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Protein

2,4-dienoyl-CoA reductase, mitochondrial

Gene

Decr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA (By similarity).By similarity

Catalytic activityi

Trans-2,3-didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei91NADPBy similarity1
Binding sitei91SubstrateBy similarity1
Binding sitei117NADPBy similarity1
Binding sitei119SubstrateBy similarity1
Binding sitei149SubstrateBy similarity1
Active sitei199Proton acceptorSequence analysis1
Binding sitei214NADPBy similarity1
Binding sitei251SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi66 – 71NADPBy similarity6
Nucleotide bindingi240 – 243NADPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid metabolism, Lipid metabolism
LigandNADP

Enzyme and pathway databases

ReactomeiR-MMU-77288 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids

Names & Taxonomyi

Protein namesi
Recommended name:
2,4-dienoyl-CoA reductase, mitochondrial (EC:1.3.1.34)
Alternative name(s):
2,4-dienoyl-CoA reductase [NADPH]
Short name:
4-enoyl-CoA reductase [NADPH]
Gene namesi
Name:Decr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1914710 Decr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 34MitochondrionBy similarityAdd BLAST34
ChainiPRO_000003196635 – 3352,4-dienoyl-CoA reductase, mitochondrialAdd BLAST301

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei42N6-acetyllysine; alternateCombined sources1
Modified residuei42N6-succinyllysine; alternateCombined sources1
Modified residuei49N6-acetyllysine; alternateCombined sources1
Modified residuei49N6-succinyllysine; alternateCombined sources1
Modified residuei69PhosphothreonineBy similarity1
Modified residuei73N6-succinyllysineCombined sources1
Modified residuei97N6-acetyllysine; alternateCombined sources1
Modified residuei97N6-succinyllysine; alternateCombined sources1
Modified residuei106N6-acetyllysine; alternateCombined sources1
Modified residuei106N6-succinyllysine; alternateCombined sources1
Modified residuei244N6-acetyllysine; alternateCombined sources1
Modified residuei244N6-succinyllysine; alternateCombined sources1
Modified residuei260N6-acetyllysine; alternateCombined sources1
Modified residuei260N6-succinyllysine; alternateCombined sources1
Modified residuei315N6-acetyllysineCombined sources1
Modified residuei319N6-acetyllysine; alternateCombined sources1
Modified residuei319N6-succinyllysine; alternateCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9CQ62
MaxQBiQ9CQ62
PaxDbiQ9CQ62
PRIDEiQ9CQ62

PTM databases

iPTMnetiQ9CQ62
PhosphoSitePlusiQ9CQ62

Expressioni

Gene expression databases

BgeeiENSMUSG00000028223
CleanExiMM_DECR1
ExpressionAtlasiQ9CQ62 baseline and differential
GenevisibleiQ9CQ62 MM

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

IntActiQ9CQ62, 4 interactors
MINTiQ9CQ62
STRINGi10090.ENSMUSP00000029877

Structurei

3D structure databases

ProteinModelPortaliQ9CQ62
SMRiQ9CQ62
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0725 Eukaryota
COG1028 LUCA
GeneTreeiENSGT00910000144022
HOVERGENiHBG005465
InParanoidiQ9CQ62
KOiK13236
OMAiDRIPCGR
OrthoDBiEOG091G0GO6
PhylomeDBiQ9CQ62
TreeFamiTF315256

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR002347 SDR_fam
PRINTSiPR00081 GDHRDH
SUPFAMiSSF51735 SSF51735, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CQ62-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLGRAFFA GVSRLPCDPG PQRFFSFGTK TLYQSKDAPQ SKFFQPVLKP
60 70 80 90 100
MLPPDAFQGK VAFITGGGTG LGKAMTTFLS TLGAQCVIAS RNIDVLKATA
110 120 130 140 150
EEISSKTGNK VHAIRCDVRD PDMVHNTVLE LIKVAGHPDV VINNAAGNFI
160 170 180 190 200
SPSERLTPNG WKTITDIVLN GTAYVTLEIG KQLIKAQKGA AFLAITTIYA
210 220 230 240 250
ESGSGFVMPS SSAKSGVEAM NKSLAAEWGR YGMRFNIIQP GPIKTKGAFS
260 270 280 290 300
RLDPTGRFEK EMIDRIPCGR LGTMEELANL ATFLCSDYAS WINGAVIRFD
310 320 330
GGEEVFLSGE FNSLKKVTKE EWDIIEGLIR KTKGS
Length:335
Mass (Da):36,214
Last modified:June 1, 2001 - v1
Checksum:iC064AC03F818E25A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti203G → V in BAB22333 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002756 mRNA Translation: BAB22333.1
AK004725 mRNA Translation: BAB23508.1
AK015692 mRNA Translation: BAB29933.1
BC046972 mRNA Translation: AAH46972.1
CCDSiCCDS17985.1
RefSeqiNP_080448.1, NM_026172.3
UniGeneiMm.393293

Genome annotation databases

EnsembliENSMUST00000029877; ENSMUSP00000029877; ENSMUSG00000028223
GeneIDi67460
KEGGimmu:67460
UCSCiuc008sbm.1 mouse

Similar proteinsi

Entry informationi

Entry nameiDECR_MOUSE
AccessioniPrimary (citable) accession number: Q9CQ62
Secondary accession number(s): Q9DCI7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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