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Protein

Myeloid-derived growth factor

Gene

Mydgf

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway.1 Publication

GO - Biological processi

  • angiogenesis Source: UniProtKB-KW
  • apoptotic process Source: UniProtKB-KW
  • negative regulation of apoptotic process Source: UniProtKB
  • positive regulation of angiogenesis Source: UniProtKB
  • positive regulation of endothelial cell proliferation Source: UniProtKB
  • positive regulation of MAPK cascade Source: UniProtKB
  • positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
  • positive regulation of protein kinase B signaling Source: UniProtKB
  • positive regulation of protein phosphorylation Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Angiogenesis, Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Myeloid-derived growth factor1 Publication
Short name:
MYDGF1 Publication
Alternative name(s):
Interleukin-251 Publication
Short name:
IL-251 Publication
Stromal cell-derived growth factor SF201 Publication
Gene namesi
Name:Mydgf1 Publication
Synonyms:D17Wsu104eImported, Il251 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2156020. Mydgf.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum-Golgi intermediate compartment Source: UniProtKB-SubCell
  • extracellular exosome Source: MGI
  • extracellular region Source: UniProtKB
  • extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Disruption phenotypei

Mice show normal postnatal body mass gain, develop normally and are fertile. Show larger infarct collagen-rich scars and more severe heart contractile dysfunction compared to wild-type mice after ischemia and reperfusion (IR) injury.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424By similarityAdd
BLAST
Chaini25 – 166142Myeloid-derived growth factorPRO_0000021009Add
BLAST

Proteomic databases

EPDiQ9CPT4.
MaxQBiQ9CPT4.
PaxDbiQ9CPT4.
PRIDEiQ9CPT4.

2D gel databases

REPRODUCTION-2DPAGEQ9CPT4.

PTM databases

PhosphoSiteiQ9CPT4.

Expressioni

Tissue specificityi

Expressed in prostate, spleen and lung, and weakly expressed in the left ventricle (LF) and liver. Expressed predominantly in inflammatory cells, such as monocytes and macrophages, and weakly expressed in neutrophils, T-cells, B-cells, endothelial cells and cardiac myocytes, after myocardial infarction (MI) (at protein level).1 Publication

Inductioni

Up-regulated by ischemia/hypoxia and reperfusion (IR) injury in the left ventricle (at protein level) (PubMed:25581518). Up-regulated during adipocyte differentiation (at protein level) (PubMed:15378209).2 Publications

Gene expression databases

BgeeiQ9CPT4.
GenevisibleiQ9CPT4. MM.

Interactioni

Protein-protein interaction databases

IntActiQ9CPT4. 3 interactions.
MINTiMINT-4092063.
STRINGi10090.ENSMUSP00000019723.

Structurei

3D structure databases

ProteinModelPortaliQ9CPT4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MYDGF family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IKDN. Eukaryota.
ENOG41126BF. LUCA.
GeneTreeiENSGT00390000000777.
HOGENOMiHOG000236299.
HOVERGENiHBG051127.
InParanoidiQ9CPT4.
OMAiNEKWQMS.
OrthoDBiEOG7FZ00X.
PhylomeDBiQ9CPT4.
TreeFamiTF332795.

Family and domain databases

InterProiIPR018887. MYDGF.
[Graphical view]
PfamiPF10572. UPF0556. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CPT4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPSGGFWT AVVLAAAALK LAAAVSEPTT VPFDVRPGGV VHSFSQDVGP
60 70 80 90 100
GNKFTCTFTY ASQGGTNEQW QMSLGTSEDS QHFTCTIWRP QGKSYLYFTQ
110 120 130 140 150
FKAELRGAEI EYAMAYSKAA FERESDVPLK SEEFEVTKTA VSHRPGAFKA
160
ELSKLVIVAK AARSEL
Length:166
Mass (Da):17,982
Last modified:June 1, 2001 - v1
Checksum:iF95BDC6FC1D44B5B
GO

Sequence cautioni

The sequence BAB25931.2 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY038184 mRNA. Translation: AAK72580.1.
AK004074 mRNA. Translation: BAB23155.1.
AK008289 mRNA. Translation: BAB25579.1.
AK008854 mRNA. Translation: BAB25931.2. Different initiation.
AK018016 mRNA. Translation: BAB31038.1.
AK133947 mRNA. Translation: BAE21944.1.
AK148083 mRNA. Translation: BAE28335.1.
AK162834 mRNA. Translation: BAE37074.1.
BC132127 mRNA. Translation: AAI32128.1.
BC132129 mRNA. Translation: AAI32130.1.
CCDSiCCDS28898.1.
RefSeqiNP_543027.1. NM_080837.2.
UniGeneiMm.294870.

Genome annotation databases

EnsembliENSMUST00000019723; ENSMUSP00000019723; ENSMUSG00000019579.
GeneIDi28106.
KEGGimmu:28106.
UCSCiuc008dbg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY038184 mRNA. Translation: AAK72580.1.
AK004074 mRNA. Translation: BAB23155.1.
AK008289 mRNA. Translation: BAB25579.1.
AK008854 mRNA. Translation: BAB25931.2. Different initiation.
AK018016 mRNA. Translation: BAB31038.1.
AK133947 mRNA. Translation: BAE21944.1.
AK148083 mRNA. Translation: BAE28335.1.
AK162834 mRNA. Translation: BAE37074.1.
BC132127 mRNA. Translation: AAI32128.1.
BC132129 mRNA. Translation: AAI32130.1.
CCDSiCCDS28898.1.
RefSeqiNP_543027.1. NM_080837.2.
UniGeneiMm.294870.

3D structure databases

ProteinModelPortaliQ9CPT4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9CPT4. 3 interactions.
MINTiMINT-4092063.
STRINGi10090.ENSMUSP00000019723.

PTM databases

PhosphoSiteiQ9CPT4.

2D gel databases

REPRODUCTION-2DPAGEQ9CPT4.

Proteomic databases

EPDiQ9CPT4.
MaxQBiQ9CPT4.
PaxDbiQ9CPT4.
PRIDEiQ9CPT4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019723; ENSMUSP00000019723; ENSMUSG00000019579.
GeneIDi28106.
KEGGimmu:28106.
UCSCiuc008dbg.1. mouse.

Organism-specific databases

CTDi56005.
MGIiMGI:2156020. Mydgf.

Phylogenomic databases

eggNOGiENOG410IKDN. Eukaryota.
ENOG41126BF. LUCA.
GeneTreeiENSGT00390000000777.
HOGENOMiHOG000236299.
HOVERGENiHBG051127.
InParanoidiQ9CPT4.
OMAiNEKWQMS.
OrthoDBiEOG7FZ00X.
PhylomeDBiQ9CPT4.
TreeFamiTF332795.

Miscellaneous databases

NextBioi306660.
PROiQ9CPT4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CPT4.
GenevisibleiQ9CPT4. MM.

Family and domain databases

InterProiIPR018887. MYDGF.
[Graphical view]
PfamiPF10572. UPF0556. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "SF20/IL-25, a novel bone marrow stroma-derived growth factor that binds to mouse thymic shared antigen-1 and supports lymphoid cell proliferation."
    Tulin E.E., Onoda N., Nakata Y., Maeda M., Hasegawa M., Nomura H., Kitamura T.
    J. Immunol. 167:6338-6347(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
    Tissue: Bone marrow.
  2. Cited for: RETRACTION.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo, Hypothalamus, Small intestine, Stomach and Thymus.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "Profiling of the secreted proteins during 3T3-L1 adipocyte differentiation leads to the identification of novel adipokines."
    Wang P., Mariman E., Keijer J., Bouwman F., Noben J.P., Robben J., Renes J.
    Cell. Mol. Life Sci. 61:2405-2417(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INDUCTION, IDENTIFICATION BY MASS SPECTROMETRY.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.
  7. Cited for: FUNCTION, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.

Entry informationi

Entry nameiMYDGF_MOUSE
AccessioniPrimary (citable) accession number: Q9CPT4
Secondary accession number(s): A2RSI7, Q3UG74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: June 1, 2001
Last modified: May 11, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Was originally thought to signal lymphoid cells to proliferate via thymic shared antigen 1, but this work has been later retracted (PubMed:11714798, PubMed:12538725).1 Publication1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.