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Protein

Contactin-associated protein-like 2

Gene

Cntnap2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the juxtaparanodal region of the axo-glial junction.1 Publication

GO - Molecular functioni

GO - Biological processi

  • adult behavior Source: MGI
  • cell adhesion Source: BHF-UCL
  • clustering of voltage-gated potassium channels Source: BHF-UCL
  • learning Source: MGI
  • limbic system development Source: BHF-UCL
  • neuron projection development Source: MGI
  • neuron recognition Source: BHF-UCL
  • protein localization to juxtaparanode region of axon Source: BHF-UCL
  • social behavior Source: MGI
  • vocalization behavior Source: MGI
  • vocal learning Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Contactin-associated protein-like 2
Alternative name(s):
Cell recognition molecule Caspr2
Gene namesi
Name:Cntnap2
Synonyms:Kiaa0868
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1914047. Cntnap2.

Subcellular locationi

  • Membrane 1 Publication; Single-pass type I membrane protein Curated
  • Cell projectionaxon 1 Publication

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini28 – 1262ExtracellularSequence analysisAdd BLAST1235
Transmembranei1263 – 1283HelicalSequence analysisAdd BLAST21
Topological domaini1284 – 1332CytoplasmicSequence analysisAdd BLAST49

GO - Cellular componenti

  • axolemma Source: BHF-UCL
  • cell surface Source: BHF-UCL
  • early endosome Source: BHF-UCL
  • Golgi apparatus Source: BHF-UCL
  • integral component of membrane Source: UniProtKB
  • juxtaparanode region of axon Source: UniProtKB
  • membrane Source: BHF-UCL
  • voltage-gated potassium channel complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000001950728 – 1332Contactin-associated protein-like 2Add BLAST1305

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi35 ↔ 181By similarity
Glycosylationi289N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi336 ↔ 368By similarity
Glycosylationi346N-linked (GlcNAc...)Sequence analysis1
Glycosylationi363N-linked (GlcNAc...)Sequence analysis1
Glycosylationi379N-linked (GlcNAc...)Sequence analysis1
Glycosylationi436N-linked (GlcNAc...)Sequence analysis1
Glycosylationi507N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi520 ↔ 552By similarity
Glycosylationi546N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi558 ↔ 569By similarity
Disulfide bondi563 ↔ 578By similarity
Disulfide bondi580 ↔ 590By similarity
Glycosylationi630N-linked (GlcNAc...)Sequence analysis1
Glycosylationi735N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi936 ↔ 963By similarity
Disulfide bondi967 ↔ 980By similarity
Disulfide bondi974 ↔ 989By similarity
Disulfide bondi991 ↔ 1001By similarity
Glycosylationi1117N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1179 ↔ 1215By similarity
Glycosylationi1199N-linked (GlcNAc...)Sequence analysis1
Modified residuei1304PhosphoserineCombined sources1
Modified residuei1307PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9CPW0.
PeptideAtlasiQ9CPW0.
PRIDEiQ9CPW0.

PTM databases

iPTMnetiQ9CPW0.
PhosphoSitePlusiQ9CPW0.

Expressioni

Tissue specificityi

In sciatic nerve predominantly found at the juxtaparanodal regions (at protein level).1 Publication

Developmental stagei

Detected at postnatal day 8 in sciatic nerve at the paranodes and the juxtaparanodal region. Is progressively translocated to the adjacent juxtaparanodal region until it becomes completely absent from the paranodes in the adult.1 Publication

Gene expression databases

BgeeiENSMUSG00000039419.
CleanExiMM_CNTNAP2.
ExpressionAtlasiQ9CPW0. baseline and differential.
GenevisibleiQ9CPW0. MM.

Interactioni

Subunit structurei

Interacts (via C-terminus) with KCNA2.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000110288.

Structurei

3D structure databases

ProteinModelPortaliQ9CPW0.
SMRiQ9CPW0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 181F5/8 type CPROSITE-ProRule annotationAdd BLAST147
Domaini187 – 368Laminin G-like 1PROSITE-ProRule annotationAdd BLAST182
Domaini373 – 552Laminin G-like 2PROSITE-ProRule annotationAdd BLAST180
Domaini554 – 591EGF-like 1PROSITE-ProRule annotationAdd BLAST38
Domaini592 – 798Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST207
Domaini799 – 963Laminin G-like 3PROSITE-ProRule annotationAdd BLAST165
Domaini964 – 1002EGF-like 2PROSITE-ProRule annotationAdd BLAST39
Domaini1023 – 1214Laminin G-like 4PROSITE-ProRule annotationAdd BLAST192

Sequence similaritiesi

Belongs to the neurexin family.Curated
Contains 2 EGF-like domains.PROSITE-ProRule annotation
Contains 1 F5/8 type C domain.PROSITE-ProRule annotation
Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation
Contains 4 laminin G-like domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3516. Eukaryota.
ENOG410XPHG. LUCA.
GeneTreeiENSGT00760000118991.
HOGENOMiHOG000230964.
HOVERGENiHBG057718.
InParanoidiQ9CPW0.
KOiK07380.
PhylomeDBiQ9CPW0.

