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Protein

Ferritin

Gene

Ftl1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.UniRule annotation

GO - Molecular functioni

  1. ferric iron binding Source: InterPro

GO - Biological processi

  1. cellular iron ion homeostasis Source: UniProtKB-KW
  2. iron ion transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Iron storageUniRule annotation

Keywords - Ligandi

Iron, Metal-bindingUniRule annotation

Enzyme and pathway databases

ReactomeiREACT_292451. Iron uptake and transport.
REACT_342454. Golgi Associated Vesicle Biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
FerritinUniRule annotation
Gene namesi
Name:Ftl1Imported
Synonyms:Gm20746Imported
ORF Names:mCG_17237Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componentsi: Chromosome 13, Chromosome 7

Organism-specific databases

MGIiMGI:95589. Ftl1.

Expressioni

Gene expression databases

GenevestigatoriQ9CPX4.

Interactioni

Protein-protein interaction databases

MINTiMINT-217864.

Family & Domainsi

Sequence similaritiesi

Belongs to the ferritin family.UniRule annotation
Contains 1 ferritin-like diiron domain.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000119129.
HOVERGENiHBG000410.
KOiK13625.
OMAiMYLQASY.
OrthoDBiEOG7DRJ49.
TreeFamiTF313885.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00540. FERRITIN_1. 1 hit.
PS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CPX4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSQIRQNYS TEVEAAVNRL VNLHLRASYT YLSLGFFFDR DDVALEGVGH
60 70 80 90 100
FFRELAEEKR EGAERLLEFQ NDRGGRALFQ DVQKPSQDEW GKTQEAMEAA
110 120 130 140 150
LAMEKNLNQA LLDLHALGSA RADPHLCDFL ESHYLDKEVK LIKKMGNHLT
160 170 180
NLRRVAGPQP AQTGAPQGSL GEYLFERLTL KHD
Length:183
Mass (Da):20,772
Last modified:June 1, 2001 - v1
Checksum:iED39E8CCBABA590B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC151602 Genomic DNA. No translation available.
CT009486 Genomic DNA. No translation available.
BC081462 mRNA. Translation: AAH81462.1.
BC083350 mRNA. Translation: AAH83350.1.
BC085309 mRNA. Translation: AAH85309.1.
BC092259 mRNA. Translation: AAH92259.1.
BC106146 mRNA. Translation: AAI06147.1.
AK002242 mRNA. Translation: BAB21959.1.
AK002253 mRNA. Translation: BAB21967.1.
AK011009 mRNA. Translation: BAB27328.1.
AK011029 mRNA. Translation: BAB27345.1.
AK011244 mRNA. Translation: BAB27491.1.
AK088647 mRNA. Translation: BAC40475.1.
AK150480 mRNA. Translation: BAE29596.1.
AK151255 mRNA. Translation: BAE30244.1.
AK152030 mRNA. Translation: BAE30889.1.
AK152385 mRNA. Translation: BAE31173.1.
AK152393 mRNA. Translation: BAE31181.1.
AK152564 mRNA. Translation: BAE31317.1.
AK152612 mRNA. Translation: BAE31357.1.
AK159574 mRNA. Translation: BAE35195.1.
AK168735 mRNA. Translation: BAE40576.1.
AK168862 mRNA. Translation: BAE40681.1.
AK168866 mRNA. Translation: BAE40685.1.
AK169100 mRNA. Translation: BAE40883.1.
AK169159 mRNA. Translation: BAE40938.1.
CH466563 Genomic DNA. Translation: EDL37096.1.
CH466563 Genomic DNA. Translation: EDL37097.1.
RefSeqiNP_034370.2. NM_010240.2.
XP_003689256.2. XM_003689208.3.
UniGeneiMm.30357.
Mm.348374.
Mm.431913.
Mm.491102.

