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Protein

Gastric triacylglycerol lipase

Gene

Lipf

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Triacylglycerol + H2O = diacylglycerol + a carboxylate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei171 – 1711NucleophileBy similarity
Active sitei342 – 3421Charge relay systemPROSITE-ProRule annotation
Active sitei371 – 3711Charge relay systemPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Protein family/group databases

ESTHERimouse-1lipg. Acidic_Lipase.
MEROPSiS33.A57.

Names & Taxonomyi

Protein namesi
Recommended name:
Gastric triacylglycerol lipase (EC:3.1.1.3)
Short name:
GL
Short name:
Gastric lipase
Gene namesi
Name:Lipf
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1914967. Lipf.

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818By similarityAdd
BLAST
Chaini19 – 395377Gastric triacylglycerol lipasePRO_0000017767Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi33 – 331N-linked (GlcNAc...)Sequence analysis
Disulfide bondi245 ↔ 254By similarity
Glycosylationi270 – 2701N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9CPP7.
PaxDbiQ9CPP7.
PRIDEiQ9CPP7.

PTM databases

PhosphoSiteiQ9CPP7.

Expressioni

Gene expression databases

BgeeiQ9CPP7.
CleanExiMM_LIPF.
GenevisibleiQ9CPP7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025680.

Structurei

3D structure databases

ProteinModelPortaliQ9CPP7.
SMRiQ9CPP7. Positions 20-395.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2624. Eukaryota.
COG0596. LUCA.
GeneTreeiENSGT00550000074328.
HOVERGENiHBG006265.
InParanoidiQ9CPP7.
KOiK14452.
OMAiDVYLGHN.
OrthoDBiEOG71RXJN.
PhylomeDBiQ9CPP7.
TreeFamiTF315485.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR025483. Lipase_euk.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000862. Steryl_ester_lip. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CPP7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLLLVTSVL SAFGGAHGLF GKLGPKNPEA NMNVSQMITY WGYPSEEYEV
60 70 80 90 100
VTEDGYILGV YRIPYGKKNS ENIGKRPVAY LQHGLIASAT NWITNLPNNS
110 120 130 140 150
LAFILADAGY DVWLGNSRGN TWSRKNVYYS PDSVEFWAFS FDEMAKYDLP
160 170 180 190 200
ATIDFIVQKT GQEKIHYVGH SQGTTIGFIA FSTNPALAKK IKRFYALAPV
210 220 230 240 250
ATVKYTESPF KKISLIPKFL LKVIFGNKMF MPHNYLDQFL GTEVCSRELL
260 270 280 290 300
DLLCSNALFI FCGFDKKNLN VSRFDVYLGH NPAGTSTQDL FHWAQLAKSG
310 320 330 340 350
KLQAYNWGSP LQNMLHYNQK TPPYYDVSAM TVPIAVWNGG HDILADPQDV
360 370 380 390
AMLLPKLPNL LYHKEILPYN HLDFIWAMDA PQEVYNEIVT MMAED
Length:395
Mass (Da):44,637
Last modified:June 1, 2001 - v1
Checksum:iD3F96B65EA671E34
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti46 – 461E → V in BAB26703 (PubMed:16141072).Curated
Sequence conflicti82 – 821Q → L in BAB26350 (PubMed:16141072).Curated
Sequence conflicti86 – 861I → V in BAB26697 (PubMed:16141072).Curated
Sequence conflicti90 – 901T → K in BAB26240 (PubMed:16141072).Curated
Sequence conflicti151 – 1511A → T in BAB26746 (PubMed:16141072).Curated
Sequence conflicti175 – 1751T → A in BAB26346 (PubMed:16141072).Curated
Sequence conflicti182 – 1821S → F in BAB26733 (PubMed:16141072).Curated
