Reviewed, UniProtKB/Swiss-Prot Q9CPH0 (NAGZ_PASMU)

Names and origin

Protein names

Recommended name:
    Beta-hexosaminidase
    EC=3.2.1.52
Alternative name(s):
    N-acetyl-beta-glucosaminidase
    Beta-N-acetylhexosaminidase

Gene names

Name:	nagZ
Ordered Locus Names:	PM0071

Organism

Pasteurella multocida [Complete proteome] [HAMAP]

Taxonomic identifier

747 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Pasteurella

Protein attributes

Sequence length	351 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides By similarity.
Catalytic activity	Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. HAMAP MF_00364
Pathway	Cell wall biogenesis; peptidoglycan recycling. HAMAP MF_00364
Subunit structure	Monomer Potential.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.

Ontologies

Keywords
Biological process	Cell cycle Cell division Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cytoplasm
Molecular function	Glycosidase Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan turnover Inferred from electronic annotation. Source: HAMAP regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	beta-N-acetylhexosaminidase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 351	351	Beta-hexosaminidase HAMAP MF_00364		PRO_0000210793
Sites
	Active site	249	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9CPH0-1 [UniParc]. Last modified May 4, 2001. Version 1. Checksum: 320783A173611205	FASTA	351	39,667
	10 20 30 40 50 60 MSTLLIDLQG QELSQEEVEL LSHPLVAGLI LFTRNFHDRA QMQALIQSIR QRVKKPLLIT 70 80 90 100 110 120 VDQEGGRVQR FREGFTQLPA MQAFACLIDD PVQQTNMAQQ AGWQMAAEMT ALGIDLSFAP 130 140 150 160 170 180 VLDLGHQCQA IGDRSFHSQA EMTLNLASAF IDGMHQVGMA ATGKHFPGHG HVIADSHLET 190 200 210 220 230 240 PYDERPKQQI FAQDIQPFQQ LIQQNMLNAI MPAHVIYSQC DPQPASGSAY WLKQVLRQQL 250 260 270 280 290 300 GFNGAIFSDD LGMKGAGFMG NFVQRCEQSL QAGCDLLLLC NEREGVIQVL DNLKLSETEP 310 320 330 340 350 HFALRQQRLQ QLFKRKTIRW SELEATSRWL ENRKILTALQ QRWLDNKANK H

References

[1]	"Complete genomic sequence of Pasteurella multocida Pm70." May B.J., Zhang Q., Li L.L., Paustian M.L., Whittam T.S., Kapur V. Proc. Natl. Acad. Sci. U.S.A. 98:3460-3465(2001) [PubMed: 11248100] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Pm70.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE004439 Genomic DNA. Translation: AAK02155.1.
RefSeq	NP_245008.1.
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	GH3. Glycoside Hydrolase Family 3.
Genome annotation databases
GeneID	1243418.
GenomeReviews	Gene locus PM0071 in contig AE004439_GR.
KEGG	pmu:PM0071.
NMPDR	fig|272843.1.peg.71.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9CPH0.
OMA	IVTAGCD.
Enzyme and pathway databases
BRENDA	3.2.1.52. 258935.
Family and domain databases
HAMAP	MF_00364. [Tree]
InterPro	IPR019800. Glyco_hydro_3_AS. IPR001764. Glyco_hydro_3_N. [Graphical view]
Gene3D	G3DSA:3.20.20.300. Glyco_hydro_3_N. 1 hit.
Pfam	PF00933. Glyco_hydro_3. 1 hit. [Graphical view]
PROSITE	PS00775. GLYCOSYL_HYDROL_F3. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NAGZ_PASMU

Accession

Primary (citable) accession number: Q9CPH0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 4, 2001
Last sequence update:	May 4, 2001
Last modified:	November 3, 2009
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)