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Protein

Lysozyme-like protein 1

Gene

Lyzl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei54PROSITE-ProRule annotation1
Active sitei71PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase

Protein family/group databases

CAZyiGH22 Glycoside Hydrolase Family 22

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme-like protein 1 (EC:3.2.1.17)
Gene namesi
Name:Lyzl1
Synonyms:Lyc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1914578 Lyzl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000024063620 – 148Lysozyme-like protein 1Add BLAST129

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 145PROSITE-ProRule annotation
Disulfide bondi49 ↔ 133PROSITE-ProRule annotation
Glycosylationi58N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi83 ↔ 98PROSITE-ProRule annotation
Disulfide bondi94 ↔ 112PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9CPX3
PRIDEiQ9CPX3

PTM databases

PhosphoSitePlusiQ9CPX3

Expressioni

Gene expression databases

BgeeiENSMUSG00000024233
CleanExiMM_LYZL1
ExpressionAtlasiQ9CPX3 baseline and differential
GenevisibleiQ9CPX3 MM

Interactioni

Subunit structurei

Monomer.Curated

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025076

Structurei

3D structure databases

ProteinModelPortaliQ9CPX3
SMRiQ9CPX3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 22 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IVGA Eukaryota
ENOG410ZG9G LUCA
GeneTreeiENSGT00550000074398
HOGENOMiHOG000037357
HOVERGENiHBG052297
InParanoidiQ9CPX3
KOiK01185
OMAiTWCRRAK
OrthoDBiEOG091G0R9V
PhylomeDBiQ9CPX3
TreeFamiTF324882

Family and domain databases

CDDicd00119 LYZ1, 1 hit
InterProiView protein in InterPro
IPR001916 Glyco_hydro_22
IPR019799 Glyco_hydro_22_CS
IPR000974 Glyco_hydro_22_lys
IPR023346 Lysozyme-like_dom_sf
IPR030057 LYZL1/LYZL2
PANTHERiPTHR11407:SF26 PTHR11407:SF26, 1 hit
PfamiView protein in Pfam
PF00062 Lys, 1 hit
PRINTSiPR00137 LYSOZYME
PR00135 LYZLACT
SMARTiView protein in SMART
SM00263 LYZ1, 1 hit
SUPFAMiSSF53955 SSF53955, 1 hit
PROSITEiView protein in PROSITE
PS00128 LACTALBUMIN_LYSOZYME_1, 1 hit
PS51348 LACTALBUMIN_LYSOZYME_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CPX3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSVGVFALI ISFSIVAESK IYTRCKLAKI FAKAGLDNYG GFALGNWLCM
60 70 80 90 100
AYYESHYNTT AENVLEDGST DYGIFQINSF TWCRNARKHQ KNHCHVACSA
110 120 130 140
LITDDLTDAI LCAKKIVKET QGMNYWQGWK KNCENKDMSE WKRGCEVS
Length:148
Mass (Da):16,802
Last modified:June 1, 2001 - v1
Checksum:iED87F25FF85E571A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY572447 mRNA Translation: AAS77886.1
AK006241 mRNA Translation: BAB24475.1
AK006630 mRNA Translation: BAB24680.1
BC048450 mRNA Translation: AAH48450.1
CCDSiCCDS29035.1
RefSeqiNP_080368.1, NM_026092.3
UniGeneiMm.158148

Genome annotation databases

EnsembliENSMUST00000025076; ENSMUSP00000025076; ENSMUSG00000024233
GeneIDi67328
KEGGimmu:67328
UCSCiuc008dyd.1 mouse

Similar proteinsi

Entry informationi

Entry nameiLYZL1_MOUSE
AccessioniPrimary (citable) accession number: Q9CPX3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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