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Q9CPU4 (MGST3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Microsomal glutathione S-transferase 3

Short name=Microsomal GST-3
EC=2.5.1.18
Alternative name(s):
Microsomal GST-III
Gene names
Name:Mgst3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length153 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Also functions as a glutathione peroxidase By similarity.

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein Potential. Microsome membrane; Multi-pass membrane protein Potential. Microsome membrane; Lipid-anchor Potential.

Sequence similarities

Belongs to the MAPEG family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 153153Microsomal glutathione S-transferase 3
PRO_0000217742

Regions

Transmembrane9 – 2921Helical; Potential
Transmembrane71 – 9121Helical; Potential
Transmembrane120 – 14021Helical; Potential

Amino acid modifications

Lipidation1511S-palmitoyl cysteine By similarity

Experimental info

Sequence conflict1421P → R in BAB25726. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9CPU4 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: F54175ACB9C4C845

FASTA15316,958
        10         20         30         40         50         60 
MAVLSKEYGF VLLTGAASFV MVLHLAINVG KARKKYKVEY PVMYSTDPEN GHMFNCIQRA 

        70         80         90        100        110        120 
HQNTLEVYPP FLFFLTVGGV YHPRIASGLG LAWIIGRVLY AYGYYTGDPS KRYRGAVGSL 

       130        140        150 
ALFALMGTTV CSAFQHLGWI RPGLGYGSRS CHH 

« Hide

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Egg, Embryo and Small intestine.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]Lubec G., Kang S.U.
Submitted (APR-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 85-97, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK003246 mRNA. Translation: BAB22665.1.
AK003309 mRNA. Translation: BAB22706.1.
AK003476 mRNA. Translation: BAB22808.1.
AK003492 mRNA. Translation: BAB22819.1.
AK008533 mRNA. Translation: BAB25726.1.
AK135742 mRNA. Translation: BAE22638.1.
BC029669 mRNA. Translation: AAH29669.1.
CCDSCCDS15457.1.
RefSeqNP_079845.1. NM_025569.1.
UniGeneMm.218286.

3D structure databases

ProteinModelPortalQ9CPU4.
SMRQ9CPU4. Positions 7-136.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid211481. 2 interactions.
IntActQ9CPU4. 1 interaction.
STRING10090.ENSMUSP00000028005.

PTM databases

PhosphoSiteQ9CPU4.

Proteomic databases

PaxDbQ9CPU4.
PRIDEQ9CPU4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000028005; ENSMUSP00000028005; ENSMUSG00000026688.
GeneID66447.
KEGGmmu:66447.
UCSCuc007dky.1. mouse.

Organism-specific databases

CTD4259.
MGIMGI:1913697. Mgst3.

Phylogenomic databases

eggNOGNOG84007.
GeneTreeENSGT00390000008608.
HOGENOMHOG000116372.
HOVERGENHBG052472.
InParanoidQ9CPU4.
KOK00799.
OMAEYGFVIL.
OrthoDBEOG7PCJKH.
PhylomeDBQ9CPU4.
TreeFamTF105328.

Gene expression databases

BgeeQ9CPU4.
CleanExMM_MGST3.
GenevestigatorQ9CPU4.

Family and domain databases

Gene3D1.20.120.550. 1 hit.
InterProIPR023352. MAPEG-like_dom.
IPR001129. Membr-assoc_MAPEG.
[Graphical view]
PfamPF01124. MAPEG. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio321721.
PROQ9CPU4.
SOURCESearch...

Entry information

Entry nameMGST3_MOUSE
AccessionPrimary (citable) accession number: Q9CPU4
Secondary accession number(s): Q3UXC5, Q9D834
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot