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Q9CPT0

- B2L14_MOUSE

UniProt

Q9CPT0 - B2L14_MOUSE

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Protein

Apoptosis facilitator Bcl-2-like protein 14

Gene

Bcl2l14

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Plays a role in apoptosis.

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. positive regulation of extrinsic apoptotic signaling pathway Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Apoptosis facilitator Bcl-2-like protein 14
Short name:
Bcl2-L-14
Gene namesi
Name:Bcl2l14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:1914063. Bcl2l14.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. intracellular organelle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 328328Apoptosis facilitator Bcl-2-like protein 14PRO_0000143076Add
BLAST

Post-translational modificationi

Phosphorylated by MELK, leading to inhibit its pro-apoptotic function.By similarity

Proteomic databases

MaxQBiQ9CPT0.
PRIDEiQ9CPT0.

PTM databases

PhosphoSiteiQ9CPT0.

Expressioni

Gene expression databases

BgeeiQ9CPT0.
CleanExiMM_BCL2L14.
ExpressionAtlasiQ9CPT0. baseline and differential.
GenevestigatoriQ9CPT0.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FauP355454EBI-8296066,EBI-309546

Protein-protein interaction databases

IntActiQ9CPT0. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9CPT0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi213 – 22715BH3Add
BLAST
Motifi309 – 3168BH2

Sequence similaritiesi

Belongs to the Bcl-2 family.Curated

Phylogenomic databases

eggNOGiNOG315634.
GeneTreeiENSGT00390000007293.
HOGENOMiHOG000013215.
HOVERGENiHBG050649.
InParanoidiQ9CPT0.
OMAiNFSPWVQ.
OrthoDBiEOG7KM5VJ.
PhylomeDBiQ9CPT0.
TreeFamiTF336214.

Family and domain databases

InterProiIPR002475. Bcl2-like.
[Graphical view]
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CPT0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCSTSVYDLE DIPLEDDDPN SIEFKILAFY ARHHVFKNTP AVFSPKLSRT
60 70 80 90 100
RSLSQKALGT WSTDSWTQVS LPCRGSPSSE KNISLGKKKS SWRTLFRVAE
110 120 130 140 150
KEEGLPSSPK EIRAQGPQGP FPVERQSGFH NQHWPRSLSS VEQRLESEVV
160 170 180 190 200
DSKVACIANR VAEIVYSWPP PDVIHSQGGS KLKERVSEIL YFRFEGPCDS
210 220 230 240 250
KNKDGEDQII SKIVELLKFS GDQLGREIKK DKALMSSFQD GLSYSTFKTI
260 270 280 290 300
TDLFLRDVDT RGESEVKARG FKAALAIDAI AKLTAIDNHP MNRMLGFGTK
310 320
YLREYFSPWV QQNGGWEKIL GISHEEVD
Length:328
Mass (Da):36,992
Last modified:June 1, 2001 - v1
Checksum:iFAC47379F008314C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti105 – 1051L → P in AAH25541. (PubMed:15489334)Curated
Sequence conflicti156 – 1561C → F in BAB30545. (PubMed:16141072)Curated
Sequence conflicti202 – 2021Missing in AAH25541. (PubMed:15489334)Curated
Sequence conflicti269 – 2691R → Q in AAH25541. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK008682 mRNA. Translation: BAB25830.1.
AK016670 mRNA. Translation: BAB30370.1.
AK016997 mRNA. Translation: BAB30545.1.
AK018579 mRNA. Translation: BAB31290.1.
AK160247 mRNA. Translation: BAE35712.1.
BC025541 mRNA. Translation: AAH25541.1.
CCDSiCCDS20636.1.
RefSeqiNP_080054.1. NM_025778.3.
XP_006506547.1. XM_006506484.1.
UniGeneiMm.474472.

Genome annotation databases

EnsembliENSMUST00000032321; ENSMUSP00000032321; ENSMUSG00000030200.
ENSMUST00000111960; ENSMUSP00000107591; ENSMUSG00000030200.
ENSMUST00000163589; ENSMUSP00000132525; ENSMUSG00000030200.
GeneIDi66813.
KEGGimmu:66813.
UCSCiuc009ekh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK008682 mRNA. Translation: BAB25830.1 .
AK016670 mRNA. Translation: BAB30370.1 .
AK016997 mRNA. Translation: BAB30545.1 .
AK018579 mRNA. Translation: BAB31290.1 .
AK160247 mRNA. Translation: BAE35712.1 .
BC025541 mRNA. Translation: AAH25541.1 .
CCDSi CCDS20636.1.
RefSeqi NP_080054.1. NM_025778.3.
XP_006506547.1. XM_006506484.1.
UniGenei Mm.474472.

3D structure databases

ProteinModelPortali Q9CPT0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9CPT0. 1 interaction.

PTM databases

PhosphoSitei Q9CPT0.

Proteomic databases

MaxQBi Q9CPT0.
PRIDEi Q9CPT0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000032321 ; ENSMUSP00000032321 ; ENSMUSG00000030200 .
ENSMUST00000111960 ; ENSMUSP00000107591 ; ENSMUSG00000030200 .
ENSMUST00000163589 ; ENSMUSP00000132525 ; ENSMUSG00000030200 .
GeneIDi 66813.
KEGGi mmu:66813.
UCSCi uc009ekh.1. mouse.

Organism-specific databases

CTDi 79370.
MGIi MGI:1914063. Bcl2l14.

Phylogenomic databases

eggNOGi NOG315634.
GeneTreei ENSGT00390000007293.
HOGENOMi HOG000013215.
HOVERGENi HBG050649.
InParanoidi Q9CPT0.
OMAi NFSPWVQ.
OrthoDBi EOG7KM5VJ.
PhylomeDBi Q9CPT0.
TreeFami TF336214.

Miscellaneous databases

NextBioi 322715.
PROi Q9CPT0.
SOURCEi Search...

Gene expression databases

Bgeei Q9CPT0.
CleanExi MM_BCL2L14.
ExpressionAtlasi Q9CPT0. baseline and differential.
Genevestigatori Q9CPT0.

Family and domain databases

InterProi IPR002475. Bcl2-like.
[Graphical view ]
PROSITEi PS50062. BCL2_FAMILY. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Colon, Stomach and Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.

Entry informationi

Entry nameiB2L14_MOUSE
AccessioniPrimary (citable) accession number: Q9CPT0
Secondary accession number(s): Q3TVA7, Q8R141, Q9D3W3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3