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Q9CPV9

- P2Y12_MOUSE

UniProt

Q9CPV9 - P2Y12_MOUSE

Protein

P2Y purinoceptor 12

Gene

P2ry12

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Required for normal platelet aggregation and blood coagulation.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei99 – 991ADPBy similarity
    Binding sitei103 – 1031ADP; via carbonyl oxygenBy similarity
    Binding sitei111 – 1111ADPBy similarity
    Binding sitei193 – 1931ADPBy similarity
    Binding sitei197 – 1971ADPBy similarity
    Binding sitei269 – 2691ADPBy similarity
    Binding sitei286 – 2861ADPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi162 – 1654ADPBy similarity
    Nucleotide bindingi181 – 1855ADPBy similarity
    Nucleotide bindingi262 – 2654ADPBy similarity

    GO - Molecular functioni

    1. ADP receptor activity Source: MGI
    2. G-protein coupled adenosine receptor activity Source: MGI

    GO - Biological processi

    1. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: UniProtKB
    2. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: MGI
    3. calcium ion transmembrane transport Source: Ensembl
    4. cell projection organization Source: Ensembl
    5. G-protein coupled purinergic nucleotide receptor signaling pathway Source: GOC
    6. negative regulation of cell differentiation Source: Ensembl
    7. negative regulation of norepinephrine secretion Source: Ensembl
    8. platelet activation Source: MGI
    9. platelet aggregation Source: UniProtKB
    10. positive regulation of ion transport Source: MGI
    11. potassium ion transmembrane transport Source: Ensembl
    12. protein kinase B signaling Source: Ensembl
    13. regulation of calcium ion transport Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Blood coagulation, Hemostasis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    P2Y purinoceptor 12
    Short name:
    P2Y12
    Gene namesi
    Name:P2ry12
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1918089. P2ry12.

    Subcellular locationi

    GO - Cellular componenti

    1. basal plasma membrane Source: Ensembl
    2. caveola Source: Ensembl
    3. external side of plasma membrane Source: Ensembl
    4. integral component of plasma membrane Source: MGI
    5. intrinsic component of membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Mice are viable and fertile, but display impaired blood coagulation, due to defects in platelet aggregation and thrombus formation.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 347347P2Y purinoceptor 12PRO_0000070038Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi7 – 71N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi12 – 121N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi23 ↔ 276PROSITE-ProRule annotation
    Modified residuei61 – 611PhosphoserineBy similarity
    Modified residuei63 – 631PhosphoserineBy similarity
    Disulfide bondi103 ↔ 181PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ9CPV9.
    PRIDEiQ9CPV9.

    PTM databases

    PhosphoSiteiQ9CPV9.

    Expressioni

    Gene expression databases

    BgeeiQ9CPV9.
    CleanExiMM_P2RY12.
    GenevestigatoriQ9CPV9.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000051353.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CPV9.
    SMRiQ9CPV9. Positions 22-229, 245-318.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3333ExtracellularBy similarityAdd
    BLAST
    Topological domaini57 – 6711CytoplasmicBy similarityAdd
    BLAST
    Topological domaini89 – 10315ExtracellularBy similarityAdd
    BLAST
    Topological domaini125 – 14824CytoplasmicBy similarityAdd
    BLAST
    Topological domaini169 – 19123ExtracellularBy similarityAdd
    BLAST
    Topological domaini214 – 23926CytoplasmicBy similarityAdd
    BLAST
    Topological domaini266 – 28419ExtracellularBy similarityAdd
    BLAST
    Topological domaini305 – 34743CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei34 – 5623Helical; Name=1By similarityAdd
    BLAST
    Transmembranei68 – 8821Helical; Name=2By similarityAdd
    BLAST
    Transmembranei104 – 12421Helical; Name=3By similarityAdd
    BLAST
    Transmembranei149 – 16820Helical; Name=4By similarityAdd
    BLAST
    Transmembranei192 – 21322Helical; Name=5By similarityAdd
    BLAST
    Transmembranei240 – 26526Helical; Name=6By similarityAdd
    BLAST
    Transmembranei285 – 30420Helical; Name=7By similarityAdd
    BLAST

    Family & Domainsi

    Domaini

    The transmembrane domain is composed of seven transmembrane helices; most of these are not strictly perpendicular to the plane of the membrane, but are tilted and/or kinked. Agonist binding promotes a conformation change in the extracellular loops that leads to an inward movement of the transmembrane helices. Antagonists can bind to an overlapping site, but block the inward movement of the transmembrane helices By similarity.By similarity

