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Protein

Leucine-rich repeat-containing protein 18

Gene

Lrrc18

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in the regulation of spermatogenesis and sperm maturation.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 18
Alternative name(s):
Testis-specific LRR protein
Gene namesi
Name:Lrrc18
Synonyms:Mtlr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1914830. Lrrc18.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 262262Leucine-rich repeat-containing protein 18PRO_0000084473Add
BLAST

Proteomic databases

MaxQBiQ9CQ07.
PaxDbiQ9CQ07.
PRIDEiQ9CQ07.

PTM databases

iPTMnetiQ9CQ07.
PhosphoSiteiQ9CQ07.

Expressioni

Tissue specificityi

Exclusively expressed in spermatocytes and roud spermatids within seminiferous tubules during spermatogenesis.1 Publication

Inductioni

Up-regulated during sexual maturation and dowm-regulated by experimental cryptorchidism and heat stress.1 Publication

Gene expression databases

BgeeiQ9CQ07.
CleanExiMM_LRRC18.
ExpressionAtlasiQ9CQ07. baseline and differential.
GenevisibleiQ9CQ07. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041199.

Structurei

3D structure databases

ProteinModelPortaliQ9CQ07.
SMRiQ9CQ07. Positions 11-230.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati28 – 4922LRR 1Add
BLAST
Repeati51 – 7222LRR 2Add
BLAST
Repeati74 – 9522LRR 3Add
BLAST
Repeati97 – 11822LRR 4Add
BLAST
Repeati122 – 14423LRR 5Add
BLAST
Repeati145 – 16723LRR 6Add
BLAST
Repeati168 – 18922LRR 7Add
BLAST

Sequence similaritiesi

Contains 7 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00840000129676.
HOGENOMiHOG000113366.
HOVERGENiHBG056513.
InParanoidiQ9CQ07.
OrthoDBiEOG79W960.
PhylomeDBiQ9CQ07.
TreeFamiTF331129.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9CQ07-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKGGKGPKG KKITLNVAKN CIKITFDGRK RLDLSKMGIT TFPKCILRLS
60 70 80 90 100
DIDELDLSRN MIRKIPDSIA KFQNLRWLDL HSNYIDKLPE SIGQMTSLLF
110 120 130 140 150
LNVSNNRLTT NGLPVELNQL KNIRTVNLGL NHLDSVPTTL GALKELHEVG
160 170 180 190 200
LHDNLLTTIP ASIAKLPKLK KLNIKRNPFP NADESEMFVD SIKRLENLYL
210 220 230 240 250
VEEKDMCSSC LQRCQQARDK LNKIKSMAPS APRKALFSNL VSPNSTAKDA
260
QEEWRLRSPS TF
Length:262
Mass (Da):29,520
Last modified:June 1, 2001 - v1
Checksum:iDD4981A2C42CAED6
GO
Isoform 2 (identifier: Q9CQ07-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     256-262: Missing.

Show »
Length:255
Mass (Da):28,732
Checksum:iC6C0F1E494547F2B
GO

Sequence cautioni

The sequence AAH48444.1 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti32 – 321L → H in BAB24391 (PubMed:16141072).Curated
Sequence conflicti87 – 871K → M in AAH48444 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei256 – 2627Missing in isoform 2. 2 PublicationsVSP_015741

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY775400 mRNA. Translation: AAV34143.1.
AK005666 mRNA. Translation: BAB24176.3.
AK006063 mRNA. Translation: BAB24391.1.
AK014952 mRNA. Translation: BAB29635.1.
AK015365 mRNA. Translation: BAB29814.1.
AK029909 mRNA. Translation: BAC26670.1.
BC048444 mRNA. Translation: AAH48444.1. Sequence problems.
BC061072 mRNA. Translation: AAH61072.1.
CCDSiCCDS26924.1. [Q9CQ07-1]
CCDS49440.1. [Q9CQ07-2]
RefSeqiNP_001139493.1. NM_001146021.1. [Q9CQ07-2]
NP_080529.1. NM_026253.4. [Q9CQ07-1]
XP_006519520.1. XM_006519457.2. [Q9CQ07-1]
XP_006519521.1. XM_006519458.2. [Q9CQ07-1]
UniGeneiMm.46115.

Genome annotation databases

EnsembliENSMUST00000038956; ENSMUSP00000041199; ENSMUSG00000041673. [Q9CQ07-1]
ENSMUST00000120866; ENSMUSP00000113608; ENSMUSG00000041673. [Q9CQ07-2]
GeneIDi67580.
KEGGimmu:67580.
UCSCiuc007szl.2. mouse. [Q9CQ07-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY775400 mRNA. Translation: AAV34143.1.
AK005666 mRNA. Translation: BAB24176.3.
AK006063 mRNA. Translation: BAB24391.1.
AK014952 mRNA. Translation: BAB29635.1.
AK015365 mRNA. Translation: BAB29814.1.
AK029909 mRNA. Translation: BAC26670.1.
BC048444 mRNA. Translation: AAH48444.1. Sequence problems.
BC061072 mRNA. Translation: AAH61072.1.
CCDSiCCDS26924.1. [Q9CQ07-1]
CCDS49440.1. [Q9CQ07-2]
RefSeqiNP_001139493.1. NM_001146021.1. [Q9CQ07-2]
NP_080529.1. NM_026253.4. [Q9CQ07-1]
XP_006519520.1. XM_006519457.2. [Q9CQ07-1]
XP_006519521.1. XM_006519458.2. [Q9CQ07-1]
UniGeneiMm.46115.

3D structure databases

ProteinModelPortaliQ9CQ07.
SMRiQ9CQ07. Positions 11-230.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041199.

PTM databases

iPTMnetiQ9CQ07.
PhosphoSiteiQ9CQ07.

Proteomic databases

MaxQBiQ9CQ07.
PaxDbiQ9CQ07.
PRIDEiQ9CQ07.

Protocols and materials databases

DNASUi67580.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038956; ENSMUSP00000041199; ENSMUSG00000041673. [Q9CQ07-1]
ENSMUST00000120866; ENSMUSP00000113608; ENSMUSG00000041673. [Q9CQ07-2]
GeneIDi67580.
KEGGimmu:67580.
UCSCiuc007szl.2. mouse. [Q9CQ07-1]

Organism-specific databases

CTDi474354.
MGIiMGI:1914830. Lrrc18.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00840000129676.
HOGENOMiHOG000113366.
HOVERGENiHBG056513.
InParanoidiQ9CQ07.
OrthoDBiEOG79W960.
PhylomeDBiQ9CQ07.
TreeFamiTF331129.

Miscellaneous databases

PROiQ9CQ07.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CQ07.
CleanExiMM_LRRC18.
ExpressionAtlasiQ9CQ07. baseline and differential.
GenevisibleiQ9CQ07. MM.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel testis-specific gene mtLR1, which is expressed at specific stages of mouse spermatogenesis."
    Nie D.-S., Xiang Y., Wang J., Deng Y., Tan X.-J., Liang Y.-H., Lu G.-X.
    Biochem. Biophys. Res. Commun. 328:1010-1018(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INDUCTION, SUBCELLULAR LOCATION.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.

Entry informationi

Entry nameiLRC18_MOUSE
AccessioniPrimary (citable) accession number: Q9CQ07
Secondary accession number(s): Q6P8T8
, Q80ZT3, Q9CW01, Q9DA89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.