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Q9CQ33

- LZTR1_MOUSE

UniProt

Q9CQ33 - LZTR1_MOUSE

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Protein
Leucine-zipper-like transcriptional regulator 1
Gene
Lztr1, Tcfl2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Probable transcriptional regulator that may play a crucial role in embryogenesis By similarity.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-zipper-like transcriptional regulator 1
Short name:
LZTR-1
Gene namesi
Name:Lztr1
Synonyms:Tcfl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:1914113. Lztr1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 837836Leucine-zipper-like transcriptional regulator 1
PRO_0000119136Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9CQ33.
PaxDbiQ9CQ33.
PRIDEiQ9CQ33.

PTM databases

PhosphoSiteiQ9CQ33.

Expressioni

Gene expression databases

ArrayExpressiQ9CQ33.
BgeeiQ9CQ33.
CleanExiMM_LZTR1.
GenevestigatoriQ9CQ33.

Interactioni

Protein-protein interaction databases

BioGridi211770. 1 interaction.
MINTiMINT-1342142.

Structurei

3D structure databases

ProteinModelPortaliQ9CQ33.
SMRiQ9CQ33. Positions 49-321, 661-784.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati76 – 12550Kelch 1
Add
BLAST
Repeati127 – 18256Kelch 2
Add
BLAST
Repeati184 – 23552Kelch 3
Add
BLAST
Repeati236 – 28247Kelch 4
Add
BLAST
Repeati292 – 33847Kelch 5
Add
BLAST
Repeati396 – 44752Kelch 6
Add
BLAST
Domaini440 – 53495BTB 1
Add
BLAST
Domaini664 – 73370BTB 2
Add
BLAST

Sequence similaritiesi

Contains 2 BTB (POZ) domains.
Contains 6 Kelch repeats.

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiNOG145020.
GeneTreeiENSGT00720000108564.
HOGENOMiHOG000007115.
HOVERGENiHBG052380.
PhylomeDBiQ9CQ33.

Family and domain databases

Gene3Di2.120.10.80. 2 hits.
3.30.710.10. 3 hits.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
[Graphical view]
PfamiPF00651. BTB. 2 hits.
PF01344. Kelch_1. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 2 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 4 hits.
PROSITEiPS50097. BTB. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9CQ33-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAGSGGPIGS GALTGGVRSK VAPSVDFDHS CSDSVEYLTL NFGPFETVHR    50
WRRLPPCDEF VGARRSKHTV VAYKDAIYVF GGDNGKTMLN DLLRFDVKDC 100
SWCRAFTTGT PPAPRYHHSA VVYGSSMFVF GGYTGDIYSN SNLKNKNDLF 150
EYKFATGQWT EWKIEGRLPV ARSAHGATVY SDKLWIFAGY DGNARLNDMW 200
TIGLQDRELT CWEEVAQSGE IPPSCCNFPV AVCRDKMFVF SGQSGAKITN 250
NLFQFEFKDK TWTRIPTEHL LRGSPPPPQR RYGHTMVAFD RHLYVFGGAA 300
DNTLPNELHC YDVDFQTWEV VQPSSDSEVG GAEMPERASS SEDASTLTSE 350
ERSSFKKSRD VFGLDFGTTS AKQPVHLASE LPSGRLFHAA AVISDAMYIF 400
GGTVDNNIRS GEMYRFQFSC YPKCTLHEDY GRLWEGRQFC DVEFVLGEKE 450
ECVQGHVAIV TARSRWLRRK IVQAQEWLAQ KLEEDGALAP KEAPGPAVGR 500
ARPPLLRVAI REAEARPFEV LMQFLYTDKI KYPRKGHVED VLLIMDVYKL 550
ALSFQLCRLE QLCRQYIEAS VDLQNVLVVC ESAARLQLGQ LKEHCLNFIV 600
KESHFNQVIM MKEFERLSSP LIVEIVRRKQ QPPPRTPSDQ PVDIGTSLIQ 650
DMKAYLEGAG SEFCDITLLL DGQPRPAHKA ILAARSSYFE AMFRSFMPED 700
GQVNISIGEM VPSRQAFESM LRYIYYGEVN MPPEDSLYLF AAPYYYGFYN 750
NRLQAYCKQN LEMNVTVQNV LQILEAADKT QALDMKRHCL HIIVHQFTKV 800
SKLPTLRLLS QQLLLDIIDS LASHISDKQC AELGADI 837
Length:837
Mass (Da):94,476
Last modified:April 11, 2003 - v2
Checksum:i7E714AE48C4E2D63
GO
Isoform 2 (identifier: Q9CQ33-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     800-837: VSKLPTLRLL...KQCAELGADI → VRLWPQCSRS...RSLSCPRCGC

Note: May result from the retention of an intron in the cDNA in position 800. No experimental confirmation available.

