Q9CPD3 (KHSE_PASMU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homoserine kinase
Short name=HK
Short name=HSK
EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	PM0114

Organism

Pasteurella multocida (strain Pm70) [Complete proteome] [HAMAP]

Taxonomic identifier

272843 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Pasteurella

Protein attributes

Sequence length	314 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate By similarity. HAMAP MF_00384
Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00384
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00384
Subcellular location	Cytoplasm Potential HAMAP MF_00384.
Sequence similarities	Belongs to the GHMP kinase family. Homoserine kinase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 314	314	Homoserine kinase HAMAP MF_00384		PRO_0000156593
Regions
	Nucleotide binding	96 – 106	11	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9CPD3 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 1D0551283D43B63B	FASTA	314	34,211
	10 20 30 40 50 60 MLRIYAPASS ANLSVGFDTL GTAVSPIDGS LLGDVVQIEA LPSGFELESA GYFVRKLPKE 70 80 90 100 110 120 AQKNIVYQAY VLFSERLKLR NIAVRPLRLT LEKNMPIGSG LGSSACSIVA ALVALNKFHA 130 140 150 160 170 180 EPFSKMELLE MMGELEGRIS GSIHYDNVAP CYLGGVQLMV QSLGNICQQL PFFDEWYWVL 190 200 210 220 230 240 AYPGIEVSTA EARAILPKSY TRQDVISQAR HLGSFVHACH TRQAQLAALM MKDVIAEPYR 250 260 270 280 290 300 EALLPNFADV KQATRDLGAL ATGISGSGPT IFAIAPDLGT AMKLSTYLEN HYLQNNEGFV 310 HICKVDNQGA RALD

References

[1]	"Complete genomic sequence of Pasteurella multocida Pm70." May B.J., Zhang Q., Li L.L., Paustian M.L., Whittam T.S., Kapur V. Proc. Natl. Acad. Sci. U.S.A. 98:3460-3465(2001) [PubMed: 11248100] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Pm70.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE004439 Genomic DNA. Translation: AAK02198.1.
RefSeq	NP_245051.1. NC_002663.1.
3D structure databases
ProteinModelPortal	Q9CPD3.
ModBase	Search...
Proteomic databases
PRIDE	Q9CPD3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1243461.
GenomeReviews	Gene locus PM0114 in contig AE004439_GR.
KEGG	pmu:PM0114.
NMPDR	fig|272843.1.peg.114.
PATRIC	22869370. VBIPasMul88067_0118.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG646290.
OMA	GSAHADN.
ProtClustDB	PRK01212.
Enzyme and pathway databases
BioCyc	PMUL272843:PM0114-MONOMER.
Family and domain databases
HAMAP	MF_00384. Homoser_kinase. [Tree]
InterPro	IPR006204. GHMP_kinase. IPR013750. GHMP_kinase_C. IPR006203. GHMP_knse_ATP-bd_CS. IPR000870. Homoserine_kinase. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. [Graphical view]
Gene3D	G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
KO	K00872.
Pfam	PF08544. GHMP_kinases_C. 1 hit. PF00288. GHMP_kinases_N. 1 hit. [Graphical view]
PIRSF	PIRSF000676. Homoser_kin. 1 hit.
PRINTS	PR00958. HOMSERKINASE.
SUPFAM	SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMs	TIGR00191. ThrB. 1 hit.
PROSITE	PS00627. GHMP_KINASES_ATP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KHSE_PASMU

Accession

Primary (citable) accession number: Q9CPD3

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	June 1, 2001
Last modified:	January 25, 2012
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program