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Protein

Cytochrome c oxidase subunit 6C

Gene

Cox6c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.By similarity

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 6C
Alternative name(s):
Cytochrome c oxidase polypeptide VIc
Gene namesi
Name:Cox6c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:104614. Cox6c.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini4 – 1411Mitochondrial matrixBy similarityAdd
BLAST
Transmembranei15 – 5541HelicalBy similarityAdd
BLAST
Topological domaini56 – 7621Mitochondrial intermembraneBy similarityAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: MGI
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7676Cytochrome c oxidase subunit 6CPRO_0000191302Add
BLAST

Post-translational modificationi

Acetylation of Lys-61 is observed in liver mitochondria from fasted mice but not from fed mice.

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9CPQ1.
MaxQBiQ9CPQ1.
PaxDbiQ9CPQ1.
PeptideAtlasiQ9CPQ1.
PRIDEiQ9CPQ1.
TopDownProteomicsiQ9CPQ1.

PTM databases

iPTMnetiQ9CPQ1.
PhosphoSiteiQ9CPQ1.

Expressioni

Gene expression databases

BgeeiQ9CPQ1.
CleanExiMM_COX6C.
ExpressionAtlasiQ9CPQ1. baseline and differential.
GenevisibleiQ9CPQ1. MM.

Interactioni

Protein-protein interaction databases

BioGridi198845. 2 interactions.
IntActiQ9CPQ1. 2 interactions.
MINTiMINT-1843998.
STRINGi10090.ENSMUSP00000014457.

Structurei

3D structure databases

ProteinModelPortaliQ9CPQ1.
SMRiQ9CPQ1. Positions 7-76.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J83U. Eukaryota.
ENOG41124VH. LUCA.
GeneTreeiENSGT00390000004573.
HOGENOMiHOG000039249.
HOVERGENiHBG051091.
InParanoidiQ9CPQ1.
KOiK02268.
OMAiARRMKFH.
PhylomeDBiQ9CPQ1.
TreeFamiTF353619.

Family and domain databases

Gene3Di4.10.93.10. 1 hit.
InterProiIPR004204. COX6C.
[Graphical view]
PANTHERiPTHR12916. PTHR12916. 1 hit.
ProDomiPD015032. Cyt_c_oxidase_su6c. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q9CPQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSGALLPKP QMRGLLAKRL RVHIAGAFIV ALGVAAAYKF GVAEPRKKAY
60 70
AEFYRNYDSM KDFEEMRKAG IFQSAK
Length:76
Mass (Da):8,469
Last modified:January 23, 2007 - v3
Checksum:iBE02A028CF77D5F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012602 mRNA. Translation: BAB28348.1.
AK013459 mRNA. Translation: BAB28866.1.
BC024666 mRNA. Translation: AAH24666.1.
BC094413 mRNA. Translation: AAH94413.1.
CCDSiCCDS27424.1.
PIRiS16083.
RefSeqiNP_444301.1. NM_053071.2.
UniGeneiMm.548.

Genome annotation databases

EnsembliENSMUST00000014457; ENSMUSP00000014457; ENSMUSG00000014313.
ENSMUST00000153512; ENSMUSP00000123609; ENSMUSG00000014313.
GeneIDi12864.
KEGGimmu:12864.
UCSCiuc007vmi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012602 mRNA. Translation: BAB28348.1.
AK013459 mRNA. Translation: BAB28866.1.
BC024666 mRNA. Translation: AAH24666.1.
BC094413 mRNA. Translation: AAH94413.1.
CCDSiCCDS27424.1.
PIRiS16083.
RefSeqiNP_444301.1. NM_053071.2.
UniGeneiMm.548.

3D structure databases

ProteinModelPortaliQ9CPQ1.
SMRiQ9CPQ1. Positions 7-76.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198845. 2 interactions.
IntActiQ9CPQ1. 2 interactions.
MINTiMINT-1843998.
STRINGi10090.ENSMUSP00000014457.

PTM databases

iPTMnetiQ9CPQ1.
PhosphoSiteiQ9CPQ1.

Proteomic databases

EPDiQ9CPQ1.
MaxQBiQ9CPQ1.
PaxDbiQ9CPQ1.
PeptideAtlasiQ9CPQ1.
PRIDEiQ9CPQ1.
TopDownProteomicsiQ9CPQ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000014457; ENSMUSP00000014457; ENSMUSG00000014313.
ENSMUST00000153512; ENSMUSP00000123609; ENSMUSG00000014313.
GeneIDi12864.
KEGGimmu:12864.
UCSCiuc007vmi.1. mouse.

Organism-specific databases

CTDi1345.
MGIiMGI:104614. Cox6c.

Phylogenomic databases

eggNOGiENOG410J83U. Eukaryota.
ENOG41124VH. LUCA.
GeneTreeiENSGT00390000004573.
HOGENOMiHOG000039249.
HOVERGENiHBG051091.
InParanoidiQ9CPQ1.
KOiK02268.
OMAiARRMKFH.
PhylomeDBiQ9CPQ1.
TreeFamiTF353619.

Miscellaneous databases

PROiQ9CPQ1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CPQ1.
CleanExiMM_COX6C.
ExpressionAtlasiQ9CPQ1. baseline and differential.
GenevisibleiQ9CPQ1. MM.

Family and domain databases

Gene3Di4.10.93.10. 1 hit.
InterProiIPR004204. COX6C.
[Graphical view]
PANTHERiPTHR12916. PTHR12916. 1 hit.
ProDomiPD015032. Cyt_c_oxidase_su6c. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cross reactivity of monoclonal antibodies and cDNA hybridization suggest evolutionary relationships between cytochrome c oxidase subunits VIa and VIc and between VIIa and VIIb."
    Schneyder B., Mell O., Anthony G., Kadenbach B.
    Eur. J. Biochem. 198:85-92(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PRELIMINARY NUCLEOTIDE SEQUENCE.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo and Hippocampus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Liver and Mammary gland.
  4. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 21-38 AND 48-66, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6J.
    Tissue: Brain.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiCOX6C_MOUSE
AccessioniPrimary (citable) accession number: Q9CPQ1
Secondary accession number(s): Q52KC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.