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Q9CQ01 (RNT2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonuclease T2

EC=3.1.27.-
Alternative name(s):
Ribonuclease 6
Gene names
Name:Rnaset2
Synonyms:Rnase6pl
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length259 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Has ribonuclease activity, with higher activity at acidic pH. May play a role in cellular RNA catabolism. Probably is involved in lysosomal degradation of ribosomal RNA By similarity.

Subcellular location

Secreted By similarity. Endoplasmic reticulum lumen By similarity. Lysosome lumen By similarity.

Sequence similarities

Belongs to the RNase T2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Chain30 – 259230Ribonuclease T2
PRO_0000030988

Sites

Active site691 By similarity
Active site1181 By similarity
Active site1221 By similarity

Amino acid modifications

Glycosylation801N-linked (GlcNAc...) Potential
Glycosylation1101N-linked (GlcNAc...) Potential
Glycosylation2161N-linked (GlcNAc...) Potential
Disulfide bond53 ↔ 59 By similarity
Disulfide bond79 ↔ 125 By similarity
Disulfide bond188 ↔ 244 By similarity
Disulfide bond206 ↔ 217 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9CQ01 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: E0A1C1BBBEAA5033

FASTA25929,609
        10         20         30         40         50         60 
MAPAEARGAL PGWISVLGWG LALCSLCGAG PLWSGSHEWK KLILTQHWPP TVCKEVNSCQ 

        70         80         90        100        110        120 
DSLDYWTIHG LWPDRAEDCN QSWHFNLDEI KDLLRDMKIY WPDVIHRSSN RSQFWKHEWV 

       130        140        150        160        170        180 
KHGTCAAQVD ALNSEKKYFG KSLDLYKQID LNSVLQKFGI KPSINYYQLA DFKDALTRIY 

       190        200        210        220        230        240 
GVVPKIQCLM PEQGESVQTV GQIELCFTKE DLHLRNCTEP GEQLSSRQEA WLAMEASTHG 

       250 
MMVCEDGPIF YPPPTKTQH 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Embryo, Kidney and Skin.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary gland.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK018722 mRNA. Translation: BAB31368.1.
AK019234 mRNA. Translation: BAB31616.1.
AK029149 mRNA. Translation: BAC26326.1.
BC031496 mRNA. Translation: AAH31496.1.
RefSeqNP_001077407.1. NM_001083938.2.
NP_080887.1. NM_026611.2.
UniGeneMm.181237.
Mm.426736.

3D structure databases

ProteinModelPortalQ9CQ01.
SMRQ9CQ01. Positions 39-254.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000086519.

PTM databases

PhosphoSiteQ9CQ01.

Proteomic databases

PaxDbQ9CQ01.
PRIDEQ9CQ01.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000089119; ENSMUSP00000086519; ENSMUSG00000094724.
ENSMUST00000097420; ENSMUSP00000095031; ENSMUSG00000095687.
ENSMUST00000179728; ENSMUSP00000137303; ENSMUSG00000094724.
GeneID100037283.
68195.
KEGGmmu:100037283.
mmu:68195.
UCSCuc008aic.1. mouse.

Organism-specific databases

CTD100037283.
68195.
MGIMGI:1915445. Rnaset2.

Phylogenomic databases

eggNOGNOG285082.
GeneTreeENSGT00640000091563.
HOGENOMHOG000059657.
HOVERGENHBG050037.
InParanoidQ9CQ01.
KOK01166.
OMAILTHHWP.
OrthoDBEOG789CC3.
PhylomeDBQ9CQ01.
TreeFamTF315063.

Gene expression databases

BgeeQ9CQ01.
GenevestigatorQ9CQ01.

Family and domain databases

Gene3D3.90.730.10. 1 hit.
InterProIPR001568. RNase_T2-like.
IPR018188. RNase_T2_AS.
[Graphical view]
PANTHERPTHR11240. PTHR11240. 1 hit.
PfamPF00445. Ribonuclease_T2. 1 hit.
[Graphical view]
SUPFAMSSF55895. SSF55895. 1 hit.
PROSITEPS00530. RNASE_T2_1. 1 hit.
PS00531. RNASE_T2_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio326674.
PROQ9CQ01.
SOURCESearch...

Entry information

Entry nameRNT2_MOUSE
AccessionPrimary (citable) accession number: Q9CQ01
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2002
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot