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Protein

Myeloid-derived growth factor

Gene

Mydgf

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway.1 Publication

Caution

Was originally thought to signal lymphoid cells to proliferate via thymic shared antigen 1, but this work has been later retracted (PubMed:11714798, PubMed:12538725).1 Publication1 Publication

GO - Biological processi

  • angiogenesis Source: UniProtKB-KW
  • apoptotic process Source: UniProtKB-KW
  • negative regulation of apoptotic process Source: UniProtKB
  • positive regulation of angiogenesis Source: UniProtKB
  • positive regulation of endothelial cell proliferation Source: UniProtKB
  • positive regulation of MAPK cascade Source: UniProtKB
  • positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
  • positive regulation of protein kinase B signaling Source: UniProtKB
  • positive regulation of protein phosphorylation Source: UniProtKB
  • positive regulation of transcription by RNA polymerase II Source: UniProtKB

Keywordsi

Biological processAngiogenesis, Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Myeloid-derived growth factor1 Publication
Short name:
MYDGF1 Publication
Alternative name(s):
Interleukin-251 Publication
Short name:
IL-251 Publication
Stromal cell-derived growth factor SF201 Publication
Gene namesi
Name:Mydgf1 Publication
Synonyms:D17Wsu104eImported, Il251 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2156020 Mydgf

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Disruption phenotypei

Mice show normal postnatal body mass gain, develop normally and are fertile. Show larger infarct collagen-rich scars and more severe heart contractile dysfunction compared to wild-type mice after ischemia and reperfusion (IR) injury.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24By similarityAdd BLAST24
ChainiPRO_000002100925 – 166Myeloid-derived growth factorAdd BLAST142

Proteomic databases

EPDiQ9CPT4
MaxQBiQ9CPT4
PaxDbiQ9CPT4
PeptideAtlasiQ9CPT4
PRIDEiQ9CPT4

2D gel databases

REPRODUCTION-2DPAGEiQ9CPT4

PTM databases

PhosphoSitePlusiQ9CPT4

Expressioni

Tissue specificityi

Expressed in prostate, spleen and lung, and weakly expressed in the left ventricle (LF) and liver. Expressed predominantly in inflammatory cells, such as monocytes and macrophages, and weakly expressed in neutrophils, T-cells, B-cells, endothelial cells and cardiac myocytes, after myocardial infarction (MI) (at protein level).1 Publication

Inductioni

Up-regulated by ischemia/hypoxia and reperfusion (IR) injury in the left ventricle (at protein level) (PubMed:25581518). Up-regulated during adipocyte differentiation (at protein level) (PubMed:15378209).2 Publications

Gene expression databases

BgeeiENSMUSG00000019579
GenevisibleiQ9CPT4 MM

Interactioni

Protein-protein interaction databases

IntActiQ9CPT4, 3 interactors
MINTiQ9CPT4

Structurei

3D structure databases

ProteinModelPortaliQ9CPT4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MYDGF family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IKDN Eukaryota
ENOG41126BF LUCA
GeneTreeiENSGT00390000000777
HOGENOMiHOG000236299
HOVERGENiHBG051127
InParanoidiQ9CPT4
OMAiGGTNEKW
OrthoDBiEOG091G159X
PhylomeDBiQ9CPT4
TreeFamiTF332795

Family and domain databases

InterProiView protein in InterPro
IPR018887 MYDGF
PANTHERiPTHR31230 PTHR31230, 1 hit
PfamiView protein in Pfam
PF10572 UPF0556, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CPT4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPSGGFWT AVVLAAAALK LAAAVSEPTT VPFDVRPGGV VHSFSQDVGP
60 70 80 90 100
GNKFTCTFTY ASQGGTNEQW QMSLGTSEDS QHFTCTIWRP QGKSYLYFTQ
110 120 130 140 150
FKAELRGAEI EYAMAYSKAA FERESDVPLK SEEFEVTKTA VSHRPGAFKA
160
ELSKLVIVAK AARSEL
Length:166
Mass (Da):17,982
Last modified:June 1, 2001 - v1
Checksum:iF95BDC6FC1D44B5B
GO

Sequence cautioni

The sequence BAB25931 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY038184 mRNA Translation: AAK72580.1
AK004074 mRNA Translation: BAB23155.1
AK008289 mRNA Translation: BAB25579.1
AK008854 mRNA Translation: BAB25931.2 Different initiation.
AK018016 mRNA Translation: BAB31038.1
AK133947 mRNA Translation: BAE21944.1
AK148083 mRNA Translation: BAE28335.1
AK162834 mRNA Translation: BAE37074.1
BC132127 mRNA Translation: AAI32128.1
BC132129 mRNA Translation: AAI32130.1
CCDSiCCDS28898.1
RefSeqiNP_543027.1, NM_080837.2
UniGeneiMm.294870

Genome annotation databases

EnsembliENSMUST00000019723; ENSMUSP00000019723; ENSMUSG00000019579
GeneIDi28106
KEGGimmu:28106
UCSCiuc008dbg.1 mouse

Similar proteinsi

Entry informationi

Entry nameiMYDGF_MOUSE
AccessioniPrimary (citable) accession number: Q9CPT4
Secondary accession number(s): A2RSI7, Q3UG74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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