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Q9CQ33 (LZTR1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine-zipper-like transcriptional regulator 1

Short name=LZTR-1
Gene names
Name:Lztr1
Synonyms:Tcfl2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length837 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable transcriptional regulator that may play a crucial role in embryogenesis By similarity.

Sequence similarities

Contains 2 BTB (POZ) domains.

Contains 6 Kelch repeats.

Sequence caution

The sequence BAC40662.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   DomainKelch repeat
Repeat
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9CQ33-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9CQ33-2)

The sequence of this isoform differs from the canonical sequence as follows:
     800-837: VSKLPTLRLL...KQCAELGADI → VRLWPQCSRS...RSLSCPRCGC
Note: May result from the retention of an intron in the cDNA in position 800. No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 837836Leucine-zipper-like transcriptional regulator 1
PRO_0000119136

Regions

Repeat76 – 12550Kelch 1
Repeat127 – 18256Kelch 2
Repeat184 – 23552Kelch 3
Repeat236 – 28247Kelch 4
Repeat292 – 33847Kelch 5
Repeat396 – 44752Kelch 6
Domain440 – 53495BTB 1
Domain664 – 73370BTB 2

Amino acid modifications

Modified residue21N-acetylalanine By similarity

Natural variations

Alternative sequence800 – 83738VSKLP…LGADI → VRLWPQCSRSQLSPAGLGTS WPLSTILRQPRPEQARPQED SSAHPGRLVSSSFGHLCRSL SCPRCGC in isoform 2.
VSP_007170

Experimental info

Sequence conflict3301Missing in AAH34400. Ref.2
Sequence conflict3751V → A in AAH34400. Ref.2
Sequence conflict4951G → S in AAH34400. Ref.2
Sequence conflict5451M → V in BAC38905. Ref.1
Sequence conflict7071I → M in BAC40662. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 11, 2003. Version 2.
Checksum: 7E714AE48C4E2D63

FASTA83794,476
        10         20         30         40         50         60 
MAGSGGPIGS GALTGGVRSK VAPSVDFDHS CSDSVEYLTL NFGPFETVHR WRRLPPCDEF 

        70         80         90        100        110        120 
VGARRSKHTV VAYKDAIYVF GGDNGKTMLN DLLRFDVKDC SWCRAFTTGT PPAPRYHHSA 

       130        140        150        160        170        180 
VVYGSSMFVF GGYTGDIYSN SNLKNKNDLF EYKFATGQWT EWKIEGRLPV ARSAHGATVY 

       190        200        210        220        230        240 
SDKLWIFAGY DGNARLNDMW TIGLQDRELT CWEEVAQSGE IPPSCCNFPV AVCRDKMFVF 

       250        260        270        280        290        300 
SGQSGAKITN NLFQFEFKDK TWTRIPTEHL LRGSPPPPQR RYGHTMVAFD RHLYVFGGAA 

       310        320        330        340        350        360 
DNTLPNELHC YDVDFQTWEV VQPSSDSEVG GAEMPERASS SEDASTLTSE ERSSFKKSRD 

       370        380        390        400        410        420 
VFGLDFGTTS AKQPVHLASE LPSGRLFHAA AVISDAMYIF GGTVDNNIRS GEMYRFQFSC 

       430        440        450        460        470        480 
YPKCTLHEDY GRLWEGRQFC DVEFVLGEKE ECVQGHVAIV TARSRWLRRK IVQAQEWLAQ 

       490        500        510        520        530        540 
KLEEDGALAP KEAPGPAVGR ARPPLLRVAI REAEARPFEV LMQFLYTDKI KYPRKGHVED 

       550        560        570        580        590        600 
VLLIMDVYKL ALSFQLCRLE QLCRQYIEAS VDLQNVLVVC ESAARLQLGQ LKEHCLNFIV 

       610        620        630        640        650        660 
KESHFNQVIM MKEFERLSSP LIVEIVRRKQ QPPPRTPSDQ PVDIGTSLIQ DMKAYLEGAG 

       670        680        690        700        710        720 
SEFCDITLLL DGQPRPAHKA ILAARSSYFE AMFRSFMPED GQVNISIGEM VPSRQAFESM 

       730        740        750        760        770        780 
LRYIYYGEVN MPPEDSLYLF AAPYYYGFYN NRLQAYCKQN LEMNVTVQNV LQILEAADKT 

       790        800        810        820        830 
QALDMKRHCL HIIVHQFTKV SKLPTLRLLS QQLLLDIIDS LASHISDKQC AELGADI 

« Hide

Isoform 2 [UniParc].

Checksum: 208400A53DC47358
Show »

FASTA86697,687

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6J and NOD.
Tissue: Embryo, Liver, Lung and Thymus.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: Czech II.
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK004561 mRNA. Translation: BAB23373.2.
AK005037 mRNA. Translation: BAB23764.2.
AK083411 mRNA. Translation: BAC38905.1.
AK088938 mRNA. Translation: BAC40662.1. Different initiation.
BC034400 mRNA. Translation: AAH34400.1.
CCDSCCDS37272.1. [Q9CQ33-1]
RefSeqNP_080084.2. NM_025808.3. [Q9CQ33-1]
UniGeneMm.161726.

3D structure databases

ProteinModelPortalQ9CQ33.
SMRQ9CQ33. Positions 49-321, 661-784.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid211770. 1 interaction.
MINTMINT-1342142.

PTM databases

PhosphoSiteQ9CQ33.

Proteomic databases

MaxQBQ9CQ33.
PaxDbQ9CQ33.
PRIDEQ9CQ33.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000023444; ENSMUSP00000023444; ENSMUSG00000022761. [Q9CQ33-1]
GeneID66863.
KEGGmmu:66863.
UCSCuc007yla.1. mouse. [Q9CQ33-1]
uc007ylb.1. mouse. [Q9CQ33-2]

Organism-specific databases

CTD8216.
MGIMGI:1914113. Lztr1.

Phylogenomic databases

eggNOGNOG145020.
GeneTreeENSGT00720000108564.
HOGENOMHOG000007115.
HOVERGENHBG052380.
PhylomeDBQ9CQ33.

Gene expression databases

ArrayExpressQ9CQ33.
BgeeQ9CQ33.
CleanExMM_LZTR1.
GenevestigatorQ9CQ33.

Family and domain databases

Gene3D2.120.10.80. 2 hits.
3.30.710.10. 3 hits.
InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
[Graphical view]
PfamPF00651. BTB. 2 hits.
PF01344. Kelch_1. 1 hit.
[Graphical view]
SMARTSM00225. BTB. 2 hits.
[Graphical view]
SUPFAMSSF54695. SSF54695. 4 hits.
PROSITEPS50097. BTB. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSLZTR1. mouse.
NextBio322851.
PROQ9CQ33.
SOURCESearch...

Entry information

Entry nameLZTR1_MOUSE
AccessionPrimary (citable) accession number: Q9CQ33
Entry history
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: April 11, 2003
Last modified: July 9, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot