
    UniGenei Mm.25849.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1IYG NMR - A 1-120 [» ]
    ProteinModelPortali Q9CQ92.
    SMRi Q9CQ92. Positions 1-122.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 211472. 1 interaction.
    IntActi Q9CQ92. 1 interaction.
    MINTi MINT-1859640.
    STRINGi 10090.ENSMUSP00000019198.

    PTM databases

    PhosphoSitei Q9CQ92.

    Proteomic databases

    MaxQBi Q9CQ92.
    PaxDbi Q9CQ92.
    PRIDEi Q9CQ92.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000019198 ; ENSMUSP00000019198 ; ENSMUSG00000019054 .
    GeneIDi 66437.
    KEGGi mmu:66437.
    UCSCi uc009abf.2. mouse.

    Organism-specific databases

    CTDi 51024.
    MGIi MGI:1913687. Fis1.

    Phylogenomic databases

    eggNOGi NOG235677.
    GeneTreei ENSGT00390000000592.
    HOGENOMi HOG000165386.
    HOVERGENi HBG081530.
    InParanoidi Q9CQ92.
    KOi K17969.
    OMAi EIFRTSP.
    PhylomeDBi Q9CQ92.
    TreeFami TF315180.

    Miscellaneous databases

    ChiTaRSi FIS1. mouse.
    EvolutionaryTracei Q9CQ92.
    NextBioi 321685.
    PROi Q9CQ92.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9CQ92.
    Genevestigatori Q9CQ92.

    Family and domain databases

    Gene3Di 1.25.40.10. 1 hit.
    InterProi IPR016543. Fis1.
    IPR028061. Fis1_TPR_C.
    IPR028058. Fis1_TPR_N.
    IPR011990. TPR-like_helical.
    [Graphical view ]
    PANTHERi PTHR13247. PTHR13247. 1 hit.
    Pfami PF14853. Fis1_TPR_C. 1 hit.
    PF14852. Fis1_TPR_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF008835. TPR_repeat_11_Fis1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo, Liver, Small intestine and Stomach.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    3. Lubec G., Klug S., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 20-32; 54-64; 72-83 AND 96-108, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Brain and Hippocampus.
    4. "Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission."
      Loson O.C., Song Z., Chen H., Chan D.C.
      Mol. Biol. Cell 24:659-667(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. "Solution structure of RSGI RUH-001, a FIS1p-like and CGI-135 homologous domain from a mouse cDNA."
      RIKEN structural genomics initiative (RSGI)
      Submitted (AUG-2002) to the PDB data bank
      Cited for: STRUCTURE BY NMR.

    Entry informationi

    Entry nameiFIS1_MOUSE
    AccessioniPrimary (citable) accession number: Q9CQ92
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2003
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3