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Protein

Ragulator complex protein LAMTOR1

Gene

Lamtor1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cellular protein localization Source: UniProtKB
  • cellular response to amino acid stimulus Source: UniProtKB
  • cholesterol homeostasis Source: UniProtKB
  • endosomal transport Source: UniProtKB
  • endosome organization Source: UniProtKB
  • lysosome localization Source: UniProtKB
  • lysosome organization Source: UniProtKB
  • positive regulation of MAPK cascade Source: UniProtKB
  • positive regulation of TOR signaling Source: UniProtKB
  • regulation of cell growth Source: UniProtKB
  • regulation of cholesterol efflux Source: UniProtKB
  • regulation of cholesterol esterification Source: UniProtKB
  • regulation of cholesterol import Source: UniProtKB
  • regulation of receptor recycling Source: UniProtKB

Enzyme and pathway databases

ReactomeiR-MMU-1632852 Macroautophagy
R-MMU-165159 mTOR signalling
R-MMU-166208 mTORC1-mediated signalling
R-MMU-380972 Energy dependent regulation of mTOR by LKB1-AMPK
R-MMU-5628897 TP53 Regulates Metabolic Genes
R-MMU-6798695 Neutrophil degranulation
R-MMU-8943724 Regulation of PTEN gene transcription

Names & Taxonomyi

Protein namesi
Recommended name:
Ragulator complex protein LAMTOR1
Alternative name(s):
Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1
Lipid raft adaptor protein p18
Gene namesi
Name:Lamtor1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1913758 Lamtor1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Endosome, Lysosome, Membrane

Pathology & Biotechi

Disruption phenotypei

Embryos die at egg cylinder stage due to growth retardation, associated with altered endosomes and lysosomes organizations and impaired membrane protein transport in the visceral endoderm.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002742932 – 161Ragulator complex protein LAMTOR1Add BLAST160

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1
Modified residuei27PhosphoserineBy similarity1
Modified residuei28PhosphothreonineCombined sources1
Modified residuei42PhosphoserineBy similarity1
Modified residuei56PhosphoserineBy similarity1
Modified residuei98PhosphoserineBy similarity1
Modified residuei141PhosphoserineBy similarity1

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiQ9CQ22
MaxQBiQ9CQ22
PaxDbiQ9CQ22
PeptideAtlasiQ9CQ22
PRIDEiQ9CQ22

PTM databases

iPTMnetiQ9CQ22
PhosphoSitePlusiQ9CQ22
SwissPalmiQ9CQ22

Expressioni

Developmental stagei

At E6.5 expressed throughout the embryo with relative abundance in the visceral endoderm.1 Publication

Gene expression databases

BgeeiENSMUSG00000030842
CleanExiMM_2400001E08RIK
ExpressionAtlasiQ9CQ22 baseline and differential
GenevisibleiQ9CQ22 MM

Interactioni

Subunit structurei

Part of the Ragulator complex composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5. LAMTOR4 and LAMTOR5 form a heterodimer that interacts, through LAMTOR1, with a LAMTOR2, LAMTOR3 heterodimer. The Ragulator complex interacts with both the mTORC1 complex and heterodimers constituted of the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD; regulated by amino acid availability. The Ragulator complex interacts with SLC38A9; the probable amino acid sensor (By similarity). Interacts with LAMTOR2 and LAMTOR3; the interaction is direct (PubMed:19177150). Interacts with RRAGB and RRAGD; the interaction is direct indicating that it probably constitutes the main RAG-interacting subunit of the Ragulator complex. Interacts with MMP14. Interacts with CDKN1B; prevents the interaction of CDKN1B with RHOA leaving RHOA in a form accessible to activation by ARHGEF2 (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211525, 3 interactors
CORUMiQ9CQ22
IntActiQ9CQ22, 7 interactors
MINTiQ9CQ22
STRINGi10090.ENSMUSP00000033131

Structurei

3D structure databases

SMRiQ9CQ22
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni121 – 161Interaction with LAMTOR2 and LAMTOR3By similarityAdd BLAST41

Sequence similaritiesi

Belongs to the LAMTOR1 family.Curated

Phylogenomic databases

eggNOGiENOG410IH39 Eukaryota
ENOG4112AMJ LUCA
GeneTreeiENSGT00390000016789
HOVERGENiHBG081218
InParanoidiQ9CQ22
KOiK20397
OMAiHNLEQHE
OrthoDBiEOG091G0XGD
PhylomeDBiQ9CQ22
TreeFamiTF323788

Family and domain databases

InterProiView protein in InterPro
IPR026310 LAMTOR1-like
IPR028209 LAMTOR1/MEH1
PANTHERiPTHR13401 PTHR13401, 1 hit
PfamiView protein in Pfam
PF15454 LAMTOR, 1 hit
SMARTiView protein in SMART
SM01262 LAMTOR, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CQ22-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCCYSSENE DSDQDREERK LLLDPSSTPT KALNGAEPNY HSLPSARTDE
60 70 80 90 100
QALLSSILAK TASNIIDVSA ADSQGMEQHE YMDRARQYST RLAVLSSSLT
110 120 130 140 150
HWKKLPPLPS LTSQPHQVLA SEPIPFSDLQ QVSRIAAYAY SALSQIRVDA
160
KEELVVQFGI P
Length:161
Mass (Da):17,749
Last modified:June 1, 2001 - v1
Checksum:iD50CC6C05C36B457
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti82M → I in BAB28825 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009320 mRNA Translation: BAB26214.1
AK013389 mRNA Translation: BAB28825.1
AK019947 mRNA Translation: BAB31928.1
AK144476 mRNA Translation: BAE25909.1
BC020142 mRNA Translation: AAH20142.1
BC092062 mRNA Translation: AAH92062.1
BC096412 mRNA Translation: AAH96412.1
BC115458 mRNA No translation available.
BC115459 mRNA No translation available.
BC126973 mRNA Translation: AAI26974.1
CCDSiCCDS21519.1
RefSeqiNP_079881.2, NM_025605.3
UniGeneiMm.214841
Mm.30003

Genome annotation databases

EnsembliENSMUST00000033131; ENSMUSP00000033131; ENSMUSG00000030842
GeneIDi66508
KEGGimmu:66508
UCSCiuc009ipw.2 mouse

Similar proteinsi

Entry informationi

Entry nameiLTOR1_MOUSE
AccessioniPrimary (citable) accession number: Q9CQ22
Secondary accession number(s): Q9CYS0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: June 1, 2001
Last modified: April 25, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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