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Protein

NudC domain-containing protein 2

Gene

Nudcd2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
NudC domain-containing protein 2
Gene namesi
Name:Nudcd2
Synonyms:D11Ertd603e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1277103. Nudcd2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000579832 – 157NudC domain-containing protein 2Add BLAST156

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei142PhosphoserineBy similarity1
Modified residuei145PhosphotyrosineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9CQ48.
MaxQBiQ9CQ48.
PaxDbiQ9CQ48.
PeptideAtlasiQ9CQ48.
PRIDEiQ9CQ48.

PTM databases

iPTMnetiQ9CQ48.
PhosphoSitePlusiQ9CQ48.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020328.
CleanExiMM_NUDCD2.
ExpressionAtlasiQ9CQ48. baseline and differential.
GenevisibleiQ9CQ48. MM.

Interactioni

Subunit structurei

Interacts with LIS1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9CQ48. 1 interactor.
STRINGi10090.ENSMUSP00000020578.

Structurei

Secondary structure

1157
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 8Combined sources3
Beta strandi17 – 23Combined sources7
Beta strandi25 – 33Combined sources9
Helixi40 – 42Combined sources3
Beta strandi43 – 47Combined sources5
Beta strandi49 – 56Combined sources8
Beta strandi59 – 68Combined sources10
Helixi72 – 74Combined sources3
Beta strandi76 – 80Combined sources5
Beta strandi84 – 93Combined sources10
Beta strandi101 – 104Combined sources4
Beta strandi107 – 109Combined sources3
Helixi112 – 130Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RH0X-ray1.95A/B/C/D5-155[»]
ProteinModelPortaliQ9CQ48.
SMRiQ9CQ48.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9CQ48.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 104CSPROSITE-ProRule annotationAdd BLAST91

Sequence similaritiesi

Contains 1 CS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2265. Eukaryota.
ENOG410XQVU. LUCA.
GeneTreeiENSGT00390000001644.
HOGENOMiHOG000282991.
HOVERGENiHBG056555.
InParanoidiQ9CQ48.
OMAiNREAGNC.
OrthoDBiEOG091G0OQY.
PhylomeDBiQ9CQ48.
TreeFamiTF332391.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR007052. CS_dom.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PfamiPF04969. CS. 1 hit.
[Graphical view]
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS51203. CS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CQ48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAPFEERSG VVPCGTPWGQ WYQTLEEVFI EVQVPPGTRA QDIQCGLQSR
60 70 80 90 100
HVALAVGGRE ILKGKLFDST IADEGTWTLE DRKMVRIVLT KTKRDAANCW
110 120 130 140 150
TSLLESEYAA DPWVQDQMQR KLTLERFQKE NPGFDFSGAE ISGNYTKGGP

DFSNLEK
Length:157
Mass (Da):17,660
Last modified:June 1, 2001 - v1
Checksum:iC7F485C957893803
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9S → R in BAB23283 (PubMed:16141072).Curated1
Sequence conflicti9S → R in BAB27222 (PubMed:16141072).Curated1
Sequence conflicti21W → R in BAC27545 (PubMed:16141072).Curated1
Sequence conflicti150P → T in BAB23283 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004388 mRNA. Translation: BAB23283.1.
AK005909 mRNA. Translation: BAB24313.1.
AK010850 mRNA. Translation: BAB27222.1.
AK012388 mRNA. Translation: BAB28205.1.
AK031779 mRNA. Translation: BAC27545.1.
AL646055 Genomic DNA. Translation: CAI25426.1.
BC005646 mRNA. Translation: AAH05646.1.
CCDSiCCDS24549.1.
RefSeqiNP_001277626.1. NM_001290697.1.
NP_080299.4. NM_026023.5.
UniGeneiMm.276504.

Genome annotation databases

EnsembliENSMUST00000020578; ENSMUSP00000020578; ENSMUSG00000020328.
GeneIDi52653.
KEGGimmu:52653.
UCSCiuc007ily.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004388 mRNA. Translation: BAB23283.1.
AK005909 mRNA. Translation: BAB24313.1.
AK010850 mRNA. Translation: BAB27222.1.
AK012388 mRNA. Translation: BAB28205.1.
AK031779 mRNA. Translation: BAC27545.1.
AL646055 Genomic DNA. Translation: CAI25426.1.
BC005646 mRNA. Translation: AAH05646.1.
CCDSiCCDS24549.1.
RefSeqiNP_001277626.1. NM_001290697.1.
NP_080299.4. NM_026023.5.
UniGeneiMm.276504.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RH0X-ray1.95A/B/C/D5-155[»]
ProteinModelPortaliQ9CQ48.
SMRiQ9CQ48.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9CQ48. 1 interactor.
STRINGi10090.ENSMUSP00000020578.

PTM databases

iPTMnetiQ9CQ48.
PhosphoSitePlusiQ9CQ48.

Proteomic databases

EPDiQ9CQ48.
MaxQBiQ9CQ48.
PaxDbiQ9CQ48.
PeptideAtlasiQ9CQ48.
PRIDEiQ9CQ48.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020578; ENSMUSP00000020578; ENSMUSG00000020328.
GeneIDi52653.
KEGGimmu:52653.
UCSCiuc007ily.3. mouse.

Organism-specific databases

CTDi134492.
MGIiMGI:1277103. Nudcd2.

Phylogenomic databases

eggNOGiKOG2265. Eukaryota.
ENOG410XQVU. LUCA.
GeneTreeiENSGT00390000001644.
HOGENOMiHOG000282991.
HOVERGENiHBG056555.
InParanoidiQ9CQ48.
OMAiNREAGNC.
OrthoDBiEOG091G0OQY.
PhylomeDBiQ9CQ48.
TreeFamiTF332391.

Miscellaneous databases

EvolutionaryTraceiQ9CQ48.
PROiQ9CQ48.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020328.
CleanExiMM_NUDCD2.
ExpressionAtlasiQ9CQ48. baseline and differential.
GenevisibleiQ9CQ48. MM.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR007052. CS_dom.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PfamiPF04969. CS. 1 hit.
[Graphical view]
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS51203. CS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNUDC2_MOUSE
AccessioniPrimary (citable) accession number: Q9CQ48
Secondary accession number(s): Q8CD03, Q9CY63, Q9D0V4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.