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Q9CPU4

- MGST3_MOUSE

UniProt

Q9CPU4 - MGST3_MOUSE

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Protein

Microsomal glutathione S-transferase 3

Gene
Mgst3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Also functions as a glutathione peroxidase By similarity.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

  1. glutathione peroxidase activity Source: RefGenome
  2. glutathione transferase activity Source: RefGenome

GO - Biological processi

  1. metabolic process Source: GOC
  2. oxidation-reduction process Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

ReactomeiREACT_215316. Glutathione conjugation.

Names & Taxonomyi

Protein namesi
Recommended name:
Microsomal glutathione S-transferase 3 (EC:2.5.1.18)
Short name:
Microsomal GST-3
Alternative name(s):
Microsomal GST-III
Gene namesi
Name:Mgst3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1913697. Mgst3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei9 – 2921Helical; Reviewed predictionAdd
BLAST
Transmembranei71 – 9121Helical; Reviewed predictionAdd
BLAST
Transmembranei120 – 14021Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: RefGenome
  2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. nuclear envelope Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 153153Microsomal glutathione S-transferase 3PRO_0000217742Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi151 – 1511S-palmitoyl cysteine By similarity

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ9CPU4.
PRIDEiQ9CPU4.

PTM databases

PhosphoSiteiQ9CPU4.

Expressioni

Gene expression databases

BgeeiQ9CPU4.
CleanExiMM_MGST3.
GenevestigatoriQ9CPU4.

Interactioni

Protein-protein interaction databases

BioGridi211481. 2 interactions.
IntActiQ9CPU4. 1 interaction.
STRINGi10090.ENSMUSP00000028005.

Structurei

3D structure databases

ProteinModelPortaliQ9CPU4.
SMRiQ9CPU4. Positions 7-136.

Family & Domainsi

Sequence similaritiesi

Belongs to the MAPEG family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG84007.
GeneTreeiENSGT00390000008608.
HOGENOMiHOG000116372.
HOVERGENiHBG052472.
InParanoidiQ9CPU4.
KOiK00799.
OMAiEYGFVIL.
OrthoDBiEOG7PCJKH.
PhylomeDBiQ9CPU4.
TreeFamiTF105328.

Family and domain databases

Gene3Di1.20.120.550. 1 hit.
InterProiIPR023352. MAPEG-like_dom.
IPR001129. Membr-assoc_MAPEG.
[Graphical view]
PfamiPF01124. MAPEG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CPU4-1 [UniParc]FASTAAdd to Basket

« Hide

MAVLSKEYGF VLLTGAASFV MVLHLAINVG KARKKYKVEY PVMYSTDPEN    50
GHMFNCIQRA HQNTLEVYPP FLFFLTVGGV YHPRIASGLG LAWIIGRVLY 100
AYGYYTGDPS KRYRGAVGSL ALFALMGTTV CSAFQHLGWI RPGLGYGSRS 150
CHH 153
Length:153
Mass (Da):16,958
Last modified:June 1, 2001 - v1
Checksum:iF54175ACB9C4C845
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti142 – 1421P → R in BAB25726. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK003246 mRNA. Translation: BAB22665.1.
AK003309 mRNA. Translation: BAB22706.1.
AK003476 mRNA. Translation: BAB22808.1.
AK003492 mRNA. Translation: BAB22819.1.
AK008533 mRNA. Translation: BAB25726.1.
AK135742 mRNA. Translation: BAE22638.1.
BC029669 mRNA. Translation: AAH29669.1.
CCDSiCCDS15457.1.
RefSeqiNP_079845.1. NM_025569.1.
UniGeneiMm.218286.

Genome annotation databases

EnsembliENSMUST00000028005; ENSMUSP00000028005; ENSMUSG00000026688.
GeneIDi66447.
KEGGimmu:66447.
UCSCiuc007dky.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK003246 mRNA. Translation: BAB22665.1 .
AK003309 mRNA. Translation: BAB22706.1 .
AK003476 mRNA. Translation: BAB22808.1 .
AK003492 mRNA. Translation: BAB22819.1 .
AK008533 mRNA. Translation: BAB25726.1 .
AK135742 mRNA. Translation: BAE22638.1 .
BC029669 mRNA. Translation: AAH29669.1 .
CCDSi CCDS15457.1.
RefSeqi NP_079845.1. NM_025569.1.
UniGenei Mm.218286.

3D structure databases

ProteinModelPortali Q9CPU4.
SMRi Q9CPU4. Positions 7-136.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 211481. 2 interactions.
IntActi Q9CPU4. 1 interaction.
STRINGi 10090.ENSMUSP00000028005.

PTM databases

PhosphoSitei Q9CPU4.

Proteomic databases

PaxDbi Q9CPU4.
PRIDEi Q9CPU4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028005 ; ENSMUSP00000028005 ; ENSMUSG00000026688 .
GeneIDi 66447.
KEGGi mmu:66447.
UCSCi uc007dky.1. mouse.

Organism-specific databases

CTDi 4259.
MGIi MGI:1913697. Mgst3.

Phylogenomic databases

eggNOGi NOG84007.
GeneTreei ENSGT00390000008608.
HOGENOMi HOG000116372.
HOVERGENi HBG052472.
InParanoidi Q9CPU4.
KOi K00799.
OMAi EYGFVIL.
OrthoDBi EOG7PCJKH.
PhylomeDBi Q9CPU4.
TreeFami TF105328.

Enzyme and pathway databases

Reactomei REACT_215316. Glutathione conjugation.

Miscellaneous databases

NextBioi 321721.
PROi Q9CPU4.
SOURCEi Search...

Gene expression databases

Bgeei Q9CPU4.
CleanExi MM_MGST3.
Genevestigatori Q9CPU4.

Family and domain databases

Gene3Di 1.20.120.550. 1 hit.
InterProi IPR023352. MAPEG-like_dom.
IPR001129. Membr-assoc_MAPEG.
[Graphical view ]
Pfami PF01124. MAPEG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Egg, Embryo and Small intestine.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 85-97, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiMGST3_MOUSE
AccessioniPrimary (citable) accession number: Q9CPU4
Secondary accession number(s): Q3UXC5, Q9D834
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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