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Protein

ATP synthase subunit g, mitochondrial

Gene

Atp5l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ATP synthesis, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-163210. Formation of ATP by chemiosmotic coupling.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit g, mitochondrial
Short name:
ATPase subunit g
Gene namesi
Name:Atp5l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1351597. Atp5l.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CF(0), Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 103102ATP synthase subunit g, mitochondrialPRO_0000071692Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei11 – 111N6-acetyllysineCombined sources
Modified residuei24 – 241N6-acetyllysineBy similarity
Modified residuei35 – 351N6-acetyllysineCombined sources
Modified residuei54 – 541N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9CPQ8.
MaxQBiQ9CPQ8.
PaxDbiQ9CPQ8.
PeptideAtlasiQ9CPQ8.
PRIDEiQ9CPQ8.
TopDownProteomicsiQ9CPQ8.

PTM databases

iPTMnetiQ9CPQ8.
PhosphoSiteiQ9CPQ8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000038717.
GenevisibleiQ9CPQ8. MM.

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF0 seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity).By similarity

Protein-protein interaction databases

BioGridi205227. 1 interaction.
IntActiQ9CPQ8. 1 interaction.
MINTiMINT-1839867.
STRINGi10090.ENSMUSP00000136375.

Structurei

3D structure databases

ProteinModelPortaliQ9CPQ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase g subunit family.Curated

Phylogenomic databases

eggNOGiKOG4103. Eukaryota.
ENOG4111TZ1. LUCA.
GeneTreeiENSGT00390000009724.
HOGENOMiHOG000007506.
HOVERGENiHBG050614.
InParanoidiQ9CPQ8.
KOiK02140.
OMAiWQYAKVE.
OrthoDBiEOG091G16ZZ.
PhylomeDBiQ9CPQ8.
TreeFamiTF313978.

Family and domain databases

InterProiIPR016702. ATP-Synthase_su_G_mt_met.
IPR006808. ATPase_F0-cplx_gsu_mt.
[Graphical view]
PANTHERiPTHR12386. PTHR12386. 1 hit.
PfamiPF04718. ATP-synt_G. 1 hit.
[Graphical view]
PIRSFiPIRSF017835. ATP-synth_g_mitoch_animal. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CPQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKFIRNFAE KAPSMVAAAV TYSKPRLATF WHYAKVELVP PTPAEIPTAI
60 70 80 90 100
QSVKKIIQSA KTGSFKHLTV KEAVLNGLVA TEVWMWFYIG EIIGKRGIVG

YDV
Length:103
Mass (Da):11,425
Last modified:June 1, 2001 - v1
Checksum:i66BB25CECD67AA33
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti56 – 561I → M in CAA76699 (PubMed:10361692).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17223 mRNA. Translation: CAA76699.1.
AK005175 mRNA. Translation: BAB23862.1.
AK005321 mRNA. Translation: BAB23952.1.
AK005380 mRNA. Translation: BAB23987.1.
AK008002 mRNA. Translation: BAB25401.1.
AK008012 mRNA. Translation: BAB25408.1.
AK008030 mRNA. Translation: BAB25420.1.
AK008087 mRNA. Translation: BAB25451.1.
AK008183 mRNA. Translation: BAB25516.1.
AK008251 mRNA. Translation: BAB25558.1.
AK008321 mRNA. Translation: BAB25600.1.
AK009465 mRNA. Translation: BAB26305.1.
AK009468 mRNA. Translation: BAB26308.1.
AK009471 mRNA. Translation: BAB26310.1.
AK009612 mRNA. Translation: BAB26392.1.
AK009806 mRNA. Translation: BAB26514.1.
AK011038 mRNA. Translation: BAB27351.1.
AK011046 mRNA. Translation: BAB27357.1.
AK011099 mRNA. Translation: BAB27396.1.
AK019252 mRNA. Translation: BAB31628.1.
AK019274 mRNA. Translation: BAB31641.1.
AK019320 mRNA. Translation: BAB31664.1.
AK019343 mRNA. Translation: BAB31670.1.
AK019350 mRNA. Translation: BAB31672.1.
AK019355 mRNA. Translation: BAB31676.1.
BC031384 mRNA. Translation: AAH31384.1.
BC086880 mRNA. Translation: AAH86880.1.
BC089555 mRNA. Translation: AAH89555.1.
BC094407 mRNA. Translation: AAH94407.1.
CCDSiCCDS40604.1.
RefSeqiNP_038823.2. NM_013795.5.
UniGeneiMm.14663.
Mm.485732.

