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Protein

RNA-binding protein PNO1

Gene

Pno1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein PNO1
Gene namesi
Name:Pno1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1913499 Pno1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002705411 – 248RNA-binding protein PNO1Add BLAST248

Proteomic databases

EPDiQ9CPS7
MaxQBiQ9CPS7
PaxDbiQ9CPS7
PeptideAtlasiQ9CPS7
PRIDEiQ9CPS7

PTM databases

iPTMnetiQ9CPS7
PhosphoSitePlusiQ9CPS7

Expressioni

Gene expression databases

BgeeiENSMUSG00000020116
CleanExiMM_PNO1
GenevisibleiQ9CPS7 MM

Interactioni

Protein-protein interaction databases

BioGridi211326, 1 interactor
IntActiQ9CPS7, 2 interactors
MINTiQ9CPS7
STRINGi10090.ENSMUSP00000020317

Structurei

3D structure databases

ProteinModelPortaliQ9CPS7
SMRiQ9CPS7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini169 – 221KHAdd BLAST53

Sequence similaritiesi

Belongs to the PNO1 family.Curated

Phylogenomic databases

eggNOGiKOG3273 Eukaryota
COG1094 LUCA
GeneTreeiENSGT00390000018052
HOGENOMiHOG000181708
HOVERGENiHBG055635
InParanoidiQ9CPS7
KOiK11884
OMAiQLQVRFN
OrthoDBiEOG091G0L5I
PhylomeDBiQ9CPS7
TreeFamiTF300114

Family and domain databases

Gene3Di3.30.1370.10, 2 hits
InterProiView protein in InterPro
IPR004087 KH_dom
IPR036612 KH_dom_type_1_sf
SMARTiView protein in SMART
SM00322 KH, 1 hit
SUPFAMiSSF54791 SSF54791, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CPS7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METQSTGTED GFTPVTHRGG RRAKKRQAEQ SSAAGQDGEA GRMDTEEARP
60 70 80 90 100
AKRPVFPPLS GDQLLTGKEE TRKIPVPGNR YTPLKENWMK IFTPIVEHLG
110 120 130 140 150
LQIRFNLKSR NVEIRTCKDT KDVSALTKAA DFVKAFVLGF QVEDALALIR
160 170 180 190 200
LDDLFLESFE ITDVKPLKGD HLSRAIGRIA GKGGKTKFTI ENVTRTRIVL
210 220 230 240
ADVHVHILGS FQNIKMARTA ICNLILGNPP SKVYGNIRAV ASRSADRF
Length:248
Mass (Da):27,454
Last modified:June 1, 2001 - v1
Checksum:iFBA75C3F79638251
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF349950 mRNA Translation: AAK29665.1
AK007324 mRNA Translation: BAB24959.1
AK009146 mRNA Translation: BAB26104.1
AK146152 mRNA Translation: BAE26936.1
AK165942 mRNA Translation: BAE38474.1
AK168177 mRNA Translation: BAE40137.1
AL713926 Genomic DNA No translation available.
BC020037 mRNA Translation: AAH20037.1
CCDSiCCDS24449.1
RefSeqiNP_079719.1, NM_025443.2
UniGeneiMm.27831

Genome annotation databases

EnsembliENSMUST00000020317; ENSMUSP00000020317; ENSMUSG00000020116
GeneIDi66249
KEGGimmu:66249
UCSCiuc007icc.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPNO1_MOUSE
AccessioniPrimary (citable) accession number: Q9CPS7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health