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Protein

Thioredoxin domain-containing protein 9

Gene

Txndc9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Significantly diminishes the chaperonin TCP1 complex ATPase activity, thus negatively impacts protein folding, including that of actin or tubulin.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin domain-containing protein 9
Alternative name(s):
ATP-binding protein associated with cell differentiation
Gene namesi
Name:Txndc9
Synonyms:Apacd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2138153. Txndc9.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: MGI
  • cytoplasm Source: MGI
  • midbody Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 226226Thioredoxin domain-containing protein 9PRO_0000120167Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei188 – 1881PhosphoserineBy similarity
Modified residuei221 – 2211PhosphoserineBy similarity
Modified residuei223 – 2231PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9CQ79.
MaxQBiQ9CQ79.
PaxDbiQ9CQ79.
PeptideAtlasiQ9CQ79.
PRIDEiQ9CQ79.

PTM databases

iPTMnetiQ9CQ79.
PhosphoSiteiQ9CQ79.

Expressioni

Tissue specificityi

Expressed in testis, liver, heart, kidney, brain, spleen and lung.1 Publication

Gene expression databases

BgeeiQ9CQ79.
CleanExiMM_TXNDC9.
ExpressionAtlasiQ9CQ79. baseline and differential.
GenevisibleiQ9CQ79. MM.

Interactioni

Subunit structurei

Forms ternary complexes with the chaperonin TCP1 complex, spanning the cylindrical chaperonin cavity and contacting at least 2 subunits.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000072096.

Structurei

3D structure databases

ProteinModelPortaliQ9CQ79.
SMRiQ9CQ79. Positions 71-179.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini75 – 180106ThioredoxinAdd
BLAST

Sequence similaritiesi

Contains 1 thioredoxin domain.Curated

Phylogenomic databases

eggNOGiKOG1672. Eukaryota.
COG0526. LUCA.
GeneTreeiENSGT00390000015645.
HOGENOMiHOG000171916.
HOVERGENiHBG054120.
InParanoidiQ9CQ79.
OMAiTKFIKLN.
OrthoDBiEOG7ZSHV3.
PhylomeDBiQ9CQ79.
TreeFamiTF313442.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CQ79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGNGSVDMF SEVLENQFLQ AAKLVENHLD SEIQKLDQIG EDELELLKEK
60 70 80 90 100
RLAALRKAQQ QKQEWLSKGH GEYREIGSER DFFQEVKESE KVVCHFYRDT
110 120 130 140 150
TFRCKILDRH LAILAKKHLE TKFLKLNVEK APFLCERLRI KVIPTLALLR
160 170 180 190 200
DGKTQDYVVG FTDLGNTDDF TTETLEWRLG CSDVINYSGN LMEPPFQSQK
210 220
KFGTNFTKLE KKTIRGKKYD SDSDDD
Length:226
Mass (Da):26,260
Last modified:June 1, 2001 - v1
Checksum:iB90255DDAEE402BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002893 mRNA. Translation: BAB22438.1.
AK006170 mRNA. Translation: BAB24440.1.
AK010709 mRNA. Translation: BAB27134.1.
AK011424 mRNA. Translation: BAB27611.1.
AK016756 mRNA. Translation: BAB30412.1.
AK028525 mRNA. Translation: BAC25991.1.
AK153857 mRNA. Translation: BAE32213.1.
AK167045 mRNA. Translation: BAE39213.1.
BC022947 mRNA. Translation: AAH22947.1.
BC083077 mRNA. Translation: AAH83077.1.
CCDSiCCDS14898.1.
RefSeqiNP_742051.1. NM_172054.4.
XP_006496420.1. XM_006496357.2.
XP_006496421.1. XM_006496358.2.
UniGeneiMm.28438.

Genome annotation databases

EnsembliENSMUST00000162031; ENSMUSP00000125491; ENSMUSG00000058407.
ENSMUST00000195032; ENSMUSP00000141595; ENSMUSG00000058407.
ENSMUST00000195247; ENSMUSP00000141609; ENSMUSG00000058407.
GeneIDi98258.
KEGGimmu:98258.
UCSCiuc007asm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002893 mRNA. Translation: BAB22438.1.
AK006170 mRNA. Translation: BAB24440.1.
AK010709 mRNA. Translation: BAB27134.1.
AK011424 mRNA. Translation: BAB27611.1.
AK016756 mRNA. Translation: BAB30412.1.
AK028525 mRNA. Translation: BAC25991.1.
AK153857 mRNA. Translation: BAE32213.1.
AK167045 mRNA. Translation: BAE39213.1.
BC022947 mRNA. Translation: AAH22947.1.
BC083077 mRNA. Translation: AAH83077.1.
CCDSiCCDS14898.1.
RefSeqiNP_742051.1. NM_172054.4.
XP_006496420.1. XM_006496357.2.
XP_006496421.1. XM_006496358.2.
UniGeneiMm.28438.

3D structure databases

ProteinModelPortaliQ9CQ79.
SMRiQ9CQ79. Positions 71-179.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000072096.

PTM databases

iPTMnetiQ9CQ79.
PhosphoSiteiQ9CQ79.

Proteomic databases

EPDiQ9CQ79.
MaxQBiQ9CQ79.
PaxDbiQ9CQ79.
PeptideAtlasiQ9CQ79.
PRIDEiQ9CQ79.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000162031; ENSMUSP00000125491; ENSMUSG00000058407.
ENSMUST00000195032; ENSMUSP00000141595; ENSMUSG00000058407.
ENSMUST00000195247; ENSMUSP00000141609; ENSMUSG00000058407.
GeneIDi98258.
KEGGimmu:98258.
UCSCiuc007asm.1. mouse.

Organism-specific databases

CTDi10190.
MGIiMGI:2138153. Txndc9.

Phylogenomic databases

eggNOGiKOG1672. Eukaryota.
COG0526. LUCA.
GeneTreeiENSGT00390000015645.
HOGENOMiHOG000171916.
HOVERGENiHBG054120.
InParanoidiQ9CQ79.
OMAiTKFIKLN.
OrthoDBiEOG7ZSHV3.
PhylomeDBiQ9CQ79.
TreeFamiTF313442.

Miscellaneous databases

PROiQ9CQ79.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CQ79.
CleanExiMM_TXNDC9.
ExpressionAtlasiQ9CQ79. baseline and differential.
GenevisibleiQ9CQ79. MM.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo, Embryonic stem cell, Kidney, Skin, Testis and Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  3. "An evolutionarily conserved gene required for proper microtubule architecture in Caenorhabditis elegans."
    Ogawa S., Matsubayashi Y., Nishida E.
    Genes Cells 9:83-93(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiTXND9_MOUSE
AccessioniPrimary (citable) accession number: Q9CQ79
Secondary accession number(s): Q3TKD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2001
Last modified: July 6, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.