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Q9CPR5

- RM15_MOUSE

UniProt

Q9CPR5 - RM15_MOUSE

Protein

39S ribosomal protein L15, mitochondrial

Gene

Mrpl15

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. structural constituent of ribosome Source: MGI

    GO - Biological processi

    1. mitochondrial genome maintenance Source: MGI
    2. translation Source: MGI

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    39S ribosomal protein L15, mitochondrial
    Short name:
    L15mt
    Short name:
    MRP-L15
    Gene namesi
    Name:Mrpl15
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1351639. Mrpl15.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial large ribosomal subunit Source: MGI
    2. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2020MitochondrionBy similarityAdd
    BLAST
    Chaini21 – 29527539S ribosomal protein L15, mitochondrialPRO_0000257839Add
    BLAST

    Proteomic databases

    MaxQBiQ9CPR5.
    PaxDbiQ9CPR5.
    PRIDEiQ9CPR5.

    PTM databases

    PhosphoSiteiQ9CPR5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9CPR5.
    BgeeiQ9CPR5.
    CleanExiMM_MRPL15.
    GenevestigatoriQ9CPR5.

    Interactioni

    Protein-protein interaction databases

    BioGridi205202. 6 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CPR5.
    SMRiQ9CPR5. Positions 21-176.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi33 – 6331Arg-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ribosomal protein L15P family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0200.
    GeneTreeiENSGT00390000009040.
    HOVERGENiHBG088294.
    InParanoidiQ9CPR5.
    KOiK02876.
    OMAiFRNIFAK.
    OrthoDBiEOG7NKKNG.
    PhylomeDBiQ9CPR5.
    TreeFamiTF105918.

    Family and domain databases

    HAMAPiMF_01341. Ribosomal_L15.
    InterProiIPR005749. Ribosomal_L15_bac-type.
    IPR021131. Ribosomal_L18e/L15P.
    [Graphical view]
    PANTHERiPTHR12934. PTHR12934. 1 hit.
    PfamiPF00828. Ribosomal_L18e. 1 hit.
    [Graphical view]
    SUPFAMiSSF52080. SSF52080. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9CPR5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAGTARGCGT SLDLLRSLPR VSLANLKPSP NSRKRERRPR DRRRGRKCGR    50
    GHKGERQRGT RPRLGFEGGQ TPFYIRIPKY GFNEGHSFRH QYQPLSLRRL 100
    QYLIDLGRVD PTQPIDLTQL VNGRGVTIQP LKRDYGVQLV EEGADTFQAK 150
    INIEVQLASE LAIAAIEKNG GVVTTAFYDP RSLEILCKPI PFFLRGQPIP 200
    KRMLPPESLV PYYTDAKNRG YLADPAKFPE ARLELAMKFG YVLPDITKDE 250
    LFRMLSARKD PRQIFFGLAP GWVVNMADKK ILKPTDENLL KYYSS 295
    Length:295
    Mass (Da):33,542
    Last modified:June 1, 2001 - v1
    Checksum:i2CAA781E82E4670C
    GO
    Isoform 2 (identifier: Q9CPR5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         184-204: EILCKPIPFFLRGQPIPKRML → GHLMHSSDFHGFSARYSIHIK
         205-295: Missing.

    Show »
    Length:204
    Mass (Da):23,018
    Checksum:iE9EBEF2A98811C16
    GO

    Sequence cautioni

    The sequence BAB27054.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1 – 11M → L in BAB27054. (PubMed:16141072)Curated
    Sequence conflicti13 – 131D → G in BAB27054. (PubMed:16141072)Curated
    Sequence conflicti36 – 361E → G in BAB27054. (PubMed:16141072)Curated
    Sequence conflicti119 – 1191Q → K in BAE29929. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei184 – 20421EILCK…PKRML → GHLMHSSDFHGFSARYSIHI K in isoform 2. 2 PublicationsVSP_021370Add
    BLAST
    Alternative sequencei205 – 29591Missing in isoform 2. 2 PublicationsVSP_021371Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK003367 mRNA. Translation: BAB22741.1.
    AK010474 mRNA. Translation: BAB26967.1.
    AK010604 mRNA. Translation: BAB27054.1. Different initiation.
    AK017804 mRNA. Translation: BAB30943.1.
    AK017824 mRNA. Translation: BAB30958.1.
    AK019175 mRNA. Translation: BAB31589.1.
    AK019249 mRNA. Translation: BAB31626.1.
    AK150880 mRNA. Translation: BAE29929.1.
    AK160660 mRNA. Translation: BAE35948.1.
    BC021304 mRNA. Translation: AAH21304.1.
    BC027233 mRNA. Translation: AAH27233.1.
    CCDSiCCDS35504.1. [Q9CPR5-2]
    CCDS48211.1. [Q9CPR5-1]
    RefSeqiNP_001171129.1. NM_001177658.1. [Q9CPR5-1]
    NP_079576.1. NM_025300.4. [Q9CPR5-2]
    UniGeneiMm.182927.

