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Protein

Cyclin-dependent kinase 2-associated protein 2

Gene

Cdk2ap2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in regulating the self-renewal of embryonic stem cells (ESCs) and in maintaining cell survival during terminal differentiation of ESCs (PubMed:22548356). Regulates microtubule organization of metaphase II oocytes (PubMed:12944431). Inhibits cell cycle G1/S phase transition by repressing CDK2 expression and activation; represses CDK2 activation by inhibiting its interaction with cyclin E and A (By similarity).By similarity2 Publications

GO - Biological processi

  • negative regulation of G1/S transition of mitotic cell cycle Source: UniProtKB
  • regulation of microtubule cytoskeleton organization Source: UniProtKB
  • regulation of stem cell division Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 2-associated protein 2
Short name:
CDK2-associated protein 2
Alternative name(s):
DOC-1-related protein
Short name:
DOC-1R
Gene namesi
Name:Cdk2ap2
Synonyms:D19Ertd144e, Doc1r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1098779. Cdk2ap2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • microtubule Source: UniProtKB
  • nucleus Source: UniProtKB

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000799641 – 127Cyclin-dependent kinase 2-associated protein 2Add BLAST127

Post-translational modificationi

Phosphorylated by MAPK1 and CDK2.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9CPY4.
PaxDbiQ9CPY4.
PeptideAtlasiQ9CPY4.
PRIDEiQ9CPY4.

PTM databases

iPTMnetiQ9CPY4.
PhosphoSitePlusiQ9CPY4.

Expressioni

Tissue specificityi

Oocytes (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000024856.
CleanExiMM_CDK2AP2.
ExpressionAtlasiQ9CPY4. baseline and differential.
GenevisibleiQ9CPY4. MM.

Interactioni

Subunit structurei

Interacts with MAPK1 (PubMed:12944431). Interacts with CDK2 and CDK2AP1 (By similarity).By similarity1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025779.

Structurei

3D structure databases

ProteinModelPortaliQ9CPY4.
SMRiQ9CPY4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni65 – 107Interaction with CDK2By similarityAdd BLAST43

Sequence similaritiesi

Belongs to the CDK2AP family.Curated

Phylogenomic databases

eggNOGiKOG4713. Eukaryota.
ENOG41126TJ. LUCA.
GeneTreeiENSGT00390000006964.
HOGENOMiHOG000035115.
HOVERGENiHBG002074.
InParanoidiQ9CPY4.
OMAiMKPPGTQ.
OrthoDBiEOG091G1364.
PhylomeDBiQ9CPY4.
TreeFamiTF101037.

Family and domain databases

InterProiView protein in InterPro
IPR017266. DOC_1/2.
PANTHERiPTHR22607. PTHR22607. 1 hit.
PfamiView protein in Pfam
PF09806. CDK2AP. 1 hit.
PIRSFiPIRSF037709. CDK2-associated_p2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CPY4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYKPIAPAP SSTPGSSTPG PGTPVPTAGS VPSPSGSVPG AAAPFRPLFN
60 70 80 90 100
DFGPPSMGYV QAMKPPGSQG SQSTYTDLLS VIEEMGKEIR PTYAGSKSAM
110 120
ERLKRGIIHA RALVRECLAE TERNART
Length:127
Mass (Da):13,202
Last modified:June 1, 2001 - v1
Checksum:iE8299A37B030EEFD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003686 mRNA. Translation: BAB22939.1.
AK012121 mRNA. Translation: BAB28046.1.
AK018035 mRNA. Translation: BAB31046.1.
BC025656 mRNA. Translation: AAH25656.1.
CCDSiCCDS29414.1.
RefSeqiNP_080649.1. NM_026373.4.
UniGeneiMm.29609.

Genome annotation databases

EnsembliENSMUST00000025779; ENSMUSP00000025779; ENSMUSG00000024856.
ENSMUST00000180435; ENSMUSP00000137712; ENSMUSG00000097485.
GeneIDi52004.
KEGGimmu:52004.
UCSCiuc008fym.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCDKA2_MOUSE
AccessioniPrimary (citable) accession number: Q9CPY4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2001
Last modified: May 10, 2017
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families