Family and domain databases

Gene3Di2.60.120.200. 5 hits.
2.60.120.260. 1 hit.
InterProiIPR029831. Caspr2.
IPR013320. ConA-like_dom.
IPR000742. EGF-like_dom.
IPR000421. FA58C.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR008979. Galactose-bd-like.
IPR001791. Laminin_G.
IPR003585. Neurexin-like.
[Graphical view]
PANTHERiPTHR10127:SF644. PTHR10127:SF644. 1 hit.
PfamiPF00754. F5_F8_type_C. 1 hit.
PF02210. Laminin_G_2. 4 hits.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
SM00181. EGF. 2 hits.
SM00231. FA58C. 1 hit.
SM00282. LamG. 4 hits.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF49899. SSF49899. 4 hits.
SSF56496. SSF56496. 1 hit.
PROSITEiPS50026. EGF_3. 2 hits.
PS01285. FA58C_1. 1 hit.
PS01286. FA58C_2. 1 hit.
PS50022. FA58C_3. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
PS50025. LAM_G_DOMAIN. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9CPW0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVMSLRAGYR AALSLWILSS FICRAWTAPS TFQKCDEPLI SGLPHVSFSS
60 70 80 90 100
SSSLSSSYAP GYAKINKRGG AGGWSPSDSD HYQWLQVDFG NRKQISAIAT
110 120 130 140 150
QGRYSSSDWV TQYRMLYSDT GRNWKPYHQD GNIWAFPGNI NSDSVVRHDL
160 170 180 190 200
QHAVVARYVR IVPLDWNGEG HIGLRAEVYG CAYWADVINF DGHGVLPYRF
210 220 230 240 250
RNKKMKTLKD VIALKFKTSE SEGVLLHGEG QQGDYITLEL KKAKLVLSLN
260 270 280 290 300
LGSNQLGPIY GHTSVTSGSL LDDHHWHSVL IERQGRSINL TLDRSMQHFR
310 320 330 340 350
TNGEFDYLDL DYEITFGGIP FSGKPSSSNR KNFKGCMESI NYNGVNITDL
360 370 380 390 400
ARRKKLGPSN MGNLSFSCVE PYTVPVFFNA TSYLEVPGRL NQDLFSVSFQ
410 420 430 440 450
FRTWNPSGLL LFSHFADNLG NVEIDLVESK VGVHINNTQT KTSQIDISSG
460 470 480 490 500
SGLNDGQWHE VRFLAKENFA VLTIDGDEAS AVRTNSPLQV KTGEKYFFGG
510 520 530 540 550
FLNHMNNASY SALQPSFQGC MQLIQVDDQL VNLYEVAQRK PGSFANVTID
560 570 580 590 600
MCAIIDRCVP NHCEHGGKCS QTWDSFKCTC DETGYSGATC HNSIYEPSCE
610 620 630 640 650
AYKHLGQTSN YYWIDPDGSG PLGPLKVYCN MTEDKVWTIV SHDLQMQTTV
660 670 680 690 700
VGYNPEKYSV TQLIYSASMD QISAITSSAE YCEQYVSYFC RMSRLLNTPD
710 720 730 740 750
GSPYTWWVGK ANEKHYYWGG SEPGIQKCAC GIERNCTDPK YYCNCDADYK
760 770 780 790 800
QWRKDAGFLS YKDHLPVSQV VVGDTDRQGS EAKLSVGPLR CQGDRNYWNA
810 820 830 840 850
ASFPNPSSYL HFSTFQGETS ADISFYFKTL IPRGVFLENL GNTDFIKLEL
860 870 880 890 900
KSATEVSFSF DVGNGPVEIV VRSPSPLNDD QWHRVTAERN VKQASLQVDR
910 920 930 940 950
LPQQIRKAPT EGHTRLELYS QLFVGGAGGQ QGFLGCIRSL RMNGVTLDLE
960 970 980 990 1000
ERAKVTSGFK SGCSGHCTSY GANCENGGKC IEKYHGYSCD CSNTAYDGTF
1010 1020 1030 1040 1050
CNKDVGAFFE EGMWLRYNFQ APAVTARDTG SRAENSADQQ QHLAPDLAQE
1060 1070 1080 1090 1100
QIHFSFSTTK APCILLYVSS LTTDFLAVLV KPTGNLQIRY NLGGTREPFN
1110 1120 1130 1140 1150
IDVDHRNMAN GQPHSVNITR HERTIILKLD HYPAVGYHLP SSSDTLFNSP
1160 1170 1180 1190 1200
KSLFLGKVIE TGKIDQEIHK YNTPGFTGCL SRVQFNHIAP LKAALRQTNA
1210 1220 1230 1240 1250
SAHVHIQGEL VESNCGASPL TLSPMSSATD PWHLDHLDSA SADFPYNPGQ
1260 1270 1280 1290 1300
GQAIRNGVNR NSAIIGGVIA VVIFTILCTL VFLIRYMFRH KGTYHTNEAK
1310 1320 1330
GAESAESADA AIMNNDPNFT ETIDESKKEW LI
Length:1,332
Mass (Da):148,197
Last modified:August 16, 2005 - v2
Checksum:i6AA097C69D83F0A5
GO
Isoform 2 (identifier: Q9CPW0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1224: Missing.

