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Protein

Anaphase-promoting complex subunit 11

Gene

Anapc11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi23Zinc 1By similarity1
Metal bindingi26Zinc 1By similarity1
Metal bindingi34Zinc 3By similarity1
Metal bindingi37Zinc 3By similarity1
Metal bindingi44Zinc 3By similarity1
Metal bindingi51Zinc 2By similarity1
Metal bindingi53Zinc 2By similarity1
Metal bindingi56Zinc 1By similarity1
Metal bindingi58Zinc 3By similarity1
Metal bindingi59Zinc 1By similarity1
Metal bindingi73Zinc 2By similarity1
Metal bindingi76Zinc 2By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri34 – 77RING-typePROSITE-ProRule annotationAdd BLAST44

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-141430 Inactivation of APC/C via direct inhibition of the APC/C complex
R-MMU-174048 APC/C:Cdc20 mediated degradation of Cyclin B
R-MMU-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-MMU-174154 APC/C:Cdc20 mediated degradation of Securin
R-MMU-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-MMU-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-MMU-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
R-MMU-176408 Regulation of APC/C activators between G1/S and early anaphase
R-MMU-176409 APC/C:Cdc20 mediated degradation of mitotic proteins
R-MMU-176412 Phosphorylation of the APC/C
R-MMU-179409 APC-Cdc20 mediated degradation of Nek2A
R-MMU-2467813 Separation of Sister Chromatids
R-MMU-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-MMU-69017 CDK-mediated phosphorylation and removal of Cdc6
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Anaphase-promoting complex subunit 11
Short name:
APC11
Alternative name(s):
Cyclosome subunit 11
Gene namesi
Name:Anapc11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1913406 Anapc11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000557481 – 84Anaphase-promoting complex subunit 11Add BLAST84

Post-translational modificationi

Auto-ubiquitinated.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiQ9CPX9
PaxDbiQ9CPX9
PeptideAtlasiQ9CPX9
PRIDEiQ9CPX9

PTM databases

iPTMnetiQ9CPX9
PhosphoSitePlusiQ9CPX9

Expressioni

Gene expression databases

BgeeiENSMUSG00000025135
GenevisibleiQ9CPX9 MM

Interactioni

Subunit structurei

The mammalian APC/C is composed of 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa. Interacts with the cullin domain of ANAPC2. Interacts with UBE2D2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211257, 3 interactors
STRINGi10090.ENSMUSP00000026128

Structurei

3D structure databases

ProteinModelPortaliQ9CPX9
SMRiQ9CPX9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The RING-type zinc finger domain coordinates an additional third zinc ion.By similarity

Sequence similaritiesi

Belongs to the RING-box family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri34 – 77RING-typePROSITE-ProRule annotationAdd BLAST44

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1493 Eukaryota
COG5194 LUCA
GeneTreeiENSGT00550000075186
HOVERGENiHBG097038
InParanoidiQ9CPX9
KOiK03358
OMAiFHIHCIM
OrthoDBiEOG091G17LB
PhylomeDBiQ9CPX9
TreeFamiTF354219

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR024991 Apc11
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF12861 zf-ANAPC11, 1 hit
PROSITEiView protein in PROSITE
PS50089 ZF_RING_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CPX9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVKIKCWNG VATWLWVAND ENCGICRMAF NGCCPDCKVP GDDCPLVWGQ
60 70 80
CSHCFHMHCI LKWLNAQQVQ QHCPMCRQEW KFKE
Length:84
Mass (Da):9,818
Last modified:June 1, 2001 - v1
Checksum:iEACBD5A194FC11AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003244 mRNA Translation: BAB22663.1
AK003612 mRNA Translation: BAB22890.1
AK003684 mRNA Translation: BAB22937.1
AK045408 mRNA Translation: BAC32348.1
AK136358 mRNA Translation: BAE22944.1
BC023039 mRNA Translation: AAH23039.1
CCDSiCCDS25745.1
RefSeqiNP_001033319.1, NM_001038230.2
NP_079665.1, NM_025389.4
UniGeneiMm.21645

Genome annotation databases

EnsembliENSMUST00000026128; ENSMUSP00000026128; ENSMUSG00000025135
ENSMUST00000093140; ENSMUSP00000097714; ENSMUSG00000025135
GeneIDi66156
KEGGimmu:66156
UCSCiuc007mtm.2 mouse

Similar proteinsi

Entry informationi

Entry nameiAPC11_MOUSE
AccessioniPrimary (citable) accession number: Q9CPX9
Secondary accession number(s): Q3UWH1, Q9CTG0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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