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Q9CPY3

- CDCA5_MOUSE

UniProt

Q9CPY3 - CDCA5_MOUSE

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Protein

Sororin

Gene

Cdca5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPAL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair.1 Publication

GO - Biological processi

  1. double-strand break repair Source: UniProtKB
  2. G1/S transition of mitotic cell cycle Source: UniProtKB
  3. mitotic chromosome condensation Source: UniProtKB
  4. mitotic metaphase plate congression Source: UniProtKB
  5. mitotic nuclear division Source: UniProtKB
  6. mitotic sister chromatid cohesion Source: UniProtKB
  7. regulation of cohesin localization to chromatin Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiREACT_196614. Establishment of Sister Chromatid Cohesion.
REACT_198961. Resolution of Sister Chromatid Cohesion.
REACT_207679. Separation of Sister Chromatids.

Names & Taxonomyi

Protein namesi
Recommended name:
Sororin
Alternative name(s):
Cell division cycle-associated protein 5
Gene namesi
Name:Cdca5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:1915099. Cdca5.

Subcellular locationi

Nucleus 1 Publication. Chromosome 1 Publication. Cytoplasm 1 Publication
Note: Associates with nuclear chromatin from S phase until metaphase and is released in the cytoplasm upon nuclear envelope breakdown.

GO - Cellular componenti

  1. chromatin Source: MGI
  2. cohesin complex Source: Ensembl
  3. cytoplasm Source: UniProtKB
  4. nuclear chromatin Source: UniProtKB
  5. nucleus Source: UniProtKB
  6. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 264264SororinPRO_0000089450Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei20 – 201PhosphoserineBy similarity
Modified residuei32 – 321PhosphoserineBy similarity
Modified residuei34 – 341PhosphoserineBy similarity
Modified residuei78 – 781PhosphoserineBy similarity
Modified residuei106 – 1061PhosphoserineBy similarity
Modified residuei114 – 1141PhosphothreonineBy similarity
Modified residuei222 – 2221PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated. Phosphorylation, as cells enter mitosis, disrupts the interaction with PDS5A and relieves the inhibition of WAPAL by CDCA5 (By similarity).By similarity
Ubiquitinated by the APC/C complex in G1, leading to its degradation.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ9CPY3.
PRIDEiQ9CPY3.

PTM databases

PhosphoSiteiQ9CPY3.

Expressioni

Gene expression databases

BgeeiQ9CPY3.
CleanExiMM_CDCA5.
GenevestigatoriQ9CPY3.

Interactioni

Subunit structurei

Interacts with the APC/C complex (By similarity). Interacts with the chromatin-bound cohesin complex; the interaction is indirect, occurs after DNA replication and requires acetylation of the cohesin component SMC3. Interacts (via the FGF motif) with PDS5A and PDS5B; the interaction is direct and prevents the interaction of PDS5A with WAPAL.By similarity1 Publication

Protein-protein interaction databases

BioGridi212479. 9 interactions.
IntActiQ9CPY3. 8 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9CPY3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi87 – 893KEN box
Motifi166 – 1683FGF motif

Domaini

The KEN box is required for the association with the APC/C complex.By similarity

Sequence similaritiesi

Belongs to the sororin family.Curated

Phylogenomic databases

eggNOGiNOG43755.
GeneTreeiENSGT00390000010028.
HOGENOMiHOG000232187.
HOVERGENiHBG080614.
InParanoidiQ9CPY3.
KOiK17390.
OMAiLEMSQKV.
OrthoDBiEOG7N8ZVV.
PhylomeDBiQ9CPY3.
TreeFamiTF101070.

