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Protein

Actin-related protein 2/3 complex subunit 5

Gene

Arpc5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

ReactomeiR-MMU-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-MMU-3928662. EPHB-mediated forward signaling.
R-MMU-5663213. RHO GTPases Activate WASPs and WAVEs.
R-MMU-6798695. Neutrophil degranulation.
R-MMU-8856828. Clathrin-mediated endocytosis.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 5
Alternative name(s):
Arp2/3 complex 16 kDa subunit
Short name:
p16-ARC
Gene namesi
Name:Arpc5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1915021. Arpc5.

Subcellular locationi

GO - Cellular componenti

  • Arp2/3 protein complex Source: MGI
  • cytoplasm Source: UniProtKB-KW
  • extracellular exosome Source: MGI
  • focal adhesion Source: MGI
  • lamellipodium Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001240552 – 151Actin-related protein 2/3 complex subunit 5Add BLAST150

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1

Post-translational modificationi

Polyubiquitinated by RNF128 with 'Lys-63'-linked chains, leading to proteasomal degradation.By similarity

Keywords - PTMi

Acetylation, Ubl conjugation

Proteomic databases

EPDiQ9CPW4.
MaxQBiQ9CPW4.
PaxDbiQ9CPW4.
PRIDEiQ9CPW4.
TopDownProteomicsiQ9CPW4.

PTM databases

iPTMnetiQ9CPW4.
PhosphoSitePlusiQ9CPW4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000008475.
CleanExiMM_ARPC5.
ExpressionAtlasiQ9CPW4. baseline and differential.
GenevisibleiQ9CPW4. MM.

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.By similarity

Protein-protein interaction databases

BioGridi212431. 1 interactor.
DIPiDIP-60589N.
IntActiQ9CPW4. 2 interactors.
MINTiMINT-1864776.
STRINGi10090.ENSMUSP00000076933.

Structurei

3D structure databases

ProteinModelPortaliQ9CPW4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ARPC5 family.Curated

Phylogenomic databases

eggNOGiKOG3380. Eukaryota.
ENOG4111FGV. LUCA.
GeneTreeiENSGT00390000014806.
HOGENOMiHOG000197215.
HOVERGENiHBG050583.
InParanoidiQ9CPW4.
KOiK05754.
OMAiADNATCQ.
OrthoDBiEOG091G0R2J.
PhylomeDBiQ9CPW4.
TreeFamiTF319716.

Family and domain databases

Gene3Di1.25.40.190. 1 hit.
InterProiIPR006789. ARPC5.
[Graphical view]
PANTHERiPTHR12644. PTHR12644. 1 hit.
PfamiPF04699. P16-Arc. 1 hit.
[Graphical view]
PIRSFiPIRSF039096. p16-ARC. 1 hit.
SUPFAMiSSF69103. SSF69103. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CPW4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKNTVSSAR FRKVDVDEYD ENKFVDEEDG GDGQAGPDEG EVDSCLRQGN
60 70 80 90 100
MTAALQAALK NPPINTKSQA VKDRAGSIVL KVLISFKAND IEKAVQSLDK
110 120 130 140 150
NGVDLLMKYI YKGFESPSDN SSAVLLQWHE KALAAGGVGS IVRVLTARKT

V
Length:151
Mass (Da):16,288
Last modified:January 23, 2007 - v3
Checksum:iF050B10DC5416E66
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti59L → Q in BAB25457 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008097 mRNA. Translation: BAB25457.1.
AK011348 mRNA. Translation: BAB27558.1.
AK011911 mRNA. Translation: BAB27911.1.
AK017669 mRNA. Translation: BAB30864.1.
AK019149 mRNA. Translation: BAB31570.1.
AK087427 mRNA. Translation: BAC39870.1.
AK149756 mRNA. Translation: BAE29064.1.
AK151654 mRNA. Translation: BAE30583.1.
AK151656 mRNA. Translation: BAE30585.1.
AK152281 mRNA. Translation: BAE31095.1.
AK153262 mRNA. Translation: BAE31852.1.
AK159407 mRNA. Translation: BAE35058.1.
AK159438 mRNA. Translation: BAE35084.1.
AK159738 mRNA. Translation: BAE35332.1.
AK166284 mRNA. Translation: BAE38681.1.
AK166335 mRNA. Translation: BAE38714.1.
AK166725 mRNA. Translation: BAE38972.1.
AK167916 mRNA. Translation: BAE39923.1.
AK168264 mRNA. Translation: BAE40212.1.
AK168986 mRNA. Translation: BAE40786.1.
BC060143 mRNA. Translation: AAH60143.1.
CCDSiCCDS35739.1.
RefSeqiNP_080645.2. NM_026369.2.
UniGeneiMm.288974.