    Genome annotation databases

    EnsembliENSMUST00000130201; ENSMUSP00000114649; ENSMUSG00000033845. [Q9CPR5-2]
    ENSMUST00000156816; ENSMUSP00000115512; ENSMUSG00000033845. [Q9CPR5-1]
    GeneIDi27395.
    KEGGimmu:27395.
    UCSCiuc007afd.3. mouse. [Q9CPR5-2]
    uc007aff.3. mouse. [Q9CPR5-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK003367 mRNA. Translation: BAB22741.1 .
    AK010474 mRNA. Translation: BAB26967.1 .
    AK010604 mRNA. Translation: BAB27054.1 . Different initiation.
    AK017804 mRNA. Translation: BAB30943.1 .
    AK017824 mRNA. Translation: BAB30958.1 .
    AK019175 mRNA. Translation: BAB31589.1 .
    AK019249 mRNA. Translation: BAB31626.1 .
    AK150880 mRNA. Translation: BAE29929.1 .
    AK160660 mRNA. Translation: BAE35948.1 .
    BC021304 mRNA. Translation: AAH21304.1 .
    BC027233 mRNA. Translation: AAH27233.1 .
    CCDSi CCDS35504.1. [Q9CPR5-2 ]
    CCDS48211.1. [Q9CPR5-1 ]
    RefSeqi NP_001171129.1. NM_001177658.1. [Q9CPR5-1 ]
    NP_079576.1. NM_025300.4. [Q9CPR5-2 ]
    UniGenei Mm.182927.

    3D structure databases

    ProteinModelPortali Q9CPR5.
    SMRi Q9CPR5. Positions 21-176.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 205202. 6 interactions.

    PTM databases

    PhosphoSitei Q9CPR5.

    Proteomic databases

    MaxQBi Q9CPR5.
    PaxDbi Q9CPR5.
    PRIDEi Q9CPR5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000130201 ; ENSMUSP00000114649 ; ENSMUSG00000033845 . [Q9CPR5-2 ]
    ENSMUST00000156816 ; ENSMUSP00000115512 ; ENSMUSG00000033845 . [Q9CPR5-1 ]
    GeneIDi 27395.
    KEGGi mmu:27395.
    UCSCi uc007afd.3. mouse. [Q9CPR5-2 ]
    uc007aff.3. mouse. [Q9CPR5-1 ]

    Organism-specific databases

    CTDi 29088.
    MGIi MGI:1351639. Mrpl15.

    Phylogenomic databases

    eggNOGi COG0200.
    GeneTreei ENSGT00390000009040.
    HOVERGENi HBG088294.
    InParanoidi Q9CPR5.
    KOi K02876.
    OMAi FRNIFAK.
    OrthoDBi EOG7NKKNG.
    PhylomeDBi Q9CPR5.
    TreeFami TF105918.

    Miscellaneous databases

    NextBioi 305370.
    PROi Q9CPR5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9CPR5.
    Bgeei Q9CPR5.
    CleanExi MM_MRPL15.
    Genevestigatori Q9CPR5.

    Family and domain databases

    HAMAPi MF_01341. Ribosomal_L15.
    InterProi IPR005749. Ribosomal_L15_bac-type.
    IPR021131. Ribosomal_L18e/L15P.
    [Graphical view ]
    PANTHERi PTHR12934. PTHR12934. 1 hit.
    Pfami PF00828. Ribosomal_L18e. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52080. SSF52080. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J.
      Tissue: Bone marrow and Embryo.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: FVB/N.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiRM15_MOUSE
    AccessioniPrimary (citable) accession number: Q9CPR5
    Secondary accession number(s): Q3UBN5, Q9CPP5, Q9CRH4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3