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Q9CPY3

- CDCA5_MOUSE

UniProt

Q9CPY3 - CDCA5_MOUSE

Protein

Sororin

Gene

Cdca5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPAL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair.1 Publication

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. double-strand break repair Source: UniProtKB
    2. G1/S transition of mitotic cell cycle Source: UniProtKB
    3. mitotic chromosome condensation Source: UniProtKB
    4. mitotic interphase Source: UniProtKB
    5. mitotic metaphase plate congression Source: UniProtKB
    6. mitotic nuclear division Source: UniProtKB
    7. mitotic sister chromatid cohesion Source: UniProtKB
    8. regulation of cohesin localization to chromatin Source: UniProtKB

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Enzyme and pathway databases

    ReactomeiREACT_196614. Establishment of Sister Chromatid Cohesion.
    REACT_198961. Resolution of Sister Chromatid Cohesion.
    REACT_207679. Separation of Sister Chromatids.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sororin
    Alternative name(s):
    Cell division cycle-associated protein 5
    Gene namesi
    Name:Cdca5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:1915099. Cdca5.

    Subcellular locationi

    Nucleus 1 Publication. Chromosome 1 Publication. Cytoplasm 1 Publication
    Note: Associates with nuclear chromatin from S phase until metaphase and is released in the cytoplasm upon nuclear envelope breakdown.

    GO - Cellular componenti

    1. chromatin Source: MGI
    2. cohesin complex Source: Ensembl
    3. cytoplasm Source: UniProtKB
    4. nuclear chromatin Source: UniProtKB
    5. nucleus Source: UniProtKB
    6. plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Chromosome, Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 264264SororinPRO_0000089450Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei20 – 201PhosphoserineBy similarity
    Modified residuei32 – 321PhosphoserineBy similarity
    Modified residuei34 – 341PhosphoserineBy similarity
    Modified residuei78 – 781PhosphoserineBy similarity
    Modified residuei106 – 1061PhosphoserineBy similarity
    Modified residuei114 – 1141PhosphothreonineBy similarity
    Modified residuei222 – 2221PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylated. Phosphorylation, as cells enter mitosis, disrupts the interaction with PDS5A and relieves the inhibition of WAPAL by CDCA5 By similarity.By similarity
    Ubiquitinated by the APC/C complex in G1, leading to its degradation.By similarity

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    PRIDEiQ9CPY3.

    PTM databases

    PhosphoSiteiQ9CPY3.

    Expressioni

    Gene expression databases

    BgeeiQ9CPY3.
    CleanExiMM_CDCA5.
    GenevestigatoriQ9CPY3.

    Interactioni

    Subunit structurei

    Interacts with the APC/C complex By similarity. Interacts with the chromatin-bound cohesin complex; the interaction is indirect, occurs after DNA replication and requires acetylation of the cohesin component SMC3. Interacts (via the FGF motif) with PDS5A and PDS5B; the interaction is direct and prevents the interaction of PDS5A with WAPAL.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi212479. 9 interactions.
    IntActiQ9CPY3. 8 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CPY3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi87 – 893KEN box
    Motifi166 – 1683FGF motif

    Domaini

    The KEN box is required for the association with the APC/C complex.By similarity

    Sequence similaritiesi

    Belongs to the sororin family.Curated

    Phylogenomic databases

    eggNOGiNOG43755.
    GeneTreeiENSGT00390000010028.
    HOGENOMiHOG000232187.
    HOVERGENiHBG080614.
    InParanoidiQ9CPY3.
    KOiK17390.
    OMAiLEMSQKV.
    OrthoDBiEOG7N8ZVV.
    PhylomeDBiQ9CPY3.
    TreeFamiTF101070.

