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Protein

Gastric triacylglycerol lipase

Gene

Lipf

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Triacylglycerol + H2O = diacylglycerol + a carboxylate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei171NucleophileBy similarity1
Active sitei342Charge relay systemPROSITE-ProRule annotation1
Active sitei371Charge relay systemPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-MMU-192456 Digestion of dietary lipid

Protein family/group databases

ESTHERimouse-1lipg Acidic_Lipase
MEROPSiS33.A57

Names & Taxonomyi

Protein namesi
Recommended name:
Gastric triacylglycerol lipase (EC:3.1.1.3)
Short name:
GL
Short name:
Gastric lipase
Gene namesi
Name:Lipf
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1914967 Lipf

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18By similarityAdd BLAST18
ChainiPRO_000001776719 – 395Gastric triacylglycerol lipaseAdd BLAST377

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi33N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi245 ↔ 254By similarity
Glycosylationi270N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9CPP7
PaxDbiQ9CPP7
PRIDEiQ9CPP7

PTM databases

PhosphoSitePlusiQ9CPP7

Expressioni

Gene expression databases

BgeeiENSMUSG00000024768
CleanExiMM_LIPF
GenevisibleiQ9CPP7 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025680

Structurei

3D structure databases

ProteinModelPortaliQ9CPP7
SMRiQ9CPP7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini81 – 376AB hydrolase-1Sequence analysisAdd BLAST296

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2624 Eukaryota
COG0596 LUCA
GeneTreeiENSGT00550000074328
HOVERGENiHBG006265
InParanoidiQ9CPP7
KOiK14452
OMAiTEVCSRE
OrthoDBiEOG091G09AX
PhylomeDBiQ9CPP7
TreeFamiTF315485

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000073 AB_hydrolase_1
IPR025483 Lipase_euk
PfamiView protein in Pfam
PF00561 Abhydrolase_1, 1 hit
PIRSFiPIRSF000862 Steryl_ester_lip, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00120 LIPASE_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CPP7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLLLVTSVL SAFGGAHGLF GKLGPKNPEA NMNVSQMITY WGYPSEEYEV
60 70 80 90 100
VTEDGYILGV YRIPYGKKNS ENIGKRPVAY LQHGLIASAT NWITNLPNNS
110 120 130 140 150
LAFILADAGY DVWLGNSRGN TWSRKNVYYS PDSVEFWAFS FDEMAKYDLP
160 170 180 190 200
ATIDFIVQKT GQEKIHYVGH SQGTTIGFIA FSTNPALAKK IKRFYALAPV
210 220 230 240 250
ATVKYTESPF KKISLIPKFL LKVIFGNKMF MPHNYLDQFL GTEVCSRELL
260 270 280 290 300
DLLCSNALFI FCGFDKKNLN VSRFDVYLGH NPAGTSTQDL FHWAQLAKSG
310 320 330 340 350
KLQAYNWGSP LQNMLHYNQK TPPYYDVSAM TVPIAVWNGG HDILADPQDV
360 370 380 390
AMLLPKLPNL LYHKEILPYN HLDFIWAMDA PQEVYNEIVT MMAED
Length:395
Mass (Da):44,637
Last modified:June 1, 2001 - v1
Checksum:iD3F96B65EA671E34
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti46E → V in BAB26703 (PubMed:16141072).Curated1
Sequence conflicti82Q → L in BAB26350 (PubMed:16141072).Curated1
Sequence conflicti86I → V in BAB26697 (PubMed:16141072).Curated1
Sequence conflicti90T → K in BAB26240 (PubMed:16141072).Curated1
Sequence conflicti151A → T in BAB26746 (PubMed:16141072).Curated1
Sequence conflicti175T → A in BAB26346 (PubMed:16141072).Curated1
Sequence conflicti182S → F in BAB26733 (PubMed:16141072).Curated1
Sequence conflicti182S → F in BAB26746 (PubMed:16141072).Curated1
Sequence conflicti197 – 198LA → FT in BAB26746 (PubMed:16141072).Curated2
Sequence conflicti198A → T in BAB26733 (PubMed:16141072).Curated1
Sequence conflicti200V → I in BAB26725 (PubMed:16141072).Curated1
Sequence conflicti214 – 215SL → HF in BAB26240 (PubMed:16141072).Curated2
Sequence conflicti215L → F in BAB26733 (PubMed:16141072).Curated1
Sequence conflicti217P → H in BAB26784 (PubMed:16141072).Curated1
Sequence conflicti217P → L in BAB26704 (PubMed:16141072).Curated1
Sequence conflicti220L → F in BAB26703 (PubMed:16141072).Curated1
Sequence conflicti220L → F in BAB26766 (PubMed:16141072).Curated1
Sequence conflicti221L → F in BAB26287 (PubMed:16141072).Curated1
Sequence conflicti233H → Y in BAB26350 (PubMed:16141072).Curated1
Sequence conflicti274F → L in BAB26283 (PubMed:16141072).Curated1
Sequence conflicti275D → G in BAB26201 (PubMed:16141072).Curated1
Sequence conflicti275D → G in BAB26711 (PubMed:16141072).Curated1
Sequence conflicti279G → P in BAC36048 (PubMed:16141072).Curated1
Sequence conflicti312Q → R in BAB26556 (PubMed:16141072).Curated1
Sequence conflicti314M → L in BAB26784 (PubMed:16141072).Curated1
Sequence conflicti321T → S in BAB26629 (PubMed:16141072).Curated1
Sequence conflicti373D → Y in BAB26359 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009300 mRNA Translation: BAB26201.1
AK009359 mRNA Translation: BAB26240.1
AK009413 mRNA Translation: BAB26272.1
AK009428 mRNA Translation: BAB26280.1
AK009431 mRNA Translation: BAB26283.1
AK009437 mRNA Translation: BAB26287.1
AK009459 mRNA Translation: BAB26300.1
AK009473 mRNA Translation: BAB26312.1
AK009474 mRNA Translation: BAB26313.1
AK009479 mRNA Translation: BAB26316.1
AK009523 mRNA Translation: BAB26338.1
AK009525 mRNA Translation: BAB26339.1
AK009537 mRNA Translation: BAB26346.1
AK009544 mRNA Translation: BAB26350.1
AK009546 mRNA Translation: BAB26352.1
AK009560 mRNA Translation: BAB26359.1
AK009571 mRNA Translation: BAB26368.1
AK009573 mRNA Translation: BAB26370.1
AK009729 mRNA Translation: BAB26466.1
AK009773 mRNA Translation: BAB26495.1
AK009875 mRNA Translation: BAB26556.1
AK009990 mRNA Translation: BAB26629.1
AK010019 mRNA Translation: BAB26647.1
AK010026 mRNA Translation: BAB26651.1
AK010035 mRNA Translation: BAB26656.1
AK010058 mRNA Translation: BAB26673.1
AK010061 mRNA Translation: BAB26675.1
AK010093 mRNA Translation: BAB26697.1
AK010103 mRNA Translation: BAB26703.1
AK010106 mRNA Translation: BAB26704.1
AK010116 mRNA Translation: BAB26711.1
AK010124 mRNA Translation: BAB26715.1
AK010125 mRNA Translation: BAB26716.1
AK010139 mRNA Translation: BAB26725.1
AK010148 mRNA Translation: BAB26733.1
AK010173 mRNA Translation: BAB26746.1
AK010203 mRNA Translation: BAB26766.1
AK010231 mRNA Translation: BAB26784.1
AK010236 mRNA Translation: BAB26787.1
AK075910 mRNA Translation: BAC36048.1
BC061067 mRNA Translation: AAH61067.1
CCDSiCCDS29754.1
RefSeqiNP_080610.1, NM_026334.3
XP_017173769.1, XM_017318280.1
UniGeneiMm.329816

Genome annotation databases

EnsembliENSMUST00000025680; ENSMUSP00000025680; ENSMUSG00000024768
GeneIDi67717
KEGGimmu:67717
UCSCiuc008hfw.1 mouse

Similar proteinsi

Entry informationi

Entry nameiLIPG_MOUSE
AccessioniPrimary (citable) accession number: Q9CPP7
Secondary accession number(s): Q8BK78
, Q9CPP8, Q9D6L1, Q9D6L9, Q9D6M9, Q9D6N8, Q9D6P3, Q9D6Q2, Q9D6Q3, Q9D6Q6, Q9D6S5, Q9D6T5, Q9D6X0, Q9D760, Q9D766, Q9D767, Q9D796, Q9D798, Q9D7C5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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