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Q9CQ33

- LZTR1_MOUSE

UniProt

Q9CQ33 - LZTR1_MOUSE

Protein

Leucine-zipper-like transcriptional regulator 1

Gene

Lztr1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 2 (11 Apr 2003)
      Previous versions | rss
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    Functioni

    Probable transcriptional regulator that may play a crucial role in embryogenesis.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine-zipper-like transcriptional regulator 1
    Short name:
    LZTR-1
    Gene namesi
    Name:Lztr1
    Synonyms:Tcfl2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:1914113. Lztr1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 837836Leucine-zipper-like transcriptional regulator 1PRO_0000119136Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9CQ33.
    PaxDbiQ9CQ33.
    PRIDEiQ9CQ33.

    PTM databases

    PhosphoSiteiQ9CQ33.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9CQ33.
    BgeeiQ9CQ33.
    CleanExiMM_LZTR1.
    GenevestigatoriQ9CQ33.

    Interactioni

    Protein-protein interaction databases

    BioGridi211770. 1 interaction.
    MINTiMINT-1342142.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CQ33.
    SMRiQ9CQ33. Positions 49-321, 661-784.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati76 – 12550Kelch 1Add
    BLAST
    Repeati127 – 18256Kelch 2Add
    BLAST
    Repeati184 – 23552Kelch 3Add
    BLAST
    Repeati236 – 28247Kelch 4Add
    BLAST
    Repeati292 – 33847Kelch 5Add
    BLAST
    Repeati396 – 44752Kelch 6Add
    BLAST
    Domaini440 – 53495BTB 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini664 – 73370BTB 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 BTB (POZ) domains.PROSITE-ProRule annotation
    Contains 6 Kelch repeats.Curated

    Keywords - Domaini

    Kelch repeat, Repeat

    Phylogenomic databases

    eggNOGiNOG145020.
    GeneTreeiENSGT00720000108564.
    HOGENOMiHOG000007115.
    HOVERGENiHBG052380.
    PhylomeDBiQ9CQ33.

    Family and domain databases

    Gene3Di2.120.10.80. 2 hits.
    3.30.710.10. 3 hits.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR015915. Kelch-typ_b-propeller.
    IPR006652. Kelch_1.
    [Graphical view]
    PfamiPF00651. BTB. 2 hits.
    PF01344. Kelch_1. 1 hit.
    [Graphical view]
    SMARTiSM00225. BTB. 2 hits.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 4 hits.
    PROSITEiPS50097. BTB. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9CQ33-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAGSGGPIGS GALTGGVRSK VAPSVDFDHS CSDSVEYLTL NFGPFETVHR    50
    WRRLPPCDEF VGARRSKHTV VAYKDAIYVF GGDNGKTMLN DLLRFDVKDC 100
    SWCRAFTTGT PPAPRYHHSA VVYGSSMFVF GGYTGDIYSN SNLKNKNDLF 150
    EYKFATGQWT EWKIEGRLPV ARSAHGATVY SDKLWIFAGY DGNARLNDMW 200
    TIGLQDRELT CWEEVAQSGE IPPSCCNFPV AVCRDKMFVF SGQSGAKITN 250
    NLFQFEFKDK TWTRIPTEHL LRGSPPPPQR RYGHTMVAFD RHLYVFGGAA 300
    DNTLPNELHC YDVDFQTWEV VQPSSDSEVG GAEMPERASS SEDASTLTSE 350
    ERSSFKKSRD VFGLDFGTTS AKQPVHLASE LPSGRLFHAA AVISDAMYIF 400
    GGTVDNNIRS GEMYRFQFSC YPKCTLHEDY GRLWEGRQFC DVEFVLGEKE 450
    ECVQGHVAIV TARSRWLRRK IVQAQEWLAQ KLEEDGALAP KEAPGPAVGR 500
    ARPPLLRVAI REAEARPFEV LMQFLYTDKI KYPRKGHVED VLLIMDVYKL 550
    ALSFQLCRLE QLCRQYIEAS VDLQNVLVVC ESAARLQLGQ LKEHCLNFIV 600
    KESHFNQVIM MKEFERLSSP LIVEIVRRKQ QPPPRTPSDQ PVDIGTSLIQ 650
    DMKAYLEGAG SEFCDITLLL DGQPRPAHKA ILAARSSYFE AMFRSFMPED 700
    GQVNISIGEM VPSRQAFESM LRYIYYGEVN MPPEDSLYLF AAPYYYGFYN 750
    NRLQAYCKQN LEMNVTVQNV LQILEAADKT QALDMKRHCL HIIVHQFTKV 800
    SKLPTLRLLS QQLLLDIIDS LASHISDKQC AELGADI 837
    Length:837
    Mass (Da):94,476
    Last modified:April 11, 2003 - v2
    Checksum:i7E714AE48C4E2D63
    GO
    Isoform 2 (identifier: Q9CQ33-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         800-837: VSKLPTLRLL...KQCAELGADI → VRLWPQCSRS...RSLSCPRCGC

    Note: May result from the retention of an intron in the cDNA in position 800. No experimental confirmation available.

