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Protein

Leucine-zipper-like transcriptional regulator 1

Gene

Lztr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Probable transcriptional regulator that may play a crucial role in embryogenesis.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-zipper-like transcriptional regulator 1
Short name:
LZTR-1
Gene namesi
Name:Lztr1
Synonyms:Tcfl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1914113. Lztr1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 837836Leucine-zipper-like transcriptional regulator 1PRO_0000119136Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9CQ33.
PaxDbiQ9CQ33.
PRIDEiQ9CQ33.

PTM databases

PhosphoSiteiQ9CQ33.

Expressioni

Gene expression databases

BgeeiQ9CQ33.
CleanExiMM_LZTR1.
ExpressionAtlasiQ9CQ33. baseline and differential.
GenevestigatoriQ9CQ33.

Interactioni

Protein-protein interaction databases

BioGridi211770. 1 interaction.
MINTiMINT-1342142.

Structurei

3D structure databases

ProteinModelPortaliQ9CQ33.
SMRiQ9CQ33. Positions 49-321, 661-784.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati76 – 12550Kelch 1Add
BLAST
Repeati127 – 18256Kelch 2Add
BLAST
Repeati184 – 23552Kelch 3Add
BLAST
Repeati236 – 28247Kelch 4Add
BLAST
Repeati292 – 33847Kelch 5Add
BLAST
Repeati396 – 44752Kelch 6Add
BLAST
Domaini440 – 53495BTB 1PROSITE-ProRule annotationAdd
BLAST
Domaini664 – 73370BTB 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 BTB (POZ) domains.PROSITE-ProRule annotation
Contains 6 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiNOG145020.
GeneTreeiENSGT00760000119086.
HOGENOMiHOG000007115.
HOVERGENiHBG052380.
InParanoidiQ9CQ33.
PhylomeDBiQ9CQ33.

Family and domain databases

Gene3Di2.120.10.80. 2 hits.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
[Graphical view]
PfamiPF00651. BTB. 2 hits.
PF01344. Kelch_1. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 2 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 4 hits.
PROSITEiPS50097. BTB. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9CQ33-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGSGGPIGS GALTGGVRSK VAPSVDFDHS CSDSVEYLTL NFGPFETVHR
60 70 80 90 100
WRRLPPCDEF VGARRSKHTV VAYKDAIYVF GGDNGKTMLN DLLRFDVKDC
110 120 130 140 150
SWCRAFTTGT PPAPRYHHSA VVYGSSMFVF GGYTGDIYSN SNLKNKNDLF
160 170 180 190 200
EYKFATGQWT EWKIEGRLPV ARSAHGATVY SDKLWIFAGY DGNARLNDMW
210 220 230 240 250
TIGLQDRELT CWEEVAQSGE IPPSCCNFPV AVCRDKMFVF SGQSGAKITN
260 270 280 290 300
NLFQFEFKDK TWTRIPTEHL LRGSPPPPQR RYGHTMVAFD RHLYVFGGAA
310 320 330 340 350
DNTLPNELHC YDVDFQTWEV VQPSSDSEVG GAEMPERASS SEDASTLTSE
360 370 380 390 400
ERSSFKKSRD VFGLDFGTTS AKQPVHLASE LPSGRLFHAA AVISDAMYIF
410 420 430 440 450
GGTVDNNIRS GEMYRFQFSC YPKCTLHEDY GRLWEGRQFC DVEFVLGEKE
460 470 480 490 500
ECVQGHVAIV TARSRWLRRK IVQAQEWLAQ KLEEDGALAP KEAPGPAVGR
510 520 530 540 550
ARPPLLRVAI REAEARPFEV LMQFLYTDKI KYPRKGHVED VLLIMDVYKL
560 570 580 590 600
ALSFQLCRLE QLCRQYIEAS VDLQNVLVVC ESAARLQLGQ LKEHCLNFIV
610 620 630 640 650
KESHFNQVIM MKEFERLSSP LIVEIVRRKQ QPPPRTPSDQ PVDIGTSLIQ
660 670 680 690 700
DMKAYLEGAG SEFCDITLLL DGQPRPAHKA ILAARSSYFE AMFRSFMPED
710 720 730 740 750
GQVNISIGEM VPSRQAFESM LRYIYYGEVN MPPEDSLYLF AAPYYYGFYN
760 770 780 790 800
NRLQAYCKQN LEMNVTVQNV LQILEAADKT QALDMKRHCL HIIVHQFTKV
810 820 830
SKLPTLRLLS QQLLLDIIDS LASHISDKQC AELGADI
Length:837
Mass (Da):94,476
Last modified:April 10, 2003 - v2
Checksum:i7E714AE48C4E2D63
GO
Isoform 2 (identifier: Q9CQ33-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     800-837: VSKLPTLRLL...KQCAELGADI → VRLWPQCSRS...RSLSCPRCGC

Note: May result from the retention of an intron in the cDNA in position 800. No experimental confirmation available.

