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Q9CPQ3

- TOM22_MOUSE

UniProt

Q9CPQ3 - TOM22_MOUSE

Protein

Mitochondrial import receptor subunit TOM22 homolog

Gene

Tomm22

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: MGI
    2. protein transmembrane transporter activity Source: Ensembl

    GO - Biological processi

    1. protein import into mitochondrial outer membrane Source: Ensembl

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Protein transport, Translocation, Transport

    Enzyme and pathway databases

    ReactomeiREACT_199101. Mitochondrial protein import.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial import receptor subunit TOM22 homolog
    Alternative name(s):
    Translocase of outer membrane 22 kDa subunit homolog
    Gene namesi
    Name:Tomm22
    Synonyms:Tom22
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:2450248. Tomm22.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: MGI
    3. mitochondrial outer membrane translocase complex Source: Ensembl
    4. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion outer membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 142141Mitochondrial import receptor subunit TOM22 homologPRO_0000076108Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei15 – 151PhosphoserineBy similarity
    Modified residuei43 – 431PhosphothreonineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9CPQ3.
    PaxDbiQ9CPQ3.
    PRIDEiQ9CPQ3.

    PTM databases

    PhosphoSiteiQ9CPQ3.

    Expressioni

    Gene expression databases

    BgeeiQ9CPQ3.
    GenevestigatoriQ9CPQ3.

    Interactioni

    Subunit structurei

    Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts with PPP2R2B and TOMM40 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi230178. 3 interactions.
    IntActiQ9CPQ3. 2 interactions.
    MINTiMINT-1844683.
    STRINGi10090.ENSMUSP00000023062.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CPQ3.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 8382CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini104 – 14239Mitochondrial intermembraneSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei84 – 10320HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni41 – 5010Import sequence; necessary for mitochondrion outer membrane localization and integration in the TOM complexBy similarity
    Regioni83 – 10321TMD; necessary for mitochondrion outer membrane localization and integration in the TOM complexBy similarityAdd
    BLAST
    Regioni123 – 14220C-tail signal; necessary for mitochondrion outer membrane localization and integration in the TOM complexBy similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi35 – 384Poly-Asp
    Compositional biasi110 – 1189Poly-Gln

    Domaini

    The N-terminal domain (residues 1-62) is important for binding to the unfolded mature imported proteins. Residues (49-71) of the cytoplasmic domain interacts with TOMM20 while the C-terminal segment (residues 63-82) binds presequence of preproteins. Requires the transmembrane domain (TMD), a short segment (the import sequence) in the cytoplasmic domain localizing separately from the TMD and the C-tail signal in the C-terminal domain for efficient targeting and integration into the TOM complex By similarity.By similarity

    Sequence similaritiesi

    Belongs to the Tom22 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG263720.
    GeneTreeiENSGT00390000016475.
    HOGENOMiHOG000067816.
    HOVERGENiHBG061819.
    InParanoidiQ9CPQ3.
    KOiK17769.
    OMAiMMPPAPG.
    OrthoDBiEOG7KWSKG.
    PhylomeDBiQ9CPQ3.
    TreeFamiTF106201.

    Family and domain databases

    InterProiIPR005683. Tom22.
    [Graphical view]
    PfamiPF04281. Tom22. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9CPQ3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAAVAAAGA GEPLSPEELL PKAEAEKAEE ELEEDDDDEL DETLSERLWG    50
    LTEMFPERVR SAAGATFDLS LFVAQKMYRF SRAALWIGTT SFMILVLPVV 100
    FETEKLQMEQ QQQLQQRQIL LGPNTGLSGG MPGALPPLPG KM 142
    Length:142
    Mass (Da):15,537
    Last modified:January 23, 2007 - v3
    Checksum:iA5182A39B6EBBFDA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti38 – 381D → H in BAB25482. (PubMed:16141072)Curated
    Sequence conflicti65 – 651A → T in BAB25482. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK008133 mRNA. Translation: BAB25482.1.
    AK009868 mRNA. Translation: BAB26553.1.
    AK013471 mRNA. Translation: BAB28871.1.
    AK049442 mRNA. Translation: BAC33752.1.
    AK150360 mRNA. Translation: BAE29495.1.
    AK152843 mRNA. Translation: BAE31536.1.
    AK167803 mRNA. Translation: BAE39830.1.
    BC056920 mRNA. Translation: AAH56920.1.
    CCDSiCCDS27646.1.
    RefSeqiNP_766197.2. NM_172609.3.
    UniGeneiMm.246435.
    Mm.485795.

    Genome annotation databases

    EnsembliENSMUST00000023062; ENSMUSP00000023062; ENSMUSG00000022427.
    GeneIDi223696.
    KEGGimmu:223696.
    UCSCiuc007wud.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK008133 mRNA. Translation: BAB25482.1 .
    AK009868 mRNA. Translation: BAB26553.1 .
    AK013471 mRNA. Translation: BAB28871.1 .
    AK049442 mRNA. Translation: BAC33752.1 .
    AK150360 mRNA. Translation: BAE29495.1 .
    AK152843 mRNA. Translation: BAE31536.1 .
    AK167803 mRNA. Translation: BAE39830.1 .
    BC056920 mRNA. Translation: AAH56920.1 .
    CCDSi CCDS27646.1.
    RefSeqi NP_766197.2. NM_172609.3.
    UniGenei Mm.246435.
    Mm.485795.

    3D structure databases

    ProteinModelPortali Q9CPQ3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 230178. 3 interactions.
    IntActi Q9CPQ3. 2 interactions.
    MINTi MINT-1844683.
    STRINGi 10090.ENSMUSP00000023062.

    PTM databases

    PhosphoSitei Q9CPQ3.

    Proteomic databases

    MaxQBi Q9CPQ3.
    PaxDbi Q9CPQ3.
    PRIDEi Q9CPQ3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023062 ; ENSMUSP00000023062 ; ENSMUSG00000022427 .
    GeneIDi 223696.
    KEGGi mmu:223696.
    UCSCi uc007wud.1. mouse.

    Organism-specific databases

    CTDi 56993.
    MGIi MGI:2450248. Tomm22.

    Phylogenomic databases

    eggNOGi NOG263720.
    GeneTreei ENSGT00390000016475.
    HOGENOMi HOG000067816.
    HOVERGENi HBG061819.
    InParanoidi Q9CPQ3.
    KOi K17769.
    OMAi MMPPAPG.
    OrthoDBi EOG7KWSKG.
    PhylomeDBi Q9CPQ3.
    TreeFami TF106201.

    Enzyme and pathway databases

    Reactomei REACT_199101. Mitochondrial protein import.

    Miscellaneous databases

    NextBioi 376826.
    PROi Q9CPQ3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9CPQ3.
    Genevestigatori Q9CPQ3.

    Family and domain databases

    InterProi IPR005683. Tom22.
    [Graphical view ]
    Pfami PF04281. Tom22. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and DBA/2.
      Tissue: Bone marrow, Hippocampus, Small intestine and Tongue.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiTOM22_MOUSE
    AccessioniPrimary (citable) accession number: Q9CPQ3
    Secondary accession number(s): Q543M4, Q9D8D3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2002
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 99 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3