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Q9CPQ3

- TOM22_MOUSE

UniProt

Q9CPQ3 - TOM22_MOUSE

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Protein

Mitochondrial import receptor subunit TOM22 homolog

Gene

Tomm22

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore (By similarity).By similarity

GO - Molecular functioni

  1. protein transmembrane transporter activity Source: Ensembl

GO - Biological processi

  1. protein import into mitochondrial outer membrane Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiREACT_199101. Mitochondrial protein import.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import receptor subunit TOM22 homolog
Alternative name(s):
Translocase of outer membrane 22 kDa subunit homolog
Gene namesi
Name:Tomm22
Synonyms:Tom22
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:2450248. Tomm22.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: MGI
  3. mitochondrial outer membrane translocase complex Source: Ensembl
  4. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 142141Mitochondrial import receptor subunit TOM22 homologPRO_0000076108Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei15 – 151PhosphoserineBy similarity
Modified residuei43 – 431PhosphothreonineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9CPQ3.
PaxDbiQ9CPQ3.
PRIDEiQ9CPQ3.

PTM databases

PhosphoSiteiQ9CPQ3.

Expressioni

Gene expression databases

BgeeiQ9CPQ3.
GenevestigatoriQ9CPQ3.

Interactioni

Subunit structurei

Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts with PPP2R2B and TOMM40 (By similarity).By similarity

Protein-protein interaction databases

BioGridi230178. 3 interactions.
IntActiQ9CPQ3. 2 interactions.
MINTiMINT-1844683.
STRINGi10090.ENSMUSP00000023062.

Structurei

3D structure databases

ProteinModelPortaliQ9CPQ3.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 8382CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini104 – 14239Mitochondrial intermembraneSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei84 – 10320HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni41 – 5010Import sequence; necessary for mitochondrion outer membrane localization and integration in the TOM complexBy similarity
Regioni83 – 10321TMD; necessary for mitochondrion outer membrane localization and integration in the TOM complexBy similarityAdd
BLAST
Regioni123 – 14220C-tail signal; necessary for mitochondrion outer membrane localization and integration in the TOM complexBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi35 – 384Poly-Asp
Compositional biasi110 – 1189Poly-Gln

Domaini

The N-terminal domain (residues 1-62) is important for binding to the unfolded mature imported proteins. Residues (49-71) of the cytoplasmic domain interacts with TOMM20 while the C-terminal segment (residues 63-82) binds presequence of preproteins. Requires the transmembrane domain (TMD), a short segment (the import sequence) in the cytoplasmic domain localizing separately from the TMD and the C-tail signal in the C-terminal domain for efficient targeting and integration into the TOM complex (By similarity).By similarity

Sequence similaritiesi

Belongs to the Tom22 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG263720.
GeneTreeiENSGT00390000016475.
HOGENOMiHOG000067816.
HOVERGENiHBG061819.
InParanoidiQ9CPQ3.
KOiK17769.
OMAiMMPPAPG.
OrthoDBiEOG7KWSKG.
PhylomeDBiQ9CPQ3.
TreeFamiTF106201.

Family and domain databases

InterProiIPR005683. Tom22.
[Graphical view]
PfamiPF04281. Tom22. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CPQ3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAAVAAAGA GEPLSPEELL PKAEAEKAEE ELEEDDDDEL DETLSERLWG
60 70 80 90 100
LTEMFPERVR SAAGATFDLS LFVAQKMYRF SRAALWIGTT SFMILVLPVV
110 120 130 140
FETEKLQMEQ QQQLQQRQIL LGPNTGLSGG MPGALPPLPG KM
Length:142
Mass (Da):15,537
Last modified:January 23, 2007 - v3
Checksum:iA5182A39B6EBBFDA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti38 – 381D → H in BAB25482. (PubMed:16141072)Curated
Sequence conflicti65 – 651A → T in BAB25482. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK008133 mRNA. Translation: BAB25482.1.
AK009868 mRNA. Translation: BAB26553.1.
AK013471 mRNA. Translation: BAB28871.1.
AK049442 mRNA. Translation: BAC33752.1.
AK150360 mRNA. Translation: BAE29495.1.
AK152843 mRNA. Translation: BAE31536.1.
AK167803 mRNA. Translation: BAE39830.1.
BC056920 mRNA. Translation: AAH56920.1.
CCDSiCCDS27646.1.
RefSeqiNP_766197.2. NM_172609.3.
UniGeneiMm.246435.
Mm.485795.

Genome annotation databases

EnsembliENSMUST00000023062; ENSMUSP00000023062; ENSMUSG00000022427.
GeneIDi223696.
KEGGimmu:223696.
UCSCiuc007wud.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK008133 mRNA. Translation: BAB25482.1 .
AK009868 mRNA. Translation: BAB26553.1 .
AK013471 mRNA. Translation: BAB28871.1 .
AK049442 mRNA. Translation: BAC33752.1 .
AK150360 mRNA. Translation: BAE29495.1 .
AK152843 mRNA. Translation: BAE31536.1 .
AK167803 mRNA. Translation: BAE39830.1 .
BC056920 mRNA. Translation: AAH56920.1 .
CCDSi CCDS27646.1.
RefSeqi NP_766197.2. NM_172609.3.
UniGenei Mm.246435.
Mm.485795.

3D structure databases

ProteinModelPortali Q9CPQ3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 230178. 3 interactions.
IntActi Q9CPQ3. 2 interactions.
MINTi MINT-1844683.
STRINGi 10090.ENSMUSP00000023062.

PTM databases

PhosphoSitei Q9CPQ3.

Proteomic databases

MaxQBi Q9CPQ3.
PaxDbi Q9CPQ3.
PRIDEi Q9CPQ3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000023062 ; ENSMUSP00000023062 ; ENSMUSG00000022427 .
GeneIDi 223696.
KEGGi mmu:223696.
UCSCi uc007wud.1. mouse.

Organism-specific databases

CTDi 56993.
MGIi MGI:2450248. Tomm22.

Phylogenomic databases

eggNOGi NOG263720.
GeneTreei ENSGT00390000016475.
HOGENOMi HOG000067816.
HOVERGENi HBG061819.
InParanoidi Q9CPQ3.
KOi K17769.
OMAi MMPPAPG.
OrthoDBi EOG7KWSKG.
PhylomeDBi Q9CPQ3.
TreeFami TF106201.

Enzyme and pathway databases

Reactomei REACT_199101. Mitochondrial protein import.

Miscellaneous databases

NextBioi 376826.
PROi Q9CPQ3.
SOURCEi Search...

Gene expression databases

Bgeei Q9CPQ3.
Genevestigatori Q9CPQ3.

Family and domain databases

InterProi IPR005683. Tom22.
[Graphical view ]
Pfami PF04281. Tom22. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and DBA/2.
    Tissue: Bone marrow, Hippocampus, Small intestine and Tongue.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiTOM22_MOUSE
AccessioniPrimary (citable) accession number: Q9CPQ3
Secondary accession number(s): Q543M4, Q9D8D3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 100 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3