Sequence conflicti182 – 1821S → F in BAB26746 (PubMed:16141072).Curated
Sequence conflicti197 – 1982LA → FT in BAB26746 (PubMed:16141072).Curated
Sequence conflicti198 – 1981A → T in BAB26733 (PubMed:16141072).Curated
Sequence conflicti200 – 2001V → I in BAB26725 (PubMed:16141072).Curated
Sequence conflicti214 – 2152SL → HF in BAB26240 (PubMed:16141072).Curated
Sequence conflicti215 – 2151L → F in BAB26733 (PubMed:16141072).Curated
Sequence conflicti217 – 2171P → H in BAB26784 (PubMed:16141072).Curated
Sequence conflicti217 – 2171P → L in BAB26704 (PubMed:16141072).Curated
Sequence conflicti220 – 2201L → F in BAB26703 (PubMed:16141072).Curated
Sequence conflicti220 – 2201L → F in BAB26766 (PubMed:16141072).Curated
Sequence conflicti221 – 2211L → F in BAB26287 (PubMed:16141072).Curated
Sequence conflicti233 – 2331H → Y in BAB26350 (PubMed:16141072).Curated
Sequence conflicti274 – 2741F → L in BAB26283 (PubMed:16141072).Curated
Sequence conflicti275 – 2751D → G in BAB26201 (PubMed:16141072).Curated
Sequence conflicti275 – 2751D → G in BAB26711 (PubMed:16141072).Curated
Sequence conflicti279 – 2791G → P in BAC36048 (PubMed:16141072).Curated
Sequence conflicti312 – 3121Q → R in BAB26556 (PubMed:16141072).Curated
Sequence conflicti314 – 3141M → L in BAB26784 (PubMed:16141072).Curated
Sequence conflicti321 – 3211T → S in BAB26629 (PubMed:16141072).Curated
Sequence conflicti373 – 3731D → Y in BAB26359 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009300 mRNA. Translation: BAB26201.1.
AK009359 mRNA. Translation: BAB26240.1.
AK009413 mRNA. Translation: BAB26272.1.
AK009428 mRNA. Translation: BAB26280.1.
AK009431 mRNA. Translation: BAB26283.1.
AK009437 mRNA. Translation: BAB26287.1.
AK009459 mRNA. Translation: BAB26300.1.
AK009473 mRNA. Translation: BAB26312.1.
AK009474 mRNA. Translation: BAB26313.1.
AK009479 mRNA. Translation: BAB26316.1.
AK009523 mRNA. Translation: BAB26338.1.
AK009525 mRNA. Translation: BAB26339.1.
AK009537 mRNA. Translation: BAB26346.1.
AK009544 mRNA. Translation: BAB26350.1.
AK009546 mRNA. Translation: BAB26352.1.
AK009560 mRNA. Translation: BAB26359.1.
AK009571 mRNA. Translation: BAB26368.1.
AK009573 mRNA. Translation: BAB26370.1.
AK009729 mRNA. Translation: BAB26466.1.
AK009773 mRNA. Translation: BAB26495.1.
AK009875 mRNA. Translation: BAB26556.1.
AK009990 mRNA. Translation: BAB26629.1.
AK010019 mRNA. Translation: BAB26647.1.
AK010026 mRNA. Translation: BAB26651.1.
AK010035 mRNA. Translation: BAB26656.1.
AK010058 mRNA. Translation: BAB26673.1.
AK010061 mRNA. Translation: BAB26675.1.
AK010093 mRNA. Translation: BAB26697.1.
AK010103 mRNA. Translation: BAB26703.1.
AK010106 mRNA. Translation: BAB26704.1.
AK010116 mRNA. Translation: BAB26711.1.
AK010124 mRNA. Translation: BAB26715.1.
AK010125 mRNA. Translation: BAB26716.1.
AK010139 mRNA. Translation: BAB26725.1.
AK010148 mRNA. Translation: BAB26733.1.
AK010173 mRNA. Translation: BAB26746.1.
AK010203 mRNA. Translation: BAB26766.1.
AK010231 mRNA. Translation: BAB26784.1.
AK010236 mRNA. Translation: BAB26787.1.
AK075910 mRNA. Translation: BAC36048.1.
BC061067 mRNA. Translation: AAH61067.1.
CCDSiCCDS29754.1.
RefSeqiNP_080610.1. NM_026334.3.
UniGeneiMm.329816.

