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Protein

Insulin-like growth factor 2 mRNA-binding protein 3

Gene

Igf2bp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation (By similarity). Binds to beta-actin/ACTB and MYC transcripts (By similarity). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processmRNA transport, Translation regulation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor 2 mRNA-binding protein 3
Short name:
IGF2 mRNA-binding protein 3
Short name:
IMP-3
Short name:
mIMP-3
Alternative name(s):
IGF-II mRNA-binding protein 3
VICKZ family member 3
Gene namesi
Name:Igf2bp3
Synonyms:Vickz3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1890359 Igf2bp3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002825391 – 579Insulin-like growth factor 2 mRNA-binding protein 3Add BLAST579

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei165PhosphoserineCombined sources1
Modified residuei184PhosphoserineBy similarity1
Cross-linki450Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki475Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei528PhosphothreonineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9CPN8
MaxQBiQ9CPN8
PaxDbiQ9CPN8
PeptideAtlasiQ9CPN8
PRIDEiQ9CPN8

PTM databases

iPTMnetiQ9CPN8
PhosphoSitePlusiQ9CPN8

Expressioni

Tissue specificityi

Expressed in oocytes, spermatogonia and spermatocytes (at protein level).3 Publications

Developmental stagei

Expressed in zygotes and blastocysts (at protein level). Expressed in gonads at 12.5 and 14.5 dpc (at protein level). Expressed in germ cells at 16.5 dpc (at protein level). Expressed in brain at 10.5 dpc and declining towards birth (at protein level). Expressed during fetal development at 7, 9.5, 10.5, 12.5, 14.5 and 17.5 dpc and declining towards birth.4 Publications

Gene expression databases

BgeeiENSMUSG00000029814
GenevisibleiQ9CPN8 MM

Interactioni

Subunit structurei

Homodimer and multimer. Interacts with IGF2BP1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi228262, 2 interactors
IntActiQ9CPN8, 3 interactors
MINTiQ9CPN8
STRINGi10090.ENSMUSP00000031838

Structurei

3D structure databases

ProteinModelPortaliQ9CPN8
SMRiQ9CPN8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 75RRM 1PROSITE-ProRule annotationAdd BLAST74
Domaini81 – 156RRM 2PROSITE-ProRule annotationAdd BLAST76
Domaini195 – 260KH 1PROSITE-ProRule annotationAdd BLAST66
Domaini276 – 343KH 2PROSITE-ProRule annotationAdd BLAST68
Domaini405 – 470KH 3PROSITE-ProRule annotationAdd BLAST66
Domaini487 – 553KH 4PROSITE-ProRule annotationAdd BLAST67

Domaini

All KH domains contribute binding to target mRNA. They are also required for RNA-dependent homo- and heterooligomerization. The integrity of KH domains seems not to be required for localization to stress granules (By similarity).By similarity

Sequence similaritiesi

Belongs to the RRM IMP/VICKZ family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2193 Eukaryota
ENOG410ZKB4 LUCA
GeneTreeiENSGT00530000063171
HOGENOMiHOG000000675
HOVERGENiHBG052725
InParanoidiQ9CPN8
KOiK13197
OMAiGPFYSVQ
OrthoDBiEOG091G17T1
PhylomeDBiQ9CPN8
TreeFamiTF320229

Family and domain databases

CDDicd12630 RRM2_IGF2BP3, 1 hit
Gene3Di3.30.1370.10, 2 hits
3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR034844 IGF2BP3_RRM2
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00013 KH_1, 4 hits
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00322 KH, 4 hits
SM00360 RRM, 2 hits
SUPFAMiSSF54791 SSF54791, 4 hits
SSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 4 hits
PS50102 RRM, 2 hits

Sequencei

Sequence statusi: Complete.

Q9CPN8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKLYIGNLS DHAGPADLES VFKDAKIPVA GPFLVKTGYA FVDCPDEGWA
60 70 80 90 100
LKAIEALSGK MELHGKPMEV EHSVPKRQRI RKLQIRNIPP HLQWEVLDSL
110 120 130 140 150
LVQYGVVESC EQVNTDSETA VVNVTYSSKD QARQALDKLN GFQLENFTLK
160 170 180 190 200
VAYIPDETAA QQNPSPQLRG RRGPGQRGSS RQASPGSVSK QKPCDLPLRL
210 220 230 240 250
LVPTQFVGAI IGKEGATIRN ITKQTQSKID VHRKENTGAA EKSITILSTP
260 270 280 290 300
EGTSAACKSI LEIMHKEAQD IKFTEEIPLK ILAHNNFVGR LIGKEGRNLK
310 320 330 340 350
KIEQDTDTKI TISPLQELTL YNPERTITVK GSVETCAKAE EEIMKKIRES
360 370 380 390 400
YENDIASMNL QAHLIPGLNL NALGLFPPTS GMPPPTSGPP STLTPPYPQF
410 420 430 440 450
EQSETETVHL FIPALSVGAI IGKQGQHIKQ LSRFAGASIK IAPAEAPDAK
460 470 480 490 500
VRMVIITGPP EAQFKAQGRI YGKIKEENFV SPKEEVKLEA HIRVPSFAAG
510 520 530 540 550
RVIGKGGKTV NELQSLSSAE VVVPRDQTPD ENDQVVVKIT GHFYACQVAQ
560 570
RKIQEILTQV KQHQQQKALQ SGPPQSRRK
Length:579
Mass (Da):63,575
Last modified:June 1, 2001 - v1
Checksum:iCABD9A4355B392B7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti161Q → R in BAE27710 (PubMed:16141072).Curated1
Sequence conflicti363H → N in BAC40370 (PubMed:16141072).Curated1
Sequence conflicti574P → H in BAE27710 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK088465 mRNA Translation: BAC40370.1
AK011689 mRNA Translation: BAB27779.1
AK147140 mRNA Translation: BAE27710.1
BC045138 mRNA Translation: AAH45138.1
BC049082 mRNA Translation: AAH49082.1
CCDSiCCDS39485.1
RefSeqiNP_076159.3, NM_023670.3
UniGeneiMm.281018

Genome annotation databases

EnsembliENSMUST00000031838; ENSMUSP00000031838; ENSMUSG00000029814
GeneIDi140488
KEGGimmu:140488
UCSCiuc009bwi.2 mouse

Similar proteinsi

Entry informationi

Entry nameiIF2B3_MOUSE
AccessioniPrimary (citable) accession number: Q9CPN8
Secondary accession number(s): Q3UHZ6, Q8C2J9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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