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Protein

Cytochrome c oxidase subunit 6C

Gene

Cox6c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.By similarity

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 6C
Alternative name(s):
Cytochrome c oxidase polypeptide VIc
Gene namesi
Name:Cox6c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:104614. Cox6c.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini4 – 1411Mitochondrial matrixBy similarityAdd
BLAST
Transmembranei15 – 5541HelicalBy similarityAdd
BLAST
Topological domaini56 – 7621Mitochondrial intermembraneBy similarityAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: MGI
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7676Cytochrome c oxidase subunit 6CPRO_0000191302Add
BLAST

Post-translational modificationi

Acetylation of Lys-61 is observed in liver mitochondria from fasted mice but not from fed mice.

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9CPQ1.
MaxQBiQ9CPQ1.
PaxDbiQ9CPQ1.
PeptideAtlasiQ9CPQ1.
PRIDEiQ9CPQ1.
TopDownProteomicsiQ9CPQ1.

PTM databases

iPTMnetiQ9CPQ1.
PhosphoSiteiQ9CPQ1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000014313.
CleanExiMM_COX6C.
ExpressionAtlasiQ9CPQ1. baseline and differential.
GenevisibleiQ9CPQ1. MM.

Interactioni

Protein-protein interaction databases

BioGridi198845. 2 interactions.
IntActiQ9CPQ1. 2 interactions.
MINTiMINT-1843998.
STRINGi10090.ENSMUSP00000014457.

Structurei

3D structure databases

ProteinModelPortaliQ9CPQ1.
SMRiQ9CPQ1. Positions 7-76.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J83U. Eukaryota.
ENOG41124VH. LUCA.
GeneTreeiENSGT00390000004573.
HOGENOMiHOG000039249.
HOVERGENiHBG051091.
InParanoidiQ9CPQ1.
KOiK02268.
OMAiARRMKFH.
OrthoDBiEOG091G10KX.
PhylomeDBiQ9CPQ1.
TreeFamiTF353619.

Family and domain databases

Gene3Di4.10.93.10. 1 hit.
InterProiIPR004204. COX6C.
[Graphical view]
PANTHERiPTHR12916. PTHR12916. 1 hit.
ProDomiPD015032. Cyt_c_oxidase_su6c. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q9CPQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSGALLPKP QMRGLLAKRL RVHIAGAFIV ALGVAAAYKF GVAEPRKKAY
60 70
AEFYRNYDSM KDFEEMRKAG IFQSAK
Length:76
Mass (Da):8,469
Last modified:January 23, 2007 - v3
Checksum:iBE02A028CF77D5F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012602 mRNA. Translation: BAB28348.1.
AK013459 mRNA. Translation: BAB28866.1.
BC024666 mRNA. Translation: AAH24666.1.
BC094413 mRNA. Translation: AAH94413.1.
CCDSiCCDS27424.1.
PIRiS16083.
RefSeqiNP_444301.1. NM_053071.2.
UniGeneiMm.548.

Genome annotation databases

EnsembliENSMUST00000014457; ENSMUSP00000014457; ENSMUSG00000014313.
ENSMUST00000153512; ENSMUSP00000123609; ENSMUSG00000014313.
GeneIDi12864.
KEGGimmu:12864.
UCSCiuc007vmi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012602 mRNA. Translation: BAB28348.1.
AK013459 mRNA. Translation: BAB28866.1.
BC024666 mRNA. Translation: AAH24666.1.
BC094413 mRNA. Translation: AAH94413.1.
CCDSiCCDS27424.1.
PIRiS16083.
RefSeqiNP_444301.1. NM_053071.2.
UniGeneiMm.548.

3D structure databases

ProteinModelPortaliQ9CPQ1.
SMRiQ9CPQ1. Positions 7-76.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198845. 2 interactions.
IntActiQ9CPQ1. 2 interactions.
MINTiMINT-1843998.
STRINGi10090.ENSMUSP00000014457.

PTM databases

iPTMnetiQ9CPQ1.
PhosphoSiteiQ9CPQ1.

Proteomic databases

EPDiQ9CPQ1.
MaxQBiQ9CPQ1.
PaxDbiQ9CPQ1.
PeptideAtlasiQ9CPQ1.
PRIDEiQ9CPQ1.
TopDownProteomicsiQ9CPQ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000014457; ENSMUSP00000014457; ENSMUSG00000014313.
ENSMUST00000153512; ENSMUSP00000123609; ENSMUSG00000014313.
GeneIDi12864.
KEGGimmu:12864.
UCSCiuc007vmi.1. mouse.

Organism-specific databases

CTDi1345.
MGIiMGI:104614. Cox6c.

Phylogenomic databases

eggNOGiENOG410J83U. Eukaryota.
ENOG41124VH. LUCA.
GeneTreeiENSGT00390000004573.
HOGENOMiHOG000039249.
HOVERGENiHBG051091.
InParanoidiQ9CPQ1.
KOiK02268.
OMAiARRMKFH.
OrthoDBiEOG091G10KX.
PhylomeDBiQ9CPQ1.
TreeFamiTF353619.

Miscellaneous databases

PROiQ9CPQ1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000014313.
CleanExiMM_COX6C.
ExpressionAtlasiQ9CPQ1. baseline and differential.
GenevisibleiQ9CPQ1. MM.

Family and domain databases

Gene3Di4.10.93.10. 1 hit.
InterProiIPR004204. COX6C.
[Graphical view]
PANTHERiPTHR12916. PTHR12916. 1 hit.
ProDomiPD015032. Cyt_c_oxidase_su6c. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX6C_MOUSE
AccessioniPrimary (citable) accession number: Q9CPQ1
Secondary accession number(s): Q52KC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.