Genome annotation databases

EnsembliENSMUST00000025680; ENSMUSP00000025680; ENSMUSG00000024768.
GeneIDi67717.
KEGGimmu:67717.
UCSCiuc008hfw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009300 mRNA. Translation: BAB26201.1.
AK009359 mRNA. Translation: BAB26240.1.
AK009413 mRNA. Translation: BAB26272.1.
AK009428 mRNA. Translation: BAB26280.1.
AK009431 mRNA. Translation: BAB26283.1.
AK009437 mRNA. Translation: BAB26287.1.
AK009459 mRNA. Translation: BAB26300.1.
AK009473 mRNA. Translation: BAB26312.1.
AK009474 mRNA. Translation: BAB26313.1.
AK009479 mRNA. Translation: BAB26316.1.
AK009523 mRNA. Translation: BAB26338.1.
AK009525 mRNA. Translation: BAB26339.1.
AK009537 mRNA. Translation: BAB26346.1.
AK009544 mRNA. Translation: BAB26350.1.
AK009546 mRNA. Translation: BAB26352.1.
AK009560 mRNA. Translation: BAB26359.1.
AK009571 mRNA. Translation: BAB26368.1.
AK009573 mRNA. Translation: BAB26370.1.
AK009729 mRNA. Translation: BAB26466.1.
AK009773 mRNA. Translation: BAB26495.1.
AK009875 mRNA. Translation: BAB26556.1.
AK009990 mRNA. Translation: BAB26629.1.
AK010019 mRNA. Translation: BAB26647.1.
AK010026 mRNA. Translation: BAB26651.1.
AK010035 mRNA. Translation: BAB26656.1.
AK010058 mRNA. Translation: BAB26673.1.
AK010061 mRNA. Translation: BAB26675.1.
AK010093 mRNA. Translation: BAB26697.1.
AK010103 mRNA. Translation: BAB26703.1.
AK010106 mRNA. Translation: BAB26704.1.
AK010116 mRNA. Translation: BAB26711.1.
AK010124 mRNA. Translation: BAB26715.1.
AK010125 mRNA. Translation: BAB26716.1.
AK010139 mRNA. Translation: BAB26725.1.
AK010148 mRNA. Translation: BAB26733.1.
AK010173 mRNA. Translation: BAB26746.1.
AK010203 mRNA. Translation: BAB26766.1.
AK010231 mRNA. Translation: BAB26784.1.
AK010236 mRNA. Translation: BAB26787.1.
AK075910 mRNA. Translation: BAC36048.1.
BC061067 mRNA. Translation: AAH61067.1.
CCDSiCCDS29754.1.
RefSeqiNP_080610.1. NM_026334.3.
UniGeneiMm.329816.

3D structure databases

ProteinModelPortaliQ9CPP7.
SMRiQ9CPP7. Positions 20-395.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025680.

Protein family/group databases

ESTHERimouse-1lipg. Acidic_Lipase.
MEROPSiS33.A57.

PTM databases

PhosphoSiteiQ9CPP7.

Proteomic databases

MaxQBiQ9CPP7.
PaxDbiQ9CPP7.
PRIDEiQ9CPP7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025680; ENSMUSP00000025680; ENSMUSG00000024768.
GeneIDi67717.
KEGGimmu:67717.
UCSCiuc008hfw.1. mouse.

Organism-specific databases

CTDi8513.
MGIiMGI:1914967. Lipf.

Phylogenomic databases

eggNOGiKOG2624. Eukaryota.
COG0596. LUCA.
GeneTreeiENSGT00550000074328.
HOVERGENiHBG006265.
InParanoidiQ9CPP7.
KOiK14452.
OMAiDVYLGHN.
OrthoDBiEOG71RXJN.
PhylomeDBiQ9CPP7.
TreeFamiTF315485.

Miscellaneous databases

PROiQ9CPP7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CPP7.
CleanExiMM_LIPF.
GenevisibleiQ9CPP7. MM.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR025483. Lipase_euk.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000862. Steryl_ester_lip. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Tongue.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart and Lung.

Entry informationi

Entry nameiLIPG_MOUSE
AccessioniPrimary (citable) accession number: Q9CPP7
Secondary accession number(s): Q8BK78
, Q9CPP8, Q9D6L1, Q9D6L9, Q9D6M9, Q9D6N8, Q9D6P3, Q9D6Q2, Q9D6Q3, Q9D6Q6, Q9D6S5, Q9D6T5, Q9D6X0, Q9D760, Q9D766, Q9D767, Q9D796, Q9D798, Q9D7C5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.