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Protein

Gastric triacylglycerol lipase

Gene

Lipf

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Triacylglycerol + H2O = diacylglycerol + a carboxylate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei171NucleophileBy similarity1
Active sitei342Charge relay systemPROSITE-ProRule annotation1
Active sitei371Charge relay systemPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Protein family/group databases

ESTHERimouse-1lipg. Acidic_Lipase.
MEROPSiS33.A57.

Names & Taxonomyi

Protein namesi
Recommended name:
Gastric triacylglycerol lipase (EC:3.1.1.3)
Short name:
GL
Short name:
Gastric lipase
Gene namesi
Name:Lipf
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1914967. Lipf.

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18By similarityAdd BLAST18
ChainiPRO_000001776719 – 395Gastric triacylglycerol lipaseAdd BLAST377

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi33N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi245 ↔ 254By similarity
Glycosylationi270N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9CPP7.
PaxDbiQ9CPP7.
PRIDEiQ9CPP7.

PTM databases

PhosphoSitePlusiQ9CPP7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024768.
CleanExiMM_LIPF.
GenevisibleiQ9CPP7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025680.

Structurei

3D structure databases

ProteinModelPortaliQ9CPP7.
SMRiQ9CPP7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini81 – 376AB hydrolase-1Sequence analysisAdd BLAST296

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2624. Eukaryota.
COG0596. LUCA.
GeneTreeiENSGT00550000074328.
HOVERGENiHBG006265.
InParanoidiQ9CPP7.
KOiK14452.
OMAiDVYLGHN.
OrthoDBiEOG091G09AX.
PhylomeDBiQ9CPP7.
TreeFamiTF315485.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR025483. Lipase_euk.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000862. Steryl_ester_lip. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CPP7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLLLVTSVL SAFGGAHGLF GKLGPKNPEA NMNVSQMITY WGYPSEEYEV
60 70 80 90 100
VTEDGYILGV YRIPYGKKNS ENIGKRPVAY LQHGLIASAT NWITNLPNNS
110 120 130 140 150
LAFILADAGY DVWLGNSRGN TWSRKNVYYS PDSVEFWAFS FDEMAKYDLP
160 170 180 190 200
ATIDFIVQKT GQEKIHYVGH SQGTTIGFIA FSTNPALAKK IKRFYALAPV
210 220 230 240 250
ATVKYTESPF KKISLIPKFL LKVIFGNKMF MPHNYLDQFL GTEVCSRELL
260 270 280 290 300
DLLCSNALFI FCGFDKKNLN VSRFDVYLGH NPAGTSTQDL FHWAQLAKSG
310 320 330 340 350
KLQAYNWGSP LQNMLHYNQK TPPYYDVSAM TVPIAVWNGG HDILADPQDV
360 370 380 390
AMLLPKLPNL LYHKEILPYN HLDFIWAMDA PQEVYNEIVT MMAED
Length:395
Mass (Da):44,637
Last modified:June 1, 2001 - v1
Checksum:iD3F96B65EA671E34
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti46E → V in BAB26703 (PubMed:16141072).Curated1
Sequence conflicti82Q → L in BAB26350 (PubMed:16141072).Curated1
Sequence conflicti86I → V in BAB26697 (PubMed:16141072).Curated1
Sequence conflicti90T → K in BAB26240 (PubMed:16141072).Curated1
Sequence conflicti151A → T in BAB26746 (PubMed:16141072).Curated1
Sequence conflicti175T → A in BAB26346 (PubMed:16141072).Curated1
Sequence conflicti182S → F in BAB26733 (PubMed:16141072).Curated1
Sequence conflicti182S → F in BAB26746 (PubMed:16141072).Curated1
Sequence conflicti197 – 198LA → FT in BAB26746 (PubMed:16141072).Curated2
Sequence conflicti198A → T in BAB26733 (PubMed:16141072).Curated1
Sequence conflicti200V → I in BAB26725 (PubMed:16141072).Curated1
Sequence conflicti214 – 215SL → HF in BAB26240 (PubMed:16141072).Curated2
Sequence conflicti215L → F in BAB26733 (PubMed:16141072).Curated1
Sequence conflicti217P → H in BAB26784 (PubMed:16141072).Curated1
Sequence conflicti217P → L in BAB26704 (PubMed:16141072).Curated1
Sequence conflicti220L → F in BAB26703 (PubMed:16141072).Curated1
Sequence conflicti220L → F in BAB26766 (PubMed:16141072).Curated1
Sequence conflicti221L → F in BAB26287 (PubMed:16141072).Curated1
Sequence conflicti233H → Y in BAB26350 (PubMed:16141072).Curated1
Sequence conflicti274F → L in BAB26283 (PubMed:16141072).Curated1
Sequence conflicti275D → G in BAB26201 (PubMed:16141072).Curated1
Sequence conflicti275D → G in BAB26711 (PubMed:16141072).Curated1
Sequence conflicti279G → P in BAC36048 (PubMed:16141072).Curated1
Sequence conflicti312Q → R in BAB26556 (PubMed:16141072).Curated1
Sequence conflicti314M → L in BAB26784 (PubMed:16141072).Curated1
Sequence conflicti321T → S in BAB26629 (PubMed:16141072).Curated1
Sequence conflicti373D → Y in BAB26359 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009300 mRNA. Translation: BAB26201.1.
AK009359 mRNA. Translation: BAB26240.1.
AK009413 mRNA. Translation: BAB26272.1.
AK009428 mRNA. Translation: BAB26280.1.
AK009431 mRNA. Translation: BAB26283.1.
AK009437 mRNA. Translation: BAB26287.1.
AK009459 mRNA. Translation: BAB26300.1.
AK009473 mRNA. Translation: BAB26312.1.
AK009474 mRNA. Translation: BAB26313.1.
AK009479 mRNA. Translation: BAB26316.1.
AK009523 mRNA. Translation: BAB26338.1.
AK009525 mRNA. Translation: BAB26339.1.
AK009537 mRNA. Translation: BAB26346.1.
AK009544 mRNA. Translation: BAB26350.1.
AK009546 mRNA. Translation: BAB26352.1.
AK009560 mRNA. Translation: BAB26359.1.
AK009571 mRNA. Translation: BAB26368.1.
AK009573 mRNA. Translation: BAB26370.1.
AK009729 mRNA. Translation: BAB26466.1.
AK009773 mRNA. Translation: BAB26495.1.
AK009875 mRNA. Translation: BAB26556.1.
AK009990 mRNA. Translation: BAB26629.1.
AK010019 mRNA. Translation: BAB26647.1.
AK010026 mRNA. Translation: BAB26651.1.
AK010035 mRNA. Translation: BAB26656.1.
AK010058 mRNA. Translation: BAB26673.1.
AK010061 mRNA. Translation: BAB26675.1.
AK010093 mRNA. Translation: BAB26697.1.
AK010103 mRNA. Translation: BAB26703.1.
AK010106 mRNA. Translation: BAB26704.1.
AK010116 mRNA. Translation: BAB26711.1.
AK010124 mRNA. Translation: BAB26715.1.
AK010125 mRNA. Translation: BAB26716.1.
AK010139 mRNA. Translation: BAB26725.1.
AK010148 mRNA. Translation: BAB26733.1.
AK010173 mRNA. Translation: BAB26746.1.
AK010203 mRNA. Translation: BAB26766.1.
AK010231 mRNA. Translation: BAB26784.1.
AK010236 mRNA. Translation: BAB26787.1.
AK075910 mRNA. Translation: BAC36048.1.
BC061067 mRNA. Translation: AAH61067.1.
CCDSiCCDS29754.1.
RefSeqiNP_080610.1. NM_026334.3.
XP_017173769.1. XM_017318280.1.
UniGeneiMm.329816.

