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Protein
Submitted name:

Growth hormone a1

Gene

Prl

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HormoneUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-MMU-1170546. Prolactin receptor signaling.
R-MMU-982772. Growth hormone receptor signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
Growth hormone a1Imported
Submitted name:
ProlactinImported
Submitted name:
Prolactin, isoform CRA_aImported
Gene namesi
Name:PrlImported
Synonyms:Gha1Imported
ORF Names:mCG_15525Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:97762. Prl.

Subcellular locationi

  • Secreted UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

SecretedSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Sequence analysisAdd
BLAST
Chaini32 – 228197Sequence analysisPRO_5007928721Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000021342.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105998.

Family & Domainsi

Sequence similaritiesi

Belongs to the somatotropin/prolactin family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410II74. Eukaryota.
ENOG410XU1S. LUCA.
GeneTreeiENSGT00730000110805.
HOGENOMiHOG000264241.
HOVERGENiHBG104895.
OMAiLHCLRRD.
OrthoDBiEOG091G0O08.
TreeFamiTF332592.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001400. Somatotropin.
IPR018116. Somatotropin_CS.
[Graphical view]
PANTHERiPTHR11417. PTHR11417. 1 hit.
PfamiPF00103. Hormone_1. 1 hit.
[Graphical view]
PRINTSiPR00836. SOMATOTROPIN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00338. SOMATOTROPIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CPQ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMNSQGSAQ KAGTLLLLLI SNLLFCQNVQ PLPICSAGDC QTSLRELFDR
60 70 80 90 100
VVILSHYIHT LYTDMFIEFD KQYVQDREFM VKVINDCPTS SLATPEDKEQ
110 120 130 140 150
ALKVPPEVLL NLILSLVQSS SDPLFQLITG VGGIQEAPEY ILSRAKEIEE
160 170 180 190 200
QNKQLLEGVE KIISQAYPEA KGNGIYFVWS QLPSLQGVDE ESKILSLRNT
210 220
IRCLRRDSHK VDNFLKVLRC QIAHQNNC
Length:228
Mass (Da):25,729
Last modified:June 1, 2001 - v1
Checksum:iAFCADF003728CD77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591843 Genomic DNA. No translation available.
BC061141 mRNA. Translation: AAH61141.1.
AK077493 mRNA. Translation: BAC36829.1.
AK133736 mRNA. Translation: BAE21811.1.
AK133752 mRNA. Translation: BAE21822.1.
AK161557 mRNA. Translation: BAE36462.1.
AK161565 mRNA. Translation: BAE36467.1.
AK161619 mRNA. Translation: BAE36497.1.
LM644166 mRNA. Translation: CDW51413.1.
CH466561 Genomic DNA. Translation: EDL32452.1.
PIRiA43789. LCMS.
RefSeqiNP_035294.2. NM_011164.2.
UniGeneiMm.1270.

Genome annotation databases

EnsembliENSMUST00000110369; ENSMUSP00000105998; ENSMUSG00000021342.
GeneIDi19109.
UCSCiuc007pxb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591843 Genomic DNA. No translation available.
BC061141 mRNA. Translation: AAH61141.1.
AK077493 mRNA. Translation: BAC36829.1.
AK133736 mRNA. Translation: BAE21811.1.
AK133752 mRNA. Translation: BAE21822.1.
AK161557 mRNA. Translation: BAE36462.1.
AK161565 mRNA. Translation: BAE36467.1.
AK161619 mRNA. Translation: BAE36497.1.
LM644166 mRNA. Translation: CDW51413.1.
CH466561 Genomic DNA. Translation: EDL32452.1.
PIRiA43789. LCMS.
RefSeqiNP_035294.2. NM_011164.2.
UniGeneiMm.1270.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105998.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000110369; ENSMUSP00000105998; ENSMUSG00000021342.
GeneIDi19109.
UCSCiuc007pxb.2. mouse.

Organism-specific databases

CTDi5617.
MGIiMGI:97762. Prl.

Phylogenomic databases

eggNOGiENOG410II74. Eukaryota.
ENOG410XU1S. LUCA.
GeneTreeiENSGT00730000110805.
HOGENOMiHOG000264241.
HOVERGENiHBG104895.
OMAiLHCLRRD.
OrthoDBiEOG091G0O08.
TreeFamiTF332592.

Enzyme and pathway databases

ReactomeiR-MMU-1170546. Prolactin receptor signaling.
R-MMU-982772. Growth hormone receptor signaling.

Miscellaneous databases

ChiTaRSiPrl. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021342.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001400. Somatotropin.
IPR018116. Somatotropin_CS.
[Graphical view]
PANTHERiPTHR11417. PTHR11417. 1 hit.
PfamiPF00103. Hormone_1. 1 hit.
[Graphical view]
PRINTSiPR00836. SOMATOTROPIN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00338. SOMATOTROPIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9CPQ2_MOUSE
AccessioniPrimary (citable) accession number: Q9CPQ2
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.