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Protein

Ferredoxin-2, mitochondrial

Gene

Fdx2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for heme A and Fe/S protein biosynthesis.By similarity

Cofactori

[2Fe-2S] clusterBy similarityNote: Binds 1 [2Fe-2S] cluster.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi96Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation1
Metal bindingi102Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation1
Metal bindingi105Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation1
Metal bindingi142Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Biological processElectron transport, Transport
Ligand2Fe-2S, Iron, Iron-sulfur, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ferredoxin-2, mitochondrial
Alternative name(s):
Adrenodoxin-like protein
Ferredoxin-1-like protein
Gene namesi
Name:Fdx2
Synonyms:Fdx1l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1915415 Fdx1l

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 43MitochondrionSequence analysisAdd BLAST43
ChainiPRO_000032595344 – 174Ferredoxin-2, mitochondrialAdd BLAST131

Proteomic databases

EPDiQ9CPW2
PaxDbiQ9CPW2
PeptideAtlasiQ9CPW2
PRIDEiQ9CPW2

PTM databases

iPTMnetiQ9CPW2
PhosphoSitePlusiQ9CPW2

Expressioni

Gene expression databases

BgeeiENSMUSG00000079677
CleanExiMM_FDX1L
GenevisibleiQ9CPW2 MM

Interactioni

Protein-protein interaction databases

IntActiQ9CPW2, 1 interactor
MINTiQ9CPW2
STRINGi10090.ENSMUSP00000010348

Structurei

3D structure databases

ProteinModelPortaliQ9CPW2
SMRiQ9CPW2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini59 – 1612Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd BLAST103

Sequence similaritiesi

Belongs to the adrenodoxin/putidaredoxin family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3309 Eukaryota
COG0633 LUCA
GeneTreeiENSGT00530000063577
HOGENOMiHOG000244518
HOVERGENiHBG055801
InParanoidiQ9CPW2
KOiK22071
OMAiWQDPKSP
OrthoDBiEOG091G0MJ2
PhylomeDBiQ9CPW2
TreeFamiTF354319

Family and domain databases

CDDicd00207 fer2, 1 hit
Gene3Di3.10.20.30, 1 hit
InterProiView protein in InterPro
IPR036010 2Fe-2S_ferredoxin-like_sf
IPR001041 2Fe-2S_ferredoxin-type
IPR001055 Adrenodoxin
IPR018298 Adrenodoxin_Fe-S_BS
IPR012675 Beta-grasp_dom_sf
PfamiView protein in Pfam
PF00111 Fer2, 1 hit
PRINTSiPR00355 ADRENODOXIN
SUPFAMiSSF54292 SSF54292, 1 hit
PROSITEiView protein in PROSITE
PS51085 2FE2S_FER_2, 1 hit
PS00814 ADX, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9CPW2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAASMARGVS ARVLLRAAGG SWGPRAGHAA VTSRTFGTTG ERRAGEEAAD
60 70 80 90 100
SPELPRDVVN VVFVDRSGKR IPVRGKVGDN VLYLAQRHGV DLEGACEASL
110 120 130 140 150
ACSTCHVYVS EAHLDLLPPP EEREDDMLDM APLLQENSRL GCQIVLTPEL
160 170
EGVEFALPKI TRNFYVDGHI PKPH
Length:174
Mass (Da):18,766
Last modified:June 1, 2001 - v1
Checksum:iF0E2506668F7038A
GO
Isoform 2 (identifier: Q9CPW2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-126: Missing.

Note: No experimental confirmation available.
Show »
Length:48
Mass (Da):5,432
Checksum:i2AF65C4C2939060F
GO

Sequence cautioni

The sequence BAB26771 differs from that shown. Reason: Frameshift at position 10.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11A → G in BAB26771 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0324981 – 126Missing in isoform 2. 1 PublicationAdd BLAST126

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008401 mRNA Translation: BAB25650.1
AK010211 mRNA Translation: BAB26771.1 Frameshift.
AK020979 mRNA Translation: BAB32267.1
BC061189 mRNA Translation: AAH61189.1
CCDSiCCDS22892.1 [Q9CPW2-1]
RefSeqiNP_001034913.1, NM_001039824.2 [Q9CPW2-1]
UniGeneiMm.490294

Genome annotation databases

EnsembliENSMUST00000010348; ENSMUSP00000010348; ENSMUSG00000079677 [Q9CPW2-1]
GeneIDi68165
KEGGimmu:68165
UCSCiuc009okb.1 mouse [Q9CPW2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiFDX2_MOUSE
AccessioniPrimary (citable) accession number: Q9CPW2
Secondary accession number(s): Q6P8M0, Q9CV00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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