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Protein

6-phosphogluconolactonase

Gene

Pgls

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.By similarity

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (G6pd2), Glucose-6-phosphate 1-dehydrogenase X (G6pdx), Glucose-6-phosphate 1-dehydrogenase (G6pdx), Glucose-6-phosphate 1-dehydrogenase 2 (G6pd2), Glucose-6-phosphate 1-dehydrogenase (G6pdx), Glucose-6-phosphate 1-dehydrogenase (G6pd2), Glucose-6-phosphate 1-dehydrogenase (G6pdx)
  2. 6-phosphogluconolactonase (Pgls)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (Pgd), 6-phosphogluconate dehydrogenase, decarboxylating (Pgd), 6-phosphogluconate dehydrogenase, decarboxylating (Pgd), 6-phosphogluconate dehydrogenase, decarboxylating (Pgd)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

ReactomeiR-MMU-71336 Pentose phosphate pathway (hexose monophosphate shunt)
UniPathwayiUPA00115; UER00409

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconolactonase (EC:3.1.1.31)
Short name:
6PGL
Gene namesi
Name:Pgls
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1913421 Pgls

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000900792 – 2576-phosphogluconolactonaseAdd BLAST256

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei49PhosphoserineCombined sources1
Modified residuei180N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9CQ60
MaxQBiQ9CQ60
PaxDbiQ9CQ60
PeptideAtlasiQ9CQ60
PRIDEiQ9CQ60
TopDownProteomicsiQ9CQ60

2D gel databases

REPRODUCTION-2DPAGEQ9CQ60

PTM databases

iPTMnetiQ9CQ60
PhosphoSitePlusiQ9CQ60
SwissPalmiQ9CQ60

Expressioni

Gene expression databases

BgeeiENSMUSG00000031807
CleanExiMM_PGLS
ExpressionAtlasiQ9CQ60 baseline and differential
GenevisibleiQ9CQ60 MM

Interactioni

Protein-protein interaction databases

IntActiQ9CQ60, 694 interactors
MINTiQ9CQ60
STRINGi10090.ENSMUSP00000034264

Structurei

3D structure databases

ProteinModelPortaliQ9CQ60
SMRiQ9CQ60
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3147 Eukaryota
COG0363 LUCA
GeneTreeiENSGT00550000075110
HOGENOMiHOG000256285
HOVERGENiHBG000030
InParanoidiQ9CQ60
KOiK01057
OMAiKQPHLAI
OrthoDBiEOG091G0NKD
PhylomeDBiQ9CQ60
TreeFamiTF318609

Family and domain databases

CDDicd01400 6PGL, 1 hit
InterProiView protein in InterPro
IPR005900 6-phosphogluconolactonase_DevB
IPR006148 Glc/Gal-6P_isomerase
IPR037171 NagB/RpiA_transferase-like
PfamiView protein in Pfam
PF01182 Glucosamine_iso, 1 hit
SUPFAMiSSF100950 SSF100950, 1 hit
TIGRFAMsiTIGR01198 pgl, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CQ60-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPAPSLIS VFSSPQELGA SLAQLVAQRA ASCLEGDRGR FALGLSGGSL
60 70 80 90 100
VSMLARDLPA AAAPAGPASF ARWTLGFCDE RLVPFDHAES TYGLYRTHLL
110 120 130 140 150
SKLPIPDSQV LTINPALPVE DAAEDYARKL RQALQGDAVP VFDLLILGVG
160 170 180 190 200
PDGHTCSLFP DHPLLQEREK IVAPISDSPK PPPQRVTLTL PVLNAAQSII
210 220 230 240 250
FVATGEGKAA VLKRILEDKE GTLPAALVQP RTGALCWFLD EAAARLLSVP

FEKHSTL
Length:257
Mass (Da):27,254
Last modified:June 1, 2001 - v1
Checksum:iC19AF8CFC21F01C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003134 mRNA Translation: BAB22594.1
AK003985 mRNA Translation: BAB23106.1
AK172066 mRNA Translation: BAE42808.1
BC006594 mRNA Translation: AAH06594.1
CCDSiCCDS22400.1
RefSeqiNP_001281198.1, NM_001294269.1
NP_079672.1, NM_025396.3
UniGeneiMm.282284
Mm.402679

Genome annotation databases

EnsembliENSMUST00000034264; ENSMUSP00000034264; ENSMUSG00000031807
GeneIDi66171
KEGGimmu:66171
UCSCiuc009meb.1 mouse

Similar proteinsi

Entry informationi

Entry namei6PGL_MOUSE
AccessioniPrimary (citable) accession number: Q9CQ60
Secondary accession number(s): Q3TA62
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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