ID   P5CR_PASMU              Reviewed;         275 AA.
AC   Q9CPE8;
DT   06-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   16-JUN-2009, entry version 40.
DE   RecName: Full=Pyrroline-5-carboxylate reductase;
DE            Short=P5C reductase;
DE            Short=P5CR;
DE            EC=1.5.1.2;
GN   Name=proC; OrderedLocusNames=PM0095;
OS   Pasteurella multocida.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Pasteurella.
OX   NCBI_TaxID=747;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Pm70;
RX   MEDLINE=21145866; PubMed=11248100; DOI=10.1073/pnas.051634598;
RA   May B.J., Zhang Q., Li L.L., Paustian M.L., Whittam T.S., Kapur V.;
RT   "Complete genomic sequence of Pasteurella multocida Pm70.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:3460-3465(2001).
CC   -!- CATALYTIC ACTIVITY: L-proline + NAD(P)(+) = 1-pyrroline-5-
CC       carboxylate + NAD(P)H.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-
CC       proline from L-glutamate 5-semialdehyde: step 1/1.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the pyrroline-5-carboxylate reductase
CC       family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AE004439; AAK02179.1; -; Genomic_DNA.
DR   RefSeq; NP_245032.1; -.
DR   GeneID; 1243442; -.
DR   GenomeReviews; AE004439_GR; PM0095.
DR   KEGG; pmu:PM0095; -.
DR   NMPDR; fig|272843.1.peg.95; -.
DR   HOGENOM; Q9CPE8; -.
DR   OMA; Q9CPE8; LKQGYPA.
DR   BRENDA; 1.5.1.2; 258935.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0004735; F:pyrroline-5-carboxylate reductase activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006561; P:proline biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR004455; NADP_OxRdtase_F420.
DR   InterPro; IPR000304; P5CR.
DR   PANTHER; PTHR11645; P5CR; 1.
DR   Pfam; PF03807; F420_oxidored; 1.
DR   PIRSF; PIRSF000193; Pyrrol-5-carb_rd; 1.
DR   TIGRFAMs; TIGR00112; proC; 1.
DR   PROSITE; PS00521; P5CR; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Complete proteome; Cytoplasm; NADP;
KW   Oxidoreductase; Proline biosynthesis.
FT   CHAIN         1    275       Pyrroline-5-carboxylate reductase.
FT                                /FTId=PRO_0000187295.
SQ   SEQUENCE   275 AA;  29556 MW;  011C7F11AD31A7D7 CRC64;
     MQAKSICFIG GGNMAQAIIF GLLKQGYPAN QITVSDPNAA KRQCLAEKGV NTVEASQTDT
     QDAVETSEVL LLAVKPQMIA AVCQGLSAVD FSQKLVISIA AGVSVTKLQS RLPTAKQIVR
     VMPNTPALVA EGMSGLFAQN SLKPEYKQFT QDLLNAVGKT CWVTQEADMH TITAGSGSSP
     AYFFLFMEAM QQALCQMNMD EDTARLLVQQ SALGAAKMVI ENPDLPIATL RENVTSKGGT
     TAAALQVLNQ QQLQHIVQQA MQACVERSQQ MEKLF
//