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Q9CPV9 (P2Y12_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
P2Y purinoceptor 12

Short name=P2Y12
Gene names
Name:P2ry12
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length347 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled purinergic nucleotide receptor signaling pathway

Inferred from mutant phenotype PubMed 11413167. Source: GOC

adenylate cyclase-modulating G-protein coupled receptor signaling pathway

Inferred from mutant phenotype PubMed 11413167. Source: MGI

calcium ion transmembrane transport

Inferred from electronic annotation. Source: Ensembl

cell projection organization

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell differentiation

Inferred from electronic annotation. Source: Ensembl

negative regulation of norepinephrine secretion

Inferred from electronic annotation. Source: Ensembl

platelet activation

Inferred from mutant phenotype PubMed 11413167. Source: MGI

platelet aggregation

Inferred from electronic annotation. Source: Ensembl

positive regulation of ion transport

Inferred from genetic interaction PubMed 15914557. Source: MGI

potassium ion transmembrane transport

Inferred from electronic annotation. Source: Ensembl

protein kinase B signaling

Inferred from electronic annotation. Source: Ensembl

regulation of calcium ion transport

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentbasal plasma membrane

Inferred from electronic annotation. Source: Ensembl

caveola

Inferred from electronic annotation. Source: Ensembl

external side of plasma membrane

Inferred from electronic annotation. Source: Ensembl

integral component of plasma membrane

Inferred by curator PubMed 11413167. Source: MGI

   Molecular_functionADP receptor activity

Inferred from mutant phenotype PubMed 11413167. Source: MGI

G-protein coupled adenosine receptor activity

Inferred from mutant phenotype PubMed 11413167. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 347347P2Y purinoceptor 12
PRO_0000070038

Regions

Topological domain1 – 3131Extracellular Potential
Transmembrane32 – 5221Helical; Name=1; Potential
Topological domain53 – 6412Cytoplasmic Potential
Transmembrane65 – 8521Helical; Name=2; Potential
Topological domain86 – 10520Extracellular Potential
Transmembrane106 – 12621Helical; Name=3; Potential
Topological domain127 – 14822Cytoplasmic Potential
Transmembrane149 – 16921Helical; Name=4; Potential
Topological domain170 – 19728Extracellular Potential
Transmembrane198 – 21821Helical; Name=5; Potential
Topological domain219 – 23921Cytoplasmic Potential
Transmembrane240 – 26021Helical; Name=6; Potential
Topological domain261 – 28727Extracellular Potential
Transmembrane288 – 30821Helical; Name=7; Potential
Topological domain309 – 34739Cytoplasmic Potential

Amino acid modifications

Modified residue611Phosphoserine By similarity
Modified residue631Phosphoserine By similarity
Glycosylation71N-linked (GlcNAc...) Potential
Glycosylation121N-linked (GlcNAc...) Potential
Disulfide bond103 ↔ 181 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9CPV9 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: F107488E57E025F1

FASTA34739,474
        10         20         30         40         50         60 
MDVPGVNTTS ANTTFSPGTS TLCVRDYKIT QVLFPLLYTV LFFAGLITNS LAMRIFFQIR 

        70         80         90        100        110        120 
SKSNFIIFLK NTVISDLLMI LTFPFKILSD AKLGAGPLRT LVCQVTSVTF YFTMYISISF 

       130        140        150        160        170        180 
LGLITIDRYL KTTRPFKTSS PSNLLGAKIL SVVIWAFMFL ISLPNMILTN RRPKDKDVTK 

       190        200        210        220        230        240 
CSFLKSEFGL VWHEIVNYIC QVIFWINFLI VIVCYSLITK ELYRSYVRTR GSAKVPKKKV 

       250        260        270        280        290        300 
NVKVFIIIAV FFICFVPFHF ARIPYTLSQT RAVFDCSAEN TLFYVKESTL WLTSLNACLD 

       310        320        330        340 
PFIYFFLCKS FRNSLTSMLR CSNSTSTSGT NKKKGQEGGE PSEETPM 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Hippocampus and Testis.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK013804 mRNA. Translation: BAB29000.1.
AK014807 mRNA. Translation: BAB29561.1.
BC027381 mRNA. Translation: AAH27381.1.
RefSeqNP_081847.3. NM_027571.3.
XP_006502146.1. XM_006502083.1.
XP_006502147.1. XM_006502084.1.
XP_006502148.1. XM_006502085.1.
UniGeneMm.422675.

3D structure databases

ProteinModelPortalQ9CPV9.
SMRQ9CPV9. Positions 7-322.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000051353.

Chemistry

GuidetoPHARMACOLOGY328.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ9CPV9.

Proteomic databases

PaxDbQ9CPV9.
PRIDEQ9CPV9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000050360; ENSMUSP00000051353; ENSMUSG00000036353.
ENSMUST00000170388; ENSMUSP00000126819; ENSMUSG00000036353.
GeneID70839.
KEGGmmu:70839.
UCSCuc008pir.2. mouse.

Organism-specific databases

CTD64805.
MGIMGI:1918089. P2ry12.

Phylogenomic databases

eggNOGNOG147554.
GeneTreeENSGT00640000091213.
HOGENOMHOG000273884.
HOVERGENHBG108228.
InParanoidQ9CPV9.
KOK04298.
OMAIKVFIII.
OrthoDBEOG7C2R1H.
PhylomeDBQ9CPV9.
TreeFamTF330969.

Gene expression databases

BgeeQ9CPV9.
CleanExMM_P2RY12.
GenevestigatorQ9CPV9.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR005394. P2Y12_rcpt.
[Graphical view]
PANTHERPTHR24233:SF0. PTHR24233:SF0. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01569. P2Y12PRNCPTR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio332388.
PROQ9CPV9.
SOURCESearch...

Entry information

Entry nameP2Y12_MOUSE
AccessionPrimary (citable) accession number: Q9CPV9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries