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Protein

NADH dehydrogenase [ubiquinone] 1 subunit C2

Gene

Ndufc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.
R-MMU-6798695. Neutrophil degranulation.
R-MMU-6799198. Complex I biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 subunit C2
Alternative name(s):
Complex I-B14.5b
Short name:
CI-B14.5b
NADH-ubiquinone oxidoreductase subunit B14.5b
Gene namesi
Name:Ndufc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1344370. Ndufc2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei57 – 76HelicalSequence analysisAdd BLAST20

GO - Cellular componenti

  • cytoplasm Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: MGI
  • mitochondrial respiratory chain complex I Source: MGI
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001188391 – 120NADH dehydrogenase [ubiquinone] 1 subunit C2Add BLAST120

Proteomic databases

EPDiQ9CQ54.
MaxQBiQ9CQ54.
PaxDbiQ9CQ54.
PeptideAtlasiQ9CQ54.
PRIDEiQ9CQ54.

PTM databases

PhosphoSitePlusiQ9CQ54.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030647.
ExpressionAtlasiQ9CQ54. baseline and differential.
GenevisibleiQ9CQ54. MM.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.By similarity

Protein-protein interaction databases

BioGridi212722. 1 interactor.
IntActiQ9CQ54. 4 interactors.
MINTiMINT-1861857.
STRINGi10090.ENSMUSP00000032882.

Structurei

3D structure databases

ProteinModelPortaliQ9CQ54.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFC2 subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4516. Eukaryota.
ENOG410Y341. LUCA.
GeneTreeiENSGT00390000010352.
HOVERGENiHBG001727.
InParanoidiQ9CQ54.
KOiK03968.
OMAiGRVPLQF.
OrthoDBiEOG091G0ZKK.
PhylomeDBiQ9CQ54.
TreeFamiTF314723.

Family and domain databases

InterProiIPR009423. NADH-UbQ_OxRdtase_b14.5b_su.
[Graphical view]
PANTHERiPTHR13099. PTHR13099. 1 hit.
PfamiPF06374. NDUF_C2. 1 hit.
[Graphical view]
PIRSFiPIRSF017834. NADH-UbQ_OxRdtase_b14.5b. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CQ54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMNGRPGHEP LKFLPDEARS LPPPKLNDPR LVYMGLLGYC TGLMDNMLRM
60 70 80 90 100
RPVMRAGLHR QLLFVTSFVF AGYFYLKRQN YLYAVKDHDM FGYIKLHPED
110 120
FPEKEKKTYA EILEPFHPVR
Length:120
Mass (Da):14,164
Last modified:June 1, 2001 - v1
Checksum:iC47218CE19B49D1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002373 mRNA. Translation: BAB22050.1.
AK008889 mRNA. Translation: BAB25955.1.
AK019002 mRNA. Translation: BAB31504.1.
AK153547 mRNA. Translation: BAE32084.1.
AK166594 mRNA. Translation: BAE38880.1.
AK168342 mRNA. Translation: BAE40279.1.
BC002097 mRNA. Translation: AAH02097.1.
CCDSiCCDS21457.1.
RefSeqiNP_077182.1. NM_024220.2.
UniGeneiMm.334031.

Genome annotation databases

EnsembliENSMUST00000032882; ENSMUSP00000032882; ENSMUSG00000030647.
GeneIDi68197.
KEGGimmu:68197.
UCSCiuc009ijd.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002373 mRNA. Translation: BAB22050.1.
AK008889 mRNA. Translation: BAB25955.1.
AK019002 mRNA. Translation: BAB31504.1.
AK153547 mRNA. Translation: BAE32084.1.
AK166594 mRNA. Translation: BAE38880.1.
AK168342 mRNA. Translation: BAE40279.1.
BC002097 mRNA. Translation: AAH02097.1.
CCDSiCCDS21457.1.
RefSeqiNP_077182.1. NM_024220.2.
UniGeneiMm.334031.

3D structure databases

ProteinModelPortaliQ9CQ54.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212722. 1 interactor.
IntActiQ9CQ54. 4 interactors.
MINTiMINT-1861857.
STRINGi10090.ENSMUSP00000032882.

PTM databases

PhosphoSitePlusiQ9CQ54.

Proteomic databases

EPDiQ9CQ54.
MaxQBiQ9CQ54.
PaxDbiQ9CQ54.
PeptideAtlasiQ9CQ54.
PRIDEiQ9CQ54.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032882; ENSMUSP00000032882; ENSMUSG00000030647.
GeneIDi68197.
KEGGimmu:68197.
UCSCiuc009ijd.2. mouse.

Organism-specific databases

CTDi4718.
MGIiMGI:1344370. Ndufc2.

Phylogenomic databases

eggNOGiKOG4516. Eukaryota.
ENOG410Y341. LUCA.
GeneTreeiENSGT00390000010352.
HOVERGENiHBG001727.
InParanoidiQ9CQ54.
KOiK03968.
OMAiGRVPLQF.
OrthoDBiEOG091G0ZKK.
PhylomeDBiQ9CQ54.
TreeFamiTF314723.

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.
R-MMU-6798695. Neutrophil degranulation.
R-MMU-6799198. Complex I biogenesis.

Miscellaneous databases

PROiQ9CQ54.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030647.
ExpressionAtlasiQ9CQ54. baseline and differential.
GenevisibleiQ9CQ54. MM.

Family and domain databases

InterProiIPR009423. NADH-UbQ_OxRdtase_b14.5b_su.
[Graphical view]
PANTHERiPTHR13099. PTHR13099. 1 hit.
PfamiPF06374. NDUF_C2. 1 hit.
[Graphical view]
PIRSFiPIRSF017834. NADH-UbQ_OxRdtase_b14.5b. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNDUC2_MOUSE
AccessioniPrimary (citable) accession number: Q9CQ54
Secondary accession number(s): Q3TLB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.