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Q9CQ82

- CENPR_MOUSE

UniProt

Q9CQ82 - CENPR_MOUSE

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Protein
Centromere protein R
Gene
Itgb3bp, Cenpr, Nrif3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Transcription coregulator that can have both coactivator and corepressor functions. Involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A-associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex By similarity.

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. centromere-specific nucleosome assembly Source: InterPro
  3. mitotic nuclear division Source: UniProtKB-KW
  4. regulation of transcription, DNA-templated Source: UniProtKB-KW
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Apoptosis, Cell cycle, Cell division, Mitosis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiREACT_198597. Deposition of new CENPA-containing nucleosomes at the centromere.
REACT_198961. Resolution of Sister Chromatid Cohesion.
REACT_202271. NRIF signals cell death from the nucleus.
REACT_207679. Separation of Sister Chromatids.

Names & Taxonomyi

Protein namesi
Recommended name:
Centromere protein R
Short name:
CENP-R
Alternative name(s):
Nuclear receptor-interacting factor 3
Gene namesi
Name:Itgb3bp
Synonyms:Cenpr, Nrif3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1914983. Itgb3bp.

Subcellular locationi

Nucleus By similarity. Chromosomecentromere By similarity. Chromosomecentromerekinetochore By similarity

GO - Cellular componenti

  1. condensed chromosome kinetochore Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 176176Centromere protein R
PRO_0000057950Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei17 – 171Phosphoserine By similarity
Modified residuei71 – 711Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9CQ82.
PRIDEiQ9CQ82.

PTM databases

PhosphoSiteiQ9CQ82.

Expressioni

Gene expression databases

ArrayExpressiQ9CQ82.
BgeeiQ9CQ82.
CleanExiMM_ITGB3BP.
GenevestigatoriQ9CQ82.

Interactioni

Subunit structurei

Homodimer; mediated by the coiled coil domain. Interacts with CCNA2 and MTA1. Interacts with NFKB1 NF-kappa-B subunit. Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU By similarity.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni20 – 5031DD1
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili82 – 11231 Reviewed prediction
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi63 – 664Nuclear localization signal By similarity
Motifi171 – 1755LXXIL motif

Domaini

The DD1 domain (also called RepD1 domain) mediates the corepressor function and is essential in the triggering of apoptosis By similarity.
Contains one Leu-Xaa-Xaa-Ile-Leu (LXXIL) motif, which is essential for the association with nuclear receptors (By similarity).

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG80433.
GeneTreeiENSGT00390000004336.
HOGENOMiHOG000049271.
HOVERGENiHBG080553.
KOiK11510.
OMAiQMSPFAS.
OrthoDBiEOG7SR4P3.
PhylomeDBiQ9CQ82.
TreeFamiTF336291.

Family and domain databases

InterProiIPR009601. CENP-R.
[Graphical view]
PANTHERiPTHR15581. PTHR15581. 1 hit.
PfamiPF06729. CENP-R. 1 hit.
[Graphical view]
PIRSFiPIRSF011860. NRIF3_coact_rcpt. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9CQ82-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MPVKRSLKLD DQFEKNSFSP SKIVRKKSIT AYSPTTGTYQ LSPFSSPATP    50
KEQEHRNGPS NETRKRSNLS SPVRQESTVK DRDGFMVLLS KIEISSEKTM 100
EIMKNLSSIQ ALEGNRQLED LIGVSLVPCS LKSEARKTKE LMTKVIKQKL 150
FEKKKSRITP KDHHLDSFEF LKAILN 176
Length:176
Mass (Da):20,026
Last modified:June 1, 2001 - v1
Checksum:iB55F0C100CAE5973
GO
Isoform 2 (identifier: Q9CQ82-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-77: Missing.
     78-84: TVKDRDG → MISLKKI

Note: No experimental confirmation available.

Show »
Length:99
Mass (Da):11,390
Checksum:i112AA4C302DED413
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7777Missing in isoform 2.
VSP_020453Add
BLAST
Alternative sequencei78 – 847TVKDRDG → MISLKKI in isoform 2.
VSP_020454

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71L → V in BAE38732. 1 Publication
Sequence conflicti50 – 501P → S in BAE38732. 1 Publication
Sequence conflicti82 – 821R → S in BAE38732. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK005779 mRNA. Translation: BAB24235.1.
AK013373 mRNA. Translation: BAB28815.1.
AK015557 mRNA. Translation: BAB29892.1.
AK045037 mRNA. Translation: BAC32192.1.
AK165072 mRNA. Translation: BAE38024.1.
AK166362 mRNA. Translation: BAE38732.1.
BC049557 mRNA. Translation: AAH49557.1.
CCDSiCCDS18387.1. [Q9CQ82-1]
RefSeqiNP_080624.1. NM_026348.3. [Q9CQ82-1]
UniGeneiMm.257094.

Genome annotation databases

EnsembliENSMUST00000146258; ENSMUSP00000117153; ENSMUSG00000028549. [Q9CQ82-1]
GeneIDi67733.
KEGGimmu:67733.
UCSCiuc008tux.1. mouse. [Q9CQ82-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK005779 mRNA. Translation: BAB24235.1 .
AK013373 mRNA. Translation: BAB28815.1 .
AK015557 mRNA. Translation: BAB29892.1 .
AK045037 mRNA. Translation: BAC32192.1 .
AK165072 mRNA. Translation: BAE38024.1 .
AK166362 mRNA. Translation: BAE38732.1 .
BC049557 mRNA. Translation: AAH49557.1 .
CCDSi CCDS18387.1. [Q9CQ82-1 ]
RefSeqi NP_080624.1. NM_026348.3. [Q9CQ82-1 ]
UniGenei Mm.257094.

3D structure databases

ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9CQ82.

Proteomic databases

MaxQBi Q9CQ82.
PRIDEi Q9CQ82.

Protocols and materials databases

DNASUi 67733.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000146258 ; ENSMUSP00000117153 ; ENSMUSG00000028549 . [Q9CQ82-1 ]
GeneIDi 67733.
KEGGi mmu:67733.
UCSCi uc008tux.1. mouse. [Q9CQ82-1 ]

Organism-specific databases

CTDi 23421.
MGIi MGI:1914983. Itgb3bp.

Phylogenomic databases

eggNOGi NOG80433.
GeneTreei ENSGT00390000004336.
HOGENOMi HOG000049271.
HOVERGENi HBG080553.
KOi K11510.
OMAi QMSPFAS.
OrthoDBi EOG7SR4P3.
PhylomeDBi Q9CQ82.
TreeFami TF336291.

Enzyme and pathway databases

Reactomei REACT_198597. Deposition of new CENPA-containing nucleosomes at the centromere.
REACT_198961. Resolution of Sister Chromatid Cohesion.
REACT_202271. NRIF signals cell death from the nucleus.
REACT_207679. Separation of Sister Chromatids.

Miscellaneous databases

NextBioi 325407.
PROi Q9CQ82.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9CQ82.
Bgeei Q9CQ82.
CleanExi MM_ITGB3BP.
Genevestigatori Q9CQ82.

Family and domain databases

InterProi IPR009601. CENP-R.
[Graphical view ]
PANTHERi PTHR15581. PTHR15581. 1 hit.
Pfami PF06729. CENP-R. 1 hit.
[Graphical view ]
PIRSFi PIRSF011860. NRIF3_coact_rcpt. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Embryo, Mammary gland, Oviduct and Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.

Entry informationi

Entry nameiCENPR_MOUSE
AccessioniPrimary (citable) accession number: Q9CQ82
Secondary accession number(s): Q3TLR0, Q3TNR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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