Q9CPH0 (NAGZ_PASMU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Beta-hexosaminidase
EC=3.2.1.52

Alternative name(s):
Beta-N-acetylhexosaminidase
N-acetyl-beta-glucosaminidase

Gene names

Name:	nagZ
Ordered Locus Names:	PM0071

Organism

Pasteurella multocida (strain Pm70) [Complete proteome] [HAMAP]

Taxonomic identifier

272843 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Pasteurella › Pasteurella multocida › Pasteurella multocida subsp. multocida

Protein attributes

Sequence length	351 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides By similarity. HAMAP-Rule MF_00364
Catalytic activity	Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. HAMAP-Rule MF_00364
Pathway	Cell wall biogenesis; peptidoglycan recycling. HAMAP-Rule MF_00364
Subunit structure	Monomer Potential.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.

Ontologies

Keywords
Biological process	Cell cycle Cell division Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cytoplasm
Molecular function	Glycosidase Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan turnover Inferred from electronic annotation. Source: HAMAP regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	beta-N-acetylhexosaminidase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 351	351	Beta-hexosaminidase HAMAP-Rule MF_00364		PRO_0000210793
Sites
	Active site	249	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9CPH0 [UniParc]. Last modified May 4, 2001. Version 1. Checksum: 320783A173611205	FASTA	351	39,667
	10 20 30 40 50 60 MSTLLIDLQG QELSQEEVEL LSHPLVAGLI LFTRNFHDRA QMQALIQSIR QRVKKPLLIT 70 80 90 100 110 120 VDQEGGRVQR FREGFTQLPA MQAFACLIDD PVQQTNMAQQ AGWQMAAEMT ALGIDLSFAP 130 140 150 160 170 180 VLDLGHQCQA IGDRSFHSQA EMTLNLASAF IDGMHQVGMA ATGKHFPGHG HVIADSHLET 190 200 210 220 230 240 PYDERPKQQI FAQDIQPFQQ LIQQNMLNAI MPAHVIYSQC DPQPASGSAY WLKQVLRQQL 250 260 270 280 290 300 GFNGAIFSDD LGMKGAGFMG NFVQRCEQSL QAGCDLLLLC NEREGVIQVL DNLKLSETEP 310 320 330 340 350 HFALRQQRLQ QLFKRKTIRW SELEATSRWL ENRKILTALQ QRWLDNKANK H

References

[1]	"Complete genomic sequence of Pasteurella multocida Pm70." May B.J., Zhang Q., Li L.L., Paustian M.L., Whittam T.S., Kapur V. Proc. Natl. Acad. Sci. U.S.A. 98:3460-3465(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Pm70.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE004439 Genomic DNA. Translation: AAK02155.1.
RefSeq	NP_245008.1. NC_002663.1.
3D structure databases
ProteinModelPortal	Q9CPH0.
SMR	Q9CPH0. Positions 1-342.
ModBase	Search...
Protein-protein interaction databases
STRING	272843.PM0071.
Protein family/group databases
CAZy	GH3. Glycoside Hydrolase Family 3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAK02155; AAK02155; PM0071.
GeneID	1243418.
KEGG	pmu:PM0071.
PATRIC	22869276. VBIPasMul88067_0073.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1472.
HOGENOM	HOG000248526.
KO	K01207.
OMA	VVLHCNG.
ProtClustDB	PRK05337.
Enzyme and pathway databases
UniPathway	UPA00544.
Family and domain databases
Gene3D	3.20.20.300. 1 hit.
HAMAP	MF_00364. NagZ.
InterPro	IPR022956. Beta_hexosaminidase_bac. IPR001764. Glyco_hydro_3_N. IPR017853. Glycoside_hydrolase_SF. [Graphical view]
Pfam	PF00933. Glyco_hydro_3. 1 hit. [Graphical view]
SUPFAM	SSF51445. Glyco_hydro_cat. 1 hit.
PROSITE	PS00775. GLYCOSYL_HYDROL_F3. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NAGZ_PASMU

Accession

Primary (citable) accession number: Q9CPH0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 4, 2001
Last sequence update:	May 4, 2001
Last modified:	May 1, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program