Show »
Length:866
Mass (Da):97,687
Checksum:i208400A53DC47358
GO

Sequence cautioni

The sequence BAC40662.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei800 – 83738VSKLP…LGADI → VRLWPQCSRSQLSPAGLGTS WPLSTILRQPRPEQARPQED SSAHPGRLVSSSFGHLCRSL SCPRCGC in isoform 2.
VSP_007170Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti330 – 3301Missing in AAH34400. 1 Publication
Sequence conflicti375 – 3751V → A in AAH34400. 1 Publication
Sequence conflicti495 – 4951G → S in AAH34400. 1 Publication
Sequence conflicti545 – 5451M → V in BAC38905. 1 Publication
Sequence conflicti707 – 7071I → M in BAC40662. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK004561 mRNA. Translation: BAB23373.2.
AK005037 mRNA. Translation: BAB23764.2.
AK083411 mRNA. Translation: BAC38905.1.
AK088938 mRNA. Translation: BAC40662.1. Different initiation.
BC034400 mRNA. Translation: AAH34400.1.
CCDSiCCDS37272.1. [Q9CQ33-1]
RefSeqiNP_080084.2. NM_025808.3. [Q9CQ33-1]
UniGeneiMm.161726.

Genome annotation databases

EnsembliENSMUST00000023444; ENSMUSP00000023444; ENSMUSG00000022761. [Q9CQ33-1]
GeneIDi66863.
KEGGimmu:66863.
UCSCiuc007yla.1. mouse. [Q9CQ33-1]
uc007ylb.1. mouse. [Q9CQ33-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK004561 mRNA. Translation: BAB23373.2 .
AK005037 mRNA. Translation: BAB23764.2 .
AK083411 mRNA. Translation: BAC38905.1 .
AK088938 mRNA. Translation: BAC40662.1 . Different initiation.
BC034400 mRNA. Translation: AAH34400.1 .
CCDSi CCDS37272.1. [Q9CQ33-1 ]
RefSeqi NP_080084.2. NM_025808.3. [Q9CQ33-1 ]
UniGenei Mm.161726.

3D structure databases

ProteinModelPortali Q9CQ33.
SMRi Q9CQ33. Positions 49-321, 661-784.
ModBasei Search...

Protein-protein interaction databases

BioGridi 211770. 1 interaction.
MINTi MINT-1342142.

PTM databases

PhosphoSitei Q9CQ33.

Proteomic databases

MaxQBi Q9CQ33.
PaxDbi Q9CQ33.
PRIDEi Q9CQ33.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000023444 ; ENSMUSP00000023444 ; ENSMUSG00000022761 . [Q9CQ33-1 ]
GeneIDi 66863.
KEGGi mmu:66863.
UCSCi uc007yla.1. mouse. [Q9CQ33-1 ]
uc007ylb.1. mouse. [Q9CQ33-2 ]

Organism-specific databases

CTDi 8216.
MGIi MGI:1914113. Lztr1.

Phylogenomic databases

eggNOGi NOG145020.
GeneTreei ENSGT00720000108564.
HOGENOMi HOG000007115.
HOVERGENi HBG052380.
PhylomeDBi Q9CQ33.

Miscellaneous databases

ChiTaRSi LZTR1. mouse.
NextBioi 322851.
PROi Q9CQ33.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9CQ33.
Bgeei Q9CQ33.
CleanExi MM_LZTR1.
Genevestigatori Q9CQ33.

Family and domain databases

Gene3Di 2.120.10.80. 2 hits.
3.30.710.10. 3 hits.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
[Graphical view ]
Pfami PF00651. BTB. 2 hits.
PF01344. Kelch_1. 1 hit.
[Graphical view ]
SMARTi SM00225. BTB. 2 hits.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 4 hits.
PROSITEi PS50097. BTB. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J and NOD.
    Tissue: Embryo, Liver, Lung and Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: Czech II.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiLZTR1_MOUSE
AccessioniPrimary (citable) accession number: Q9CQ33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: April 11, 2003
Last modified: July 9, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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