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Q9CQ48

- NUDC2_MOUSE

UniProt

Q9CQ48 - NUDC2_MOUSE

Protein

NudC domain-containing protein 2

Gene

Nudcd2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NudC domain-containing protein 2
    Gene namesi
    Name:Nudcd2
    Synonyms:D11Ertd603e
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1277103. Nudcd2.

    Subcellular locationi

    Chromosomecentromerekinetochore By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Cytoplasmcytoskeletonspindle pole By similarity
    Note: Associates with centrosomes in interphase and to spindle poles and kinetochores during mitosis.By similarity

    GO - Cellular componenti

    1. condensed chromosome kinetochore Source: UniProtKB-SubCell
    2. cytoplasm Source: UniProtKB-KW
    3. microtubule organizing center Source: UniProtKB-SubCell
    4. spindle pole Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 157156NudC domain-containing protein 2PRO_0000057983Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity
    Modified residuei145 – 1451Phosphotyrosine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9CQ48.
    PaxDbiQ9CQ48.
    PRIDEiQ9CQ48.

    PTM databases

    PhosphoSiteiQ9CQ48.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9CQ48.
    BgeeiQ9CQ48.
    CleanExiMM_NUDCD2.
    GenevestigatoriQ9CQ48.

    Interactioni

    Subunit structurei

    Interacts with LIS1.By similarity

    Protein-protein interaction databases

    IntActiQ9CQ48. 1 interaction.

    Structurei

    Secondary structure

    1
    157
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi6 – 83
    Beta strandi17 – 237
    Beta strandi25 – 339
    Helixi40 – 423
    Beta strandi43 – 475
    Beta strandi49 – 568
    Beta strandi59 – 6810
    Helixi72 – 743
    Beta strandi76 – 805
    Beta strandi84 – 9310
    Beta strandi101 – 1044
    Beta strandi107 – 1093
    Helixi112 – 13019

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2RH0X-ray1.95A/B/C/D5-155[»]
    ProteinModelPortaliQ9CQ48.
    SMRiQ9CQ48. Positions 5-137.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9CQ48.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini14 – 10491CSPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 CS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG319794.
    GeneTreeiENSGT00390000001644.
    HOGENOMiHOG000282991.
    HOVERGENiHBG056555.
    InParanoidiQ9CQ48.
    OMAiNREAGNC.
    OrthoDBiEOG7KH9N4.
    PhylomeDBiQ9CQ48.
    TreeFamiTF332391.

    Family and domain databases

    Gene3Di2.60.40.790. 1 hit.
    InterProiIPR007052. CS_dom.
    IPR008978. HSP20-like_chaperone.
    [Graphical view]
    PfamiPF04969. CS. 1 hit.
    [Graphical view]
    SUPFAMiSSF49764. SSF49764. 1 hit.
    PROSITEiPS51203. CS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9CQ48-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSAPFEERSG VVPCGTPWGQ WYQTLEEVFI EVQVPPGTRA QDIQCGLQSR    50
    HVALAVGGRE ILKGKLFDST IADEGTWTLE DRKMVRIVLT KTKRDAANCW 100
    TSLLESEYAA DPWVQDQMQR KLTLERFQKE NPGFDFSGAE ISGNYTKGGP 150
    DFSNLEK 157
    Length:157
    Mass (Da):17,660
    Last modified:June 1, 2001 - v1
    Checksum:iC7F485C957893803
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti9 – 91S → R in BAB23283. (PubMed:16141072)Curated
    Sequence conflicti9 – 91S → R in BAB27222. (PubMed:16141072)Curated
    Sequence conflicti21 – 211W → R in BAC27545. (PubMed:16141072)Curated
    Sequence conflicti150 – 1501P → T in BAB23283. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK004388 mRNA. Translation: BAB23283.1.
    AK005909 mRNA. Translation: BAB24313.1.
    AK010850 mRNA. Translation: BAB27222.1.
    AK012388 mRNA. Translation: BAB28205.1.
    AK031779 mRNA. Translation: BAC27545.1.
    AL646055 Genomic DNA. Translation: CAI25426.1.
    BC005646 mRNA. Translation: AAH05646.1.
    CCDSiCCDS24549.1.
    RefSeqiNP_001277626.1. NM_001290697.1.
    NP_080299.4. NM_026023.5.
    UniGeneiMm.276504.

    Genome annotation databases

    EnsembliENSMUST00000020578; ENSMUSP00000020578; ENSMUSG00000020328.
    GeneIDi52653.
    KEGGimmu:52653.
    UCSCiuc007ily.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK004388 mRNA. Translation: BAB23283.1 .
    AK005909 mRNA. Translation: BAB24313.1 .
    AK010850 mRNA. Translation: BAB27222.1 .
    AK012388 mRNA. Translation: BAB28205.1 .
    AK031779 mRNA. Translation: BAC27545.1 .
    AL646055 Genomic DNA. Translation: CAI25426.1 .
    BC005646 mRNA. Translation: AAH05646.1 .
    CCDSi CCDS24549.1.
    RefSeqi NP_001277626.1. NM_001290697.1.
    NP_080299.4. NM_026023.5.
    UniGenei Mm.276504.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2RH0 X-ray 1.95 A/B/C/D 5-155 [» ]
    ProteinModelPortali Q9CQ48.
    SMRi Q9CQ48. Positions 5-137.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9CQ48. 1 interaction.

    PTM databases

    PhosphoSitei Q9CQ48.

    Proteomic databases

    MaxQBi Q9CQ48.
    PaxDbi Q9CQ48.
    PRIDEi Q9CQ48.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000020578 ; ENSMUSP00000020578 ; ENSMUSG00000020328 .
    GeneIDi 52653.
    KEGGi mmu:52653.
    UCSCi uc007ily.2. mouse.

    Organism-specific databases

    CTDi 134492.
    MGIi MGI:1277103. Nudcd2.

    Phylogenomic databases

    eggNOGi NOG319794.
    GeneTreei ENSGT00390000001644.
    HOGENOMi HOG000282991.
    HOVERGENi HBG056555.
    InParanoidi Q9CQ48.
    OMAi NREAGNC.
    OrthoDBi EOG7KH9N4.
    PhylomeDBi Q9CQ48.
    TreeFami TF332391.

    Miscellaneous databases

    EvolutionaryTracei Q9CQ48.
    NextBioi 309279.
    PROi Q9CQ48.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9CQ48.
    Bgeei Q9CQ48.
    CleanExi MM_NUDCD2.
    Genevestigatori Q9CQ48.

    Family and domain databases

    Gene3Di 2.60.40.790. 1 hit.
    InterProi IPR007052. CS_dom.
    IPR008978. HSP20-like_chaperone.
    [Graphical view ]
    Pfami PF04969. CS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49764. SSF49764. 1 hit.
    PROSITEi PS51203. CS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo, Head, Liver and Testis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.
    4. "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
      Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
      J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-145, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Mast cell.
    5. "Crystal structure of NUDC domain-containing protein 2 (13542905) from Mus musculus at 1.95 A resolution."
      Joint center for structural genomics (JCSG)
      Submitted (FEB-2009) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 5-155.

    Entry informationi

    Entry nameiNUDC2_MOUSE
    AccessioniPrimary (citable) accession number: Q9CQ48
    Secondary accession number(s): Q8CD03, Q9CY63, Q9D0V4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2005
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3