Family and domain databases

InterProiIPR018605. Sororin.
[Graphical view]
PfamiPF09666. Sororin. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9CPY3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAERRTRSGG AAQRSGPRTS LTKPSKSSKR KSGSDLPNSF SEIWPRTTPA
60 70 80 90 100
VPVRKAIVLK KIVAHAVEVP DVHTVRRSPR ISFILEKENN PPLKVPTKED
110 120 130 140 150
LFKTCSVPGT PSSTPVLYTQ NVEPDSGEAE LDSRDLEMSQ KVRRSYSRLQ
160 170 180 190 200
SLGCASTSTP GRRSFFGFEG PDDLPGVSPV VCSKLIETPK VPAKDLVPAR
210 220 230 240 250
TKDLVPDSTK DLVPARTLPG ISPPVVKEKR KKKVPEILKS ELDKWAVAMN
260
AEFEAAEQFE LLIE
Length:264
Mass (Da):28,991
Last modified:June 1, 2001 - v1
Checksum:iE8543BBE3593B212
GO
Isoform 2 (identifier: Q9CPY3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-137: Missing.

Note: No experimental confirmation available.

Show »
Length:127
Mass (Da):13,979
Checksum:iE3BF12AAE025C1C8
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 137137Missing in isoform 2. 1 PublicationVSP_014402Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010540 mRNA. Translation: BAB27016.1.
AK011701 mRNA. Translation: BAB27788.1.
BC029626 mRNA. Translation: AAH29626.1.
BC052904 mRNA. Translation: AAH52904.1.
CCDSiCCDS29493.1. [Q9CPY3-1]
RefSeqiNP_080686.1. NM_026410.3. [Q9CPY3-1]
UniGeneiMm.23526.

Genome annotation databases

EnsembliENSMUST00000025704; ENSMUSP00000025704; ENSMUSG00000024791. [Q9CPY3-1]
GeneIDi67849.
KEGGimmu:67849.
UCSCiuc008ghh.1. mouse. [Q9CPY3-1]
uc008ghi.1. mouse. [Q9CPY3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010540 mRNA. Translation: BAB27016.1 .
AK011701 mRNA. Translation: BAB27788.1 .
BC029626 mRNA. Translation: AAH29626.1 .
BC052904 mRNA. Translation: AAH52904.1 .
CCDSi CCDS29493.1. [Q9CPY3-1 ]
RefSeqi NP_080686.1. NM_026410.3. [Q9CPY3-1 ]
UniGenei Mm.23526.

3D structure databases

ProteinModelPortali Q9CPY3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 212479. 9 interactions.
IntActi Q9CPY3. 8 interactions.

PTM databases

PhosphoSitei Q9CPY3.

Proteomic databases

MaxQBi Q9CPY3.
PRIDEi Q9CPY3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025704 ; ENSMUSP00000025704 ; ENSMUSG00000024791 . [Q9CPY3-1 ]
GeneIDi 67849.
KEGGi mmu:67849.
UCSCi uc008ghh.1. mouse. [Q9CPY3-1 ]
uc008ghi.1. mouse. [Q9CPY3-2 ]

Organism-specific databases

CTDi 113130.
MGIi MGI:1915099. Cdca5.

Phylogenomic databases

eggNOGi NOG43755.
GeneTreei ENSGT00390000010028.
HOGENOMi HOG000232187.
HOVERGENi HBG080614.
InParanoidi Q9CPY3.
KOi K17390.
OMAi LEMSQKV.
OrthoDBi EOG7N8ZVV.
PhylomeDBi Q9CPY3.
TreeFami TF101070.

Enzyme and pathway databases

Reactomei REACT_196614. Establishment of Sister Chromatid Cohesion.
REACT_198961. Resolution of Sister Chromatid Cohesion.
REACT_207679. Separation of Sister Chromatids.

Miscellaneous databases

NextBioi 325711.
PROi Q9CPY3.
SOURCEi Search...

Gene expression databases

Bgeei Q9CPY3.
CleanExi MM_CDCA5.
Genevestigatori Q9CPY3.

Family and domain databases

InterProi IPR018605. Sororin.
[Graphical view ]
Pfami PF09666. Sororin. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6NCr.
    Tissue: Hematopoietic stem cell.
  3. Cited for: FUNCTION, INTERACTION WITH PDS5A AND PDS5B, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiCDCA5_MOUSE
AccessioniPrimary (citable) accession number: Q9CPY3
Secondary accession number(s): Q78HI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3