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Reviewed, UniProtKB/Swiss-Prot Q9CP40 (DSBD_PASMU)

Last modified June 16, 2009. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Thiol:disulfide interchange protein dsbD
    EC=1.8.1.8
Alternative name(s):
    Protein-disulfide reductase
      Short name=Disulfide reductase
Gene names
Name: dsbD
Ordered Locus Names: PM0221
OrganismPasteurella multocida [Complete proteome] [HAMAP]
Taxonomic identifier747 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Pasteurella

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Protein attributes

Sequence length576 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps By similarity.

Catalytic activity

Protein dithiol + NAD(P)+ = protein disulfide + NAD(P)H. HAMAP MF_00399

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the thioredoxin family. DsbD subfamily.

Contains 1 thioredoxin domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 576557Thiol:disulfide interchange protein dsbD HAMAP MF_00399
PRO_0000007380

Regions

Topological domain20 – 177158Periplasmic Potential
Transmembrane178 – 19821 Potential
Topological domain199 – 22931Cytoplasmic Potential
Transmembrane230 – 25021 Potential
Topological domain251 – 2533Periplasmic Potential
Transmembrane254 – 27421 Potential
Topological domain275 – 29521Cytoplasmic Potential
Transmembrane296 – 31621 Potential
Topological domain317 – 33620Periplasmic Potential
Transmembrane337 – 35721 Potential
Topological domain358 – 36710Cytoplasmic Potential
Transmembrane368 – 38821 Potential
Topological domain389 – 3946Periplasmic Potential
Transmembrane395 – 41521 Potential
Topological domain416 – 4194Cytoplasmic Potential
Transmembrane420 – 44021 Potential
Topological domain441 – 576136Periplasmic Potential
Domain433 – 570138Thioredoxin

Amino acid modifications

Disulfide bond120 ↔ 125Redox-active By similarity
Disulfide bond193 ↔ 315Redox-active By similarity
Disulfide bond485 ↔ 488Redox-active By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q9CP40-1 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 98507447D5EDFA41

FASTA57664,465
        10         20         30         40         50         60 
MKKIFFIFFL IWTSLSVNAG VFDKKNAFLK AEQAFVFTES QQNDRLSLNW DIASGYYLYK 

        70         80         90        100        110        120 
KSLEIKGENG QLFIPQLPLA EIHQDDFFGD VEIYRHQLTF SLPFTQLSAT KQVEITYQGC 

       130        140        150        160        170        180 
TEGFCYPPET RVIALTSLER ESGQISSAVL KEESVLSELP LAEQDRLAAK LIESKYAVFW 

       190        200        210        220        230        240 
FFLFGLGLAF TPCVLPMLPL LSAIVIGREQ RPSTAKAFGL SVVYVQGMAL TYTLLGLIVA 

       250        260        270        280        290        300 
AIGLPFQVAL QSPYVLLTLS AIFVLLALSM FGLFTLQLPV SLQTKLTQYS QQQKSGVFGG 

       310        320        330        340        350        360 
VFVMGMIAGL VASPCTSAPL SGALLYVAQS GDLFTGAITL YLLALGMGLP LIFITVFGNN 

       370        380        390        400        410        420 
ILPKSGNWMI QVKNAFGFVL LALPIFLISR VFPEIEMPLW FSLAFAFSLW LLYQFRNNKG 

       430        440        450        460        470        480 
VWVFTFILGV MGYLYYSYAM NRHTPAHQTT SLSQFERITS YAQLQQVLSK NPNSLAMLDL 

       490        500        510        520        530        540 
YADWCVACKE FETHTFSDVA VQKAFTDVLL LQVDMTKNSE ANRELMQKLH VIGLPTLIFF 

       550        560        570 
NQQGQEIEGS RITGFMQASP FVDWLQKMKS IQPISQ

« Hide

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References

[1]"Complete genomic sequence of Pasteurella multocida Pm70."
May B.J., Zhang Q., Li L.L., Paustian M.L., Whittam T.S., Kapur V.
Proc. Natl. Acad. Sci. U.S.A. 98:3460-3465(2001) [PubMed: 11248100] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Pm70.

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Cross-references

Sequence databases

AE004439 Genomic DNA. Translation: AAK02305.1. Different initiation.
RefSeqNP_245158.1.

3D structure databases

HSSPHSSP built from PDB template 1JPE based on UniProtKB P36655.
ModBaseSearch...

Genome annotation databases

GeneID1243568.
GenomeReviewsGene locus PM0221 in contig AE004439_GR.
KEGGpmu:PM0221.
NMPDRfig|272843.1.peg.221.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ9CP40.

Enzyme and pathway databases

BRENDA1.8.1.8. 258935.

Family and domain databases

HAMAPMF_00399.
[Tree]
InterProIPR003834. Cyt_c_assmbl_TM.
IPR017936. Thioredoxin-like.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
IPR012335. Thioredoxin_fold.
[Graphical view]
Gene3DG3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PfamPF02683. DsbD. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view]
PROSITEPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameDSBD_PASMU
AccessionPrimary (citable) accession number: Q9CP40
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 1, 2001
Last modified: June 16, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents