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Protein

Lysozyme-like protein 1

Gene

Lyzl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei54PROSITE-ProRule annotation1
Active sitei71PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH22. Glycoside Hydrolase Family 22.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme-like protein 1 (EC:3.2.1.17)
Gene namesi
Name:Lyzl1
Synonyms:Lyc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1914578. Lyzl1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000024063620 – 148Lysozyme-like protein 1Add BLAST129

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 145PROSITE-ProRule annotation
Disulfide bondi49 ↔ 133PROSITE-ProRule annotation
Glycosylationi58N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi83 ↔ 98PROSITE-ProRule annotation
Disulfide bondi94 ↔ 112PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9CPX3.
PRIDEiQ9CPX3.

PTM databases

PhosphoSitePlusiQ9CPX3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024233.
CleanExiMM_LYZL1.
ExpressionAtlasiQ9CPX3. differential.
GenevisibleiQ9CPX3. MM.

Interactioni

Subunit structurei

Monomer.Curated

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025076.

Structurei

3D structure databases

ProteinModelPortaliQ9CPX3.
SMRiQ9CPX3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 22 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IVGA. Eukaryota.
ENOG410ZG9G. LUCA.
GeneTreeiENSGT00550000074398.
HOGENOMiHOG000037357.
HOVERGENiHBG052297.
InParanoidiQ9CPX3.
KOiK01185.
OMAiQKNHCHV.
OrthoDBiEOG091G0R9V.
PhylomeDBiQ9CPX3.
TreeFamiTF324882.

Family and domain databases

CDDicd00119. LYZ1. 1 hit.
InterProiIPR001916. Glyco_hydro_22.
IPR019799. Glyco_hydro_22_CS.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom.
IPR030057. LYZL1/LYZL2.
[Graphical view]
PANTHERiPTHR11407:SF35. PTHR11407:SF35. 1 hit.
PfamiPF00062. Lys. 1 hit.
[Graphical view]
PRINTSiPR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTiSM00263. LYZ1. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CPX3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSVGVFALI ISFSIVAESK IYTRCKLAKI FAKAGLDNYG GFALGNWLCM
60 70 80 90 100
AYYESHYNTT AENVLEDGST DYGIFQINSF TWCRNARKHQ KNHCHVACSA
110 120 130 140
LITDDLTDAI LCAKKIVKET QGMNYWQGWK KNCENKDMSE WKRGCEVS
Length:148
Mass (Da):16,802
Last modified:June 1, 2001 - v1
Checksum:iED87F25FF85E571A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY572447 mRNA. Translation: AAS77886.1.
AK006241 mRNA. Translation: BAB24475.1.
AK006630 mRNA. Translation: BAB24680.1.
BC048450 mRNA. Translation: AAH48450.1.
CCDSiCCDS29035.1.
RefSeqiNP_080368.1. NM_026092.3.
UniGeneiMm.158148.

Genome annotation databases

EnsembliENSMUST00000025076; ENSMUSP00000025076; ENSMUSG00000024233.
GeneIDi67328.
KEGGimmu:67328.
UCSCiuc008dyd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY572447 mRNA. Translation: AAS77886.1.
AK006241 mRNA. Translation: BAB24475.1.
AK006630 mRNA. Translation: BAB24680.1.
BC048450 mRNA. Translation: AAH48450.1.
CCDSiCCDS29035.1.
RefSeqiNP_080368.1. NM_026092.3.
UniGeneiMm.158148.

3D structure databases

ProteinModelPortaliQ9CPX3.
SMRiQ9CPX3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025076.

Protein family/group databases

CAZyiGH22. Glycoside Hydrolase Family 22.

PTM databases

PhosphoSitePlusiQ9CPX3.

Proteomic databases

PaxDbiQ9CPX3.
PRIDEiQ9CPX3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025076; ENSMUSP00000025076; ENSMUSG00000024233.
GeneIDi67328.
KEGGimmu:67328.
UCSCiuc008dyd.1. mouse.

Organism-specific databases

CTDi84569.
MGIiMGI:1914578. Lyzl1.

Phylogenomic databases

eggNOGiENOG410IVGA. Eukaryota.
ENOG410ZG9G. LUCA.
GeneTreeiENSGT00550000074398.
HOGENOMiHOG000037357.
HOVERGENiHBG052297.
InParanoidiQ9CPX3.
KOiK01185.
OMAiQKNHCHV.
OrthoDBiEOG091G0R9V.
PhylomeDBiQ9CPX3.
TreeFamiTF324882.

Miscellaneous databases

PROiQ9CPX3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024233.
CleanExiMM_LYZL1.
ExpressionAtlasiQ9CPX3. differential.
GenevisibleiQ9CPX3. MM.

Family and domain databases

CDDicd00119. LYZ1. 1 hit.
InterProiIPR001916. Glyco_hydro_22.
IPR019799. Glyco_hydro_22_CS.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom.
IPR030057. LYZL1/LYZL2.
[Graphical view]
PANTHERiPTHR11407:SF35. PTHR11407:SF35. 1 hit.
PfamiPF00062. Lys. 1 hit.
[Graphical view]
PRINTSiPR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTiSM00263. LYZ1. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLYZL1_MOUSE
AccessioniPrimary (citable) accession number: Q9CPX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.