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Q9CQ60

- 6PGL_MOUSE

UniProt

Q9CQ60 - 6PGL_MOUSE

Protein

6-phosphogluconolactonase

Gene

Pgls

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.By similarity

    Catalytic activityi

    6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

    Pathwayi

    GO - Molecular functioni

    1. 6-phosphogluconolactonase activity Source: UniProtKB-EC
    2. monosaccharide binding Source: Ensembl

    GO - Biological processi

    1. pentose-phosphate shunt, oxidative branch Source: Ensembl

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    UniPathwayiUPA00115; UER00409.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    6-phosphogluconolactonase (EC:3.1.1.31)
    Short name:
    6PGL
    Gene namesi
    Name:Pgls
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:1913421. Pgls.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 2572566-phosphogluconolactonasePRO_0000090079Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei180 – 1801N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9CQ60.
    PaxDbiQ9CQ60.
    PRIDEiQ9CQ60.

    2D gel databases

    REPRODUCTION-2DPAGEQ9CQ60.

    PTM databases

    PhosphoSiteiQ9CQ60.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9CQ60.
    BgeeiQ9CQ60.
    CleanExiMM_PGLS.
    GenevestigatoriQ9CQ60.

    Interactioni

    Protein-protein interaction databases

    IntActiQ9CQ60. 694 interactions.
    MINTiMINT-4086324.
    STRINGi10090.ENSMUSP00000034264.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CQ60.
    SMRiQ9CQ60. Positions 21-247.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0363.
    GeneTreeiENSGT00550000075110.
    HOGENOMiHOG000256285.
    HOVERGENiHBG000030.
    InParanoidiQ9CQ60.
    KOiK01057.
    OMAiTYGLYKS.
    OrthoDBiEOG7RZ5QV.
    PhylomeDBiQ9CQ60.
    TreeFamiTF318609.

    Family and domain databases

    InterProiIPR005900. 6-phosphogluconolactonase_DevB.
    IPR006148. Glc/Gal-6P_isomerase.
    [Graphical view]
    PfamiPF01182. Glucosamine_iso. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01198. pgl. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9CQ60-1 [UniParc]FASTAAdd to Basket

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    MAAPAPSLIS VFSSPQELGA SLAQLVAQRA ASCLEGDRGR FALGLSGGSL    50
    VSMLARDLPA AAAPAGPASF ARWTLGFCDE RLVPFDHAES TYGLYRTHLL 100
    SKLPIPDSQV LTINPALPVE DAAEDYARKL RQALQGDAVP VFDLLILGVG 150
    PDGHTCSLFP DHPLLQEREK IVAPISDSPK PPPQRVTLTL PVLNAAQSII 200
    FVATGEGKAA VLKRILEDKE GTLPAALVQP RTGALCWFLD EAAARLLSVP 250
    FEKHSTL 257
    Length:257
    Mass (Da):27,254
    Last modified:June 1, 2001 - v1
    Checksum:iC19AF8CFC21F01C5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK003134 mRNA. Translation: BAB22594.1.
    AK003985 mRNA. Translation: BAB23106.1.
    AK172066 mRNA. Translation: BAE42808.1.
    BC006594 mRNA. Translation: AAH06594.1.
    CCDSiCCDS22400.1.
    RefSeqiNP_079672.1. NM_025396.3.
    UniGeneiMm.282284.
    Mm.402679.

    Genome annotation databases

    EnsembliENSMUST00000034264; ENSMUSP00000034264; ENSMUSG00000031807.
    GeneIDi66171.
    KEGGimmu:66171.
    UCSCiuc009meb.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK003134 mRNA. Translation: BAB22594.1 .
    AK003985 mRNA. Translation: BAB23106.1 .
    AK172066 mRNA. Translation: BAE42808.1 .
    BC006594 mRNA. Translation: AAH06594.1 .
    CCDSi CCDS22400.1.
    RefSeqi NP_079672.1. NM_025396.3.
    UniGenei Mm.282284.
    Mm.402679.

    3D structure databases

    ProteinModelPortali Q9CQ60.
    SMRi Q9CQ60. Positions 21-247.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9CQ60. 694 interactions.
    MINTi MINT-4086324.
    STRINGi 10090.ENSMUSP00000034264.

    PTM databases

    PhosphoSitei Q9CQ60.

    2D gel databases

    REPRODUCTION-2DPAGE Q9CQ60.

    Proteomic databases

    MaxQBi Q9CQ60.
    PaxDbi Q9CQ60.
    PRIDEi Q9CQ60.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000034264 ; ENSMUSP00000034264 ; ENSMUSG00000031807 .
    GeneIDi 66171.
    KEGGi mmu:66171.
    UCSCi uc009meb.1. mouse.

    Organism-specific databases

    CTDi 25796.
    MGIi MGI:1913421. Pgls.

    Phylogenomic databases

    eggNOGi COG0363.
    GeneTreei ENSGT00550000075110.
    HOGENOMi HOG000256285.
    HOVERGENi HBG000030.
    InParanoidi Q9CQ60.
    KOi K01057.
    OMAi TYGLYKS.
    OrthoDBi EOG7RZ5QV.
    PhylomeDBi Q9CQ60.
    TreeFami TF318609.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00409 .

    Miscellaneous databases

    NextBioi 320850.
    PROi Q9CQ60.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9CQ60.
    Bgeei Q9CQ60.
    CleanExi MM_PGLS.
    Genevestigatori Q9CQ60.

    Family and domain databases

    InterProi IPR005900. 6-phosphogluconolactonase_DevB.
    IPR006148. Glc/Gal-6P_isomerase.
    [Graphical view ]
    Pfami PF01182. Glucosamine_iso. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01198. pgl. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Heart and Spleen.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.

    Entry informationi

    Entry namei6PGL_MOUSE
    AccessioniPrimary (citable) accession number: Q9CQ60
    Secondary accession number(s): Q3TA62
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 31, 2004
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3