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Q9CPT0 (B2L14_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Apoptosis facilitator Bcl-2-like protein 14

Short name=Bcl2-L-14
Gene names
Name:Bcl2l14
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length328 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a role in apoptosis.

Subcellular location

Cytoplasm By similarity.

Post-translational modification

Phosphorylated by MELK, leading to inhibit its pro-apoptotic function By similarity.

Sequence similarities

Belongs to the Bcl-2 family.

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

FauP355454EBI-8296066,EBI-309546

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 328328Apoptosis facilitator Bcl-2-like protein 14
PRO_0000143076

Regions

Motif213 – 22715BH3
Motif309 – 3168BH2

Experimental info

Sequence conflict1051L → P in AAH25541. Ref.2
Sequence conflict1561C → F in BAB30545. Ref.1
Sequence conflict2021Missing in AAH25541. Ref.2
Sequence conflict2691R → Q in AAH25541. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9CPT0 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: FAC47379F008314C

FASTA32836,992
        10         20         30         40         50         60 
MCSTSVYDLE DIPLEDDDPN SIEFKILAFY ARHHVFKNTP AVFSPKLSRT RSLSQKALGT 

        70         80         90        100        110        120 
WSTDSWTQVS LPCRGSPSSE KNISLGKKKS SWRTLFRVAE KEEGLPSSPK EIRAQGPQGP 

       130        140        150        160        170        180 
FPVERQSGFH NQHWPRSLSS VEQRLESEVV DSKVACIANR VAEIVYSWPP PDVIHSQGGS 

       190        200        210        220        230        240 
KLKERVSEIL YFRFEGPCDS KNKDGEDQII SKIVELLKFS GDQLGREIKK DKALMSSFQD 

       250        260        270        280        290        300 
GLSYSTFKTI TDLFLRDVDT RGESEVKARG FKAALAIDAI AKLTAIDNHP MNRMLGFGTK 

       310        320 
YLREYFSPWV QQNGGWEKIL GISHEEVD 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Colon, Stomach and Testis.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK008682 mRNA. Translation: BAB25830.1.
AK016670 mRNA. Translation: BAB30370.1.
AK016997 mRNA. Translation: BAB30545.1.
AK018579 mRNA. Translation: BAB31290.1.
AK160247 mRNA. Translation: BAE35712.1.
BC025541 mRNA. Translation: AAH25541.1.
RefSeqNP_080054.1. NM_025778.3.
XP_006506547.1. XM_006506484.1.
UniGeneMm.474472.

3D structure databases

ProteinModelPortalQ9CPT0.
SMRQ9CPT0. Positions 206-320.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9CPT0. 1 interaction.

PTM databases

PhosphoSiteQ9CPT0.

Proteomic databases

PRIDEQ9CPT0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000032321; ENSMUSP00000032321; ENSMUSG00000030200.
ENSMUST00000111960; ENSMUSP00000107591; ENSMUSG00000030200.
ENSMUST00000163589; ENSMUSP00000132525; ENSMUSG00000030200.
GeneID66813.
KEGGmmu:66813.
UCSCuc009ekh.1. mouse.

Organism-specific databases

CTD79370.
MGIMGI:1914063. Bcl2l14.

Phylogenomic databases

eggNOGNOG315634.
GeneTreeENSGT00390000007293.
HOGENOMHOG000013215.
HOVERGENHBG050649.
InParanoidQ9CPT0.
OMANFSPWVQ.
OrthoDBEOG7KM5VJ.
PhylomeDBQ9CPT0.
TreeFamTF336214.

Gene expression databases

ArrayExpressQ9CPT0.
BgeeQ9CPT0.
CleanExMM_BCL2L14.
GenevestigatorQ9CPT0.

Family and domain databases

InterProIPR002475. Bcl2-like.
[Graphical view]
PROSITEPS50062. BCL2_FAMILY. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio322715.
PROQ9CPT0.
SOURCESearch...

Entry information

Entry nameB2L14_MOUSE
AccessionPrimary (citable) accession number: Q9CPT0
Secondary accession number(s): Q3TVA7, Q8R141, Q9D3W3
Entry history
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot