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Protein

39S ribosomal protein L15, mitochondrial

Gene

Mrpl15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • cellular response to leukemia inhibitory factor Source: MGI
  • mitochondrial genome maintenance Source: MGI
  • translation Source: MGI

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-MMU-5389840 Mitochondrial translation elongation
R-MMU-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L15, mitochondrial
Short name:
L15mt
Short name:
MRP-L15
Gene namesi
Name:Mrpl15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1351639 Mrpl15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 20MitochondrionBy similarityAdd BLAST20
ChainiPRO_000025783921 – 29539S ribosomal protein L15, mitochondrialAdd BLAST275

Proteomic databases

EPDiQ9CPR5
PaxDbiQ9CPR5
PeptideAtlasiQ9CPR5
PRIDEiQ9CPR5

PTM databases

iPTMnetiQ9CPR5
PhosphoSitePlusiQ9CPR5

Expressioni

Gene expression databases

BgeeiENSMUSG00000033845
CleanExiMM_MRPL15
ExpressionAtlasiQ9CPR5 baseline and differential
GenevisibleiQ9CPR5 MM

Interactioni

Subunit structurei

Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000115512

Structurei

3D structure databases

ProteinModelPortaliQ9CPR5
SMRiQ9CPR5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi33 – 63Arg-richAdd BLAST31

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0846 Eukaryota
COG0200 LUCA
GeneTreeiENSGT00390000009040
HOVERGENiHBG088294
InParanoidiQ9CPR5
KOiK02876
OMAiYEPYYKG
OrthoDBiEOG091G0VT9
PhylomeDBiQ9CPR5
TreeFamiTF105918

Family and domain databases

HAMAPiMF_01341 Ribosomal_L15, 1 hit
InterProiView protein in InterPro
IPR036227 L18e/L15P_sf
IPR030878 Ribosomal_L15
IPR005749 Ribosomal_L15_bac-type
IPR021131 Ribosomal_L18e/L15P
PANTHERiPTHR12934 PTHR12934, 1 hit
PfamiView protein in Pfam
PF00828 Ribosomal_L27A, 1 hit
SUPFAMiSSF52080 SSF52080, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9CPR5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGTARGCGT SLDLLRSLPR VSLANLKPSP NSRKRERRPR DRRRGRKCGR
60 70 80 90 100
GHKGERQRGT RPRLGFEGGQ TPFYIRIPKY GFNEGHSFRH QYQPLSLRRL
110 120 130 140 150
QYLIDLGRVD PTQPIDLTQL VNGRGVTIQP LKRDYGVQLV EEGADTFQAK
160 170 180 190 200
INIEVQLASE LAIAAIEKNG GVVTTAFYDP RSLEILCKPI PFFLRGQPIP
210 220 230 240 250
KRMLPPESLV PYYTDAKNRG YLADPAKFPE ARLELAMKFG YVLPDITKDE
260 270 280 290
LFRMLSARKD PRQIFFGLAP GWVVNMADKK ILKPTDENLL KYYSS
Length:295
Mass (Da):33,542
Last modified:June 1, 2001 - v1
Checksum:i2CAA781E82E4670C
GO
Isoform 2 (identifier: Q9CPR5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     184-204: EILCKPIPFFLRGQPIPKRML → GHLMHSSDFHGFSARYSIHIK
     205-295: Missing.

Show »
Length:204
Mass (Da):23,018
Checksum:iE9EBEF2A98811C16
GO

Sequence cautioni

The sequence BAB27054 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1M → L in BAB27054 (PubMed:16141072).Curated1
Sequence conflicti13D → G in BAB27054 (PubMed:16141072).Curated1
Sequence conflicti36E → G in BAB27054 (PubMed:16141072).Curated1
Sequence conflicti119Q → K in BAE29929 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_021370184 – 204EILCK…PKRML → GHLMHSSDFHGFSARYSIHI K in isoform 2. 2 PublicationsAdd BLAST21
Alternative sequenceiVSP_021371205 – 295Missing in isoform 2. 2 PublicationsAdd BLAST91

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003367 mRNA Translation: BAB22741.1
AK010474 mRNA Translation: BAB26967.1
AK010604 mRNA Translation: BAB27054.1 Different initiation.
AK017804 mRNA Translation: BAB30943.1
AK017824 mRNA Translation: BAB30958.1
AK019175 mRNA Translation: BAB31589.1
AK019249 mRNA Translation: BAB31626.1
AK150880 mRNA Translation: BAE29929.1
AK160660 mRNA Translation: BAE35948.1
BC021304 mRNA Translation: AAH21304.1
BC027233 mRNA Translation: AAH27233.1
CCDSiCCDS35504.1 [Q9CPR5-2]
CCDS48211.1 [Q9CPR5-1]
RefSeqiNP_001171129.1, NM_001177658.1 [Q9CPR5-1]
NP_079576.1, NM_025300.4 [Q9CPR5-2]
UniGeneiMm.182927

Genome annotation databases

EnsembliENSMUST00000130201; ENSMUSP00000114649; ENSMUSG00000033845 [Q9CPR5-2]
ENSMUST00000156816; ENSMUSP00000115512; ENSMUSG00000033845 [Q9CPR5-1]
GeneIDi27395
KEGGimmu:27395
UCSCiuc007afd.3 mouse [Q9CPR5-2]
uc007aff.3 mouse [Q9CPR5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRM15_MOUSE
AccessioniPrimary (citable) accession number: Q9CPR5
Secondary accession number(s): Q3UBN5, Q9CPP5, Q9CRH4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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