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Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3

Gene

Ndufa3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.By similarity

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3
Alternative name(s):
Complex I-B9
Short name:
CI-B9
NADH-ubiquinone oxidoreductase B9 subunit
Gene namesi
Name:Ndufa3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1913341. Ndufa3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei19 – 39HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001187942 – 84NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3Add BLAST83

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9CQ91.
PaxDbiQ9CQ91.
PeptideAtlasiQ9CQ91.
PRIDEiQ9CQ91.

PTM databases

PhosphoSitePlusiQ9CQ91.

Expressioni

Gene expression databases

BgeeiENSMUSG00000035674.
ExpressionAtlasiQ9CQ91. baseline and differential.
GenevisibleiQ9CQ91. MM.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.By similarity

Protein-protein interaction databases

CORUMiQ9CQ91.
STRINGi10090.ENSMUSP00000075953.

Structurei

3D structure databases

SMRiQ9CQ91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFA3 subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J189. Eukaryota.
ENOG411212S. LUCA.
GeneTreeiENSGT00390000004322.
HOGENOMiHOG000015319.
HOVERGENiHBG006495.
InParanoidiQ9CQ91.
KOiK03947.
PhylomeDBiQ9CQ91.
TreeFamiTF333021.

Family and domain databases

InterProiView protein in InterPro
IPR026626. NDUFA3.
PANTHERiPTHR15221. PTHR15221. 1 hit.
PfamiView protein in Pfam
PF14987. NADHdh_A3. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CQ91-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGRISAFLK NAWAKEPVLV VSFSVWGLAI IMPMISPYTK YASMINKATP
60 70 80
YNYPVPVRDD GNMPDVPSHP QDPLGPSLDW LKNL
Length:84
Mass (Da):9,331
Last modified:June 1, 2001 - v1
Checksum:iB05E59B217D95A92
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019099 mRNA. Translation: BAB31545.1.
AK003133 mRNA. Translation: BAB22593.1.
BC120712 mRNA. Translation: AAI20713.1.
BC120714 mRNA. Translation: AAI20715.1.
CCDSiCCDS39728.1.
RefSeqiNP_079624.1. NM_025348.2.
UniGeneiMm.17851.

Genome annotation databases

EnsembliENSMUST00000076657; ENSMUSP00000075953; ENSMUSG00000035674.
GeneIDi66091.
KEGGimmu:66091.
UCSCiuc009eve.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiNDUA3_MOUSE
AccessioniPrimary (citable) accession number: Q9CQ91
Secondary accession number(s): Q0VBA7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: June 1, 2001
Last modified: September 27, 2017
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families