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Q9CPW5 (SSRB_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Translocon-associated protein subunit beta

Short name=TRAP-beta
Alternative name(s):
Signal sequence receptor subunit beta
Short name=SSR-beta
Gene names
Name:Ssr2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length183 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

Subunit structure

Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with TMEM173/STING By similarity.

Subcellular location

Endoplasmic reticulum membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the TRAP-beta family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 By similarity
Chain18 – 183166Translocon-associated protein subunit beta
PRO_0000033291

Regions

Topological domain18 – 146129Lumenal Potential
Transmembrane147 – 16721Helical; Potential
Topological domain168 – 18316Cytoplasmic Potential

Amino acid modifications

Glycosylation881N-linked (GlcNAc...) (high mannose) Ref.3 Ref.4
Glycosylation1041N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict1321G → E in BAB32009. Ref.1
Sequence conflict1631I → M in AAH10214. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9CPW5 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: EFC743A84F02A4AF

FASTA18320,019
        10         20         30         40         50         60 
MRLLAVVVLA LLAVSQAEEG ARLLASKSLL NRYAVEGRDL TLQYNIYNVG SSAALDVELS 

        70         80         90        100        110        120 
DDSFPPEDFG IVSGMLNVKW DRIAPASNVS HTVVLRPLKA GYFNFTSATI TYLAQEDGPV 

       130        140        150        160        170        180 
VIGSTSAPGQ GGILAQREFD RRFSPHFLDW AAFGVMTLPS IGIPLLLWYS SKRKYDTPKP 


KKN 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Cerebellum, Embryonic heart, Embryonic stem cell and Pancreas.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary tumor.
[3]"High throughput quantitative glycomics and glycoform-focused proteomics of murine dermis and epidermis."
Uematsu R., Furukawa J., Nakagawa H., Shinohara Y., Deguchi K., Monde K., Nishimura S.
Mol. Cell. Proteomics 4:1977-1989(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-88.
Tissue: Epidermis.
[4]"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-88.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK005340 mRNA. Translation: BAB23962.1.
AK007538 mRNA. Translation: BAB25097.1.
AK007720 mRNA. Translation: BAB25211.1.
AK010565 mRNA. Translation: BAB27030.1.
AK020145 mRNA. Translation: BAB32009.1.
AK050505 mRNA. Translation: BAC34295.1.
AK084530 mRNA. Translation: BAC39212.1.
BC010214 mRNA. Translation: AAH10214.1.
CCDSCCDS17480.1.
RefSeqNP_079724.1. NM_025448.3.
XP_006501941.1. XM_006501878.1.
UniGeneMm.7091.

3D structure databases

ProteinModelPortalQ9CPW5.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9CPW5.

Proteomic databases

PaxDbQ9CPW5.
PRIDEQ9CPW5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000035785; ENSMUSP00000045456; ENSMUSG00000041355.
GeneID66256.
KEGGmmu:66256.
UCSCuc008pvs.1. mouse.

Organism-specific databases

CTD6746.
MGIMGI:1913506. Ssr2.

Phylogenomic databases

eggNOGNOG292722.
GeneTreeENSGT00390000005125.
HOGENOMHOG000007980.
HOVERGENHBG000858.
InParanoidQ9CPW5.
KOK13250.
OMAKALRECK.
OrthoDBEOG7X0VK4.
PhylomeDBQ9CPW5.
TreeFamTF314461.

Gene expression databases

BgeeQ9CPW5.
CleanExMM_SSR2.
GenevestigatorQ9CPW5.

Family and domain databases

InterProIPR008856. TRAP_beta.
[Graphical view]
PANTHERPTHR12861. PTHR12861. 1 hit.
PfamPF05753. TRAP_beta. 1 hit.
[Graphical view]
PIRSFPIRSF016400. TRAP_beta. 1 hit.
ProtoNetSearch...

Other

NextBio321109.
PROQ9CPW5.
SOURCESearch...

Entry information

Entry nameSSRB_MOUSE
AccessionPrimary (citable) accession number: Q9CPW5
Secondary accession number(s): Q91Z43, Q9CR94, Q9CX54
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot