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Protein

NADH dehydrogenase [ubiquinone] 1 subunit C2

Gene

Ndufc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 subunit C2
Alternative name(s):
Complex I-B14.5b
Short name:
CI-B14.5b
NADH-ubiquinone oxidoreductase subunit B14.5b
Gene namesi
Name:Ndufc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1344370. Ndufc2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei57 – 7620HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytoplasm Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: MGI
  • mitochondrial respiratory chain complex I Source: MGI
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 120120NADH dehydrogenase [ubiquinone] 1 subunit C2PRO_0000118839Add
BLAST

Proteomic databases

EPDiQ9CQ54.
MaxQBiQ9CQ54.
PaxDbiQ9CQ54.
PRIDEiQ9CQ54.

PTM databases

PhosphoSiteiQ9CQ54.

Expressioni

Gene expression databases

BgeeiQ9CQ54.
GenevisibleiQ9CQ54. MM.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.By similarity

Protein-protein interaction databases

BioGridi212722. 1 interaction.
IntActiQ9CQ54. 4 interactions.
MINTiMINT-1861857.
STRINGi10090.ENSMUSP00000032882.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFC2 subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4516. Eukaryota.
ENOG410Y341. LUCA.
GeneTreeiENSGT00390000010352.
HOVERGENiHBG001727.
InParanoidiQ9CQ54.
KOiK03968.
OMAiGRVPLQF.
OrthoDBiEOG7VHT0D.
PhylomeDBiQ9CQ54.
TreeFamiTF314723.

Family and domain databases

InterProiIPR009423. NADH-UbQ_OxRdtase_b14.5b_su.
[Graphical view]
PANTHERiPTHR13099. PTHR13099. 1 hit.
PfamiPF06374. NDUF_C2. 1 hit.
[Graphical view]
PIRSFiPIRSF017834. NADH-UbQ_OxRdtase_b14.5b. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CQ54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMNGRPGHEP LKFLPDEARS LPPPKLNDPR LVYMGLLGYC TGLMDNMLRM
60 70 80 90 100
RPVMRAGLHR QLLFVTSFVF AGYFYLKRQN YLYAVKDHDM FGYIKLHPED
110 120
FPEKEKKTYA EILEPFHPVR
Length:120
Mass (Da):14,164
Last modified:June 1, 2001 - v1
Checksum:iC47218CE19B49D1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002373 mRNA. Translation: BAB22050.1.
AK008889 mRNA. Translation: BAB25955.1.
AK019002 mRNA. Translation: BAB31504.1.
AK153547 mRNA. Translation: BAE32084.1.
AK166594 mRNA. Translation: BAE38880.1.
AK168342 mRNA. Translation: BAE40279.1.
BC002097 mRNA. Translation: AAH02097.1.
CCDSiCCDS21457.1.
RefSeqiNP_077182.1. NM_024220.2.
XP_006543322.1. XM_006543259.2.
UniGeneiMm.334031.

Genome annotation databases

EnsembliENSMUST00000032882; ENSMUSP00000032882; ENSMUSG00000030647.
GeneIDi102641347.
68197.
KEGGimmu:102641347.
mmu:68197.
UCSCiuc009ijd.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002373 mRNA. Translation: BAB22050.1.
AK008889 mRNA. Translation: BAB25955.1.
AK019002 mRNA. Translation: BAB31504.1.
AK153547 mRNA. Translation: BAE32084.1.
AK166594 mRNA. Translation: BAE38880.1.
AK168342 mRNA. Translation: BAE40279.1.
BC002097 mRNA. Translation: AAH02097.1.
CCDSiCCDS21457.1.
RefSeqiNP_077182.1. NM_024220.2.
XP_006543322.1. XM_006543259.2.
UniGeneiMm.334031.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212722. 1 interaction.
IntActiQ9CQ54. 4 interactions.
MINTiMINT-1861857.
STRINGi10090.ENSMUSP00000032882.

PTM databases

PhosphoSiteiQ9CQ54.

Proteomic databases

EPDiQ9CQ54.
MaxQBiQ9CQ54.
PaxDbiQ9CQ54.
PRIDEiQ9CQ54.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032882; ENSMUSP00000032882; ENSMUSG00000030647.
GeneIDi102641347.
68197.
KEGGimmu:102641347.
mmu:68197.
UCSCiuc009ijd.2. mouse.

Organism-specific databases

CTDi4718.
MGIiMGI:1344370. Ndufc2.

Phylogenomic databases

eggNOGiKOG4516. Eukaryota.
ENOG410Y341. LUCA.
GeneTreeiENSGT00390000010352.
HOVERGENiHBG001727.
InParanoidiQ9CQ54.
KOiK03968.
OMAiGRVPLQF.
OrthoDBiEOG7VHT0D.
PhylomeDBiQ9CQ54.
TreeFamiTF314723.

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Miscellaneous databases

NextBioi326682.
PROiQ9CQ54.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CQ54.
GenevisibleiQ9CQ54. MM.

Family and domain databases

InterProiIPR009423. NADH-UbQ_OxRdtase_b14.5b_su.
[Graphical view]
PANTHERiPTHR13099. PTHR13099. 1 hit.
PfamiPF06374. NDUF_C2. 1 hit.
[Graphical view]
PIRSFiPIRSF017834. NADH-UbQ_OxRdtase_b14.5b. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow, Kidney, Pancreas and Stomach.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.
  3. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 31-49; 79-104 AND 107-120, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6J.
    Tissue: Brain.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiNDUC2_MOUSE
AccessioniPrimary (citable) accession number: Q9CQ54
Secondary accession number(s): Q3TLB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: June 1, 2001
Last modified: March 16, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.