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Protein

N-acylneuraminate-9-phosphatase

Gene

Nanp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

N-acylneuraminate 9-phosphate + H2O = N-acylneuraminate + phosphate.

Cofactori

Mg2+By similarity

Enzyme regulationi

Inhibited by vanadate and calcium.By similarity

Pathwayi: N-acetylneuraminate biosynthesis

This protein is involved in the pathway N-acetylneuraminate biosynthesis, which is part of Amino-sugar metabolism.
View all proteins of this organism that are known to be involved in the pathway N-acetylneuraminate biosynthesis and in Amino-sugar metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei164Substrate1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

ReactomeiR-MMU-4085001. Sialic acid metabolism.
UniPathwayiUPA00630.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acylneuraminate-9-phosphatase (EC:3.1.3.29)
Alternative name(s):
Haloacid dehalogenase-like hydrolase domain-containing protein 4
Neu5Ac-9-Pase
Gene namesi
Name:Nanp
Synonyms:Hdhd4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componentsi: Chromosome 17, Chromosome 2

Organism-specific databases

MGIiMGI:1914561. Nanp.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000839391 – 248N-acylneuraminate-9-phosphataseAdd BLAST248

Proteomic databases

EPDiQ9CPT3.
MaxQBiQ9CPT3.
PaxDbiQ9CPT3.
PeptideAtlasiQ9CPT3.
PRIDEiQ9CPT3.

PTM databases

iPTMnetiQ9CPT3.
PhosphoSitePlusiQ9CPT3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000043346.
GenevisibleiQ9CPT3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000094869.

Structurei

Secondary structure

1248
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi8 – 11Combined sources4
Turni15 – 17Combined sources3
Helixi20 – 37Combined sources18
Helixi44 – 57Combined sources14
Helixi68 – 84Combined sources17
Helixi90 – 106Combined sources17
Helixi112 – 122Combined sources11
Beta strandi125 – 131Combined sources7
Helixi135 – 145Combined sources11
Helixi148 – 150Combined sources3
Beta strandi152 – 156Combined sources5
Helixi157 – 159Combined sources3
Beta strandi160 – 162Combined sources3
Helixi167 – 177Combined sources11
Helixi181 – 183Combined sources3
Beta strandi184 – 189Combined sources6
Turni191 – 193Combined sources3
Helixi194 – 200Combined sources7
Beta strandi204 – 209Combined sources6
Beta strandi224 – 229Combined sources6
Helixi230 – 232Combined sources3
Helixi233 – 240Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GFHX-ray1.90A1-248[»]
ProteinModelPortaliQ9CPT3.
SMRiQ9CPT3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9CPT3.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni12 – 14Substrate binding3
Regioni131 – 132Substrate binding2

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3085. Eukaryota.
COG1011. LUCA.
GeneTreeiENSGT00390000003094.
HOGENOMiHOG000248345.
HOVERGENiHBG051895.
InParanoidiQ9CPT3.
KOiK01097.
OMAiVRATVWI.
OrthoDBiEOG091G0G6E.
PhylomeDBiQ9CPT3.
TreeFamiTF324589.

Family and domain databases

Gene3Di3.40.50.1000. 3 hits.
InterProiIPR023214. HAD-like_dom.
IPR006439. HAD-SF_hydro_IA.
IPR011950. HAD-SF_hydro_IA_CTE7.
[Graphical view]
PfamiPF13419. HAD_2. 1 hit.
[Graphical view]
PRINTSiPR00413. HADHALOGNASE.
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR02253. CTE7. 1 hit.
TIGR01549. HAD-SF-IA-v1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CPT3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLSRVRAVF FDLDNTLIDT AGASRRGMLE VIKLLQSKYH YKEEAEIICD
60 70 80 90 100
KVQVKLSKEC FHPYSTCITD VRTSHWEEAI QETKGGADNR KLAEECYFLW
110 120 130 140 150
KSTRLQHMIL ADDVKAMLTE LRKEVRLLLL TNGDRQTQRE KIEACACQSY
160 170 180 190 200
FDAIVIGGEQ KEEKPAPSIF YHCCDLLGVQ PGDCVMVGDT LETDIQGGLN
210 220 230 240
AGLKATVWIN KSGRVPLTSS PMPHYMVSSV LELPALLQSI DCKVSMSV
Length:248
Mass (Da):27,808
Last modified:June 1, 2001 - v1
Checksum:iFA1703873D7CC069
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005566 mRNA. Translation: BAB24126.1.
AK021344 mRNA. Translation: BAB32381.1.
BC018527 mRNA. Translation: AAH18527.1.
BC083086 mRNA. Translation: AAH83086.1.
CCDSiCCDS16864.1.
RefSeqiNP_080362.1. NM_026086.2.
UniGeneiMm.480682.

Genome annotation databases

EnsembliENSMUST00000057074; ENSMUSP00000094869; ENSMUSG00000043346.
ENSMUST00000066640; ENSMUSP00000063895; ENSMUSG00000053916.
GeneIDi67311.
KEGGimmu:67311.
UCSCiuc008muv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005566 mRNA. Translation: BAB24126.1.
AK021344 mRNA. Translation: BAB32381.1.
BC018527 mRNA. Translation: AAH18527.1.
BC083086 mRNA. Translation: AAH83086.1.
CCDSiCCDS16864.1.
RefSeqiNP_080362.1. NM_026086.2.
UniGeneiMm.480682.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GFHX-ray1.90A1-248[»]
ProteinModelPortaliQ9CPT3.
SMRiQ9CPT3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000094869.

PTM databases

iPTMnetiQ9CPT3.
PhosphoSitePlusiQ9CPT3.

Proteomic databases

EPDiQ9CPT3.
MaxQBiQ9CPT3.
PaxDbiQ9CPT3.
PeptideAtlasiQ9CPT3.
PRIDEiQ9CPT3.

Protocols and materials databases

DNASUi67311.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057074; ENSMUSP00000094869; ENSMUSG00000043346.
ENSMUST00000066640; ENSMUSP00000063895; ENSMUSG00000053916.
GeneIDi67311.
KEGGimmu:67311.
UCSCiuc008muv.2. mouse.

Organism-specific databases

CTDi140838.
MGIiMGI:1914561. Nanp.

Phylogenomic databases

eggNOGiKOG3085. Eukaryota.
COG1011. LUCA.
GeneTreeiENSGT00390000003094.
HOGENOMiHOG000248345.
HOVERGENiHBG051895.
InParanoidiQ9CPT3.
KOiK01097.
OMAiVRATVWI.
OrthoDBiEOG091G0G6E.
PhylomeDBiQ9CPT3.
TreeFamiTF324589.

Enzyme and pathway databases

UniPathwayiUPA00630.
ReactomeiR-MMU-4085001. Sialic acid metabolism.

Miscellaneous databases

EvolutionaryTraceiQ9CPT3.
PROiQ9CPT3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000043346.
GenevisibleiQ9CPT3. MM.

Family and domain databases

Gene3Di3.40.50.1000. 3 hits.
InterProiIPR023214. HAD-like_dom.
IPR006439. HAD-SF_hydro_IA.
IPR011950. HAD-SF_hydro_IA_CTE7.
[Graphical view]
PfamiPF13419. HAD_2. 1 hit.
[Graphical view]
PRINTSiPR00413. HADHALOGNASE.
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR02253. CTE7. 1 hit.
TIGR01549. HAD-SF-IA-v1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNANP_MOUSE
AccessioniPrimary (citable) accession number: Q9CPT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.