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Q9CQ82

- CENPR_MOUSE

UniProt

Q9CQ82 - CENPR_MOUSE

Protein

Centromere protein R

Gene

Itgb3bp

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Transcription coregulator that can have both coactivator and corepressor functions. Involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A-associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex By similarity.By similarity

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. CENP-A containing nucleosome assembly Source: InterPro
    3. mitotic nuclear division Source: UniProtKB-KW
    4. regulation of transcription, DNA-templated Source: UniProtKB-KW
    5. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Repressor

    Keywords - Biological processi

    Apoptosis, Cell cycle, Cell division, Mitosis, Transcription, Transcription regulation

    Enzyme and pathway databases

    ReactomeiREACT_198597. Deposition of new CENPA-containing nucleosomes at the centromere.
    REACT_198961. Resolution of Sister Chromatid Cohesion.
    REACT_202271. NRIF signals cell death from the nucleus.
    REACT_207679. Separation of Sister Chromatids.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Centromere protein R
    Short name:
    CENP-R
    Alternative name(s):
    Nuclear receptor-interacting factor 3
    Gene namesi
    Name:Itgb3bp
    Synonyms:Cenpr, Nrif3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1914983. Itgb3bp.

    Subcellular locationi

    Nucleus By similarity. Chromosomecentromere By similarity. Chromosomecentromerekinetochore By similarity

    GO - Cellular componenti

    1. condensed chromosome kinetochore Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Centromere, Chromosome, Kinetochore, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 176176Centromere protein RPRO_0000057950Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei17 – 171PhosphoserineBy similarity
    Modified residuei71 – 711PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9CQ82.
    PRIDEiQ9CQ82.

    PTM databases

    PhosphoSiteiQ9CQ82.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9CQ82.
    BgeeiQ9CQ82.
    CleanExiMM_ITGB3BP.
    GenevestigatoriQ9CQ82.

    Interactioni

    Subunit structurei

    Homodimer; mediated by the coiled coil domain. Interacts with CCNA2 and MTA1. Interacts with NFKB1 NF-kappa-B subunit. Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU By similarity.By similarity

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni20 – 5031DD1Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili82 – 11231Sequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi63 – 664Nuclear localization signalBy similarity
    Motifi171 – 1755LXXIL motif

    Domaini

    The DD1 domain (also called RepD1 domain) mediates the corepressor function and is essential in the triggering of apoptosis.By similarity
    Contains one Leu-Xaa-Xaa-Ile-Leu (LXXIL) motif, which is essential for the association with nuclear receptors.By similarity

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG80433.
    GeneTreeiENSGT00390000004336.
    HOGENOMiHOG000049271.
    HOVERGENiHBG080553.
    KOiK11510.
    OMAiQMSPFAS.
    OrthoDBiEOG7SR4P3.
    PhylomeDBiQ9CQ82.
    TreeFamiTF336291.

    Family and domain databases

    InterProiIPR009601. CENP-R.
    [Graphical view]
    PANTHERiPTHR15581. PTHR15581. 1 hit.
    PfamiPF06729. CENP-R. 1 hit.
    [Graphical view]
    PIRSFiPIRSF011860. NRIF3_coact_rcpt. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9CQ82-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPVKRSLKLD DQFEKNSFSP SKIVRKKSIT AYSPTTGTYQ LSPFSSPATP    50
    KEQEHRNGPS NETRKRSNLS SPVRQESTVK DRDGFMVLLS KIEISSEKTM 100
    EIMKNLSSIQ ALEGNRQLED LIGVSLVPCS LKSEARKTKE LMTKVIKQKL 150
    FEKKKSRITP KDHHLDSFEF LKAILN 176
    Length:176
    Mass (Da):20,026
    Last modified:June 1, 2001 - v1
    Checksum:iB55F0C100CAE5973
    GO
    Isoform 2 (identifier: Q9CQ82-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-77: Missing.
         78-84: TVKDRDG → MISLKKI

    Note: No experimental confirmation available.

