Myl9

Functionⁱ

Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion.By similarity

Miscellaneous

This chain binds calcium.By similarity

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Calcium bindingⁱ	42 – 53	Add BLAST		12

GO - Molecular functionⁱ

calcium ion binding Source: InterPro
myosin heavy chain binding
Source: MGI
Inferred from physical interactionⁱ
- 24825904

Complete GO annotation...

GO - Biological processⁱ

platelet aggregation Source: MGI

Complete GO annotation...

Keywordsⁱ

Molecular function	Motor protein, Muscle protein, Myosin
Ligand	Calcium, Metal-binding

Enzyme and pathway databases

Reactomeⁱ	R-MMU-445355. Smooth Muscle Contraction. R-MMU-5627123. RHO GTPases activate PAKs.

Reactomeⁱ

R-MMU-445355. Smooth Muscle Contraction.
R-MMU-5627123. RHO GTPases activate PAKs.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Myosin regulatory light polypeptide 9 Alternative name(s): Myosin regulatory light chain 2, smooth muscle isoform Myosin regulatory light chain 9
Gene namesⁱ	Name:Myl9 Synonyms:Myrl2
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 2

Organism-specific databases

MGIⁱ	MGI:2138915. Myl9.

Subcellular locationⁱ

GO - Cellular componentⁱ

myosin II complex
Source: MGI
Inferred from direct assayⁱ
- 21126233
stress fiber
Source: MGI
Inferred from direct assayⁱ
- 21126233
Z disc
Source: MGI
Inferred from direct assayⁱ
- 21126233

Complete GO annotation...

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedBy similarity
ChainⁱPRO_0000198736	2 – 172	Myosin regulatory light polypeptide 9Add BLAST		171

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylserineBy similarity	1
Modified residueⁱ	19	Phosphothreonine; by MLCK, CIT and ROCK2By similarity	1
Modified residueⁱ	20	Phosphoserine; by CDC42BP, CIT, MLCK, PAK1, ROCK1, ROCK2, DAPK1, DAPK2 and ZIPK/DAPK31 Publication	1

Post-translational modificationⁱ

Phosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity. It is required to generate the driving force in the migration of the cells but not necessary for localization of myosin-2 at the leading edge.By similarity

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9CQ19.
PaxDbⁱ	Q9CQ19.
PeptideAtlas More...PeptideAtlasⁱ	Q9CQ19.
PRIDEⁱ	Q9CQ19.

PTM databases

iPTMnetⁱ	Q9CQ19.
PhosphoSitePlusⁱ	Q9CQ19.
SwissPalmⁱ	Q9CQ19.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000067818.
CleanExⁱ	MM_MYL9.
Genevisibleⁱ	Q9CQ19. MM.

Interactionⁱ

Subunit structureⁱ

Myosin is a hexamer of 2 heavy chains and 4 light chains: interacts with myosin heavy chain MYO19.1 Publication

GO - Molecular functionⁱ

myosin heavy chain binding
Source: MGI
Inferred from physical interactionⁱ
- 24825904

Complete GO annotation...

Protein-protein interaction databases

BioGridⁱ	221155. 1 interactor.
IntActⁱ	Q9CQ19. 3 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-4102187.
STRINGⁱ	10090.ENSMUSP00000085913.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9CQ19.
SMRⁱ	Q9CQ19.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	29 – 64	EF-hand 1PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	98 – 133	EF-hand 2PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	134 – 169	EF-hand 3PROSITE-ProRule annotationAdd BLAST	36

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG0031. Eukaryota. COG5126. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119196.
HOGENOMⁱ	HOG000233018.
HOVERGENⁱ	HBG012180.
InParanoidⁱ	Q9CQ19.
KEGG Orthology (KO) More...KOⁱ	K12755.
OMAⁱ	FNYREWV.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0QF6.
PhylomeDBⁱ	Q9CQ19.
TreeFamⁱ	TF314218.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00051. EFh. 1 hit.
InterProⁱ	View protein in InterPro IPR011992. EF-hand-dom_pair. IPR018247. EF_Hand_1_Ca_BS. IPR002048. EF_hand_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13405. EF-hand_6. 1 hit. PF13833. EF-hand_8. 1 hit.
SMARTⁱ	View protein in SMART SM00054. EFh. 2 hits.
SUPFAMⁱ	SSF47473. SSF47473. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00018. EF_HAND_1. 1 hit. PS50222. EF_HAND_2. 3 hits.