Genome annotation databases

EnsembliENSMUST00000043675; ENSMUSP00000047960; ENSMUSG00000038717.
GeneIDi27425.
KEGGimmu:27425.
UCSCiuc009per.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17223 mRNA. Translation: CAA76699.1.
AK005175 mRNA. Translation: BAB23862.1.
AK005321 mRNA. Translation: BAB23952.1.
AK005380 mRNA. Translation: BAB23987.1.
AK008002 mRNA. Translation: BAB25401.1.
AK008012 mRNA. Translation: BAB25408.1.
AK008030 mRNA. Translation: BAB25420.1.
AK008087 mRNA. Translation: BAB25451.1.
AK008183 mRNA. Translation: BAB25516.1.
AK008251 mRNA. Translation: BAB25558.1.
AK008321 mRNA. Translation: BAB25600.1.
AK009465 mRNA. Translation: BAB26305.1.
AK009468 mRNA. Translation: BAB26308.1.
AK009471 mRNA. Translation: BAB26310.1.
AK009612 mRNA. Translation: BAB26392.1.
AK009806 mRNA. Translation: BAB26514.1.
AK011038 mRNA. Translation: BAB27351.1.
AK011046 mRNA. Translation: BAB27357.1.
AK011099 mRNA. Translation: BAB27396.1.
AK019252 mRNA. Translation: BAB31628.1.
AK019274 mRNA. Translation: BAB31641.1.
AK019320 mRNA. Translation: BAB31664.1.
AK019343 mRNA. Translation: BAB31670.1.
AK019350 mRNA. Translation: BAB31672.1.
AK019355 mRNA. Translation: BAB31676.1.
BC031384 mRNA. Translation: AAH31384.1.
BC086880 mRNA. Translation: AAH86880.1.
BC089555 mRNA. Translation: AAH89555.1.
BC094407 mRNA. Translation: AAH94407.1.
CCDSiCCDS40604.1.
RefSeqiNP_038823.2. NM_013795.5.
UniGeneiMm.14663.
Mm.485732.

3D structure databases

ProteinModelPortaliQ9CPQ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205227. 1 interaction.
IntActiQ9CPQ8. 1 interaction.
MINTiMINT-1839867.
STRINGi10090.ENSMUSP00000136375.

PTM databases

iPTMnetiQ9CPQ8.
PhosphoSiteiQ9CPQ8.

Proteomic databases

EPDiQ9CPQ8.
MaxQBiQ9CPQ8.
PaxDbiQ9CPQ8.
PeptideAtlasiQ9CPQ8.
PRIDEiQ9CPQ8.
TopDownProteomicsiQ9CPQ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043675; ENSMUSP00000047960; ENSMUSG00000038717.
GeneIDi27425.
KEGGimmu:27425.
UCSCiuc009per.2. mouse.

Organism-specific databases

CTDi10632.
MGIiMGI:1351597. Atp5l.

Phylogenomic databases

eggNOGiKOG4103. Eukaryota.
ENOG4111TZ1. LUCA.
GeneTreeiENSGT00390000009724.
HOGENOMiHOG000007506.
HOVERGENiHBG050614.
InParanoidiQ9CPQ8.
KOiK02140.
OMAiWQYAKVE.
OrthoDBiEOG091G16ZZ.
PhylomeDBiQ9CPQ8.
TreeFamiTF313978.

Enzyme and pathway databases

ReactomeiR-MMU-163210. Formation of ATP by chemiosmotic coupling.

Miscellaneous databases

PROiQ9CPQ8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038717.
GenevisibleiQ9CPQ8. MM.

Family and domain databases

InterProiIPR016702. ATP-Synthase_su_G_mt_met.
IPR006808. ATPase_F0-cplx_gsu_mt.
[Graphical view]
PANTHERiPTHR12386. PTHR12386. 1 hit.
PfamiPF04718. ATP-synt_G. 1 hit.
[Graphical view]
PIRSFiPIRSF017835. ATP-synth_g_mitoch_animal. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiATP5L_MOUSE
AccessioniPrimary (citable) accession number: Q9CPQ8
Secondary accession number(s): O70590, Q5M9M8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.