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Q9CQ60

- 6PGL_MOUSE

UniProt

Q9CQ60 - 6PGL_MOUSE

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Protein

6-phosphogluconolactonase

Gene

Pgls

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.By similarity

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

Pathwayi

GO - Molecular functioni

  1. 6-phosphogluconolactonase activity Source: UniProtKB-EC
  2. monosaccharide binding Source: Ensembl

GO - Biological processi

  1. pentose-phosphate shunt, oxidative branch Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

UniPathwayiUPA00115; UER00409.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconolactonase (EC:3.1.1.31)
Short name:
6PGL
Gene namesi
Name:Pgls
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:1913421. Pgls.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 2572566-phosphogluconolactonasePRO_0000090079Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei180 – 1801N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9CQ60.
PaxDbiQ9CQ60.
PRIDEiQ9CQ60.

2D gel databases

REPRODUCTION-2DPAGEQ9CQ60.

PTM databases

PhosphoSiteiQ9CQ60.

Expressioni

Gene expression databases

BgeeiQ9CQ60.
CleanExiMM_PGLS.
ExpressionAtlasiQ9CQ60. baseline and differential.
GenevestigatoriQ9CQ60.

Interactioni

Protein-protein interaction databases

IntActiQ9CQ60. 694 interactions.
MINTiMINT-4086324.
STRINGi10090.ENSMUSP00000034264.

Structurei

3D structure databases

ProteinModelPortaliQ9CQ60.
SMRiQ9CQ60. Positions 21-247.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0363.
GeneTreeiENSGT00550000075110.
HOGENOMiHOG000256285.
HOVERGENiHBG000030.
InParanoidiQ9CQ60.
KOiK01057.
OMAiTYGLYKS.
OrthoDBiEOG7RZ5QV.
PhylomeDBiQ9CQ60.
TreeFamiTF318609.

Family and domain databases

InterProiIPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view]
PfamiPF01182. Glucosamine_iso. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01198. pgl. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CQ60-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAPAPSLIS VFSSPQELGA SLAQLVAQRA ASCLEGDRGR FALGLSGGSL
60 70 80 90 100
VSMLARDLPA AAAPAGPASF ARWTLGFCDE RLVPFDHAES TYGLYRTHLL
110 120 130 140 150
SKLPIPDSQV LTINPALPVE DAAEDYARKL RQALQGDAVP VFDLLILGVG
160 170 180 190 200
PDGHTCSLFP DHPLLQEREK IVAPISDSPK PPPQRVTLTL PVLNAAQSII
210 220 230 240 250
FVATGEGKAA VLKRILEDKE GTLPAALVQP RTGALCWFLD EAAARLLSVP

FEKHSTL
Length:257
Mass (Da):27,254
Last modified:June 1, 2001 - v1
Checksum:iC19AF8CFC21F01C5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK003134 mRNA. Translation: BAB22594.1.
AK003985 mRNA. Translation: BAB23106.1.
AK172066 mRNA. Translation: BAE42808.1.
BC006594 mRNA. Translation: AAH06594.1.
CCDSiCCDS22400.1.
RefSeqiNP_001281198.1. NM_001294269.1.
NP_079672.1. NM_025396.3.
UniGeneiMm.282284.
Mm.402679.

Genome annotation databases

EnsembliENSMUST00000034264; ENSMUSP00000034264; ENSMUSG00000031807.
GeneIDi66171.
KEGGimmu:66171.
UCSCiuc009meb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK003134 mRNA. Translation: BAB22594.1 .
AK003985 mRNA. Translation: BAB23106.1 .
AK172066 mRNA. Translation: BAE42808.1 .
BC006594 mRNA. Translation: AAH06594.1 .
CCDSi CCDS22400.1.
RefSeqi NP_001281198.1. NM_001294269.1.
NP_079672.1. NM_025396.3.
UniGenei Mm.282284.
Mm.402679.

3D structure databases

ProteinModelPortali Q9CQ60.
SMRi Q9CQ60. Positions 21-247.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9CQ60. 694 interactions.
MINTi MINT-4086324.
STRINGi 10090.ENSMUSP00000034264.

PTM databases

PhosphoSitei Q9CQ60.

2D gel databases

REPRODUCTION-2DPAGE Q9CQ60.

Proteomic databases

MaxQBi Q9CQ60.
PaxDbi Q9CQ60.
PRIDEi Q9CQ60.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000034264 ; ENSMUSP00000034264 ; ENSMUSG00000031807 .
GeneIDi 66171.
KEGGi mmu:66171.
UCSCi uc009meb.1. mouse.

Organism-specific databases

CTDi 25796.
MGIi MGI:1913421. Pgls.

Phylogenomic databases

eggNOGi COG0363.
GeneTreei ENSGT00550000075110.
HOGENOMi HOG000256285.
HOVERGENi HBG000030.
InParanoidi Q9CQ60.
KOi K01057.
OMAi TYGLYKS.
OrthoDBi EOG7RZ5QV.
PhylomeDBi Q9CQ60.
TreeFami TF318609.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00409 .

Miscellaneous databases

NextBioi 320850.
PROi Q9CQ60.
SOURCEi Search...

Gene expression databases

Bgeei Q9CQ60.
CleanExi MM_PGLS.
ExpressionAtlasi Q9CQ60. baseline and differential.
Genevestigatori Q9CQ60.

Family and domain databases

InterProi IPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view ]
Pfami PF01182. Glucosamine_iso. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01198. pgl. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Heart and Spleen.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry namei6PGL_MOUSE
AccessioniPrimary (citable) accession number: Q9CQ60
Secondary accession number(s): Q3TA62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3