Show »
Length:866
Mass (Da):97,687
Checksum:i208400A53DC47358
GO

Sequence cautioni

The sequence BAC40662.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti330 – 3301Missing in AAH34400 (PubMed:15489334).Curated
Sequence conflicti375 – 3751V → A in AAH34400 (PubMed:15489334).Curated
Sequence conflicti495 – 4951G → S in AAH34400 (PubMed:15489334).Curated
Sequence conflicti545 – 5451M → V in BAC38905 (PubMed:16141072).Curated
Sequence conflicti707 – 7071I → M in BAC40662 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei800 – 83738VSKLP…LGADI → VRLWPQCSRSQLSPAGLGTS WPLSTILRQPRPEQARPQED SSAHPGRLVSSSFGHLCRSL SCPRCGC in isoform 2. 1 PublicationVSP_007170Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004561 mRNA. Translation: BAB23373.2.
AK005037 mRNA. Translation: BAB23764.2.
AK083411 mRNA. Translation: BAC38905.1.
AK088938 mRNA. Translation: BAC40662.1. Different initiation.
BC034400 mRNA. Translation: AAH34400.1.
CCDSiCCDS37272.1. [Q9CQ33-1]
RefSeqiNP_080084.2. NM_025808.3. [Q9CQ33-1]
UniGeneiMm.161726.

Genome annotation databases

EnsembliENSMUST00000023444; ENSMUSP00000023444; ENSMUSG00000022761. [Q9CQ33-1]
GeneIDi66863.
KEGGimmu:66863.
UCSCiuc007yla.1. mouse. [Q9CQ33-1]
uc007ylb.1. mouse. [Q9CQ33-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004561 mRNA. Translation: BAB23373.2.
AK005037 mRNA. Translation: BAB23764.2.
AK083411 mRNA. Translation: BAC38905.1.
AK088938 mRNA. Translation: BAC40662.1. Different initiation.
BC034400 mRNA. Translation: AAH34400.1.
CCDSiCCDS37272.1. [Q9CQ33-1]
RefSeqiNP_080084.2. NM_025808.3. [Q9CQ33-1]
UniGeneiMm.161726.

3D structure databases

ProteinModelPortaliQ9CQ33.
SMRiQ9CQ33. Positions 49-321, 661-784.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211770. 1 interaction.
MINTiMINT-1342142.

PTM databases

PhosphoSiteiQ9CQ33.

Proteomic databases

MaxQBiQ9CQ33.
PaxDbiQ9CQ33.
PRIDEiQ9CQ33.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023444; ENSMUSP00000023444; ENSMUSG00000022761. [Q9CQ33-1]
GeneIDi66863.
KEGGimmu:66863.
UCSCiuc007yla.1. mouse. [Q9CQ33-1]
uc007ylb.1. mouse. [Q9CQ33-2]

Organism-specific databases

CTDi8216.
MGIiMGI:1914113. Lztr1.

Phylogenomic databases

eggNOGiNOG145020.
GeneTreeiENSGT00760000119086.
HOGENOMiHOG000007115.
HOVERGENiHBG052380.
InParanoidiQ9CQ33.
PhylomeDBiQ9CQ33.

Miscellaneous databases

NextBioi322851.
PROiQ9CQ33.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CQ33.
CleanExiMM_LZTR1.
ExpressionAtlasiQ9CQ33. baseline and differential.
GenevestigatoriQ9CQ33.

Family and domain databases

Gene3Di2.120.10.80. 2 hits.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
[Graphical view]
PfamiPF00651. BTB. 2 hits.
PF01344. Kelch_1. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 2 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 4 hits.
PROSITEiPS50097. BTB. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J and NOD.
    Tissue: Embryo, Liver, Lung and Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: Czech II.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiLZTR1_MOUSE
AccessioniPrimary (citable) accession number: Q9CQ33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 10, 2003
Last sequence update: April 10, 2003
Last modified: March 3, 2015
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.