Note: No experimental confirmation available.
Show »
Length:108
Mass (Da):11,899
Checksum:iF0EB322C735B773E
GO

Sequence cautioni

The sequence BAC98042 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti357G → E in AAH64467 (PubMed:15489334).Curated1
Sequence conflicti538Q → H in AAH64467 (PubMed:15489334).Curated1
Sequence conflicti1192K → N in AAH64467 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0149771 – 1224Missing in isoform 2. 2 PublicationsAdd BLAST1224

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017341 mRNA. No translation available.
AK013139 mRNA. Translation: BAB28674.1.
AK129232 mRNA. Translation: BAC98042.1. Different initiation.
BC029826 mRNA. Translation: AAH29826.1.
BC064467 mRNA. Translation: AAH64467.1.
CCDSiCCDS20094.1. [Q9CPW0-2]
CCDS39475.1. [Q9CPW0-1]
RefSeqiNP_001004357.2. NM_001004357.2.
NP_080047.1. NM_025771.3. [Q9CPW0-2]
UniGeneiMm.440084.

Genome annotation databases

EnsembliENSMUST00000060839; ENSMUSP00000056299; ENSMUSG00000039419. [Q9CPW0-2]
ENSMUST00000199100; ENSMUSP00000143528; ENSMUSG00000039419. [Q9CPW0-2]
GeneIDi66797.
KEGGimmu:66797.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017341 mRNA. No translation available.
AK013139 mRNA. Translation: BAB28674.1.
AK129232 mRNA. Translation: BAC98042.1. Different initiation.
BC029826 mRNA. Translation: AAH29826.1.
BC064467 mRNA. Translation: AAH64467.1.
CCDSiCCDS20094.1. [Q9CPW0-2]
CCDS39475.1. [Q9CPW0-1]
RefSeqiNP_001004357.2. NM_001004357.2.
NP_080047.1. NM_025771.3. [Q9CPW0-2]
UniGeneiMm.440084.

3D structure databases

ProteinModelPortaliQ9CPW0.
SMRiQ9CPW0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000110288.

PTM databases

iPTMnetiQ9CPW0.
PhosphoSitePlusiQ9CPW0.

Proteomic databases

PaxDbiQ9CPW0.
PeptideAtlasiQ9CPW0.
PRIDEiQ9CPW0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060839; ENSMUSP00000056299; ENSMUSG00000039419. [Q9CPW0-2]
ENSMUST00000199100; ENSMUSP00000143528; ENSMUSG00000039419. [Q9CPW0-2]
GeneIDi66797.
KEGGimmu:66797.

Organism-specific databases

CTDi26047.
MGIiMGI:1914047. Cntnap2.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3516. Eukaryota.
ENOG410XPHG. LUCA.
GeneTreeiENSGT00760000118991.
HOGENOMiHOG000230964.
HOVERGENiHBG057718.
InParanoidiQ9CPW0.
KOiK07380.
PhylomeDBiQ9CPW0.

Miscellaneous databases

ChiTaRSiCntnap2. mouse.
PROiQ9CPW0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039419.
CleanExiMM_CNTNAP2.
ExpressionAtlasiQ9CPW0. baseline and differential.
GenevisibleiQ9CPW0. MM.

Family and domain databases

Gene3Di2.60.120.200. 5 hits.
2.60.120.260. 1 hit.
InterProiIPR029831. Caspr2.
IPR013320. ConA-like_dom.
IPR000742. EGF-like_dom.
IPR000421. FA58C.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR008979. Galactose-bd-like.
IPR001791. Laminin_G.
IPR003585. Neurexin-like.
[Graphical view]
PANTHERiPTHR10127:SF644. PTHR10127:SF644. 1 hit.
PfamiPF00754. F5_F8_type_C. 1 hit.
PF02210. Laminin_G_2. 4 hits.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
SM00181. EGF. 2 hits.
SM00231. FA58C. 1 hit.
SM00282. LamG. 4 hits.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF49899. SSF49899. 4 hits.
SSF56496. SSF56496. 1 hit.
PROSITEiPS50026. EGF_3. 2 hits.
PS01285. FA58C_1. 1 hit.
PS01286. FA58C_2. 1 hit.
PS50022. FA58C_3. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
PS50025. LAM_G_DOMAIN. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCNTP2_MOUSE
AccessioniPrimary (citable) accession number: Q9CPW0
Secondary accession number(s): Q6P2K4, Q6ZQ31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: August 16, 2005
Last modified: November 2, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.