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Protein

Probable low affinity copper uptake protein 2

Gene

Slc31a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in low-affinity copper uptake.Curated

GO - Biological processi

  • cellular copper ion homeostasis Source: MGI
  • ion transport Source: UniProtKB-KW
  • regulation of copper ion transmembrane transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Copper transport, Ion transport, Transport

Keywords - Ligandi

Copper

Names & Taxonomyi

Protein namesi
Recommended name:
Probable low affinity copper uptake protein 2
Alternative name(s):
Copper transporter 2
Short name:
CTR2
Solute carrier family 31 member 2
Gene namesi
Name:Slc31a2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1333844. Slc31a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei23 – 4321HelicalSequence analysisAdd
BLAST
Transmembranei94 – 11421HelicalSequence analysisAdd
BLAST
Transmembranei120 – 14021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • late endosome Source: MGI
  • membrane Source: MGI
  • recycling endosome Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 143143Probable low affinity copper uptake protein 2PRO_0000195044Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei75 – 751PhosphothreonineCombined sources
Modified residuei77 – 771PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9CPU9.
PaxDbiQ9CPU9.
PRIDEiQ9CPU9.

PTM databases

iPTMnetiQ9CPU9.
PhosphoSiteiQ9CPU9.

Expressioni

Gene expression databases

BgeeiQ9CPU9.
CleanExiMM_SLC31A2.
ExpressionAtlasiQ9CPU9. baseline and differential.
GenevisibleiQ9CPU9. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081578.

Structurei

3D structure databases

ProteinModelPortaliQ9CPU9.
SMRiQ9CPU9. Positions 92-119.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3386. Eukaryota.
ENOG4111I8D. LUCA.
GeneTreeiENSGT00530000063415.
HOGENOMiHOG000195393.
HOVERGENiHBG106679.
InParanoidiQ9CPU9.
KOiK14687.
OMAiCILYEAI.
OrthoDBiEOG7CCBT8.
PhylomeDBiQ9CPU9.
TreeFamiTF315142.

Family and domain databases

InterProiIPR007274. Cop_transporter.
[Graphical view]
PANTHERiPTHR12483. PTHR12483. 1 hit.
PfamiPF04145. Ctr. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CPU9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPMHFIFSDE AVLLFDFWRV HSPTGMALSV LVVLLLAVLY EGIKVGKAKL
60 70 80 90 100
LHKTLESLPA TNSQQFILGP DQDSTGSRST SDNRTRLRWF LCYFGQSLVH
110 120 130 140
VIQVVIGYFV MLAVMSYNTW IFLGVVLGSA VGYYLAYPLL NMT
Length:143
Mass (Da):16,069
Last modified:June 1, 2001 - v1
Checksum:iF3AC3A5302909139
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008473 mRNA. Translation: BAB25688.1.
AK003269 mRNA. Translation: BAB22682.1.
AK007579 mRNA. Translation: BAB25117.1.
AL683829 Genomic DNA. Translation: CAD83039.1.
BC029183 mRNA. Translation: AAH29183.1.
CCDSiCCDS18236.1.
RefSeqiNP_001277447.1. NM_001290518.1.
NP_079562.1. NM_025286.3.
UniGeneiMm.292539.

Genome annotation databases

EnsembliENSMUST00000084530; ENSMUSP00000081578; ENSMUSG00000066152.
GeneIDi20530.
KEGGimmu:20530.
UCSCiuc008tee.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008473 mRNA. Translation: BAB25688.1.
AK003269 mRNA. Translation: BAB22682.1.
AK007579 mRNA. Translation: BAB25117.1.
AL683829 Genomic DNA. Translation: CAD83039.1.
BC029183 mRNA. Translation: AAH29183.1.
CCDSiCCDS18236.1.
RefSeqiNP_001277447.1. NM_001290518.1.
NP_079562.1. NM_025286.3.
UniGeneiMm.292539.

3D structure databases

ProteinModelPortaliQ9CPU9.
SMRiQ9CPU9. Positions 92-119.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081578.

PTM databases

iPTMnetiQ9CPU9.
PhosphoSiteiQ9CPU9.

Proteomic databases

MaxQBiQ9CPU9.
PaxDbiQ9CPU9.
PRIDEiQ9CPU9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000084530; ENSMUSP00000081578; ENSMUSG00000066152.
GeneIDi20530.
KEGGimmu:20530.
UCSCiuc008tee.2. mouse.

Organism-specific databases

CTDi1318.
MGIiMGI:1333844. Slc31a2.

Phylogenomic databases

eggNOGiKOG3386. Eukaryota.
ENOG4111I8D. LUCA.
GeneTreeiENSGT00530000063415.
HOGENOMiHOG000195393.
HOVERGENiHBG106679.
InParanoidiQ9CPU9.
KOiK14687.
OMAiCILYEAI.
OrthoDBiEOG7CCBT8.
PhylomeDBiQ9CPU9.
TreeFamiTF315142.

Miscellaneous databases

ChiTaRSiSlc31a2. mouse.
NextBioi298783.
PROiQ9CPU9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CPU9.
CleanExiMM_SLC31A2.
ExpressionAtlasiQ9CPU9. baseline and differential.
GenevisibleiQ9CPU9. MM.

Family and domain databases

InterProiIPR007274. Cop_transporter.
[Graphical view]
PANTHERiPTHR12483. PTHR12483. 1 hit.
PfamiPF04145. Ctr. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Pancreas and Small intestine.
  2. Bates K.
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  4. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-75 AND SER-77, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney, Pancreas and Spleen.

Entry informationi

Entry nameiCOPT2_MOUSE
AccessioniPrimary (citable) accession number: Q9CPU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: June 1, 2001
Last modified: January 20, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.