Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mediator of RNA polymerase II transcription subunit 21

Gene

Med21

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • blastocyst development Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • protein ubiquitination Source: MGI
  • stem cell population maintenance Source: MGI
  • transcription by RNA polymerase II Source: MGI

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 21
Alternative name(s):
Mediator complex subunit 21
RNA polymerase II holoenzyme component SRB7
Short name:
RNAPII complex component SRB7
Gene namesi
Name:Med21
Synonyms:Srb7, Surb7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1347064 Med21

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003059471 – 144Mediator of RNA polymerase II transcription subunit 21Add BLAST144

Proteomic databases

EPDiQ9CQ39
MaxQBiQ9CQ39
PaxDbiQ9CQ39
PeptideAtlasiQ9CQ39
PRIDEiQ9CQ39

PTM databases

iPTMnetiQ9CQ39
PhosphoSitePlusiQ9CQ39

Expressioni

Tissue specificityi

Expressed in brain, heart, kidney, liver, lung, skeletal muscles, spleen and testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000030291
CleanExiMM_MED21
ExpressionAtlasiQ9CQ39 baseline and differential
GenevisibleiQ9CQ39 MM

Interactioni

Subunit structurei

Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with THRA in a ligand-dependent fashion (By similarity). Interacts with PPARG.By similarity1 Publication

Protein-protein interaction databases

BioGridi223831, 8 interactors
ComplexPortaliCPX-3264 Core mediator complex
CORUMiQ9CQ39
DIPiDIP-59522N
IntActiQ9CQ39, 5 interactors
MINTiQ9CQ39
STRINGi10090.ENSMUSP00000032429

Structurei

3D structure databases

ProteinModelPortaliQ9CQ39
SMRiQ9CQ39
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Mediator complex subunit 21 family.Curated

Phylogenomic databases

eggNOGiKOG1510 Eukaryota
ENOG4111I75 LUCA
GeneTreeiENSGT00390000014557
HOGENOMiHOG000006767
HOVERGENiHBG009229
InParanoidiQ9CQ39
KOiK15152
OMAiCNSVGIL
OrthoDBiEOG091G11IM
PhylomeDBiQ9CQ39

Family and domain databases

InterProiView protein in InterPro
IPR037212 Med7/Med21-like
IPR021384 Mediator_Med21
PANTHERiPTHR13381 PTHR13381, 1 hit
PfamiView protein in Pfam
PF11221 Med21, 1 hit
SUPFAMiSSF140718 SSF140718, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CQ39-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADRLTQLQD AVNSLADQFC NAIGVLQQCG PPASFSNIQT AINKDQPANP
60 70 80 90 100
TEEYAQLFAA LIARTAKDID VLIDSLPSEE STAALQAASL YKLEEENHEA
110 120 130 140
ATCLEDVVYR GDMLLEKIQS ALADIAQSQL KTRSVTHSHS LPDS
Length:144
Mass (Da):15,588
Last modified:June 1, 2001 - v1
Checksum:iCCFEA1DF0B6B53AC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti137H → R in AAH12286 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009742 mRNA Translation: BAB26472.1
AK012217 mRNA Translation: BAB28104.1
AK014428 mRNA Translation: BAB29343.1
AK019417 mRNA Translation: BAB31711.1
BC012286 mRNA Translation: AAH12286.1
CCDSiCCDS20700.1
RefSeqiNP_079591.1, NM_025315.3
UniGeneiMm.26212

Genome annotation databases

EnsembliENSMUST00000032429; ENSMUSP00000032429; ENSMUSG00000030291
ENSMUST00000204040; ENSMUSP00000145512; ENSMUSG00000030291
GeneIDi108098
KEGGimmu:108098
UCSCiuc009esg.1 mouse

Similar proteinsi

Entry informationi

Entry nameiMED21_MOUSE
AccessioniPrimary (citable) accession number: Q9CQ39
Secondary accession number(s): Q921I5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: June 1, 2001
Last modified: June 20, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health