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Q9CQ01

- RNT2_MOUSE

UniProt

Q9CQ01 - RNT2_MOUSE

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Protein

Ribonuclease T2

Gene
Rnaset2, Rnase6pl
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Has ribonuclease activity, with higher activity at acidic pH. May play a role in cellular RNA catabolism. Probably is involved in lysosomal degradation of ribosomal RNA By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei69 – 691 By similarity
Active sitei118 – 1181 By similarity
Active sitei122 – 1221 By similarity

GO - Molecular functioni

  1. ribonuclease activity Source: UniProtKB
  2. ribonuclease T2 activity Source: InterPro
  3. RNA binding Source: InterPro

GO - Biological processi

  1. RNA catabolic process Source: UniProtKB
  2. RNA phosphodiester bond hydrolysis Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease T2 (EC:3.1.27.-)
Alternative name(s):
Ribonuclease 6
Gene namesi
Name:Rnaset2
Synonyms:Rnase6pl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1915445. Rnaset2.

Subcellular locationi

Secreted By similarity. Endoplasmic reticulum lumen By similarity. Lysosome lumen By similarity

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB
  2. extracellular space Source: UniProtKB
  3. lysosomal lumen Source: UniProtKB-SubCell
  4. lysosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Lysosome, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929 Reviewed predictionAdd
BLAST
Chaini30 – 259230Ribonuclease T2PRO_0000030988Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi53 ↔ 59 By similarity
Disulfide bondi79 ↔ 125 By similarity
Glycosylationi80 – 801N-linked (GlcNAc...) Reviewed prediction
Glycosylationi110 – 1101N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi188 ↔ 244 By similarity
Disulfide bondi206 ↔ 217 By similarity
Glycosylationi216 – 2161N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9CQ01.
PaxDbiQ9CQ01.
PRIDEiQ9CQ01.

PTM databases

PhosphoSiteiQ9CQ01.

Expressioni

Gene expression databases

BgeeiQ9CQ01.
GenevestigatoriQ9CQ01.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000086519.

Structurei

3D structure databases

ProteinModelPortaliQ9CQ01.
SMRiQ9CQ01. Positions 39-254.

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase T2 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG285082.
GeneTreeiENSGT00640000091563.
HOGENOMiHOG000059657.
HOVERGENiHBG050037.
InParanoidiQ9CQ01.
KOiK01166.
OMAiILTHHWP.
OrthoDBiEOG789CC3.
PhylomeDBiQ9CQ01.
TreeFamiTF315063.

Family and domain databases

Gene3Di3.90.730.10. 1 hit.
InterProiIPR001568. RNase_T2-like.
IPR018188. RNase_T2_AS.
[Graphical view]
PANTHERiPTHR11240. PTHR11240. 1 hit.
PfamiPF00445. Ribonuclease_T2. 1 hit.
[Graphical view]
SUPFAMiSSF55895. SSF55895. 1 hit.
PROSITEiPS00530. RNASE_T2_1. 1 hit.
PS00531. RNASE_T2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CQ01-1 [UniParc]FASTAAdd to Basket

« Hide

MAPAEARGAL PGWISVLGWG LALCSLCGAG PLWSGSHEWK KLILTQHWPP    50
TVCKEVNSCQ DSLDYWTIHG LWPDRAEDCN QSWHFNLDEI KDLLRDMKIY 100
WPDVIHRSSN RSQFWKHEWV KHGTCAAQVD ALNSEKKYFG KSLDLYKQID 150
LNSVLQKFGI KPSINYYQLA DFKDALTRIY GVVPKIQCLM PEQGESVQTV 200
GQIELCFTKE DLHLRNCTEP GEQLSSRQEA WLAMEASTHG MMVCEDGPIF 250
YPPPTKTQH 259
Length:259
Mass (Da):29,609
Last modified:June 1, 2001 - v1
Checksum:iE0A1C1BBBEAA5033
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK018722 mRNA. Translation: BAB31368.1.
AK019234 mRNA. Translation: BAB31616.1.
AK029149 mRNA. Translation: BAC26326.1.
BC031496 mRNA. Translation: AAH31496.1.
CCDSiCCDS37433.1.
RefSeqiNP_001077407.1. NM_001083938.2.
NP_080887.1. NM_026611.2.
UniGeneiMm.181237.
Mm.426736.

Genome annotation databases

EnsembliENSMUST00000089119; ENSMUSP00000086519; ENSMUSG00000094724.
ENSMUST00000097420; ENSMUSP00000095031; ENSMUSG00000095687.
ENSMUST00000179728; ENSMUSP00000137303; ENSMUSG00000094724.
GeneIDi100037283.
68195.
KEGGimmu:100037283.
mmu:68195.
UCSCiuc008aic.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK018722 mRNA. Translation: BAB31368.1 .
AK019234 mRNA. Translation: BAB31616.1 .
AK029149 mRNA. Translation: BAC26326.1 .
BC031496 mRNA. Translation: AAH31496.1 .
CCDSi CCDS37433.1.
RefSeqi NP_001077407.1. NM_001083938.2.
NP_080887.1. NM_026611.2.
UniGenei Mm.181237.
Mm.426736.

3D structure databases

ProteinModelPortali Q9CQ01.
SMRi Q9CQ01. Positions 39-254.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000086519.

PTM databases

PhosphoSitei Q9CQ01.

Proteomic databases

MaxQBi Q9CQ01.
PaxDbi Q9CQ01.
PRIDEi Q9CQ01.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000089119 ; ENSMUSP00000086519 ; ENSMUSG00000094724 .
ENSMUST00000097420 ; ENSMUSP00000095031 ; ENSMUSG00000095687 .
ENSMUST00000179728 ; ENSMUSP00000137303 ; ENSMUSG00000094724 .
GeneIDi 100037283.
68195.
KEGGi mmu:100037283.
mmu:68195.
UCSCi uc008aic.1. mouse.

Organism-specific databases

CTDi 100037283.
68195.
MGIi MGI:1915445. Rnaset2.

Phylogenomic databases

eggNOGi NOG285082.
GeneTreei ENSGT00640000091563.
HOGENOMi HOG000059657.
HOVERGENi HBG050037.
InParanoidi Q9CQ01.
KOi K01166.
OMAi ILTHHWP.
OrthoDBi EOG789CC3.
PhylomeDBi Q9CQ01.
TreeFami TF315063.

Miscellaneous databases

NextBioi 326674.
PROi Q9CQ01.
SOURCEi Search...

Gene expression databases

Bgeei Q9CQ01.
Genevestigatori Q9CQ01.

Family and domain databases

Gene3Di 3.90.730.10. 1 hit.
InterProi IPR001568. RNase_T2-like.
IPR018188. RNase_T2_AS.
[Graphical view ]
PANTHERi PTHR11240. PTHR11240. 1 hit.
Pfami PF00445. Ribonuclease_T2. 1 hit.
[Graphical view ]
SUPFAMi SSF55895. SSF55895. 1 hit.
PROSITEi PS00530. RNASE_T2_1. 1 hit.
PS00531. RNASE_T2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo, Kidney and Skin.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.

Entry informationi

Entry nameiRNT2_MOUSE
AccessioniPrimary (citable) accession number: Q9CQ01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2002
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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