Genome annotation databases

EnsembliENSMUST00000077755; ENSMUSP00000076933; ENSMUSG00000008475.
GeneIDi67771.
KEGGimmu:67771.
UCSCiuc007czj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008097 mRNA. Translation: BAB25457.1.
AK011348 mRNA. Translation: BAB27558.1.
AK011911 mRNA. Translation: BAB27911.1.
AK017669 mRNA. Translation: BAB30864.1.
AK019149 mRNA. Translation: BAB31570.1.
AK087427 mRNA. Translation: BAC39870.1.
AK149756 mRNA. Translation: BAE29064.1.
AK151654 mRNA. Translation: BAE30583.1.
AK151656 mRNA. Translation: BAE30585.1.
AK152281 mRNA. Translation: BAE31095.1.
AK153262 mRNA. Translation: BAE31852.1.
AK159407 mRNA. Translation: BAE35058.1.
AK159438 mRNA. Translation: BAE35084.1.
AK159738 mRNA. Translation: BAE35332.1.
AK166284 mRNA. Translation: BAE38681.1.
AK166335 mRNA. Translation: BAE38714.1.
AK166725 mRNA. Translation: BAE38972.1.
AK167916 mRNA. Translation: BAE39923.1.
AK168264 mRNA. Translation: BAE40212.1.
AK168986 mRNA. Translation: BAE40786.1.
BC060143 mRNA. Translation: AAH60143.1.
CCDSiCCDS35739.1.
RefSeqiNP_080645.2. NM_026369.2.
UniGeneiMm.288974.

3D structure databases

ProteinModelPortaliQ9CPW4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212431. 1 interactor.
DIPiDIP-60589N.
IntActiQ9CPW4. 2 interactors.
MINTiMINT-1864776.
STRINGi10090.ENSMUSP00000076933.

PTM databases

iPTMnetiQ9CPW4.
PhosphoSitePlusiQ9CPW4.

Proteomic databases

EPDiQ9CPW4.
MaxQBiQ9CPW4.
PaxDbiQ9CPW4.
PRIDEiQ9CPW4.
TopDownProteomicsiQ9CPW4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000077755; ENSMUSP00000076933; ENSMUSG00000008475.
GeneIDi67771.
KEGGimmu:67771.
UCSCiuc007czj.2. mouse.

Organism-specific databases

CTDi10092.
MGIiMGI:1915021. Arpc5.

Phylogenomic databases

eggNOGiKOG3380. Eukaryota.
ENOG4111FGV. LUCA.
GeneTreeiENSGT00390000014806.
HOGENOMiHOG000197215.
HOVERGENiHBG050583.
InParanoidiQ9CPW4.
KOiK05754.
OMAiADNATCQ.
OrthoDBiEOG091G0R2J.
PhylomeDBiQ9CPW4.
TreeFamiTF319716.

Enzyme and pathway databases

ReactomeiR-MMU-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-MMU-3928662. EPHB-mediated forward signaling.
R-MMU-5663213. RHO GTPases Activate WASPs and WAVEs.
R-MMU-6798695. Neutrophil degranulation.
R-MMU-8856828. Clathrin-mediated endocytosis.

Miscellaneous databases

ChiTaRSiArpc5. mouse.
PROiQ9CPW4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000008475.
CleanExiMM_ARPC5.
ExpressionAtlasiQ9CPW4. baseline and differential.
GenevisibleiQ9CPW4. MM.

Family and domain databases

Gene3Di1.25.40.190. 1 hit.
InterProiIPR006789. ARPC5.
[Graphical view]
PANTHERiPTHR12644. PTHR12644. 1 hit.
PfamiPF04699. P16-Arc. 1 hit.
[Graphical view]
PIRSFiPIRSF039096. p16-ARC. 1 hit.
SUPFAMiSSF69103. SSF69103. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiARPC5_MOUSE
AccessioniPrimary (citable) accession number: Q9CPW4
Secondary accession number(s): Q3U9T3, Q9D8E7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.