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Q9CPV9

- P2Y12_MOUSE

UniProt

Q9CPV9 - P2Y12_MOUSE

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Protein
P2Y purinoceptor 12
Gene
P2ry12
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Required for normal platelet aggregation and blood coagulation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei99 – 991ADP By similarity
Binding sitei103 – 1031ADP; via carbonyl oxygen By similarity
Binding sitei111 – 1111ADP By similarity
Binding sitei193 – 1931ADP By similarity
Binding sitei197 – 1971ADP By similarity
Binding sitei269 – 2691ADP By similarity
Binding sitei286 – 2861ADP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi162 – 1654ADP By similarity
Nucleotide bindingi181 – 1855ADP By similarity
Nucleotide bindingi262 – 2654ADP By similarity

GO - Molecular functioni

  1. ADP receptor activity Source: MGI
  2. G-protein coupled adenosine receptor activity Source: MGI

GO - Biological processi

  1. G-protein coupled purinergic nucleotide receptor signaling pathway Source: GOC
  2. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: UniProtKB
  3. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: MGI
  4. calcium ion transmembrane transport Source: Ensembl
  5. cell projection organization Source: Ensembl
  6. negative regulation of cell differentiation Source: Ensembl
  7. negative regulation of norepinephrine secretion Source: Ensembl
  8. platelet activation Source: MGI
  9. platelet aggregation Source: UniProtKB
  10. positive regulation of ion transport Source: MGI
  11. potassium ion transmembrane transport Source: Ensembl
  12. protein kinase B signaling Source: Ensembl
  13. regulation of calcium ion transport Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Blood coagulation, Hemostasis

Names & Taxonomyi

Protein namesi
Recommended name:
P2Y purinoceptor 12
Short name:
P2Y12
Gene namesi
Name:P2ry12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1918089. P2ry12.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3333Extracellular By similarity
Add
BLAST
Transmembranei34 – 5623Helical; Name=1; By similarity
Add
BLAST
Topological domaini57 – 6711Cytoplasmic By similarity
Add
BLAST
Transmembranei68 – 8821Helical; Name=2; By similarity
Add
BLAST
Topological domaini89 – 10315Extracellular By similarity
Add
BLAST
Transmembranei104 – 12421Helical; Name=3; By similarity
Add
BLAST
Topological domaini125 – 14824Cytoplasmic By similarity
Add
BLAST
Transmembranei149 – 16820Helical; Name=4; By similarity
Add
BLAST
Topological domaini169 – 19123Extracellular By similarity
Add
BLAST
Transmembranei192 – 21322Helical; Name=5; By similarity
Add
BLAST
Topological domaini214 – 23926Cytoplasmic By similarity
Add
BLAST
Transmembranei240 – 26526Helical; Name=6; By similarity
Add
BLAST
Topological domaini266 – 28419Extracellular By similarity
Add
BLAST
Transmembranei285 – 30420Helical; Name=7; By similarity
Add
BLAST
Topological domaini305 – 34743Cytoplasmic By similarity
Add
BLAST

GO - Cellular componenti

  1. basal plasma membrane Source: Ensembl
  2. caveola Source: Ensembl
  3. external side of plasma membrane Source: Ensembl
  4. integral component of plasma membrane Source: MGI
  5. intrinsic component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice are viable and fertile, but display impaired blood coagulation, due to defects in platelet aggregation and thrombus formation.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 347347P2Y purinoceptor 12
PRO_0000070038Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi7 – 71N-linked (GlcNAc...) Reviewed prediction
Glycosylationi12 – 121N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi23 ↔ 276 By similarity
Modified residuei61 – 611Phosphoserine By similarity
Modified residuei63 – 631Phosphoserine By similarity
Disulfide bondi103 ↔ 181 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9CPV9.
PRIDEiQ9CPV9.

PTM databases

PhosphoSiteiQ9CPV9.

Expressioni

Gene expression databases

BgeeiQ9CPV9.
CleanExiMM_P2RY12.
GenevestigatoriQ9CPV9.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051353.

Structurei

3D structure databases

ProteinModelPortaliQ9CPV9.
SMRiQ9CPV9. Positions 22-229, 245-318.

