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Q9CQ48 (NUDC2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NudC domain-containing protein 2
Gene names
Name:Nudcd2
Synonyms:D11Ertd603e
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length157 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone By similarity.

Subunit structure

Interacts with LIS1 By similarity.

Subcellular location

Chromosomecentromerekinetochore By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Cytoplasmcytoskeletonspindle pole By similarity. Note: Associates with centrosomes in interphase and to spindle poles and kinetochores during mitosis By similarity.

Sequence similarities

Contains 1 CS domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 157156NudC domain-containing protein 2
PRO_0000057983

Regions

Domain14 – 10491CS

Amino acid modifications

Modified residue21N-acetylserine By similarity
Modified residue1451Phosphotyrosine Ref.4

Experimental info

Sequence conflict91S → R in BAB23283. Ref.1
Sequence conflict91S → R in BAB27222. Ref.1
Sequence conflict211W → R in BAC27545. Ref.1
Sequence conflict1501P → T in BAB23283. Ref.1

Secondary structure

.......................... 157
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9CQ48 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: C7F485C957893803

FASTA15717,660
        10         20         30         40         50         60 
MSAPFEERSG VVPCGTPWGQ WYQTLEEVFI EVQVPPGTRA QDIQCGLQSR HVALAVGGRE 

        70         80         90        100        110        120 
ILKGKLFDST IADEGTWTLE DRKMVRIVLT KTKRDAANCW TSLLESEYAA DPWVQDQMQR 

       130        140        150 
KLTLERFQKE NPGFDFSGAE ISGNYTKGGP DFSNLEK 

« Hide

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Embryo, Head, Liver and Testis.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary tumor.
[4]"Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-145, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Mast cell.
[5]"Crystal structure of NUDC domain-containing protein 2 (13542905) from Mus musculus at 1.95 A resolution."
Joint center for structural genomics (JCSG)
Submitted (FEB-2009) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 5-155.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK004388 mRNA. Translation: BAB23283.1.
AK005909 mRNA. Translation: BAB24313.1.
AK010850 mRNA. Translation: BAB27222.1.
AK012388 mRNA. Translation: BAB28205.1.
AK031779 mRNA. Translation: BAC27545.1.
AL646055 Genomic DNA. Translation: CAI25426.1.
BC005646 mRNA. Translation: AAH05646.1.
CCDSCCDS24549.1.
RefSeqNP_001277626.1. NM_001290697.1.
NP_080299.4. NM_026023.5.
UniGeneMm.276504.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2RH0X-ray1.95A/B/C/D5-155[»]
ProteinModelPortalQ9CQ48.
SMRQ9CQ48. Positions 5-137.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9CQ48. 1 interaction.

PTM databases

PhosphoSiteQ9CQ48.

Proteomic databases

MaxQBQ9CQ48.
PaxDbQ9CQ48.
PRIDEQ9CQ48.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000020578; ENSMUSP00000020578; ENSMUSG00000020328.
GeneID52653.
KEGGmmu:52653.
UCSCuc007ily.2. mouse.

Organism-specific databases

CTD134492.
MGIMGI:1277103. Nudcd2.

Phylogenomic databases

eggNOGNOG319794.
GeneTreeENSGT00390000001644.
HOGENOMHOG000282991.
HOVERGENHBG056555.
InParanoidQ9CQ48.
OMANREAGNC.
OrthoDBEOG7KH9N4.
PhylomeDBQ9CQ48.
TreeFamTF332391.

Gene expression databases

ArrayExpressQ9CQ48.
BgeeQ9CQ48.
CleanExMM_NUDCD2.
GenevestigatorQ9CQ48.

Family and domain databases

Gene3D2.60.40.790. 1 hit.
InterProIPR007052. CS_dom.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PfamPF04969. CS. 1 hit.
[Graphical view]
SUPFAMSSF49764. SSF49764. 1 hit.
PROSITEPS51203. CS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ9CQ48.
NextBio309279.
PROQ9CQ48.
SOURCESearch...

Entry information

Entry nameNUDC2_MOUSE
AccessionPrimary (citable) accession number: Q9CQ48
Secondary accession number(s): Q8CD03, Q9CY63, Q9D0V4
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot