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Protein

NudC domain-containing protein 2

Gene

Nudcd2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
NudC domain-containing protein 2
Gene namesi
Name:Nudcd2
Synonyms:D11Ertd603e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1277103. Nudcd2.

Subcellular locationi

Chromosomecentromerekinetochore By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Cytoplasmcytoskeletonspindle pole By similarity
Note: Associates with centrosomes in interphase and to spindle poles and kinetochores during mitosis.By similarity

GO - Cellular componenti

  1. condensed chromosome kinetochore Source: UniProtKB-SubCell
  2. cytoplasm Source: MGI
  3. extracellular vesicular exosome Source: MGI
  4. intracellular Source: MGI
  5. microtubule cytoskeleton Source: MGI
  6. microtubule organizing center Source: UniProtKB-SubCell
  7. spindle pole Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 157156NudC domain-containing protein 2PRO_0000057983Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei145 – 1451Phosphotyrosine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9CQ48.
PaxDbiQ9CQ48.
PRIDEiQ9CQ48.

PTM databases

PhosphoSiteiQ9CQ48.

Expressioni

Gene expression databases

BgeeiQ9CQ48.
CleanExiMM_NUDCD2.
ExpressionAtlasiQ9CQ48. baseline and differential.
GenevestigatoriQ9CQ48.

Interactioni

Subunit structurei

Interacts with LIS1.By similarity

Protein-protein interaction databases

IntActiQ9CQ48. 1 interaction.

Structurei

Secondary structure

1
157
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 83Combined sources
Beta strandi17 – 237Combined sources
Beta strandi25 – 339Combined sources
Helixi40 – 423Combined sources
Beta strandi43 – 475Combined sources
Beta strandi49 – 568Combined sources
Beta strandi59 – 6810Combined sources
Helixi72 – 743Combined sources
Beta strandi76 – 805Combined sources
Beta strandi84 – 9310Combined sources
Beta strandi101 – 1044Combined sources
Beta strandi107 – 1093Combined sources
Helixi112 – 13019Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2RH0X-ray1.95A/B/C/D5-155[»]
ProteinModelPortaliQ9CQ48.
SMRiQ9CQ48. Positions 5-137.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9CQ48.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 10491CSPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 CS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG319794.
GeneTreeiENSGT00390000001644.
HOGENOMiHOG000282991.
HOVERGENiHBG056555.
InParanoidiQ9CQ48.
OMAiNREAGNC.
OrthoDBiEOG7KH9N4.
PhylomeDBiQ9CQ48.
TreeFamiTF332391.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR007052. CS_dom.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PfamiPF04969. CS. 1 hit.
[Graphical view]
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS51203. CS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CQ48-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSAPFEERSG VVPCGTPWGQ WYQTLEEVFI EVQVPPGTRA QDIQCGLQSR
60 70 80 90 100
HVALAVGGRE ILKGKLFDST IADEGTWTLE DRKMVRIVLT KTKRDAANCW
110 120 130 140 150
TSLLESEYAA DPWVQDQMQR KLTLERFQKE NPGFDFSGAE ISGNYTKGGP

DFSNLEK
Length:157
Mass (Da):17,660
Last modified:June 1, 2001 - v1
Checksum:iC7F485C957893803
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91S → R in BAB23283. (PubMed:16141072)Curated
Sequence conflicti9 – 91S → R in BAB27222. (PubMed:16141072)Curated
Sequence conflicti21 – 211W → R in BAC27545. (PubMed:16141072)Curated
Sequence conflicti150 – 1501P → T in BAB23283. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004388 mRNA. Translation: BAB23283.1.
AK005909 mRNA. Translation: BAB24313.1.
AK010850 mRNA. Translation: BAB27222.1.
AK012388 mRNA. Translation: BAB28205.1.
AK031779 mRNA. Translation: BAC27545.1.
AL646055 Genomic DNA. Translation: CAI25426.1.
BC005646 mRNA. Translation: AAH05646.1.
CCDSiCCDS24549.1.
RefSeqiNP_001277626.1. NM_001290697.1.
NP_080299.4. NM_026023.5.
UniGeneiMm.276504.

Genome annotation databases

EnsembliENSMUST00000020578; ENSMUSP00000020578; ENSMUSG00000020328.
GeneIDi52653.
KEGGimmu:52653.
UCSCiuc007ily.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004388 mRNA. Translation: BAB23283.1.
AK005909 mRNA. Translation: BAB24313.1.
AK010850 mRNA. Translation: BAB27222.1.
AK012388 mRNA. Translation: BAB28205.1.
AK031779 mRNA. Translation: BAC27545.1.
AL646055 Genomic DNA. Translation: CAI25426.1.
BC005646 mRNA. Translation: AAH05646.1.
CCDSiCCDS24549.1.
RefSeqiNP_001277626.1. NM_001290697.1.
NP_080299.4. NM_026023.5.
UniGeneiMm.276504.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2RH0X-ray1.95A/B/C/D5-155[»]
ProteinModelPortaliQ9CQ48.
SMRiQ9CQ48. Positions 5-137.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9CQ48. 1 interaction.

PTM databases

PhosphoSiteiQ9CQ48.

Proteomic databases

MaxQBiQ9CQ48.
PaxDbiQ9CQ48.
PRIDEiQ9CQ48.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020578; ENSMUSP00000020578; ENSMUSG00000020328.
GeneIDi52653.
KEGGimmu:52653.
UCSCiuc007ily.2. mouse.

Organism-specific databases

CTDi134492.
MGIiMGI:1277103. Nudcd2.

Phylogenomic databases

eggNOGiNOG319794.
GeneTreeiENSGT00390000001644.
HOGENOMiHOG000282991.
HOVERGENiHBG056555.
InParanoidiQ9CQ48.
OMAiNREAGNC.
OrthoDBiEOG7KH9N4.
PhylomeDBiQ9CQ48.
TreeFamiTF332391.

Miscellaneous databases

EvolutionaryTraceiQ9CQ48.
NextBioi309279.
PROiQ9CQ48.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CQ48.
CleanExiMM_NUDCD2.
ExpressionAtlasiQ9CQ48. baseline and differential.
GenevestigatoriQ9CQ48.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR007052. CS_dom.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PfamiPF04969. CS. 1 hit.
[Graphical view]
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS51203. CS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo, Head, Liver and Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  4. "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
    Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
    J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-145, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Mast cell.
  5. "Crystal structure of NUDC domain-containing protein 2 (13542905) from Mus musculus at 1.95 A resolution."
    Joint center for structural genomics (JCSG)
    Submitted (FEB-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 5-155.

Entry informationi

Entry nameiNUDC2_MOUSE
AccessioniPrimary (citable) accession number: Q9CQ48
Secondary accession number(s): Q8CD03, Q9CY63, Q9D0V4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 1, 2001
Last modified: February 4, 2015
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.