    Family and domain databases

    InterProiIPR018605. Sororin.
    [Graphical view]
    PfamiPF09666. Sororin. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9CPY3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAERRTRSGG AAQRSGPRTS LTKPSKSSKR KSGSDLPNSF SEIWPRTTPA    50
    VPVRKAIVLK KIVAHAVEVP DVHTVRRSPR ISFILEKENN PPLKVPTKED 100
    LFKTCSVPGT PSSTPVLYTQ NVEPDSGEAE LDSRDLEMSQ KVRRSYSRLQ 150
    SLGCASTSTP GRRSFFGFEG PDDLPGVSPV VCSKLIETPK VPAKDLVPAR 200
    TKDLVPDSTK DLVPARTLPG ISPPVVKEKR KKKVPEILKS ELDKWAVAMN 250
    AEFEAAEQFE LLIE 264
    Length:264
    Mass (Da):28,991
    Last modified:June 1, 2001 - v1
    Checksum:iE8543BBE3593B212
    GO
    Isoform 2 (identifier: Q9CPY3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-137: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:127
    Mass (Da):13,979
    Checksum:iE3BF12AAE025C1C8
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 137137Missing in isoform 2. 1 PublicationVSP_014402Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK010540 mRNA. Translation: BAB27016.1.
    AK011701 mRNA. Translation: BAB27788.1.
    BC029626 mRNA. Translation: AAH29626.1.
    BC052904 mRNA. Translation: AAH52904.1.
    CCDSiCCDS29493.1. [Q9CPY3-1]
    RefSeqiNP_080686.1. NM_026410.3. [Q9CPY3-1]
    UniGeneiMm.23526.

    Genome annotation databases

    EnsembliENSMUST00000025704; ENSMUSP00000025704; ENSMUSG00000024791. [Q9CPY3-1]
    GeneIDi67849.
    KEGGimmu:67849.
    UCSCiuc008ghh.1. mouse. [Q9CPY3-1]
    uc008ghi.1. mouse. [Q9CPY3-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK010540 mRNA. Translation: BAB27016.1 .
    AK011701 mRNA. Translation: BAB27788.1 .
    BC029626 mRNA. Translation: AAH29626.1 .
    BC052904 mRNA. Translation: AAH52904.1 .
    CCDSi CCDS29493.1. [Q9CPY3-1 ]
    RefSeqi NP_080686.1. NM_026410.3. [Q9CPY3-1 ]
    UniGenei Mm.23526.

    3D structure databases

    ProteinModelPortali Q9CPY3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 212479. 9 interactions.
    IntActi Q9CPY3. 8 interactions.

    PTM databases

    PhosphoSitei Q9CPY3.

    Proteomic databases

    PRIDEi Q9CPY3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000025704 ; ENSMUSP00000025704 ; ENSMUSG00000024791 . [Q9CPY3-1 ]
    GeneIDi 67849.
    KEGGi mmu:67849.
    UCSCi uc008ghh.1. mouse. [Q9CPY3-1 ]
    uc008ghi.1. mouse. [Q9CPY3-2 ]

    Organism-specific databases

    CTDi 113130.
    MGIi MGI:1915099. Cdca5.

    Phylogenomic databases

    eggNOGi NOG43755.
    GeneTreei ENSGT00390000010028.
    HOGENOMi HOG000232187.
    HOVERGENi HBG080614.
    InParanoidi Q9CPY3.
    KOi K17390.
    OMAi LEMSQKV.
    OrthoDBi EOG7N8ZVV.
    PhylomeDBi Q9CPY3.
    TreeFami TF101070.

    Enzyme and pathway databases

    Reactomei REACT_196614. Establishment of Sister Chromatid Cohesion.
    REACT_198961. Resolution of Sister Chromatid Cohesion.
    REACT_207679. Separation of Sister Chromatids.

    Miscellaneous databases

    NextBioi 325711.
    PROi Q9CPY3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9CPY3.
    CleanExi MM_CDCA5.
    Genevestigatori Q9CPY3.

    Family and domain databases

    InterProi IPR018605. Sororin.
    [Graphical view ]
    Pfami PF09666. Sororin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6NCr.
      Tissue: Hematopoietic stem cell.
    3. Cited for: FUNCTION, INTERACTION WITH PDS5A AND PDS5B, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiCDCA5_MOUSE
    AccessioniPrimary (citable) accession number: Q9CPY3
    Secondary accession number(s): Q78HI6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3