Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

F-box only protein 32

Gene

Fbxo32

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1 (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

  • cellular response to dexamethasone stimulus Source: MGI
  • protein ubiquitination Source: UniProtKB
  • response to denervation involved in regulation of muscle adaptation Source: UniProtKB

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-8951664. Neddylation.
R-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 32
Alternative name(s):
Atrogin-1
Muscle atrophy F-box protein
Short name:
MAFbx
Gene namesi
Name:Fbxo32
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1914981. Fbxo32.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001199231 – 355F-box only protein 32Add BLAST355

Proteomic databases

PaxDbiQ9CPU7.
PeptideAtlasiQ9CPU7.
PRIDEiQ9CPU7.

PTM databases

PhosphoSitePlusiQ9CPU7.

Expressioni

Tissue specificityi

Specifically expressed in cardiac and skeletal muscle.

Gene expression databases

BgeeiENSMUSG00000022358.
CleanExiMM_FBXO32.
GenevisibleiQ9CPU7. MM.

Interactioni

Subunit structurei

Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO32) formed of CUL1, SKP1, RBX1 and FBXO32.By similarity

Protein-protein interaction databases

BioGridi212401. 156 interactors.
CORUMiQ9CPU7.
IntActiQ9CPU7. 2 interactors.
STRINGi10090.ENSMUSP00000022986.

Structurei

3D structure databases

ProteinModelPortaliQ9CPU7.
SMRiQ9CPU7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini223 – 271F-boxAdd BLAST49

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi62 – 67Nuclear localization signalBy similarity6
Motifi169 – 173Nuclear export signalBy similarity5
Motifi280 – 295Bipartite nuclear localization signalBy similarityAdd BLAST16

Phylogenomic databases

eggNOGiKOG3926. Eukaryota.
ENOG410YPWK. LUCA.
GeneTreeiENSGT00390000004915.
HOGENOMiHOG000263478.
HOVERGENiHBG051572.
InParanoidiQ9CPU7.
KOiK10305.
OMAiCRHCHIL.
OrthoDBiEOG091G0M92.
PhylomeDBiQ9CPU7.
TreeFamiTF313070.

Family and domain databases

InterProiView protein in InterPro
IPR036047. F-box-like_dom_sf.
SUPFAMiSSF81383. SSF81383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CPU7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFLGQDWRS PGQSWVKTAD GWKRFLDEKS GSFVSDLSSY CNKEVYSKEN
60 70 80 90 100
LFSSLNYDVA AKKRKKDIQN SKTKTQYFHQ EKWIYVHKGS TKERHGYCTL
110 120 130 140 150
GEAFNRLDFS TAILDSRRFN YVVRLLELIA KSQLTSLSGI AQKNFMNILE
160 170 180 190 200
KVVLKVLEDQ QNIRLIRELL QTLYTSLCTL VQRVGKSVLV GNINMWVYRM
210 220 230 240 250
ETILHWQQQL NSIQISRPAF KGLTITDLPV CLQLNIMQRL SDGRDLVSLG
260 270 280 290 300
QAAPDLHVLS EDRLLWKRLC QYHFSERQIR KRLILSDKGQ LDWKKMYFKL
310 320 330 340 350
VRCYPRREQY GVTLQLCKHC HILSWKGTDH PCTANNPESC SVSLSPQDFI

NLFKF
Length:355
Mass (Da):41,504
Last modified:June 1, 2001 - v1
Checksum:iF464997EB97909A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF441120 mRNA. Translation: AAL49563.1.
AK014793 mRNA. Translation: BAB29555.1.
AK014612 mRNA. Translation: BAB29463.1.
BC027211 mRNA. Translation: AAH27211.1.
CCDSiCCDS27491.1.
RefSeqiNP_080622.1. NM_026346.3.
UniGeneiMm.25683.

Genome annotation databases

EnsembliENSMUST00000022986; ENSMUSP00000022986; ENSMUSG00000022358.
GeneIDi67731.
KEGGimmu:67731.
UCSCiuc007vtk.3. mouse.

Similar proteinsi

Entry informationi

Entry nameiFBX32_MOUSE
AccessioniPrimary (citable) accession number: Q9CPU7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: June 1, 2001
Last modified: November 22, 2017
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways