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Protein
Submitted name:

Prolactin

Gene

Prl

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Keywords - Molecular functioni

HormoneUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-MMU-1170546. Prolactin receptor signaling.
R-MMU-982772. Growth hormone receptor signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
ProlactinImported
Gene namesi
Name:PrlImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:97762. Prl.

Subcellular locationi

  • Secreted UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

SecretedSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence analysisAdd
BLAST
Chaini29 – 225197Sequence analysisPRO_5007928765Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000021342.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105998.

Family & Domainsi

Sequence similaritiesi

Belongs to the somatotropin/prolactin family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410II74. Eukaryota.
ENOG410XU1S. LUCA.
GeneTreeiENSGT00730000110805.
HOVERGENiHBG104895.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001400. Somatotropin.
IPR018116. Somatotropin_CS.
[Graphical view]
PANTHERiPTHR11417. PTHR11417. 1 hit.
PfamiPF00103. Hormone_1. 1 hit.
[Graphical view]
PRINTSiPR00836. SOMATOTROPIN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00338. SOMATOTROPIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CPQ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSQGSAQKG TLLLLLISNL LFCQNVQPLP ICSAGDCQTS LRELFDRVVI
60 70 80 90 100
LSHYIHTLYT DMFIEFDKQY VQDREFMVKV INDCPTSSLA TPEDKEQALK
110 120 130 140 150
VPPEVLLNLI LSLVQSSSDP LFQLITGVGG IQEAPEYILS RAKEIEEQNK
160 170 180 190 200
QLLEGVEKII SQAYPEAKGN GIYFVWSQLP SLQGVDEESK ILSLRNTIRC
210 220
LRRDSHKVDN FLKVLRCQIA HQNNC
Length:225
Mass (Da):25,425
Last modified:June 1, 2003 - v2
Checksum:i027245C6EEA3E3DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591843 Genomic DNA. No translation available.
AK017520 mRNA. Translation: BAB30786.2.
AK017584 mRNA. Translation: BAB30821.2.
UniGeneiMm.1270.

Genome annotation databases

EnsembliENSMUST00000018061; ENSMUSP00000018061; ENSMUSG00000021342.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591843 Genomic DNA. No translation available.
AK017520 mRNA. Translation: BAB30786.2.
AK017584 mRNA. Translation: BAB30821.2.
UniGeneiMm.1270.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105998.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000018061; ENSMUSP00000018061; ENSMUSG00000021342.

Organism-specific databases

MGIiMGI:97762. Prl.

Phylogenomic databases

eggNOGiENOG410II74. Eukaryota.
ENOG410XU1S. LUCA.
GeneTreeiENSGT00730000110805.
HOVERGENiHBG104895.

Enzyme and pathway databases

ReactomeiR-MMU-1170546. Prolactin receptor signaling.
R-MMU-982772. Growth hormone receptor signaling.

Miscellaneous databases

ChiTaRSiPrl. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021342.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001400. Somatotropin.
IPR018116. Somatotropin_CS.
[Graphical view]
PANTHERiPTHR11417. PTHR11417. 1 hit.
PfamiPF00103. Hormone_1. 1 hit.
[Graphical view]
PRINTSiPR00836. SOMATOTROPIN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00338. SOMATOTROPIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9CPQ0_MOUSE
AccessioniPrimary (citable) accession number: Q9CPQ0
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2003
Last modified: September 7, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.