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Protein

Cytochrome c oxidase subunit 6C

Gene

Cox6c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.By similarity

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 6C
Alternative name(s):
Cytochrome c oxidase polypeptide VIc
Gene namesi
Name:Cox6c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:104614 Cox6c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini4 – 14Mitochondrial matrixBy similarityAdd BLAST11
Transmembranei15 – 55HelicalBy similarityAdd BLAST41
Topological domaini56 – 76Mitochondrial intermembraneBy similarityAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001913021 – 76Cytochrome c oxidase subunit 6CAdd BLAST76

Post-translational modificationi

Acetylation of Lys-61 is observed in liver mitochondria from fasted mice but not from fed mice.

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9CPQ1
MaxQBiQ9CPQ1
PaxDbiQ9CPQ1
PeptideAtlasiQ9CPQ1
PRIDEiQ9CPQ1
TopDownProteomicsiQ9CPQ1

PTM databases

iPTMnetiQ9CPQ1
PhosphoSitePlusiQ9CPQ1

Expressioni

Gene expression databases

BgeeiENSMUSG00000014313
CleanExiMM_COX6C
ExpressionAtlasiQ9CPQ1 baseline and differential
GenevisibleiQ9CPQ1 MM

Interactioni

Protein-protein interaction databases

BioGridi198845, 2 interactors
CORUMiQ9CPQ1
IntActiQ9CPQ1, 2 interactors
MINTiQ9CPQ1
STRINGi10090.ENSMUSP00000014457

Structurei

3D structure databases

ProteinModelPortaliQ9CPQ1
SMRiQ9CPQ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J83U Eukaryota
ENOG41124VH LUCA
GeneTreeiENSGT00390000004573
HOGENOMiHOG000039249
HOVERGENiHBG051091
InParanoidiQ9CPQ1
KOiK02268
OMAiARRMKFH
OrthoDBiEOG091G10KX
PhylomeDBiQ9CPQ1
TreeFamiTF353619

Family and domain databases

CDDicd00927 Cyt_c_Oxidase_VIc, 1 hit
Gene3Di4.10.93.10, 1 hit
InterProiView protein in InterPro
IPR004204 COX6C
IPR034884 Cytochrome_c_oxidase_VIc/VIIs
IPR037169 Cytochrome_c_oxidase_VIc_sf
PANTHERiPTHR12916 PTHR12916, 1 hit
PfamiView protein in Pfam
PF02937 COX6C, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD015032 Cyt_c_oxidase_su6c, 1 hit
SUPFAMiSSF81415 SSF81415, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CPQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSGALLPKP QMRGLLAKRL RVHIAGAFIV ALGVAAAYKF GVAEPRKKAY
60 70
AEFYRNYDSM KDFEEMRKAG IFQSAK
Length:76
Mass (Da):8,469
Last modified:January 23, 2007 - v3
Checksum:iBE02A028CF77D5F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012602 mRNA Translation: BAB28348.1
AK013459 mRNA Translation: BAB28866.1
BC024666 mRNA Translation: AAH24666.1
BC094413 mRNA Translation: AAH94413.1
CCDSiCCDS27424.1
PIRiS16083
RefSeqiNP_444301.1, NM_053071.2
UniGeneiMm.548

Genome annotation databases

EnsembliENSMUST00000014457; ENSMUSP00000014457; ENSMUSG00000014313
ENSMUST00000153512; ENSMUSP00000123609; ENSMUSG00000014313
ENSMUST00000156915; ENSMUSP00000122391; ENSMUSG00000014313
GeneIDi12864
KEGGimmu:12864
UCSCiuc007vmi.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCOX6C_MOUSE
AccessioniPrimary (citable) accession number: Q9CPQ1
Secondary accession number(s): Q52KC6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 122 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health