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Protein

Mitochondrial import receptor subunit TOM22 homolog

Gene

Tomm22

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-MMU-5205685. Pink/Parkin Mediated Mitophagy.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import receptor subunit TOM22 homolog
Alternative name(s):
Translocase of outer membrane 22 kDa subunit homolog
Gene namesi
Name:Tomm22
Synonyms:Tom22
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2450248. Tomm22.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 83CytoplasmicSequence analysisAdd BLAST82
Transmembranei84 – 103HelicalSequence analysisAdd BLAST20
Topological domaini104 – 142Mitochondrial intermembraneSequence analysisAdd BLAST39

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000761082 – 142Mitochondrial import receptor subunit TOM22 homologAdd BLAST141

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei15PhosphoserineBy similarity1
Modified residuei43PhosphothreonineBy similarity1
Modified residuei45PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9CPQ3.
MaxQBiQ9CPQ3.
PaxDbiQ9CPQ3.
PeptideAtlasiQ9CPQ3.
PRIDEiQ9CPQ3.
TopDownProteomicsiQ9CPQ3.

PTM databases

iPTMnetiQ9CPQ3.
PhosphoSitePlusiQ9CPQ3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000022427.
GenevisibleiQ9CPQ3. MM.

Interactioni

Subunit structurei

Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts with PPP2R2B and TOMM40 (By similarity).By similarity

Protein-protein interaction databases

BioGridi230178. 3 interactors.
IntActiQ9CPQ3. 2 interactors.
MINTiMINT-1844683.
STRINGi10090.ENSMUSP00000023062.

Structurei

3D structure databases

ProteinModelPortaliQ9CPQ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni41 – 50Import sequence; necessary for mitochondrion outer membrane localization and integration in the TOM complexBy similarity10
Regioni83 – 103TMD; necessary for mitochondrion outer membrane localization and integration in the TOM complexBy similarityAdd BLAST21
Regioni123 – 142C-tail signal; necessary for mitochondrion outer membrane localization and integration in the TOM complexBy similarityAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi35 – 38Poly-Asp4
Compositional biasi110 – 118Poly-Gln9

Domaini

The N-terminal domain (residues 1-62) is important for binding to the unfolded mature imported proteins. Residues (49-71) of the cytoplasmic domain interacts with TOMM20 while the C-terminal segment (residues 63-82) binds presequence of preproteins. Requires the transmembrane domain (TMD), a short segment (the import sequence) in the cytoplasmic domain localizing separately from the TMD and the C-tail signal in the C-terminal domain for efficient targeting and integration into the TOM complex (By similarity).By similarity

Sequence similaritiesi

Belongs to the Tom22 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4111. Eukaryota.
ENOG41122K3. LUCA.
GeneTreeiENSGT00390000016475.
HOGENOMiHOG000067816.
HOVERGENiHBG061819.
InParanoidiQ9CPQ3.
KOiK17769.
OMAiFYTFSCN.
OrthoDBiEOG091G0XN1.
PhylomeDBiQ9CPQ3.
TreeFamiTF106201.

Family and domain databases

InterProiIPR005683. Tom22.
[Graphical view]
PfamiPF04281. Tom22. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CPQ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAVAAAGA GEPLSPEELL PKAEAEKAEE ELEEDDDDEL DETLSERLWG
60 70 80 90 100
LTEMFPERVR SAAGATFDLS LFVAQKMYRF SRAALWIGTT SFMILVLPVV
110 120 130 140
FETEKLQMEQ QQQLQQRQIL LGPNTGLSGG MPGALPPLPG KM
Length:142
Mass (Da):15,537
Last modified:January 23, 2007 - v3
Checksum:iA5182A39B6EBBFDA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti38D → H in BAB25482 (PubMed:16141072).Curated1
Sequence conflicti65A → T in BAB25482 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008133 mRNA. Translation: BAB25482.1.
AK009868 mRNA. Translation: BAB26553.1.
AK013471 mRNA. Translation: BAB28871.1.
AK049442 mRNA. Translation: BAC33752.1.
AK150360 mRNA. Translation: BAE29495.1.
AK152843 mRNA. Translation: BAE31536.1.
AK167803 mRNA. Translation: BAE39830.1.
BC056920 mRNA. Translation: AAH56920.1.
CCDSiCCDS27646.1.
RefSeqiNP_766197.2. NM_172609.3.
UniGeneiMm.246435.
Mm.485795.

Genome annotation databases

EnsembliENSMUST00000023062; ENSMUSP00000023062; ENSMUSG00000022427.
GeneIDi223696.
KEGGimmu:223696.
UCSCiuc007wud.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008133 mRNA. Translation: BAB25482.1.
AK009868 mRNA. Translation: BAB26553.1.
AK013471 mRNA. Translation: BAB28871.1.
AK049442 mRNA. Translation: BAC33752.1.
AK150360 mRNA. Translation: BAE29495.1.
AK152843 mRNA. Translation: BAE31536.1.
AK167803 mRNA. Translation: BAE39830.1.
BC056920 mRNA. Translation: AAH56920.1.
CCDSiCCDS27646.1.
RefSeqiNP_766197.2. NM_172609.3.
UniGeneiMm.246435.
Mm.485795.

3D structure databases

ProteinModelPortaliQ9CPQ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230178. 3 interactors.
IntActiQ9CPQ3. 2 interactors.
MINTiMINT-1844683.
STRINGi10090.ENSMUSP00000023062.

PTM databases

iPTMnetiQ9CPQ3.
PhosphoSitePlusiQ9CPQ3.

Proteomic databases

EPDiQ9CPQ3.
MaxQBiQ9CPQ3.
PaxDbiQ9CPQ3.
PeptideAtlasiQ9CPQ3.
PRIDEiQ9CPQ3.
TopDownProteomicsiQ9CPQ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023062; ENSMUSP00000023062; ENSMUSG00000022427.
GeneIDi223696.
KEGGimmu:223696.
UCSCiuc007wud.1. mouse.

Organism-specific databases

CTDi56993.
MGIiMGI:2450248. Tomm22.

Phylogenomic databases

eggNOGiKOG4111. Eukaryota.
ENOG41122K3. LUCA.
GeneTreeiENSGT00390000016475.
HOGENOMiHOG000067816.
HOVERGENiHBG061819.
InParanoidiQ9CPQ3.
KOiK17769.
OMAiFYTFSCN.
OrthoDBiEOG091G0XN1.
PhylomeDBiQ9CPQ3.
TreeFamiTF106201.

Enzyme and pathway databases

ReactomeiR-MMU-5205685. Pink/Parkin Mediated Mitophagy.

Miscellaneous databases

PROiQ9CPQ3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022427.
GenevisibleiQ9CPQ3. MM.

Family and domain databases

InterProiIPR005683. Tom22.
[Graphical view]
PfamiPF04281. Tom22. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTOM22_MOUSE
AccessioniPrimary (citable) accession number: Q9CPQ3
Secondary accession number(s): Q543M4, Q9D8D3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.