Genome annotation databases

EnsembliENSMUST00000090860; ENSMUSP00000088372; ENSMUSG00000062382.
ENSMUST00000094434; ENSMUSP00000092002; ENSMUSG00000050708.
GeneIDi100862446.
14325.
KEGGimmu:100862446.
mmu:14325.
UCSCiuc009gvf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC151602 Genomic DNA. No translation available.
CT009486 Genomic DNA. No translation available.
BC081462 mRNA. Translation: AAH81462.1.
BC083350 mRNA. Translation: AAH83350.1.
BC085309 mRNA. Translation: AAH85309.1.
BC092259 mRNA. Translation: AAH92259.1.
BC106146 mRNA. Translation: AAI06147.1.
AK002242 mRNA. Translation: BAB21959.1.
AK002253 mRNA. Translation: BAB21967.1.
AK011009 mRNA. Translation: BAB27328.1.
AK011029 mRNA. Translation: BAB27345.1.
AK011244 mRNA. Translation: BAB27491.1.
AK088647 mRNA. Translation: BAC40475.1.
AK150480 mRNA. Translation: BAE29596.1.
AK151255 mRNA. Translation: BAE30244.1.
AK152030 mRNA. Translation: BAE30889.1.
AK152385 mRNA. Translation: BAE31173.1.
AK152393 mRNA. Translation: BAE31181.1.
AK152564 mRNA. Translation: BAE31317.1.
AK152612 mRNA. Translation: BAE31357.1.
AK159574 mRNA. Translation: BAE35195.1.
AK168735 mRNA. Translation: BAE40576.1.
AK168862 mRNA. Translation: BAE40681.1.
AK168866 mRNA. Translation: BAE40685.1.
AK169100 mRNA. Translation: BAE40883.1.
AK169159 mRNA. Translation: BAE40938.1.
CH466563 Genomic DNA. Translation: EDL37096.1.
CH466563 Genomic DNA. Translation: EDL37097.1.
RefSeqiNP_034370.2. NM_010240.2.
XP_003689256.2. XM_003689208.3.
UniGeneiMm.30357.
Mm.348374.
Mm.431913.
Mm.491102.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-217864.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000090860; ENSMUSP00000088372; ENSMUSG00000062382.
ENSMUST00000094434; ENSMUSP00000092002; ENSMUSG00000050708.
GeneIDi100862446.
14325.
KEGGimmu:100862446.
mmu:14325.
UCSCiuc009gvf.1. mouse.

Organism-specific databases

CTDi14325.
MGIiMGI:95589. Ftl1.

Phylogenomic databases

GeneTreeiENSGT00760000119129.
HOVERGENiHBG000410.
KOiK13625.
OMAiMYLQASY.
OrthoDBiEOG7DRJ49.
TreeFamiTF313885.

Enzyme and pathway databases

ReactomeiREACT_292451. Iron uptake and transport.
REACT_342454. Golgi Associated Vesicle Biogenesis.

Miscellaneous databases

ChiTaRSiFtl1. mouse.
NextBioi285769.
SOURCEiSearch...

Gene expression databases

GenevestigatoriQ9CPX4.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00540. FERRITIN_1. 1 hit.
PS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: AmnionImported, Bone marrowImported, KidneyImported, LiverImported, ThymusImported and Whole bodyImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: AmnionImported, Bone marrowImported, KidneyImported, LiverImported, ThymusImported and Whole bodyImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: AmnionImported, Bone marrowImported, KidneyImported, LiverImported, ThymusImported and Whole bodyImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported, LiverImported and Whole bodyImported.
  5. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: AmnionImported, Bone marrowImported, KidneyImported, LiverImported, ThymusImported and Whole bodyImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: AmnionImported, Bone marrowImported, KidneyImported, LiverImported, ThymusImported and Whole bodyImported.
  7. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
    Tissue: ThymusImported.
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6Imported, FVB/NImported and FVB/N-3Imported.
    Tissue: BrainImported, ColonImported, LiverImported and Mammary tumor. MMTV-LTR/INT3 model. 5 month old mouse. Taken by biopsy.Imported.
  10. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Bone marrowImported.
  11. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: AmnionImported and KidneyImported.
  12. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: AmnionImported, Bone marrowImported, KidneyImported, LiverImported, ThymusImported and Whole bodyImported.
  13. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: AmnionImported, Bone marrowImported, KidneyImported, LiverImported, ThymusImported and Whole bodyImported.
  14. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  15. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  16. Ensembl
    Submitted (JUN-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.
  17. Ensembl
    Submitted (MAY-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ9CPX4_MOUSE
AccessioniPrimary (citable) accession number: Q9CPX4
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: April 29, 2015
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.