Genome annotation databases

EnsembliENSMUST00000025680; ENSMUSP00000025680; ENSMUSG00000024768.
GeneIDi67717.
KEGGimmu:67717.
UCSCiuc008hfw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009300 mRNA. Translation: BAB26201.1.
AK009359 mRNA. Translation: BAB26240.1.
AK009413 mRNA. Translation: BAB26272.1.
AK009428 mRNA. Translation: BAB26280.1.
AK009431 mRNA. Translation: BAB26283.1.
AK009437 mRNA. Translation: BAB26287.1.
AK009459 mRNA. Translation: BAB26300.1.
AK009473 mRNA. Translation: BAB26312.1.
AK009474 mRNA. Translation: BAB26313.1.
AK009479 mRNA. Translation: BAB26316.1.
AK009523 mRNA. Translation: BAB26338.1.
AK009525 mRNA. Translation: BAB26339.1.
AK009537 mRNA. Translation: BAB26346.1.
AK009544 mRNA. Translation: BAB26350.1.
AK009546 mRNA. Translation: BAB26352.1.
AK009560 mRNA. Translation: BAB26359.1.
AK009571 mRNA. Translation: BAB26368.1.
AK009573 mRNA. Translation: BAB26370.1.
AK009729 mRNA. Translation: BAB26466.1.
AK009773 mRNA. Translation: BAB26495.1.
AK009875 mRNA. Translation: BAB26556.1.
AK009990 mRNA. Translation: BAB26629.1.
AK010019 mRNA. Translation: BAB26647.1.
AK010026 mRNA. Translation: BAB26651.1.
AK010035 mRNA. Translation: BAB26656.1.
AK010058 mRNA. Translation: BAB26673.1.
AK010061 mRNA. Translation: BAB26675.1.
AK010093 mRNA. Translation: BAB26697.1.
AK010103 mRNA. Translation: BAB26703.1.
AK010106 mRNA. Translation: BAB26704.1.
AK010116 mRNA. Translation: BAB26711.1.
AK010124 mRNA. Translation: BAB26715.1.
AK010125 mRNA. Translation: BAB26716.1.
AK010139 mRNA. Translation: BAB26725.1.
AK010148 mRNA. Translation: BAB26733.1.
AK010173 mRNA. Translation: BAB26746.1.
AK010203 mRNA. Translation: BAB26766.1.
AK010231 mRNA. Translation: BAB26784.1.
AK010236 mRNA. Translation: BAB26787.1.
AK075910 mRNA. Translation: BAC36048.1.
BC061067 mRNA. Translation: AAH61067.1.
CCDSiCCDS29754.1.
RefSeqiNP_080610.1. NM_026334.3.
XP_017173769.1. XM_017318280.1.
UniGeneiMm.329816.

3D structure databases

ProteinModelPortaliQ9CPP7.
SMRiQ9CPP7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025680.

Protein family/group databases

ESTHERimouse-1lipg. Acidic_Lipase.
MEROPSiS33.A57.

PTM databases

PhosphoSitePlusiQ9CPP7.

Proteomic databases

MaxQBiQ9CPP7.
PaxDbiQ9CPP7.
PRIDEiQ9CPP7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025680; ENSMUSP00000025680; ENSMUSG00000024768.
GeneIDi67717.
KEGGimmu:67717.
UCSCiuc008hfw.1. mouse.

Organism-specific databases

CTDi8513.
MGIiMGI:1914967. Lipf.

Phylogenomic databases

eggNOGiKOG2624. Eukaryota.
COG0596. LUCA.
GeneTreeiENSGT00550000074328.
HOVERGENiHBG006265.
InParanoidiQ9CPP7.
KOiK14452.
OMAiDVYLGHN.
OrthoDBiEOG091G09AX.
PhylomeDBiQ9CPP7.
TreeFamiTF315485.

Miscellaneous databases

PROiQ9CPP7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024768.
CleanExiMM_LIPF.
GenevisibleiQ9CPP7. MM.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR025483. Lipase_euk.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000862. Steryl_ester_lip. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLIPG_MOUSE
AccessioniPrimary (citable) accession number: Q9CPP7
Secondary accession number(s): Q8BK78
, Q9CPP8, Q9D6L1, Q9D6L9, Q9D6M9, Q9D6N8, Q9D6P3, Q9D6Q2, Q9D6Q3, Q9D6Q6, Q9D6S5, Q9D6T5, Q9D6X0, Q9D760, Q9D766, Q9D767, Q9D796, Q9D798, Q9D7C5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.