Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Vesicle transport protein USE1

Gene

Use1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.By similarity

GO - Biological processi

  • endoplasmic reticulum organization Source: MGI
  • endoplasmic reticulum tubular network organization Source: MGI
  • protein transport Source: UniProtKB-KW
  • regulation of ER to Golgi vesicle-mediated transport Source: MGI
  • vesicle-mediated transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle transport protein USE1
Alternative name(s):
Protein D12
USE1-like protein
Gene namesi
Name:Use1
Synonyms:Use1l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1914273. Use1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 242242CytoplasmicSequence analysisAdd
BLAST
Transmembranei243 – 26321Helical; Anchor for type IV membrane proteinSequence analysisAdd
BLAST
Topological domaini264 – 2707LumenalSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 270270Vesicle transport protein USE1PRO_0000215580Add
BLAST

Proteomic databases

EPDiQ9CQ56.
MaxQBiQ9CQ56.
PaxDbiQ9CQ56.
PRIDEiQ9CQ56.

PTM databases

iPTMnetiQ9CQ56.
PhosphoSiteiQ9CQ56.

Expressioni

Gene expression databases

BgeeiENSMUSG00000002395.
ExpressionAtlasiQ9CQ56. baseline and differential.
GenevisibleiQ9CQ56. MM.

Interactioni

Subunit structurei

Component of a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L and SEC22B. Interacts directly with STX18 (By similarity).By similarity

Protein-protein interaction databases

BioGridi211882. 3 interactions.
STRINGi10090.ENSMUSP00000105680.

Structurei

3D structure databases

ProteinModelPortaliQ9CQ56.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili206 – 24237Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the USE1 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2678. Eukaryota.
ENOG410ZN7C. LUCA.
GeneTreeiENSGT00390000014361.
HOGENOMiHOG000007677.
HOVERGENiHBG079328.
InParanoidiQ9CQ56.
KOiK08507.
PhylomeDBiQ9CQ56.
TreeFamiTF325006.

Family and domain databases

InterProiIPR019150. Vesicle_transport_protein_Use1.
[Graphical view]
PfamiPF09753. Use1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9CQ56-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQAEGAYHR PLATSRLELN LVRLLCRCES MAAEKREPDE WRLEKYVGAL
60 70 80 90 100
EDMLQALKVQ ASKPASEVIS EYSRKVDFLK GMLQAEKLTS SSEKALANQF
110 120 130 140 150
LAPGRVPTTA KERVPATKTV HLQSRARYTS EMRSELLGME PSGECEVDMR
160 170 180 190 200
KRAAKGSRPA DERQSASELD LVLQRHQGLQ EKLAEEMLGL ARSLKTNTLA
210 220 230 240 250
AQSVIKKDNQ TLSHSLKMAD QNLEKLKLES ERLEQHAQKS VNWLLWAMLI
260 270
VVCFVFISMI LFIRIMPRLK
Length:270
Mass (Da):30,594
Last modified:June 1, 2001 - v1
Checksum:iC2CEFCE54C7A30DB
GO
Isoform 2 (identifier: Q9CQ56-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: Missing.
     153-153: A → AS

Note: No experimental confirmation available.
Show »
Length:190
Mass (Da):21,473
Checksum:iC85F570FF002B58B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti29 – 291E → D in AAK26661 (Ref. 1) Curated
Sequence conflicti38 – 381P → L in AAK26661 (Ref. 1) Curated
Sequence conflicti194 – 1941L → F in AAK26661 (Ref. 1) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8181Missing in isoform 2. 1 PublicationVSP_012666Add
BLAST
Alternative sequencei153 – 1531A → AS in isoform 2. 1 PublicationVSP_012667

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF353245 mRNA. Translation: AAK26661.1.
AK008573 mRNA. Translation: BAB25752.1.
AK012490 mRNA. Translation: BAB28275.1.
AK160726 mRNA. Translation: BAE35971.1.
BC038519 mRNA. Translation: AAH38519.1.
BC075695 mRNA. Translation: AAH75695.1.
CCDSiCCDS22390.1. [Q9CQ56-1]
RefSeqiNP_001139252.1. NM_001145780.1.
NP_080193.1. NM_025917.4. [Q9CQ56-1]
UniGeneiMm.41890.

Genome annotation databases

EnsembliENSMUST00000019169; ENSMUSP00000019169; ENSMUSG00000002395. [Q9CQ56-1]
ENSMUST00000110054; ENSMUSP00000105681; ENSMUSG00000002395. [Q9CQ56-1]
GeneIDi67023.
KEGGimmu:67023.
UCSCiuc009mcp.2. mouse. [Q9CQ56-1]
uc009mcs.2. mouse. [Q9CQ56-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF353245 mRNA. Translation: AAK26661.1.
AK008573 mRNA. Translation: BAB25752.1.
AK012490 mRNA. Translation: BAB28275.1.
AK160726 mRNA. Translation: BAE35971.1.
BC038519 mRNA. Translation: AAH38519.1.
BC075695 mRNA. Translation: AAH75695.1.
CCDSiCCDS22390.1. [Q9CQ56-1]
RefSeqiNP_001139252.1. NM_001145780.1.
NP_080193.1. NM_025917.4. [Q9CQ56-1]
UniGeneiMm.41890.

3D structure databases

ProteinModelPortaliQ9CQ56.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211882. 3 interactions.
STRINGi10090.ENSMUSP00000105680.

PTM databases

iPTMnetiQ9CQ56.
PhosphoSiteiQ9CQ56.

Proteomic databases

EPDiQ9CQ56.
MaxQBiQ9CQ56.
PaxDbiQ9CQ56.
PRIDEiQ9CQ56.

Protocols and materials databases

DNASUi67023.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019169; ENSMUSP00000019169; ENSMUSG00000002395. [Q9CQ56-1]
ENSMUST00000110054; ENSMUSP00000105681; ENSMUSG00000002395. [Q9CQ56-1]
GeneIDi67023.
KEGGimmu:67023.
UCSCiuc009mcp.2. mouse. [Q9CQ56-1]
uc009mcs.2. mouse. [Q9CQ56-2]

Organism-specific databases

CTDi55850.
MGIiMGI:1914273. Use1.

Phylogenomic databases

eggNOGiKOG2678. Eukaryota.
ENOG410ZN7C. LUCA.
GeneTreeiENSGT00390000014361.
HOGENOMiHOG000007677.
HOVERGENiHBG079328.
InParanoidiQ9CQ56.
KOiK08507.
PhylomeDBiQ9CQ56.
TreeFamiTF325006.

Enzyme and pathway databases

ReactomeiR-MMU-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Miscellaneous databases

PROiQ9CQ56.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000002395.
ExpressionAtlasiQ9CQ56. baseline and differential.
GenevisibleiQ9CQ56. MM.

Family and domain databases

InterProiIPR019150. Vesicle_transport_protein_Use1.
[Graphical view]
PfamiPF09753. Use1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUSE1_MOUSE
AccessioniPrimary (citable) accession number: Q9CQ56
Secondary accession number(s): Q3TUK0, Q80V73, Q99MB6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.