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Q9CPW5

- SSRB_MOUSE

UniProt

Q9CPW5 - SSRB_MOUSE

Protein

Translocon-associated protein subunit beta

Gene

Ssr2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

    Enzyme and pathway databases

    ReactomeiREACT_196445. SRP-dependent cotranslational protein targeting to membrane.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Translocon-associated protein subunit beta
    Short name:
    TRAP-beta
    Alternative name(s):
    Signal sequence receptor subunit beta
    Short name:
    SSR-beta
    Gene namesi
    Name:Ssr2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1913506. Ssr2.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717By similarityAdd
    BLAST
    Chaini18 – 183166Translocon-associated protein subunit betaPRO_0000033291Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi88 – 881N-linked (GlcNAc...) (high mannose)2 Publications
    Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9CPW5.
    PRIDEiQ9CPW5.

    PTM databases

    PhosphoSiteiQ9CPW5.

    Expressioni

    Gene expression databases

    BgeeiQ9CPW5.
    CleanExiMM_SSR2.
    GenevestigatoriQ9CPW5.

    Interactioni

    Subunit structurei

    Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with TMEM173/STING By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CPW5.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini18 – 146129LumenalSequence AnalysisAdd
    BLAST
    Topological domaini168 – 18316CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei147 – 16721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TRAP-beta family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG292722.
    GeneTreeiENSGT00390000005125.
    HOGENOMiHOG000007980.
    HOVERGENiHBG000858.
    InParanoidiQ9CPW5.
    KOiK13250.
    OMAiKALRECK.
    OrthoDBiEOG7X0VK4.
    PhylomeDBiQ9CPW5.
    TreeFamiTF314461.

    Family and domain databases

    InterProiIPR008856. TRAP_beta.
    [Graphical view]
    PANTHERiPTHR12861. PTHR12861. 1 hit.
    PfamiPF05753. TRAP_beta. 1 hit.
    [Graphical view]
    PIRSFiPIRSF016400. TRAP_beta. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9CPW5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLLAVVVLA LLAVSQAEEG ARLLASKSLL NRYAVEGRDL TLQYNIYNVG    50
    SSAALDVELS DDSFPPEDFG IVSGMLNVKW DRIAPASNVS HTVVLRPLKA 100
    GYFNFTSATI TYLAQEDGPV VIGSTSAPGQ GGILAQREFD RRFSPHFLDW 150
    AAFGVMTLPS IGIPLLLWYS SKRKYDTPKP KKN 183
    Length:183
    Mass (Da):20,019
    Last modified:June 1, 2001 - v1
    Checksum:iEFC743A84F02A4AF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti132 – 1321G → E in BAB32009. (PubMed:16141072)Curated
    Sequence conflicti163 – 1631I → M in AAH10214. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK005340 mRNA. Translation: BAB23962.1.
    AK007538 mRNA. Translation: BAB25097.1.
    AK007720 mRNA. Translation: BAB25211.1.
    AK010565 mRNA. Translation: BAB27030.1.
    AK020145 mRNA. Translation: BAB32009.1.
    AK050505 mRNA. Translation: BAC34295.1.
    AK084530 mRNA. Translation: BAC39212.1.
    BC010214 mRNA. Translation: AAH10214.1.
    CCDSiCCDS17480.1.
    RefSeqiNP_079724.1. NM_025448.3.
    XP_006501941.1. XM_006501878.1.
    UniGeneiMm.7091.

    Genome annotation databases

    EnsembliENSMUST00000035785; ENSMUSP00000045456; ENSMUSG00000041355.
    GeneIDi66256.
    KEGGimmu:66256.
    UCSCiuc008pvs.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK005340 mRNA. Translation: BAB23962.1 .
    AK007538 mRNA. Translation: BAB25097.1 .
    AK007720 mRNA. Translation: BAB25211.1 .
    AK010565 mRNA. Translation: BAB27030.1 .
    AK020145 mRNA. Translation: BAB32009.1 .
    AK050505 mRNA. Translation: BAC34295.1 .
    AK084530 mRNA. Translation: BAC39212.1 .
    BC010214 mRNA. Translation: AAH10214.1 .
    CCDSi CCDS17480.1.
    RefSeqi NP_079724.1. NM_025448.3.
    XP_006501941.1. XM_006501878.1.
    UniGenei Mm.7091.

    3D structure databases

    ProteinModelPortali Q9CPW5.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9CPW5.

    Proteomic databases

    PaxDbi Q9CPW5.
    PRIDEi Q9CPW5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000035785 ; ENSMUSP00000045456 ; ENSMUSG00000041355 .
    GeneIDi 66256.
    KEGGi mmu:66256.
    UCSCi uc008pvs.1. mouse.

    Organism-specific databases

    CTDi 6746.
    MGIi MGI:1913506. Ssr2.

    Phylogenomic databases

    eggNOGi NOG292722.
    GeneTreei ENSGT00390000005125.
    HOGENOMi HOG000007980.
    HOVERGENi HBG000858.
    InParanoidi Q9CPW5.
    KOi K13250.
    OMAi KALRECK.
    OrthoDBi EOG7X0VK4.
    PhylomeDBi Q9CPW5.
    TreeFami TF314461.

    Enzyme and pathway databases

    Reactomei REACT_196445. SRP-dependent cotranslational protein targeting to membrane.

    Miscellaneous databases

    NextBioi 321109.
    PROi Q9CPW5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9CPW5.
    CleanExi MM_SSR2.
    Genevestigatori Q9CPW5.

    Family and domain databases

    InterProi IPR008856. TRAP_beta.
    [Graphical view ]
    PANTHERi PTHR12861. PTHR12861. 1 hit.
    Pfami PF05753. TRAP_beta. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF016400. TRAP_beta. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Cerebellum, Embryonic heart, Embryonic stem cell and Pancreas.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.
    3. "High throughput quantitative glycomics and glycoform-focused proteomics of murine dermis and epidermis."
      Uematsu R., Furukawa J., Nakagawa H., Shinohara Y., Deguchi K., Monde K., Nishimura S.
      Mol. Cell. Proteomics 4:1977-1989(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-88.
      Tissue: Epidermis.
    4. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-88.

    Entry informationi

    Entry nameiSSRB_MOUSE
    AccessioniPrimary (citable) accession number: Q9CPW5
    Secondary accession number(s): Q91Z43, Q9CR94, Q9CX54
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2005
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3