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q9CQ19-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSSKRAKAKT TKKRPQRATS NVFAMFDQSQ IQEFKEAFNM IDQNRDGFID 
        60         70         80         90        100
KEDLHDMLAS LGKNPTDEYL EGMMNEAPGP INFTMFLTMF GEKLNGTDPE 
       110        120        130        140        150
DVIRNAFACF DEEASGFIHE DHLRELLTTM GDRFTDEEVD EMYREAPIDK 
       160        170 
KGNFNYVEFT RILKHGAKDK DD

Length:172

Mass (Da):19,854

Last modified:January 23, 2007 - v3

Checksum:ⁱD588C708BF5A2D56

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	132	D → V in BAE35452 (PubMed:16141072).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK007972 mRNA. Translation: BAB25381.1. AK020258 mRNA. Translation: BAB32043.1. AK159880 mRNA. Translation: BAE35452.1. BC049974 mRNA. Translation: AAH49974.2. BC055439 mRNA. Translation: AAH55439.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS50779.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_742116.1. NM_172118.1. XP_006500516.1. XM_006500453.3.
UniGeneⁱ	Mm.271770.

Genome annotation databases

Ensemblⁱ	ENSMUST00000088552; ENSMUSP00000085913; ENSMUSG00000067818.
GeneIDⁱ	98932.
KEGGⁱ	mmu:98932.
UCSC genome browser More...UCSCⁱ	uc008nnw.2. mouse.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK007972 mRNA. Translation: BAB25381.1. AK020258 mRNA. Translation: BAB32043.1. AK159880 mRNA. Translation: BAE35452.1. BC049974 mRNA. Translation: AAH49974.2. BC055439 mRNA. Translation: AAH55439.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS50779.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_742116.1. NM_172118.1. XP_006500516.1. XM_006500453.3.
UniGeneⁱ	Mm.271770.

3D structure databases

ProteinModelPortalⁱ	Q9CQ19.
SMRⁱ	Q9CQ19.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	221155. 1 interactor.
IntActⁱ	Q9CQ19. 3 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-4102187.
STRINGⁱ	10090.ENSMUSP00000085913.

PTM databases

iPTMnetⁱ	Q9CQ19.
PhosphoSitePlusⁱ	Q9CQ19.
SwissPalmⁱ	Q9CQ19.

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9CQ19.
PaxDbⁱ	Q9CQ19.
PeptideAtlas More...PeptideAtlasⁱ	Q9CQ19.
PRIDEⁱ	Q9CQ19.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000088552; ENSMUSP00000085913; ENSMUSG00000067818.
GeneIDⁱ	98932.
KEGGⁱ	mmu:98932.
UCSC genome browser More...UCSCⁱ	uc008nnw.2. mouse.

Organism-specific databases

CTDⁱ	10398.
MGIⁱ	MGI:2138915. Myl9.

Phylogenomic databases

eggNOGⁱ	KOG0031. Eukaryota. COG5126. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119196.
HOGENOMⁱ	HOG000233018.
HOVERGENⁱ	HBG012180.
InParanoidⁱ	Q9CQ19.
KEGG Orthology (KO) More...KOⁱ	K12755.
OMAⁱ	FNYREWV.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0QF6.
PhylomeDBⁱ	Q9CQ19.
TreeFamⁱ	TF314218.

Enzyme and pathway databases

Reactomeⁱ	R-MMU-445355. Smooth Muscle Contraction. R-MMU-5627123. RHO GTPases activate PAKs.

Reactomeⁱ

R-MMU-445355. Smooth Muscle Contraction.
R-MMU-5627123. RHO GTPases activate PAKs.

Miscellaneous databases

ChiTaRSⁱ	Myl9. mouse.
Protein Ontology More...PROⁱ	PR:Q9CQ19.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000067818.
CleanExⁱ	MM_MYL9.
Genevisibleⁱ	Q9CQ19. MM.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00051. EFh. 1 hit.
InterProⁱ	View protein in InterPro IPR011992. EF-hand-dom_pair. IPR018247. EF_Hand_1_Ca_BS. IPR002048. EF_hand_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13405. EF-hand_6. 1 hit. PF13833. EF-hand_8. 1 hit.
SMARTⁱ	View protein in SMART SM00054. EFh. 2 hits.
SUPFAMⁱ	SSF47473. SSF47473. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00018. EF_HAND_1. 1 hit. PS50222. EF_HAND_2. 3 hits.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MYL9_MOUSE
Accessionⁱ	Q9CQ19Primary (citable) accession number: Q9CQ19 Secondary accession number(s): Q3TW15, Q80X77
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 28, 2003
	Last sequence update:	January 23, 2007
	Last modified:	July 5, 2017
	This is version 136 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9CQ19 (MYL9_MOUSE)

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Myosin regulatory light polypeptide 9

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