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Protein

ORM1-like protein 3

Gene

Ormdl3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-1660661. Sphingolipid de novo biosynthesis.
R-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
ORM1-like protein 3
Gene namesi
Name:Ormdl3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1913862. Ormdl3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Transmembranei43 – 63HelicalSequence analysisAdd BLAST21
Transmembranei95 – 117HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002156401 – 153ORM1-like protein 3Add BLAST153

Proteomic databases

MaxQBiQ9CPZ6.
PaxDbiQ9CPZ6.
PeptideAtlasiQ9CPZ6.
PRIDEiQ9CPZ6.
TopDownProteomicsiQ9CPZ6.

PTM databases

iPTMnetiQ9CPZ6.
PhosphoSitePlusiQ9CPZ6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000038150.
CleanExiMM_ORMDL3.
GenevisibleiQ9CPZ6. MM.

Interactioni

Subunit structurei

Interacts with SPTLC1.By similarity

Protein-protein interaction databases

IntActiQ9CPZ6. 1 interactor.
STRINGi10090.ENSMUSP00000053056.

Structurei

3D structure databases

ProteinModelPortaliQ9CPZ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ORM family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3319. Eukaryota.
COG5081. LUCA.
GeneTreeiENSGT00390000015817.
HOGENOMiHOG000192741.
HOVERGENiHBG080033.
InParanoidiQ9CPZ6.
OMAiHFIINTI.
OrthoDBiEOG091G0S5I.
PhylomeDBiQ9CPZ6.
TreeFamiTF323369.

Family and domain databases

InterProiIPR007203. ORMDL.
IPR029883. ORML3.
[Graphical view]
PANTHERiPTHR12665. PTHR12665. 1 hit.
PTHR12665:SF11. PTHR12665:SF11. 1 hit.
PfamiPF04061. ORMDL. 1 hit.
[Graphical view]
PIRSFiPIRSF018147. ORMDL. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CPZ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVGTAHSEV NPNTRVMNSR GIWLSYVLAI GLLHVVLLSI PFVSVPVVWT
60 70 80 90 100
LTNLIHNLGM YIFLHTVKGT PFETPDQGKA RLLTHWEQMD YGVQFTASRK
110 120 130 140 150
FLTITPIVLY FLTSFYTKYD QVHFILNTVS LMTVLIPKLP QLHGVRIFGI

NKY
Length:153
Mass (Da):17,477
Last modified:June 1, 2001 - v1
Checksum:iE37EB8D0E958EB2D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti58L → Q in BAC39898 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009621 mRNA. Translation: BAB26397.1.
AK012718 mRNA. Translation: BAB28432.1.
AK154085 mRNA. Translation: BAE32363.1.
AK087497 mRNA. Translation: BAC39898.1.
AL591125 Genomic DNA. Translation: CAM24381.1.
CH466556 Genomic DNA. Translation: EDL16151.1.
BC026412 mRNA. Translation: AAH26412.1.
BC046594 mRNA. Translation: AAH46594.1.
CCDSiCCDS25355.1.
RefSeqiNP_079937.1. NM_025661.4.
UniGeneiMm.180546.

Genome annotation databases

EnsembliENSMUST00000052919; ENSMUSP00000053056; ENSMUSG00000038150.
GeneIDi66612.
KEGGimmu:66612.
UCSCiuc007lgr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009621 mRNA. Translation: BAB26397.1.
AK012718 mRNA. Translation: BAB28432.1.
AK154085 mRNA. Translation: BAE32363.1.
AK087497 mRNA. Translation: BAC39898.1.
AL591125 Genomic DNA. Translation: CAM24381.1.
CH466556 Genomic DNA. Translation: EDL16151.1.
BC026412 mRNA. Translation: AAH26412.1.
BC046594 mRNA. Translation: AAH46594.1.
CCDSiCCDS25355.1.
RefSeqiNP_079937.1. NM_025661.4.
UniGeneiMm.180546.

3D structure databases

ProteinModelPortaliQ9CPZ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9CPZ6. 1 interactor.
STRINGi10090.ENSMUSP00000053056.

PTM databases

iPTMnetiQ9CPZ6.
PhosphoSitePlusiQ9CPZ6.

Proteomic databases

MaxQBiQ9CPZ6.
PaxDbiQ9CPZ6.
PeptideAtlasiQ9CPZ6.
PRIDEiQ9CPZ6.
TopDownProteomicsiQ9CPZ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000052919; ENSMUSP00000053056; ENSMUSG00000038150.
GeneIDi66612.
KEGGimmu:66612.
UCSCiuc007lgr.1. mouse.

Organism-specific databases

CTDi94103.
MGIiMGI:1913862. Ormdl3.

Phylogenomic databases

eggNOGiKOG3319. Eukaryota.
COG5081. LUCA.
GeneTreeiENSGT00390000015817.
HOGENOMiHOG000192741.
HOVERGENiHBG080033.
InParanoidiQ9CPZ6.
OMAiHFIINTI.
OrthoDBiEOG091G0S5I.
PhylomeDBiQ9CPZ6.
TreeFamiTF323369.

Enzyme and pathway databases

ReactomeiR-MMU-1660661. Sphingolipid de novo biosynthesis.
R-MMU-6798695. Neutrophil degranulation.

Miscellaneous databases

ChiTaRSiOrmdl3. mouse.
PROiQ9CPZ6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038150.
CleanExiMM_ORMDL3.
GenevisibleiQ9CPZ6. MM.

Family and domain databases

InterProiIPR007203. ORMDL.
IPR029883. ORML3.
[Graphical view]
PANTHERiPTHR12665. PTHR12665. 1 hit.
PTHR12665:SF11. PTHR12665:SF11. 1 hit.
PfamiPF04061. ORMDL. 1 hit.
[Graphical view]
PIRSFiPIRSF018147. ORMDL. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiORML3_MOUSE
AccessioniPrimary (citable) accession number: Q9CPZ6
Secondary accession number(s): A2A4X7, Q8BN65, Q8R0U5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.