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Q9CPT0

- B2L14_MOUSE

UniProt

Q9CPT0 - B2L14_MOUSE

Protein

Apoptosis facilitator Bcl-2-like protein 14

Gene

Bcl2l14

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Plays a role in apoptosis.

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. positive regulation of extrinsic apoptotic signaling pathway Source: Ensembl

    Keywords - Biological processi

    Apoptosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Apoptosis facilitator Bcl-2-like protein 14
    Short name:
    Bcl2-L-14
    Gene namesi
    Name:Bcl2l14
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:1914063. Bcl2l14.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytosol Source: Ensembl
    2. intracellular organelle Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 328328Apoptosis facilitator Bcl-2-like protein 14PRO_0000143076Add
    BLAST

    Post-translational modificationi

    Phosphorylated by MELK, leading to inhibit its pro-apoptotic function.By similarity

    Proteomic databases

    MaxQBiQ9CPT0.
    PRIDEiQ9CPT0.

    PTM databases

    PhosphoSiteiQ9CPT0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9CPT0.
    BgeeiQ9CPT0.
    CleanExiMM_BCL2L14.
    GenevestigatoriQ9CPT0.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    FauP355454EBI-8296066,EBI-309546

    Protein-protein interaction databases

    IntActiQ9CPT0. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CPT0.
    SMRiQ9CPT0. Positions 212-320.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi213 – 22715BH3Add
    BLAST
    Motifi309 – 3168BH2

    Sequence similaritiesi

    Belongs to the Bcl-2 family.Curated

    Phylogenomic databases

    eggNOGiNOG315634.
    GeneTreeiENSGT00390000007293.
    HOGENOMiHOG000013215.
    HOVERGENiHBG050649.
    InParanoidiQ9CPT0.
    OMAiNFSPWVQ.
    OrthoDBiEOG7KM5VJ.
    PhylomeDBiQ9CPT0.
    TreeFamiTF336214.

    Family and domain databases

    InterProiIPR002475. Bcl2-like.
    [Graphical view]
    PROSITEiPS50062. BCL2_FAMILY. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9CPT0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCSTSVYDLE DIPLEDDDPN SIEFKILAFY ARHHVFKNTP AVFSPKLSRT    50
    RSLSQKALGT WSTDSWTQVS LPCRGSPSSE KNISLGKKKS SWRTLFRVAE 100
    KEEGLPSSPK EIRAQGPQGP FPVERQSGFH NQHWPRSLSS VEQRLESEVV 150
    DSKVACIANR VAEIVYSWPP PDVIHSQGGS KLKERVSEIL YFRFEGPCDS 200
    KNKDGEDQII SKIVELLKFS GDQLGREIKK DKALMSSFQD GLSYSTFKTI 250
    TDLFLRDVDT RGESEVKARG FKAALAIDAI AKLTAIDNHP MNRMLGFGTK 300
    YLREYFSPWV QQNGGWEKIL GISHEEVD 328
    Length:328
    Mass (Da):36,992
    Last modified:June 1, 2001 - v1
    Checksum:iFAC47379F008314C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti105 – 1051L → P in AAH25541. (PubMed:15489334)Curated
    Sequence conflicti156 – 1561C → F in BAB30545. (PubMed:16141072)Curated
    Sequence conflicti202 – 2021Missing in AAH25541. (PubMed:15489334)Curated
    Sequence conflicti269 – 2691R → Q in AAH25541. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK008682 mRNA. Translation: BAB25830.1.
    AK016670 mRNA. Translation: BAB30370.1.
    AK016997 mRNA. Translation: BAB30545.1.
    AK018579 mRNA. Translation: BAB31290.1.
    AK160247 mRNA. Translation: BAE35712.1.
    BC025541 mRNA. Translation: AAH25541.1.
    CCDSiCCDS20636.1.
    RefSeqiNP_080054.1. NM_025778.3.
    XP_006506547.1. XM_006506484.1.
    UniGeneiMm.474472.

    Genome annotation databases

    EnsembliENSMUST00000032321; ENSMUSP00000032321; ENSMUSG00000030200.
    ENSMUST00000111960; ENSMUSP00000107591; ENSMUSG00000030200.
    ENSMUST00000163589; ENSMUSP00000132525; ENSMUSG00000030200.
    GeneIDi66813.
    KEGGimmu:66813.
    UCSCiuc009ekh.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK008682 mRNA. Translation: BAB25830.1 .
    AK016670 mRNA. Translation: BAB30370.1 .
    AK016997 mRNA. Translation: BAB30545.1 .
    AK018579 mRNA. Translation: BAB31290.1 .
    AK160247 mRNA. Translation: BAE35712.1 .
    BC025541 mRNA. Translation: AAH25541.1 .
    CCDSi CCDS20636.1.
    RefSeqi NP_080054.1. NM_025778.3.
    XP_006506547.1. XM_006506484.1.
    UniGenei Mm.474472.

    3D structure databases

    ProteinModelPortali Q9CPT0.
    SMRi Q9CPT0. Positions 212-320.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9CPT0. 1 interaction.

    PTM databases

    PhosphoSitei Q9CPT0.

    Proteomic databases

    MaxQBi Q9CPT0.
    PRIDEi Q9CPT0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000032321 ; ENSMUSP00000032321 ; ENSMUSG00000030200 .
    ENSMUST00000111960 ; ENSMUSP00000107591 ; ENSMUSG00000030200 .
    ENSMUST00000163589 ; ENSMUSP00000132525 ; ENSMUSG00000030200 .
    GeneIDi 66813.
    KEGGi mmu:66813.
    UCSCi uc009ekh.1. mouse.

    Organism-specific databases

    CTDi 79370.
    MGIi MGI:1914063. Bcl2l14.

    Phylogenomic databases

    eggNOGi NOG315634.
    GeneTreei ENSGT00390000007293.
    HOGENOMi HOG000013215.
    HOVERGENi HBG050649.
    InParanoidi Q9CPT0.
    OMAi NFSPWVQ.
    OrthoDBi EOG7KM5VJ.
    PhylomeDBi Q9CPT0.
    TreeFami TF336214.

    Miscellaneous databases

    NextBioi 322715.
    PROi Q9CPT0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9CPT0.
    Bgeei Q9CPT0.
    CleanExi MM_BCL2L14.
    Genevestigatori Q9CPT0.

    Family and domain databases

    InterProi IPR002475. Bcl2-like.
    [Graphical view ]
    PROSITEi PS50062. BCL2_FAMILY. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Colon, Stomach and Testis.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiB2L14_MOUSE
    AccessioniPrimary (citable) accession number: Q9CPT0
    Secondary accession number(s): Q3TVA7, Q8R141, Q9D3W3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 21, 2004
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3