Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

6-phosphogluconolactonase

Gene

Pgls

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.By similarity

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

Pathwayi

GO - Molecular functioni

  1. 6-phosphogluconolactonase activity Source: MGI
  2. monosaccharide binding Source: Ensembl

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. pentose-phosphate shunt Source: MGI
  3. pentose-phosphate shunt, oxidative branch Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

ReactomeiREACT_246505. Pentose phosphate pathway (hexose monophosphate shunt).
UniPathwayiUPA00115; UER00409.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconolactonase (EC:3.1.1.31)
Short name:
6PGL
Gene namesi
Name:Pgls
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:1913421. Pgls.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. extracellular vesicular exosome Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 2572566-phosphogluconolactonasePRO_0000090079Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei49 – 491PhosphoserineBy similarity
Modified residuei180 – 1801N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9CQ60.
PaxDbiQ9CQ60.
PRIDEiQ9CQ60.

2D gel databases

REPRODUCTION-2DPAGEQ9CQ60.

PTM databases

PhosphoSiteiQ9CQ60.

Expressioni

Gene expression databases

BgeeiQ9CQ60.
CleanExiMM_PGLS.
ExpressionAtlasiQ9CQ60. baseline and differential.
GenevestigatoriQ9CQ60.

Interactioni

Protein-protein interaction databases

IntActiQ9CQ60. 694 interactions.
MINTiMINT-4086324.
STRINGi10090.ENSMUSP00000034264.

Structurei

3D structure databases

ProteinModelPortaliQ9CQ60.
SMRiQ9CQ60. Positions 21-247.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0363.
GeneTreeiENSGT00550000075110.
HOGENOMiHOG000256285.
HOVERGENiHBG000030.
InParanoidiQ9CQ60.
KOiK01057.
OMAiCKERGAF.
OrthoDBiEOG7RZ5QV.
PhylomeDBiQ9CQ60.
TreeFamiTF318609.

Family and domain databases

InterProiIPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view]
PfamiPF01182. Glucosamine_iso. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01198. pgl. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CQ60-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPAPSLIS VFSSPQELGA SLAQLVAQRA ASCLEGDRGR FALGLSGGSL
60 70 80 90 100
VSMLARDLPA AAAPAGPASF ARWTLGFCDE RLVPFDHAES TYGLYRTHLL
110 120 130 140 150
SKLPIPDSQV LTINPALPVE DAAEDYARKL RQALQGDAVP VFDLLILGVG
160 170 180 190 200
PDGHTCSLFP DHPLLQEREK IVAPISDSPK PPPQRVTLTL PVLNAAQSII
210 220 230 240 250
FVATGEGKAA VLKRILEDKE GTLPAALVQP RTGALCWFLD EAAARLLSVP

FEKHSTL
Length:257
Mass (Da):27,254
Last modified:June 1, 2001 - v1
Checksum:iC19AF8CFC21F01C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003134 mRNA. Translation: BAB22594.1.
AK003985 mRNA. Translation: BAB23106.1.
AK172066 mRNA. Translation: BAE42808.1.
BC006594 mRNA. Translation: AAH06594.1.
CCDSiCCDS22400.1.
RefSeqiNP_001281198.1. NM_001294269.1.
NP_079672.1. NM_025396.3.
UniGeneiMm.282284.
Mm.402679.

Genome annotation databases

EnsembliENSMUST00000034264; ENSMUSP00000034264; ENSMUSG00000031807.
GeneIDi66171.
KEGGimmu:66171.
UCSCiuc009meb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003134 mRNA. Translation: BAB22594.1.
AK003985 mRNA. Translation: BAB23106.1.
AK172066 mRNA. Translation: BAE42808.1.
BC006594 mRNA. Translation: AAH06594.1.
CCDSiCCDS22400.1.
RefSeqiNP_001281198.1. NM_001294269.1.
NP_079672.1. NM_025396.3.
UniGeneiMm.282284.
Mm.402679.

3D structure databases

ProteinModelPortaliQ9CQ60.
SMRiQ9CQ60. Positions 21-247.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9CQ60. 694 interactions.
MINTiMINT-4086324.
STRINGi10090.ENSMUSP00000034264.

PTM databases

PhosphoSiteiQ9CQ60.

2D gel databases

REPRODUCTION-2DPAGEQ9CQ60.

Proteomic databases

MaxQBiQ9CQ60.
PaxDbiQ9CQ60.
PRIDEiQ9CQ60.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034264; ENSMUSP00000034264; ENSMUSG00000031807.
GeneIDi66171.
KEGGimmu:66171.
UCSCiuc009meb.1. mouse.

Organism-specific databases

CTDi25796.
MGIiMGI:1913421. Pgls.

Phylogenomic databases

eggNOGiCOG0363.
GeneTreeiENSGT00550000075110.
HOGENOMiHOG000256285.
HOVERGENiHBG000030.
InParanoidiQ9CQ60.
KOiK01057.
OMAiCKERGAF.
OrthoDBiEOG7RZ5QV.
PhylomeDBiQ9CQ60.
TreeFamiTF318609.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00409.
ReactomeiREACT_246505. Pentose phosphate pathway (hexose monophosphate shunt).

Miscellaneous databases

NextBioi320850.
PROiQ9CQ60.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CQ60.
CleanExiMM_PGLS.
ExpressionAtlasiQ9CQ60. baseline and differential.
GenevestigatoriQ9CQ60.

Family and domain databases

InterProiIPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view]
PfamiPF01182. Glucosamine_iso. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01198. pgl. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Heart and Spleen.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry namei6PGL_MOUSE
AccessioniPrimary (citable) accession number: Q9CQ60
Secondary accession number(s): Q3TA62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: June 1, 2001
Last modified: March 4, 2015
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.