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Protein

ORM1-like protein 3

Gene

Ormdl3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling (By similarity).By similarity

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-1660661 Sphingolipid de novo biosynthesis
R-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
ORM1-like protein 3
Gene namesi
Name:Ormdl3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1913862 Ormdl3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Transmembranei43 – 63HelicalSequence analysisAdd BLAST21
Transmembranei95 – 117HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002156401 – 153ORM1-like protein 3Add BLAST153

Proteomic databases

MaxQBiQ9CPZ6
PaxDbiQ9CPZ6
PeptideAtlasiQ9CPZ6
PRIDEiQ9CPZ6
TopDownProteomicsiQ9CPZ6

PTM databases

iPTMnetiQ9CPZ6
PhosphoSitePlusiQ9CPZ6

Expressioni

Gene expression databases

BgeeiENSMUSG00000038150
CleanExiMM_ORMDL3
GenevisibleiQ9CPZ6 MM

Interactioni

Subunit structurei

Interacts with SPTLC1.By similarity

Protein-protein interaction databases

IntActiQ9CPZ6, 1 interactor
STRINGi10090.ENSMUSP00000053056

Family & Domainsi

Sequence similaritiesi

Belongs to the ORM family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3319 Eukaryota
COG5081 LUCA
GeneTreeiENSGT00390000015817
HOGENOMiHOG000192741
HOVERGENiHBG080033
InParanoidiQ9CPZ6
OMAiIDNGAQY
OrthoDBiEOG091G0S5I
PhylomeDBiQ9CPZ6
TreeFamiTF323369

Family and domain databases

InterProiView protein in InterPro
IPR007203 ORMDL
IPR029883 ORML3
PANTHERiPTHR12665 PTHR12665, 1 hit
PTHR12665:SF11 PTHR12665:SF11, 1 hit
PfamiView protein in Pfam
PF04061 ORMDL, 1 hit
PIRSFiPIRSF018147 ORMDL, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CPZ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVGTAHSEV NPNTRVMNSR GIWLSYVLAI GLLHVVLLSI PFVSVPVVWT
60 70 80 90 100
LTNLIHNLGM YIFLHTVKGT PFETPDQGKA RLLTHWEQMD YGVQFTASRK
110 120 130 140 150
FLTITPIVLY FLTSFYTKYD QVHFILNTVS LMTVLIPKLP QLHGVRIFGI

NKY
Length:153
Mass (Da):17,477
Last modified:June 1, 2001 - v1
Checksum:iE37EB8D0E958EB2D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti58L → Q in BAC39898 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009621 mRNA Translation: BAB26397.1
AK012718 mRNA Translation: BAB28432.1
AK154085 mRNA Translation: BAE32363.1
AK087497 mRNA Translation: BAC39898.1
AL591125 Genomic DNA Translation: CAM24381.1
CH466556 Genomic DNA Translation: EDL16151.1
BC026412 mRNA Translation: AAH26412.1
BC046594 mRNA Translation: AAH46594.1
CCDSiCCDS25355.1
RefSeqiNP_079937.1, NM_025661.4
UniGeneiMm.180546

Genome annotation databases

EnsembliENSMUST00000052919; ENSMUSP00000053056; ENSMUSG00000038150
GeneIDi66612
KEGGimmu:66612
UCSCiuc007lgr.1 mouse

Similar proteinsi

Entry informationi

Entry nameiORML3_MOUSE
AccessioniPrimary (citable) accession number: Q9CPZ6
Secondary accession number(s): A2A4X7, Q8BN65, Q8R0U5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health