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Protein

Ribonuclease T2

Gene

Rnaset2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Has ribonuclease activity, with higher activity at acidic pH. May play a role in cellular RNA catabolism. Probably is involved in lysosomal degradation of ribosomal RNA (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei69 – 691By similarity
Active sitei118 – 1181By similarity
Active sitei122 – 1221By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease T2 (EC:3.1.27.-)
Alternative name(s):
Ribonuclease 6
Gene namesi
Name:Rnaset2
Synonyms:Rnase6pl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1915445. Rnaset2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Lysosome, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence AnalysisAdd
BLAST
Chaini30 – 259230Ribonuclease T2PRO_0000030988Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi53 ↔ 59By similarity
Disulfide bondi79 ↔ 125By similarity
Glycosylationi80 – 801N-linked (GlcNAc...)Sequence Analysis
Glycosylationi110 – 1101N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi188 ↔ 244By similarity
Disulfide bondi206 ↔ 217By similarity
Glycosylationi216 – 2161N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9CQ01.
PaxDbiQ9CQ01.
PRIDEiQ9CQ01.

PTM databases

PhosphoSiteiQ9CQ01.

Expressioni

Gene expression databases

BgeeiQ9CQ01.
ExpressionAtlasiQ9CQ01. baseline.
GenevisibleiQ9CQ01. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000095031.

Structurei

3D structure databases

ProteinModelPortaliQ9CQ01.
SMRiQ9CQ01. Positions 39-254.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase T2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG285082.
GeneTreeiENSGT00640000091563.
HOGENOMiHOG000059657.
HOVERGENiHBG050037.
InParanoidiQ9CQ01.
KOiK01166.
OMAiQIEICFD.
OrthoDBiEOG789CC3.
PhylomeDBiQ9CQ01.
TreeFamiTF315063.

Family and domain databases

Gene3Di3.90.730.10. 1 hit.
InterProiIPR001568. RNase_T2-like.
IPR018188. RNase_T2_AS.
[Graphical view]
PANTHERiPTHR11240. PTHR11240. 1 hit.
PfamiPF00445. Ribonuclease_T2. 1 hit.
[Graphical view]
SUPFAMiSSF55895. SSF55895. 1 hit.
PROSITEiPS00530. RNASE_T2_1. 1 hit.
PS00531. RNASE_T2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CQ01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPAEARGAL PGWISVLGWG LALCSLCGAG PLWSGSHEWK KLILTQHWPP
60 70 80 90 100
TVCKEVNSCQ DSLDYWTIHG LWPDRAEDCN QSWHFNLDEI KDLLRDMKIY
110 120 130 140 150
WPDVIHRSSN RSQFWKHEWV KHGTCAAQVD ALNSEKKYFG KSLDLYKQID
160 170 180 190 200
LNSVLQKFGI KPSINYYQLA DFKDALTRIY GVVPKIQCLM PEQGESVQTV
210 220 230 240 250
GQIELCFTKE DLHLRNCTEP GEQLSSRQEA WLAMEASTHG MMVCEDGPIF

YPPPTKTQH
Length:259
Mass (Da):29,609
Last modified:June 1, 2001 - v1
Checksum:iE0A1C1BBBEAA5033
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018722 mRNA. Translation: BAB31368.1.
AK019234 mRNA. Translation: BAB31616.1.
AK029149 mRNA. Translation: BAC26326.1.
BC031496 mRNA. Translation: AAH31496.1.
CCDSiCCDS37433.1.
RefSeqiNP_001077407.1. NM_001083938.2.
NP_080887.1. NM_026611.2.
UniGeneiMm.181237.
Mm.426736.

Genome annotation databases

EnsembliENSMUST00000089119; ENSMUSP00000086519; ENSMUSG00000094724.
ENSMUST00000097420; ENSMUSP00000095031; ENSMUSG00000095687.
ENSMUST00000179728; ENSMUSP00000137303; ENSMUSG00000094724.
GeneIDi100037283.
68195.
KEGGimmu:100037283.
mmu:68195.
UCSCiuc008aic.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018722 mRNA. Translation: BAB31368.1.
AK019234 mRNA. Translation: BAB31616.1.
AK029149 mRNA. Translation: BAC26326.1.
BC031496 mRNA. Translation: AAH31496.1.
CCDSiCCDS37433.1.
RefSeqiNP_001077407.1. NM_001083938.2.
NP_080887.1. NM_026611.2.
UniGeneiMm.181237.
Mm.426736.

3D structure databases

ProteinModelPortaliQ9CQ01.
SMRiQ9CQ01. Positions 39-254.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000095031.

PTM databases

PhosphoSiteiQ9CQ01.

Proteomic databases

MaxQBiQ9CQ01.
PaxDbiQ9CQ01.
PRIDEiQ9CQ01.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000089119; ENSMUSP00000086519; ENSMUSG00000094724.
ENSMUST00000097420; ENSMUSP00000095031; ENSMUSG00000095687.
ENSMUST00000179728; ENSMUSP00000137303; ENSMUSG00000094724.
GeneIDi100037283.
68195.
KEGGimmu:100037283.
mmu:68195.
UCSCiuc008aic.1. mouse.

Organism-specific databases

CTDi100037283.
68195.
MGIiMGI:1915445. Rnaset2.

Phylogenomic databases

eggNOGiNOG285082.
GeneTreeiENSGT00640000091563.
HOGENOMiHOG000059657.
HOVERGENiHBG050037.
InParanoidiQ9CQ01.
KOiK01166.
OMAiQIEICFD.
OrthoDBiEOG789CC3.
PhylomeDBiQ9CQ01.
TreeFamiTF315063.

Miscellaneous databases

NextBioi326674.
PROiQ9CQ01.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CQ01.
ExpressionAtlasiQ9CQ01. baseline.
GenevisibleiQ9CQ01. MM.

Family and domain databases

Gene3Di3.90.730.10. 1 hit.
InterProiIPR001568. RNase_T2-like.
IPR018188. RNase_T2_AS.
[Graphical view]
PANTHERiPTHR11240. PTHR11240. 1 hit.
PfamiPF00445. Ribonuclease_T2. 1 hit.
[Graphical view]
SUPFAMiSSF55895. SSF55895. 1 hit.
PROSITEiPS00530. RNASE_T2_1. 1 hit.
PS00531. RNASE_T2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo, Kidney and Skin.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.

Entry informationi

Entry nameiRNT2_MOUSE
AccessioniPrimary (citable) accession number: Q9CQ01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2002
Last sequence update: June 1, 2001
Last modified: June 24, 2015
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.