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Protein

DNA polymerase epsilon subunit 4

Gene

Pole4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in allowing polymerase epsilon to carry out its replication and/or repair function.

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-174430. Telomere C-strand synthesis initiation.
R-MMU-68952. DNA replication initiation.
R-MMU-68962. Activation of the pre-replicative complex.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase epsilon subunit 4 (EC:2.7.7.7)
Alternative name(s):
DNA polymerase II subunit 4
DNA polymerase epsilon subunit p12
Gene namesi
Name:Pole4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1914229. Pole4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001917472 – 118DNA polymerase epsilon subunit 4Add BLAST117

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei11PhosphothreonineBy similarity1
Modified residuei25PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9CQ36.
PaxDbiQ9CQ36.
PRIDEiQ9CQ36.

2D gel databases

REPRODUCTION-2DPAGEQ9CQ36.

PTM databases

iPTMnetiQ9CQ36.
PhosphoSitePlusiQ9CQ36.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030042.
ExpressionAtlasiQ9CQ36. baseline and differential.
GenevisibleiQ9CQ36. MM.

Interactioni

Subunit structurei

Component of the epsilon DNA polymerase complex consisting of four subunits: POLE, POLE2, POLE3 and POLE4. Interaction with POLE3 is a prerequisite for further binding with POLE and POLE2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093462.

Structurei

3D structure databases

ProteinModelPortaliQ9CQ36.
SMRiQ9CQ36.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG1658. Eukaryota.
ENOG41122NU. LUCA.
GeneTreeiENSGT00530000063560.
HOGENOMiHOG000007271.
HOVERGENiHBG051399.
InParanoidiQ9CQ36.
KOiK03506.
PhylomeDBiQ9CQ36.
TreeFamiTF103009.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR003958. CBFA_NFYB_domain.
IPR009072. Histone-fold.
[Graphical view]
PfamiPF00808. CBFD_NFYB_HMF. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CQ36-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAAAGSG TPREEEAPGG EAAASQAQAP TSAPGGVRLS RLPLARVKAL
60 70 80 90 100
VKADPDVTLA GQEAIFILAR AAELFVETIA KDAYCCAQQG KRKTLQRRDL
110
DNAIEAVDEF AFLEGTLD
Length:118
Mass (Da):12,240
Last modified:June 1, 2001 - v1
Checksum:iCE6B47CD7BC93A09
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010135 mRNA. Translation: BAB26722.1.
AK010300 mRNA. Translation: BAB26833.1.
AK011595 mRNA. Translation: BAB27723.1.
AK160582 mRNA. Translation: BAE35889.1.
AK167631 mRNA. Translation: BAE39682.1.
BC023189 mRNA. Translation: AAH23189.1.
CCDSiCCDS39524.1.
RefSeqiNP_080158.1. NM_025882.3.
UniGeneiMm.195753.

Genome annotation databases

EnsembliENSMUST00000095786; ENSMUSP00000093462; ENSMUSG00000030042.
GeneIDi66979.
KEGGimmu:66979.
UCSCiuc009clk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010135 mRNA. Translation: BAB26722.1.
AK010300 mRNA. Translation: BAB26833.1.
AK011595 mRNA. Translation: BAB27723.1.
AK160582 mRNA. Translation: BAE35889.1.
AK167631 mRNA. Translation: BAE39682.1.
BC023189 mRNA. Translation: AAH23189.1.
CCDSiCCDS39524.1.
RefSeqiNP_080158.1. NM_025882.3.
UniGeneiMm.195753.

3D structure databases

ProteinModelPortaliQ9CQ36.
SMRiQ9CQ36.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093462.

PTM databases

iPTMnetiQ9CQ36.
PhosphoSitePlusiQ9CQ36.

2D gel databases

REPRODUCTION-2DPAGEQ9CQ36.

Proteomic databases

EPDiQ9CQ36.
PaxDbiQ9CQ36.
PRIDEiQ9CQ36.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000095786; ENSMUSP00000093462; ENSMUSG00000030042.
GeneIDi66979.
KEGGimmu:66979.
UCSCiuc009clk.1. mouse.

Organism-specific databases

CTDi56655.
MGIiMGI:1914229. Pole4.

Phylogenomic databases

eggNOGiKOG1658. Eukaryota.
ENOG41122NU. LUCA.
GeneTreeiENSGT00530000063560.
HOGENOMiHOG000007271.
HOVERGENiHBG051399.
InParanoidiQ9CQ36.
KOiK03506.
PhylomeDBiQ9CQ36.
TreeFamiTF103009.

Enzyme and pathway databases

ReactomeiR-MMU-174430. Telomere C-strand synthesis initiation.
R-MMU-68952. DNA replication initiation.
R-MMU-68962. Activation of the pre-replicative complex.

Miscellaneous databases

ChiTaRSiPole4. mouse.
PROiQ9CQ36.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030042.
ExpressionAtlasiQ9CQ36. baseline and differential.
GenevisibleiQ9CQ36. MM.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR003958. CBFA_NFYB_domain.
IPR009072. Histone-fold.
[Graphical view]
PfamiPF00808. CBFD_NFYB_HMF. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDPOE4_MOUSE
AccessioniPrimary (citable) accession number: Q9CQ36
Secondary accession number(s): Q3TJ13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.