Family & Domainsi

Domaini

The transmembrane domain is composed of seven transmembrane helices; most of these are not strictly perpendicular to the plane of the membrane, but are tilted and/or kinked. Agonist binding promotes a conformation change in the extracellular loops that leads to an inward movement of the transmembrane helices. Antagonists can bind to an overlapping site, but block the inward movement of the transmembrane helices By similarity.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG147554.
GeneTreeiENSGT00640000091213.
HOGENOMiHOG000273884.
HOVERGENiHBG108228.
InParanoidiQ9CPV9.
KOiK04298.
OMAiIKVFIII.
OrthoDBiEOG7C2R1H.
PhylomeDBiQ9CPV9.
TreeFamiTF330969.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR005394. P2Y12_rcpt.
[Graphical view]
PANTHERiPTHR24233:SF0. PTHR24233:SF0. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01569. P2Y12PRNCPTR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CPV9-1 [UniParc]FASTAAdd to Basket

« Hide

MDVPGVNTTS ANTTFSPGTS TLCVRDYKIT QVLFPLLYTV LFFAGLITNS    50
LAMRIFFQIR SKSNFIIFLK NTVISDLLMI LTFPFKILSD AKLGAGPLRT 100
LVCQVTSVTF YFTMYISISF LGLITIDRYL KTTRPFKTSS PSNLLGAKIL 150
SVVIWAFMFL ISLPNMILTN RRPKDKDVTK CSFLKSEFGL VWHEIVNYIC 200
QVIFWINFLI VIVCYSLITK ELYRSYVRTR GSAKVPKKKV NVKVFIIIAV 250
FFICFVPFHF ARIPYTLSQT RAVFDCSAEN TLFYVKESTL WLTSLNACLD 300
PFIYFFLCKS FRNSLTSMLR CSNSTSTSGT NKKKGQEGGE PSEETPM 347
Length:347
Mass (Da):39,474
Last modified:June 1, 2001 - v1
Checksum:iF107488E57E025F1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK013804 mRNA. Translation: BAB29000.1.
AK014807 mRNA. Translation: BAB29561.1.
BC027381 mRNA. Translation: AAH27381.1.
CCDSiCCDS17373.1.
RefSeqiNP_081847.3. NM_027571.3.
XP_006502146.1. XM_006502083.1.
XP_006502147.1. XM_006502084.1.
XP_006502148.1. XM_006502085.1.
UniGeneiMm.422675.

Genome annotation databases

EnsembliENSMUST00000050360; ENSMUSP00000051353; ENSMUSG00000036353.
ENSMUST00000170388; ENSMUSP00000126819; ENSMUSG00000036353.
GeneIDi70839.
KEGGimmu:70839.
UCSCiuc008pir.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK013804 mRNA. Translation: BAB29000.1 .
AK014807 mRNA. Translation: BAB29561.1 .
BC027381 mRNA. Translation: AAH27381.1 .
CCDSi CCDS17373.1.
RefSeqi NP_081847.3. NM_027571.3.
XP_006502146.1. XM_006502083.1.
XP_006502147.1. XM_006502084.1.
XP_006502148.1. XM_006502085.1.
UniGenei Mm.422675.

3D structure databases

ProteinModelPortali Q9CPV9.
SMRi Q9CPV9. Positions 22-229, 245-318.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000051353.

Chemistry

GuidetoPHARMACOLOGYi 328.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q9CPV9.

Proteomic databases

PaxDbi Q9CPV9.
PRIDEi Q9CPV9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000050360 ; ENSMUSP00000051353 ; ENSMUSG00000036353 .
ENSMUST00000170388 ; ENSMUSP00000126819 ; ENSMUSG00000036353 .
GeneIDi 70839.
KEGGi mmu:70839.
UCSCi uc008pir.2. mouse.

Organism-specific databases

CTDi 64805.
MGIi MGI:1918089. P2ry12.

Phylogenomic databases

eggNOGi NOG147554.
GeneTreei ENSGT00640000091213.
HOGENOMi HOG000273884.
HOVERGENi HBG108228.
InParanoidi Q9CPV9.
KOi K04298.
OMAi IKVFIII.
OrthoDBi EOG7C2R1H.
PhylomeDBi Q9CPV9.
TreeFami TF330969.

Miscellaneous databases

NextBioi 332388.
PROi Q9CPV9.
SOURCEi Search...

Gene expression databases

Bgeei Q9CPV9.
CleanExi MM_P2RY12.
Genevestigatori Q9CPV9.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR005394. P2Y12_rcpt.
[Graphical view ]
PANTHERi PTHR24233:SF0. PTHR24233:SF0. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01569. P2Y12PRNCPTR.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Hippocampus and Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  3. "P2Y12 regulates platelet adhesion/activation, thrombus growth, and thrombus stability in injured arteries."
    Andre P., Delaney S.M., LaRocca T., Vincent D., DeGuzman F., Jurek M., Koller B., Phillips D.R., Conley P.B.
    J. Clin. Invest. 112:398-406(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiP2Y12_MOUSE
AccessioniPrimary (citable) accession number: Q9CPV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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