Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

2,4-dienoyl-CoA reductase, mitochondrial

Gene

Decr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA (By similarity).By similarity

Catalytic activityi

Trans-2,3-didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei91NADPBy similarity1
Binding sitei91SubstrateBy similarity1
Binding sitei117NADPBy similarity1
Binding sitei119SubstrateBy similarity1
Binding sitei149SubstrateBy similarity1
Active sitei199Proton acceptorSequence analysis1
Binding sitei214NADPBy similarity1
Binding sitei251SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi66 – 71NADPBy similarity6
Nucleotide bindingi240 – 243NADPBy similarity4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

ReactomeiR-MMU-77288. mitochondrial fatty acid beta-oxidation of unsaturated fatty acids.

Names & Taxonomyi

Protein namesi
Recommended name:
2,4-dienoyl-CoA reductase, mitochondrial (EC:1.3.1.34)
Alternative name(s):
2,4-dienoyl-CoA reductase [NADPH]
Short name:
4-enoyl-CoA reductase [NADPH]
Gene namesi
Name:Decr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1914710. Decr1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • extracellular exosome Source: MGI
  • mitochondrion Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 34MitochondrionBy similarityAdd BLAST34
ChainiPRO_000003196635 – 3352,4-dienoyl-CoA reductase, mitochondrialAdd BLAST301

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei42N6-acetyllysine; alternateCombined sources1
Modified residuei42N6-succinyllysine; alternateCombined sources1
Modified residuei49N6-acetyllysine; alternateCombined sources1
Modified residuei49N6-succinyllysine; alternateCombined sources1
Modified residuei69PhosphothreonineBy similarity1
Modified residuei73N6-succinyllysineCombined sources1
Modified residuei97N6-acetyllysine; alternateCombined sources1
Modified residuei97N6-succinyllysine; alternateCombined sources1
Modified residuei106N6-acetyllysine; alternateCombined sources1
Modified residuei106N6-succinyllysine; alternateCombined sources1
Modified residuei244N6-acetyllysine; alternateCombined sources1
Modified residuei244N6-succinyllysine; alternateCombined sources1
Modified residuei260N6-acetyllysine; alternateCombined sources1
Modified residuei260N6-succinyllysine; alternateCombined sources1
Modified residuei315N6-acetyllysineCombined sources1
Modified residuei319N6-acetyllysine; alternateCombined sources1
Modified residuei319N6-succinyllysine; alternateCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9CQ62.
MaxQBiQ9CQ62.
PaxDbiQ9CQ62.
PRIDEiQ9CQ62.

PTM databases

iPTMnetiQ9CQ62.
PhosphoSitePlusiQ9CQ62.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028223.
CleanExiMM_DECR1.
ExpressionAtlasiQ9CQ62. baseline and differential.
GenevisibleiQ9CQ62. MM.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

IntActiQ9CQ62. 4 interactors.
MINTiMINT-1860375.
STRINGi10090.ENSMUSP00000029877.

Structurei

3D structure databases

ProteinModelPortaliQ9CQ62.
SMRiQ9CQ62.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0725. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00760000118868.
HOVERGENiHBG005465.
InParanoidiQ9CQ62.
KOiK13236.
OMAiFQSKFFP.
OrthoDBiEOG091G0GO6.
PhylomeDBiQ9CQ62.
TreeFamiTF315256.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CQ62-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLGRAFFA GVSRLPCDPG PQRFFSFGTK TLYQSKDAPQ SKFFQPVLKP
60 70 80 90 100
MLPPDAFQGK VAFITGGGTG LGKAMTTFLS TLGAQCVIAS RNIDVLKATA
110 120 130 140 150
EEISSKTGNK VHAIRCDVRD PDMVHNTVLE LIKVAGHPDV VINNAAGNFI
160 170 180 190 200
SPSERLTPNG WKTITDIVLN GTAYVTLEIG KQLIKAQKGA AFLAITTIYA
210 220 230 240 250
ESGSGFVMPS SSAKSGVEAM NKSLAAEWGR YGMRFNIIQP GPIKTKGAFS
260 270 280 290 300
RLDPTGRFEK EMIDRIPCGR LGTMEELANL ATFLCSDYAS WINGAVIRFD
310 320 330
GGEEVFLSGE FNSLKKVTKE EWDIIEGLIR KTKGS
Length:335
Mass (Da):36,214
Last modified:June 1, 2001 - v1
Checksum:iC064AC03F818E25A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti203G → V in BAB22333 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002756 mRNA. Translation: BAB22333.1.
AK004725 mRNA. Translation: BAB23508.1.
AK015692 mRNA. Translation: BAB29933.1.
BC046972 mRNA. Translation: AAH46972.1.
CCDSiCCDS17985.1.
RefSeqiNP_080448.1. NM_026172.3.
UniGeneiMm.393293.

Genome annotation databases

EnsembliENSMUST00000029877; ENSMUSP00000029877; ENSMUSG00000028223.
GeneIDi67460.
KEGGimmu:67460.
UCSCiuc008sbm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002756 mRNA. Translation: BAB22333.1.
AK004725 mRNA. Translation: BAB23508.1.
AK015692 mRNA. Translation: BAB29933.1.
BC046972 mRNA. Translation: AAH46972.1.
CCDSiCCDS17985.1.
RefSeqiNP_080448.1. NM_026172.3.
UniGeneiMm.393293.

3D structure databases

ProteinModelPortaliQ9CQ62.
SMRiQ9CQ62.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9CQ62. 4 interactors.
MINTiMINT-1860375.
STRINGi10090.ENSMUSP00000029877.

PTM databases

iPTMnetiQ9CQ62.
PhosphoSitePlusiQ9CQ62.

Proteomic databases

EPDiQ9CQ62.
MaxQBiQ9CQ62.
PaxDbiQ9CQ62.
PRIDEiQ9CQ62.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029877; ENSMUSP00000029877; ENSMUSG00000028223.
GeneIDi67460.
KEGGimmu:67460.
UCSCiuc008sbm.1. mouse.

Organism-specific databases

CTDi1666.
MGIiMGI:1914710. Decr1.

Phylogenomic databases

eggNOGiKOG0725. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00760000118868.
HOVERGENiHBG005465.
InParanoidiQ9CQ62.
KOiK13236.
OMAiFQSKFFP.
OrthoDBiEOG091G0GO6.
PhylomeDBiQ9CQ62.
TreeFamiTF315256.

Enzyme and pathway databases

ReactomeiR-MMU-77288. mitochondrial fatty acid beta-oxidation of unsaturated fatty acids.

Miscellaneous databases

PROiQ9CQ62.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028223.
CleanExiMM_DECR1.
ExpressionAtlasiQ9CQ62. baseline and differential.
GenevisibleiQ9CQ62. MM.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDECR_MOUSE
AccessioniPrimary (citable) accession number: Q9CQ62
Secondary accession number(s): Q9DCI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.