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG147554.
    GeneTreeiENSGT00640000091213.
    HOGENOMiHOG000273884.
    HOVERGENiHBG108228.
    InParanoidiQ9CPV9.
    KOiK04298.
    OMAiIKVFIII.
    OrthoDBiEOG7C2R1H.
    PhylomeDBiQ9CPV9.
    TreeFamiTF330969.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR005394. P2Y12_rcpt.
    [Graphical view]
    PANTHERiPTHR24233:SF0. PTHR24233:SF0. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01569. P2Y12PRNCPTR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9CPV9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDVPGVNTTS ANTTFSPGTS TLCVRDYKIT QVLFPLLYTV LFFAGLITNS    50
    LAMRIFFQIR SKSNFIIFLK NTVISDLLMI LTFPFKILSD AKLGAGPLRT 100
    LVCQVTSVTF YFTMYISISF LGLITIDRYL KTTRPFKTSS PSNLLGAKIL 150
    SVVIWAFMFL ISLPNMILTN RRPKDKDVTK CSFLKSEFGL VWHEIVNYIC 200
    QVIFWINFLI VIVCYSLITK ELYRSYVRTR GSAKVPKKKV NVKVFIIIAV 250
    FFICFVPFHF ARIPYTLSQT RAVFDCSAEN TLFYVKESTL WLTSLNACLD 300
    PFIYFFLCKS FRNSLTSMLR CSNSTSTSGT NKKKGQEGGE PSEETPM 347
    Length:347
    Mass (Da):39,474
    Last modified:June 1, 2001 - v1
    Checksum:iF107488E57E025F1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK013804 mRNA. Translation: BAB29000.1.
    AK014807 mRNA. Translation: BAB29561.1.
    BC027381 mRNA. Translation: AAH27381.1.
    CCDSiCCDS17373.1.
    RefSeqiNP_081847.3. NM_027571.3.
    XP_006502146.1. XM_006502083.1.
    XP_006502147.1. XM_006502084.1.
    XP_006502148.1. XM_006502085.1.
    UniGeneiMm.422675.

    Genome annotation databases

    EnsembliENSMUST00000050360; ENSMUSP00000051353; ENSMUSG00000036353.
    ENSMUST00000170388; ENSMUSP00000126819; ENSMUSG00000036353.
    GeneIDi70839.
    KEGGimmu:70839.
    UCSCiuc008pir.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK013804 mRNA. Translation: BAB29000.1 .
    AK014807 mRNA. Translation: BAB29561.1 .
    BC027381 mRNA. Translation: AAH27381.1 .
    CCDSi CCDS17373.1.
    RefSeqi NP_081847.3. NM_027571.3.
    XP_006502146.1. XM_006502083.1.
    XP_006502147.1. XM_006502084.1.
    XP_006502148.1. XM_006502085.1.
    UniGenei Mm.422675.

    3D structure databases

    ProteinModelPortali Q9CPV9.
    SMRi Q9CPV9. Positions 22-229, 245-318.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000051353.

    Chemistry

    GuidetoPHARMACOLOGYi 328.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9CPV9.

    Proteomic databases

    PaxDbi Q9CPV9.
    PRIDEi Q9CPV9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000050360 ; ENSMUSP00000051353 ; ENSMUSG00000036353 .
    ENSMUST00000170388 ; ENSMUSP00000126819 ; ENSMUSG00000036353 .
    GeneIDi 70839.
    KEGGi mmu:70839.
    UCSCi uc008pir.2. mouse.

    Organism-specific databases

    CTDi 64805.
    MGIi MGI:1918089. P2ry12.

    Phylogenomic databases

    eggNOGi NOG147554.
    GeneTreei ENSGT00640000091213.
    HOGENOMi HOG000273884.
    HOVERGENi HBG108228.
    InParanoidi Q9CPV9.
    KOi K04298.
    OMAi IKVFIII.
    OrthoDBi EOG7C2R1H.
    PhylomeDBi Q9CPV9.
    TreeFami TF330969.

    Miscellaneous databases

    NextBioi 332388.
    PROi Q9CPV9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9CPV9.
    CleanExi MM_P2RY12.
    Genevestigatori Q9CPV9.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR005394. P2Y12_rcpt.
    [Graphical view ]
    PANTHERi PTHR24233:SF0. PTHR24233:SF0. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01569. P2Y12PRNCPTR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Hippocampus and Testis.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.
    3. "P2Y12 regulates platelet adhesion/activation, thrombus growth, and thrombus stability in injured arteries."
      Andre P., Delaney S.M., LaRocca T., Vincent D., DeGuzman F., Jurek M., Koller B., Phillips D.R., Conley P.B.
      J. Clin. Invest. 112:398-406(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiP2Y12_MOUSE
    AccessioniPrimary (citable) accession number: Q9CPV9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 27, 2002
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3