Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein CutA

Gene

Cuta

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CutA
Alternative name(s):
Brain acetylcholinesterase putative membrane anchor
Gene namesi
Name:Cuta
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1914925. Cuta.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232Sequence analysisAdd
BLAST
Chaini33 – 177145Protein CutAPRO_0000006380Add
BLAST

Proteomic databases

EPDiQ9CQ89.
MaxQBiQ9CQ89.
PaxDbiQ9CQ89.
PRIDEiQ9CQ89.

PTM databases

PhosphoSiteiQ9CQ89.

Expressioni

Gene expression databases

BgeeiQ9CQ89.
CleanExiMM_CUTA.
ExpressionAtlasiQ9CQ89. baseline and differential.
GenevisibleiQ9CQ89. MM.

Interactioni

Subunit structurei

Homotrimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025027.

Structurei

3D structure databases

ProteinModelPortaliQ9CQ89.
SMRiQ9CQ89. Positions 59-167.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CutA family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3338. Eukaryota.
COG1324. LUCA.
GeneTreeiENSGT00390000017030.
HOGENOMiHOG000222826.
HOVERGENiHBG051265.
InParanoidiQ9CQ89.
KOiK03926.
OMAiPVEQGNS.
OrthoDBiEOG7PP591.
PhylomeDBiQ9CQ89.
TreeFamiTF313269.

Family and domain databases

InterProiIPR004323. Ion_tolerance_CutA.
IPR011322. N-reg_PII-like_a/b.
[Graphical view]
PANTHERiPTHR23419. PTHR23419. 1 hit.
PfamiPF03091. CutA1. 1 hit.
[Graphical view]
SUPFAMiSSF54913. SSF54913. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9CQ89-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNWGRAPGVL LGGGATLLLS FLWMPALLPV ASRLLLLPRA LLSMASGSPP
60 70 80 90 100
SQPPPASGSG YVPGSVSAAF VTCPNEKVAK EIARAVVEKR LAACVNLIPQ
110 120 130 140 150
ITSIYEWKGK IEEDSEVLMM IKTQSSLVPA LTEFVRSVHP YEVAEVIALP
160 170
VEQGNPPYLH WVHQVTESVS NSGTALP
Length:177
Mass (Da):18,865
Last modified:March 29, 2005 - v3
Checksum:iDCCE4AAD48C140C9
GO
Isoform 2 (identifier: Q9CQ89-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     120-136: MIKTQSSLVPALTEFVR → VRKFPPCLAPLTTLALS
     137-177: Missing.

Note: Due to intron retention.
Show »
Length:136
Mass (Da):14,337
Checksum:iBA7A980CF0627A0C
GO

Sequence cautioni

The sequence BAB22389.2 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB22913.2 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAE35000.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti143 – 1431V → L in BAE35000 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei120 – 13617MIKTQ…TEFVR → VRKFPPCLAPLTTLALS in isoform 2. 1 PublicationVSP_013227Add
BLAST
Alternative sequencei137 – 17741Missing in isoform 2. 1 PublicationVSP_013228Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002828 mRNA. Translation: BAB22389.2. Different initiation.
AK003647 mRNA. Translation: BAB22913.2. Different initiation.
AK004197 mRNA. Translation: BAB23217.3.
AK159336 mRNA. Translation: BAE35000.1. Different initiation.
BC024422 mRNA. Translation: AAH24422.2.
BC037500 mRNA. Translation: AAH37500.1. Sequence problems.
CCDSiCCDS28557.1. [Q9CQ89-1]
RefSeqiNP_080583.3. NM_026307.3. [Q9CQ89-1]
NP_081224.1. NM_026948.3.
UniGeneiMm.439919.

Genome annotation databases

EnsembliENSMUST00000025027; ENSMUSP00000025027; ENSMUSG00000024194. [Q9CQ89-1]
GeneIDi67675.
KEGGimmu:67675.
UCSCiuc008bex.2. mouse. [Q9CQ89-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002828 mRNA. Translation: BAB22389.2. Different initiation.
AK003647 mRNA. Translation: BAB22913.2. Different initiation.
AK004197 mRNA. Translation: BAB23217.3.
AK159336 mRNA. Translation: BAE35000.1. Different initiation.
BC024422 mRNA. Translation: AAH24422.2.
BC037500 mRNA. Translation: AAH37500.1. Sequence problems.
CCDSiCCDS28557.1. [Q9CQ89-1]
RefSeqiNP_080583.3. NM_026307.3. [Q9CQ89-1]
NP_081224.1. NM_026948.3.
UniGeneiMm.439919.

3D structure databases

ProteinModelPortaliQ9CQ89.
SMRiQ9CQ89. Positions 59-167.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025027.

PTM databases

PhosphoSiteiQ9CQ89.

Proteomic databases

EPDiQ9CQ89.
MaxQBiQ9CQ89.
PaxDbiQ9CQ89.
PRIDEiQ9CQ89.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025027; ENSMUSP00000025027; ENSMUSG00000024194. [Q9CQ89-1]
GeneIDi67675.
KEGGimmu:67675.
UCSCiuc008bex.2. mouse. [Q9CQ89-1]

Organism-specific databases

CTDi51596.
MGIiMGI:1914925. Cuta.

Phylogenomic databases

eggNOGiKOG3338. Eukaryota.
COG1324. LUCA.
GeneTreeiENSGT00390000017030.
HOGENOMiHOG000222826.
HOVERGENiHBG051265.
InParanoidiQ9CQ89.
KOiK03926.
OMAiPVEQGNS.
OrthoDBiEOG7PP591.
PhylomeDBiQ9CQ89.
TreeFamiTF313269.

Miscellaneous databases

ChiTaRSiCuta. mouse.
NextBioi325223.
PROiQ9CQ89.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CQ89.
CleanExiMM_CUTA.
ExpressionAtlasiQ9CQ89. baseline and differential.
GenevisibleiQ9CQ89. MM.

Family and domain databases

InterProiIPR004323. Ion_tolerance_CutA.
IPR011322. N-reg_PII-like_a/b.
[Graphical view]
PANTHERiPTHR23419. PTHR23419. 1 hit.
PfamiPF03091. CutA1. 1 hit.
[Graphical view]
SUPFAMiSSF54913. SSF54913. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Embryo and Kidney.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 15-177 (ISOFORM 2).
    Strain: Czech II and FVB/N-3.
    Tissue: Lung and Mammary tumor.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiCUTA_MOUSE
AccessioniPrimary (citable) accession number: Q9CQ89
Secondary accession number(s): Q3TXB6, Q8CI44, Q9D1L4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 29, 2005
Last modified: March 16, 2016
This is version 106 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.