    Show »
    Length:99
    Mass (Da):11,390
    Checksum:i112AA4C302DED413
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti7 – 71L → V in BAE38732. (PubMed:16141072)Curated
    Sequence conflicti50 – 501P → S in BAE38732. (PubMed:16141072)Curated
    Sequence conflicti82 – 821R → S in BAE38732. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 7777Missing in isoform 2. 1 PublicationVSP_020453Add
    BLAST
    Alternative sequencei78 – 847TVKDRDG → MISLKKI in isoform 2. 1 PublicationVSP_020454

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK005779 mRNA. Translation: BAB24235.1.
    AK013373 mRNA. Translation: BAB28815.1.
    AK015557 mRNA. Translation: BAB29892.1.
    AK045037 mRNA. Translation: BAC32192.1.
    AK165072 mRNA. Translation: BAE38024.1.
    AK166362 mRNA. Translation: BAE38732.1.
    BC049557 mRNA. Translation: AAH49557.1.
    CCDSiCCDS18387.1. [Q9CQ82-1]
    RefSeqiNP_080624.1. NM_026348.3. [Q9CQ82-1]
    UniGeneiMm.257094.

    Genome annotation databases

    EnsembliENSMUST00000146258; ENSMUSP00000117153; ENSMUSG00000028549. [Q9CQ82-1]
    GeneIDi67733.
    KEGGimmu:67733.
    UCSCiuc008tux.1. mouse. [Q9CQ82-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK005779 mRNA. Translation: BAB24235.1 .
    AK013373 mRNA. Translation: BAB28815.1 .
    AK015557 mRNA. Translation: BAB29892.1 .
    AK045037 mRNA. Translation: BAC32192.1 .
    AK165072 mRNA. Translation: BAE38024.1 .
    AK166362 mRNA. Translation: BAE38732.1 .
    BC049557 mRNA. Translation: AAH49557.1 .
    CCDSi CCDS18387.1. [Q9CQ82-1 ]
    RefSeqi NP_080624.1. NM_026348.3. [Q9CQ82-1 ]
    UniGenei Mm.257094.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9CQ82.

    Proteomic databases

    MaxQBi Q9CQ82.
    PRIDEi Q9CQ82.

    Protocols and materials databases

    DNASUi 67733.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000146258 ; ENSMUSP00000117153 ; ENSMUSG00000028549 . [Q9CQ82-1 ]
    GeneIDi 67733.
    KEGGi mmu:67733.
    UCSCi uc008tux.1. mouse. [Q9CQ82-1 ]

    Organism-specific databases

    CTDi 23421.
    MGIi MGI:1914983. Itgb3bp.

    Phylogenomic databases

    eggNOGi NOG80433.
    GeneTreei ENSGT00390000004336.
    HOGENOMi HOG000049271.
    HOVERGENi HBG080553.
    KOi K11510.
    OMAi QMSPFAS.
    OrthoDBi EOG7SR4P3.
    PhylomeDBi Q9CQ82.
    TreeFami TF336291.

    Enzyme and pathway databases

    Reactomei REACT_198597. Deposition of new CENPA-containing nucleosomes at the centromere.
    REACT_198961. Resolution of Sister Chromatid Cohesion.
    REACT_202271. NRIF signals cell death from the nucleus.
    REACT_207679. Separation of Sister Chromatids.

    Miscellaneous databases

    NextBioi 325407.
    PROi Q9CQ82.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9CQ82.
    Bgeei Q9CQ82.
    CleanExi MM_ITGB3BP.
    Genevestigatori Q9CQ82.

    Family and domain databases

    InterProi IPR009601. CENP-R.
    [Graphical view ]
    PANTHERi PTHR15581. PTHR15581. 1 hit.
    Pfami PF06729. CENP-R. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF011860. NRIF3_coact_rcpt. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J.
      Tissue: Embryo, Mammary gland, Oviduct and Testis.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.

    Entry informationi

    Entry nameiCENPR_MOUSE
    AccessioniPrimary (citable) accession number: Q9CQ82
    Secondary accession number(s): Q3TLR0, Q3TNR4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3