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Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2

Gene

Ndufa2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

GO - Molecular functioni

  • NADH dehydrogenase (ubiquinone) activity Source: MGI
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2
Alternative name(s):
Complex I-B8
Short name:
CI-B8
NADH-ubiquinone oxidoreductase B8 subunit
Gene namesi
Name:Ndufa2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1343103. Ndufa2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 9998NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2PRO_0000118790Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Disulfide bondi24 ↔ 58Redox-activeBy similarity
Modified residuei64 – 641N6-acetyllysine; alternateCombined sources
Modified residuei64 – 641N6-succinyllysine; alternateCombined sources
Modified residuei75 – 751N6-acetyllysineCombined sources

Post-translational modificationi

Acetylation of Lys-64 and Lys-75 is observed in liver mitochondria from fasted mice but not from fed mice.

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

EPDiQ9CQ75.
MaxQBiQ9CQ75.
PaxDbiQ9CQ75.
PeptideAtlasiQ9CQ75.
PRIDEiQ9CQ75.

PTM databases

iPTMnetiQ9CQ75.
PhosphoSiteiQ9CQ75.

Expressioni

Gene expression databases

BgeeiENSMUSG00000014294.
GenevisibleiQ9CQ75. MM.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.By similarity

Protein-protein interaction databases

BioGridi201716. 1 interaction.
IntActiQ9CQ75. 4 interactions.
MINTiMINT-1860636.
STRINGi10090.ENSMUSP00000014438.

Structurei

3D structure databases

ProteinModelPortaliQ9CQ75.
SMRiQ9CQ75. Positions 15-99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG3446. Eukaryota.
ENOG41124JV. LUCA.
GeneTreeiENSGT00390000006178.
HOGENOMiHOG000201916.
HOVERGENiHBG082012.
InParanoidiQ9CQ75.
KOiK03946.
OMAiSAGTRQF.
OrthoDBiEOG091G10SA.
PhylomeDBiQ9CQ75.
TreeFamiTF300229.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR016464. NADH_Ub_cplx-1_asu_su-2.
IPR007741. Ribosome/NADH_DH.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR12878. PTHR12878. 1 hit.
PfamiPF05047. L51_S25_CI-B8. 1 hit.
[Graphical view]
PIRSFiPIRSF005822. NDUA2. 1 hit.
SMARTiSM00916. L51_S25_CI-B8. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CQ75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAASRAV GAKLGLREIR VHLCQRSPGS QGVRDFIVQR YVELKKAHPN
60 70 80 90
LPILIRECSE VQPKLWARYA FGQEKTVSLN NLSADEVTRA MQNVLSGKA
Length:99
Mass (Da):10,916
Last modified:January 23, 2007 - v3
Checksum:iBB06EFCADD6E30EC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 121A → T in AAD30475 (PubMed:10318868).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF124786 mRNA. Translation: AAD30475.1.
AK003608 mRNA. Translation: BAB22887.1.
AK018732 mRNA. Translation: BAB31375.1.
BC006815 mRNA. Translation: AAH06815.1.
CCDSiCCDS29161.1.
RefSeqiNP_035015.2. NM_010885.5.
UniGeneiMm.29867.

Genome annotation databases

EnsembliENSMUST00000014438; ENSMUSP00000014438; ENSMUSG00000014294.
GeneIDi17991.
KEGGimmu:17991.
UCSCiuc008eoj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF124786 mRNA. Translation: AAD30475.1.
AK003608 mRNA. Translation: BAB22887.1.
AK018732 mRNA. Translation: BAB31375.1.
BC006815 mRNA. Translation: AAH06815.1.
CCDSiCCDS29161.1.
RefSeqiNP_035015.2. NM_010885.5.
UniGeneiMm.29867.

3D structure databases

ProteinModelPortaliQ9CQ75.
SMRiQ9CQ75. Positions 15-99.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201716. 1 interaction.
IntActiQ9CQ75. 4 interactions.
MINTiMINT-1860636.
STRINGi10090.ENSMUSP00000014438.

PTM databases

iPTMnetiQ9CQ75.
PhosphoSiteiQ9CQ75.

Proteomic databases

EPDiQ9CQ75.
MaxQBiQ9CQ75.
PaxDbiQ9CQ75.
PeptideAtlasiQ9CQ75.
PRIDEiQ9CQ75.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000014438; ENSMUSP00000014438; ENSMUSG00000014294.
GeneIDi17991.
KEGGimmu:17991.
UCSCiuc008eoj.2. mouse.

Organism-specific databases

CTDi4695.
MGIiMGI:1343103. Ndufa2.

Phylogenomic databases

eggNOGiKOG3446. Eukaryota.
ENOG41124JV. LUCA.
GeneTreeiENSGT00390000006178.
HOGENOMiHOG000201916.
HOVERGENiHBG082012.
InParanoidiQ9CQ75.
KOiK03946.
OMAiSAGTRQF.
OrthoDBiEOG091G10SA.
PhylomeDBiQ9CQ75.
TreeFamiTF300229.

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Miscellaneous databases

PROiQ9CQ75.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000014294.
GenevisibleiQ9CQ75. MM.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR016464. NADH_Ub_cplx-1_asu_su-2.
IPR007741. Ribosome/NADH_DH.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR12878. PTHR12878. 1 hit.
PfamiPF05047. L51_S25_CI-B8. 1 hit.
[Graphical view]
PIRSFiPIRSF005822. NDUA2. 1 hit.
SMARTiSM00916. L51_S25_CI-B8. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNDUA2_MOUSE
AccessioniPrimary (citable) accession number: Q9CQ75
Secondary accession number(s): Q9WUB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2003
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.