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Protein

Microsomal glutathione S-transferase 3

Gene

Mgst3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Also functions as a glutathione peroxidase.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

  1. glutathione peroxidase activity Source: GO_Central
  2. glutathione transferase activity Source: GO_Central

GO - Biological processi

  1. metabolic process Source: GOC
  2. oxidation-reduction process Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

ReactomeiREACT_215316. Glutathione conjugation.
REACT_237136. Aflatoxin activation and detoxification.

Names & Taxonomyi

Protein namesi
Recommended name:
Microsomal glutathione S-transferase 3 (EC:2.5.1.18)
Short name:
Microsomal GST-3
Alternative name(s):
Microsomal GST-III
Gene namesi
Name:Mgst3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1913697. Mgst3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei9 – 2921HelicalSequence AnalysisAdd
BLAST
Transmembranei71 – 9121HelicalSequence AnalysisAdd
BLAST
Transmembranei120 – 14021HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: GO_Central
  2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. extracellular vesicular exosome Source: MGI
  4. integral component of membrane Source: UniProtKB-KW
  5. membrane Source: MGI
  6. nuclear envelope Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 153153Microsomal glutathione S-transferase 3PRO_0000217742Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi151 – 1511S-palmitoyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

MaxQBiQ9CPU4.
PaxDbiQ9CPU4.
PRIDEiQ9CPU4.

PTM databases

PhosphoSiteiQ9CPU4.

Expressioni

Gene expression databases

BgeeiQ9CPU4.
CleanExiMM_MGST3.
GenevestigatoriQ9CPU4.

Interactioni

Protein-protein interaction databases

BioGridi211481. 2 interactions.
IntActiQ9CPU4. 1 interaction.
STRINGi10090.ENSMUSP00000028005.

Structurei

3D structure databases

ProteinModelPortaliQ9CPU4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MAPEG family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG84007.
GeneTreeiENSGT00390000008608.
HOGENOMiHOG000116372.
HOVERGENiHBG052472.
InParanoidiQ9CPU4.
KOiK00799.
OMAiDPENGHM.
OrthoDBiEOG7PCJKH.
PhylomeDBiQ9CPU4.
TreeFamiTF105328.

Family and domain databases

Gene3Di1.20.120.550. 1 hit.
InterProiIPR023352. MAPEG-like_dom.
IPR001129. Membr-assoc_MAPEG.
[Graphical view]
PfamiPF01124. MAPEG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CPU4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVLSKEYGF VLLTGAASFV MVLHLAINVG KARKKYKVEY PVMYSTDPEN
60 70 80 90 100
GHMFNCIQRA HQNTLEVYPP FLFFLTVGGV YHPRIASGLG LAWIIGRVLY
110 120 130 140 150
AYGYYTGDPS KRYRGAVGSL ALFALMGTTV CSAFQHLGWI RPGLGYGSRS

CHH
Length:153
Mass (Da):16,958
Last modified:June 1, 2001 - v1
Checksum:iF54175ACB9C4C845
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti142 – 1421P → R in BAB25726 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003246 mRNA. Translation: BAB22665.1.
AK003309 mRNA. Translation: BAB22706.1.
AK003476 mRNA. Translation: BAB22808.1.
AK003492 mRNA. Translation: BAB22819.1.
AK008533 mRNA. Translation: BAB25726.1.
AK135742 mRNA. Translation: BAE22638.1.
BC029669 mRNA. Translation: AAH29669.1.
CCDSiCCDS15457.1.
RefSeqiNP_079845.1. NM_025569.1.
UniGeneiMm.218286.

Genome annotation databases

EnsembliENSMUST00000028005; ENSMUSP00000028005; ENSMUSG00000026688.
GeneIDi66447.
KEGGimmu:66447.
UCSCiuc007dky.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003246 mRNA. Translation: BAB22665.1.
AK003309 mRNA. Translation: BAB22706.1.
AK003476 mRNA. Translation: BAB22808.1.
AK003492 mRNA. Translation: BAB22819.1.
AK008533 mRNA. Translation: BAB25726.1.
AK135742 mRNA. Translation: BAE22638.1.
BC029669 mRNA. Translation: AAH29669.1.
CCDSiCCDS15457.1.
RefSeqiNP_079845.1. NM_025569.1.
UniGeneiMm.218286.

3D structure databases

ProteinModelPortaliQ9CPU4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211481. 2 interactions.
IntActiQ9CPU4. 1 interaction.
STRINGi10090.ENSMUSP00000028005.

PTM databases

PhosphoSiteiQ9CPU4.

Proteomic databases

MaxQBiQ9CPU4.
PaxDbiQ9CPU4.
PRIDEiQ9CPU4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028005; ENSMUSP00000028005; ENSMUSG00000026688.
GeneIDi66447.
KEGGimmu:66447.
UCSCiuc007dky.1. mouse.

Organism-specific databases

CTDi4259.
MGIiMGI:1913697. Mgst3.

Phylogenomic databases

eggNOGiNOG84007.
GeneTreeiENSGT00390000008608.
HOGENOMiHOG000116372.
HOVERGENiHBG052472.
InParanoidiQ9CPU4.
KOiK00799.
OMAiDPENGHM.
OrthoDBiEOG7PCJKH.
PhylomeDBiQ9CPU4.
TreeFamiTF105328.

Enzyme and pathway databases

ReactomeiREACT_215316. Glutathione conjugation.
REACT_237136. Aflatoxin activation and detoxification.

Miscellaneous databases

NextBioi321721.
PROiQ9CPU4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CPU4.
CleanExiMM_MGST3.
GenevestigatoriQ9CPU4.

Family and domain databases

Gene3Di1.20.120.550. 1 hit.
InterProiIPR023352. MAPEG-like_dom.
IPR001129. Membr-assoc_MAPEG.
[Graphical view]
PfamiPF01124. MAPEG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Egg, Embryo and Small intestine.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 85-97, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiMGST3_MOUSE
AccessioniPrimary (citable) accession number: Q9CPU4
Secondary accession number(s): Q3UXC5, Q9D834
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: June 1, 2001
Last modified: February 4, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.