    Show »
    Length:866
    Mass (Da):97,687
    Checksum:i208400A53DC47358
    GO

    Sequence cautioni

    The sequence BAC40662.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti330 – 3301Missing in AAH34400. (PubMed:15489334)Curated
    Sequence conflicti375 – 3751V → A in AAH34400. (PubMed:15489334)Curated
    Sequence conflicti495 – 4951G → S in AAH34400. (PubMed:15489334)Curated
    Sequence conflicti545 – 5451M → V in BAC38905. (PubMed:16141072)Curated
    Sequence conflicti707 – 7071I → M in BAC40662. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei800 – 83738VSKLP…LGADI → VRLWPQCSRSQLSPAGLGTS WPLSTILRQPRPEQARPQED SSAHPGRLVSSSFGHLCRSL SCPRCGC in isoform 2. 1 PublicationVSP_007170Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK004561 mRNA. Translation: BAB23373.2.
    AK005037 mRNA. Translation: BAB23764.2.
    AK083411 mRNA. Translation: BAC38905.1.
    AK088938 mRNA. Translation: BAC40662.1. Different initiation.
    BC034400 mRNA. Translation: AAH34400.1.
    CCDSiCCDS37272.1. [Q9CQ33-1]
    RefSeqiNP_080084.2. NM_025808.3. [Q9CQ33-1]
    UniGeneiMm.161726.

    Genome annotation databases

    EnsembliENSMUST00000023444; ENSMUSP00000023444; ENSMUSG00000022761. [Q9CQ33-1]
    GeneIDi66863.
    KEGGimmu:66863.
    UCSCiuc007yla.1. mouse. [Q9CQ33-1]
    uc007ylb.1. mouse. [Q9CQ33-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK004561 mRNA. Translation: BAB23373.2 .
    AK005037 mRNA. Translation: BAB23764.2 .
    AK083411 mRNA. Translation: BAC38905.1 .
    AK088938 mRNA. Translation: BAC40662.1 . Different initiation.
    BC034400 mRNA. Translation: AAH34400.1 .
    CCDSi CCDS37272.1. [Q9CQ33-1 ]
    RefSeqi NP_080084.2. NM_025808.3. [Q9CQ33-1 ]
    UniGenei Mm.161726.

    3D structure databases

    ProteinModelPortali Q9CQ33.
    SMRi Q9CQ33. Positions 49-321, 661-784.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 211770. 1 interaction.
    MINTi MINT-1342142.

    PTM databases

    PhosphoSitei Q9CQ33.

    Proteomic databases

    MaxQBi Q9CQ33.
    PaxDbi Q9CQ33.
    PRIDEi Q9CQ33.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023444 ; ENSMUSP00000023444 ; ENSMUSG00000022761 . [Q9CQ33-1 ]
    GeneIDi 66863.
    KEGGi mmu:66863.
    UCSCi uc007yla.1. mouse. [Q9CQ33-1 ]
    uc007ylb.1. mouse. [Q9CQ33-2 ]

    Organism-specific databases

    CTDi 8216.
    MGIi MGI:1914113. Lztr1.

    Phylogenomic databases

    eggNOGi NOG145020.
    GeneTreei ENSGT00720000108564.
    HOGENOMi HOG000007115.
    HOVERGENi HBG052380.
    PhylomeDBi Q9CQ33.

    Miscellaneous databases

    ChiTaRSi LZTR1. mouse.
    NextBioi 322851.
    PROi Q9CQ33.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9CQ33.
    Bgeei Q9CQ33.
    CleanExi MM_LZTR1.
    Genevestigatori Q9CQ33.

    Family and domain databases

    Gene3Di 2.120.10.80. 2 hits.
    3.30.710.10. 3 hits.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR015915. Kelch-typ_b-propeller.
    IPR006652. Kelch_1.
    [Graphical view ]
    Pfami PF00651. BTB. 2 hits.
    PF01344. Kelch_1. 1 hit.
    [Graphical view ]
    SMARTi SM00225. BTB. 2 hits.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 4 hits.
    PROSITEi PS50097. BTB. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J and NOD.
      Tissue: Embryo, Liver, Lung and Thymus.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: Czech II.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiLZTR1_MOUSE
    AccessioniPrimary (citable) accession number: Q9CQ33
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 11, 2003
    Last sequence update: April 11, 2003
    Last modified: October 1, 2014
    This is version 100 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3