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Protein

Migration and invasion enhancer 1

Gene

Mien1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Migration and invasion enhancer 1
Gene namesi
Name:Mien1
Synonyms:Rdx12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1913678. Mien1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi30 – 301C → S: No effect on interaction with GPX1. 1 Publication
Mutagenesisi33 – 331C → S: No effect on interaction with GPX1. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 112111Migration and invasion enhancer 1PRO_0000265100Add
BLAST
Propeptidei113 – 1153Removed in mature formBy similarityPRO_0000396009

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Disulfide bondi30 ↔ 33Redox-activeBy similarity
Lipidationi112 – 1121S-geranylgeranyl cysteineBy similarity

Post-translational modificationi

Isoprenylation facilitates association with the plasma membrane and enhances the migratory phenotype of cells by inducing increased filopodia formation.By similarity

Keywords - PTMi

Acetylation, Disulfide bond, Lipoprotein, Prenylation

Proteomic databases

EPDiQ9CQ86.
MaxQBiQ9CQ86.
PaxDbiQ9CQ86.
PeptideAtlasiQ9CQ86.
PRIDEiQ9CQ86.

PTM databases

iPTMnetiQ9CQ86.
PhosphoSiteiQ9CQ86.

Expressioni

Tissue specificityi

Widely expressed with highest levels in kidney followed by brain and testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000002580.
CleanExiMM_1810046J19RIK.
GenevisibleiQ9CQ86. MM.

Interactioni

Subunit structurei

Interacts with GPX1.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000002655.

Structurei

3D structure databases

ProteinModelPortaliQ9CQ86.
SMRiQ9CQ86. Positions 1-115.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SelWTH family.Curated

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiENOG410J06V. Eukaryota.
ENOG41127T6. LUCA.
GeneTreeiENSGT00390000010440.
HOGENOMiHOG000275576.
HOVERGENiHBG059755.
InParanoidiQ9CQ86.
KOiK07401.
OMAiCLAFPQH.
OrthoDBiEOG091G13XN.
PhylomeDBiQ9CQ86.
TreeFamiTF326627.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR011893. Selenoprotein_Rdx-typ.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF10262. Rdx. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR02174. CXXU_selWTH. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CQ86-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGEPAPVSV VPPPGEVEAG SGVHIVVEYC KPCGFEATYL ELASAVKEEY
60 70 80 90 100
PGIEIESRLG GTGAFEIEIN GQLVFSKLEN GGFPYEKDLM EAIRRASNGE
110
PVEKITNSRP PCVIL
Length:115
Mass (Da):12,295
Last modified:June 1, 2001 - v1
Checksum:iB36A0340DFBA737A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002959 mRNA. Translation: BAB22480.1.
AK007795 mRNA. Translation: BAB25261.1.
AK009922 mRNA. Translation: BAB26586.1.
AK041314 mRNA. Translation: BAC30901.1.
AL591390 Genomic DNA. Translation: CAM22009.1.
CH466556 Genomic DNA. Translation: EDL16143.1.
BC021589 mRNA. Translation: AAH21589.1.
CCDSiCCDS25350.1.
RefSeqiNP_079835.1. NM_025559.2.
UniGeneiMm.259614.

Genome annotation databases

EnsembliENSMUST00000002655; ENSMUSP00000002655; ENSMUSG00000002580.
GeneIDi103742.
KEGGimmu:103742.
UCSCiuc007lgj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002959 mRNA. Translation: BAB22480.1.
AK007795 mRNA. Translation: BAB25261.1.
AK009922 mRNA. Translation: BAB26586.1.
AK041314 mRNA. Translation: BAC30901.1.
AL591390 Genomic DNA. Translation: CAM22009.1.
CH466556 Genomic DNA. Translation: EDL16143.1.
BC021589 mRNA. Translation: AAH21589.1.
CCDSiCCDS25350.1.
RefSeqiNP_079835.1. NM_025559.2.
UniGeneiMm.259614.

3D structure databases

ProteinModelPortaliQ9CQ86.
SMRiQ9CQ86. Positions 1-115.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000002655.

PTM databases

iPTMnetiQ9CQ86.
PhosphoSiteiQ9CQ86.

Proteomic databases

EPDiQ9CQ86.
MaxQBiQ9CQ86.
PaxDbiQ9CQ86.
PeptideAtlasiQ9CQ86.
PRIDEiQ9CQ86.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000002655; ENSMUSP00000002655; ENSMUSG00000002580.
GeneIDi103742.
KEGGimmu:103742.
UCSCiuc007lgj.1. mouse.

Organism-specific databases

CTDi84299.
MGIiMGI:1913678. Mien1.

Phylogenomic databases

eggNOGiENOG410J06V. Eukaryota.
ENOG41127T6. LUCA.
GeneTreeiENSGT00390000010440.
HOGENOMiHOG000275576.
HOVERGENiHBG059755.
InParanoidiQ9CQ86.
KOiK07401.
OMAiCLAFPQH.
OrthoDBiEOG091G13XN.
PhylomeDBiQ9CQ86.
TreeFamiTF326627.

Miscellaneous databases

PROiQ9CQ86.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000002580.
CleanExiMM_1810046J19RIK.
GenevisibleiQ9CQ86. MM.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR011893. Selenoprotein_Rdx-typ.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF10262. Rdx. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR02174. CXXU_selWTH. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMIEN1_MOUSE
AccessioniPrimary (citable) accession number: Q9CQ86
Secondary accession number(s): A2A556
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.