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Q9CPU4

- MGST3_MOUSE

UniProt

Q9CPU4 - MGST3_MOUSE

Protein

Microsomal glutathione S-transferase 3

Gene

Mgst3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Also functions as a glutathione peroxidase.By similarity

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.

    GO - Molecular functioni

    1. glutathione peroxidase activity Source: RefGenome
    2. glutathione transferase activity Source: RefGenome

    GO - Biological processi

    1. metabolic process Source: GOC
    2. oxidation-reduction process Source: GOC

    Keywords - Molecular functioni

    Transferase

    Enzyme and pathway databases

    ReactomeiREACT_215316. Glutathione conjugation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Microsomal glutathione S-transferase 3 (EC:2.5.1.18)
    Short name:
    Microsomal GST-3
    Alternative name(s):
    Microsomal GST-III
    Gene namesi
    Name:Mgst3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1913697. Mgst3.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: RefGenome
    2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. nuclear envelope Source: RefGenome

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 153153Microsomal glutathione S-transferase 3PRO_0000217742Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi151 – 1511S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiQ9CPU4.
    PRIDEiQ9CPU4.

    PTM databases

    PhosphoSiteiQ9CPU4.

    Expressioni

    Gene expression databases

    BgeeiQ9CPU4.
    CleanExiMM_MGST3.
    GenevestigatoriQ9CPU4.

    Interactioni

    Protein-protein interaction databases

    BioGridi211481. 2 interactions.
    IntActiQ9CPU4. 1 interaction.
    STRINGi10090.ENSMUSP00000028005.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CPU4.
    SMRiQ9CPU4. Positions 7-136.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei9 – 2921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei71 – 9121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei120 – 14021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MAPEG family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG84007.
    GeneTreeiENSGT00390000008608.
    HOGENOMiHOG000116372.
    HOVERGENiHBG052472.
    InParanoidiQ9CPU4.
    KOiK00799.
    OMAiEYGFVIL.
    OrthoDBiEOG7PCJKH.
    PhylomeDBiQ9CPU4.
    TreeFamiTF105328.

    Family and domain databases

    Gene3Di1.20.120.550. 1 hit.
    InterProiIPR023352. MAPEG-like_dom.
    IPR001129. Membr-assoc_MAPEG.
    [Graphical view]
    PfamiPF01124. MAPEG. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9CPU4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVLSKEYGF VLLTGAASFV MVLHLAINVG KARKKYKVEY PVMYSTDPEN    50
    GHMFNCIQRA HQNTLEVYPP FLFFLTVGGV YHPRIASGLG LAWIIGRVLY 100
    AYGYYTGDPS KRYRGAVGSL ALFALMGTTV CSAFQHLGWI RPGLGYGSRS 150
    CHH 153
    Length:153
    Mass (Da):16,958
    Last modified:June 1, 2001 - v1
    Checksum:iF54175ACB9C4C845
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti142 – 1421P → R in BAB25726. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK003246 mRNA. Translation: BAB22665.1.
    AK003309 mRNA. Translation: BAB22706.1.
    AK003476 mRNA. Translation: BAB22808.1.
    AK003492 mRNA. Translation: BAB22819.1.
    AK008533 mRNA. Translation: BAB25726.1.
    AK135742 mRNA. Translation: BAE22638.1.
    BC029669 mRNA. Translation: AAH29669.1.
    CCDSiCCDS15457.1.
    RefSeqiNP_079845.1. NM_025569.1.
    UniGeneiMm.218286.

    Genome annotation databases

    EnsembliENSMUST00000028005; ENSMUSP00000028005; ENSMUSG00000026688.
    GeneIDi66447.
    KEGGimmu:66447.
    UCSCiuc007dky.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK003246 mRNA. Translation: BAB22665.1 .
    AK003309 mRNA. Translation: BAB22706.1 .
    AK003476 mRNA. Translation: BAB22808.1 .
    AK003492 mRNA. Translation: BAB22819.1 .
    AK008533 mRNA. Translation: BAB25726.1 .
    AK135742 mRNA. Translation: BAE22638.1 .
    BC029669 mRNA. Translation: AAH29669.1 .
    CCDSi CCDS15457.1.
    RefSeqi NP_079845.1. NM_025569.1.
    UniGenei Mm.218286.

    3D structure databases

    ProteinModelPortali Q9CPU4.
    SMRi Q9CPU4. Positions 7-136.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 211481. 2 interactions.
    IntActi Q9CPU4. 1 interaction.
    STRINGi 10090.ENSMUSP00000028005.

    PTM databases

    PhosphoSitei Q9CPU4.

    Proteomic databases

    PaxDbi Q9CPU4.
    PRIDEi Q9CPU4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000028005 ; ENSMUSP00000028005 ; ENSMUSG00000026688 .
    GeneIDi 66447.
    KEGGi mmu:66447.
    UCSCi uc007dky.1. mouse.

    Organism-specific databases

    CTDi 4259.
    MGIi MGI:1913697. Mgst3.

    Phylogenomic databases

    eggNOGi NOG84007.
    GeneTreei ENSGT00390000008608.
    HOGENOMi HOG000116372.
    HOVERGENi HBG052472.
    InParanoidi Q9CPU4.
    KOi K00799.
    OMAi EYGFVIL.
    OrthoDBi EOG7PCJKH.
    PhylomeDBi Q9CPU4.
    TreeFami TF105328.

    Enzyme and pathway databases

    Reactomei REACT_215316. Glutathione conjugation.

    Miscellaneous databases

    NextBioi 321721.
    PROi Q9CPU4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9CPU4.
    CleanExi MM_MGST3.
    Genevestigatori Q9CPU4.

    Family and domain databases

    Gene3Di 1.20.120.550. 1 hit.
    InterProi IPR023352. MAPEG-like_dom.
    IPR001129. Membr-assoc_MAPEG.
    [Graphical view ]
    Pfami PF01124. MAPEG. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Egg, Embryo and Small intestine.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. Lubec G., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 85-97, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiMGST3_MOUSE
    AccessioniPrimary (citable) accession number: Q9CPU4
    Secondary accession number(s): Q3UXC5, Q9D834
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3