Reviewed, UniProtKB/Swiss-Prot Q9CP11 (CDD_PASMU)

Names and origin

Protein names

Recommended name:
    Cytidine deaminase
    EC=3.5.4.5
Alternative name(s):
    Cytidine aminohydrolase
      Short name=CDA

Gene names

Name:	cdd
Ordered Locus Names:	PM0259

Organism

Pasteurella multocida [Complete proteome] [HAMAP]

Taxonomic identifier

747 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Pasteurella

Protein attributes

Sequence length	294 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis By similarity.
Catalytic activity	Cytidine + H2O = uridine + NH3. HAMAP MF_01558
Cofactor	Binds 1 zinc ion By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the cytidine and deoxycytidylate deaminase family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cytidine metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	cytidine deaminase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 294	294	Cytidine deaminase HAMAP MF_01558		PRO_0000171656
Regions
	Region	90 – 92	3	Substrate binding By similarity
Sites
	Active site	105	1	Proton donor By similarity
	Metal binding	103	1	Zinc; catalytic By similarity
	Metal binding	130	1	Zinc; catalytic By similarity
	Metal binding	133	1	Zinc; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9CP11-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: B490DEDF9BF351CA	FASTA	294	32,994
	10 20 30 40 50 60 MSEKIRKTLS LIESQQLAQD VWHILQEQHF KGMLPYFTVE HLCTKHQLTP QQLALKLLPI 70 80 90 100 110 120 AAAYSLAPIS QFHVGAIAIG QRGAYYFGAN LEFASTHIQQ TVHAEQSAIS HAWMNHESAI 130 140 150 160 170 180 TDVVVNYTPC GHCRQFMNEL KTAPQLKIHL PHSQNNLLHS YLPDAFGPAD LDIQHFLLDA 190 200 210 220 230 240 QNNQLTYETQ DPVMLTALEC ANAAHAPYSK SYHGIAIETK DKQIYRGSYA ENAAFNPSLP 250 260 270 280 290 ALQVALNHLL LSGDTLQNIQ RIVMIEKANH LCYRHMAEDL VANLVDIPLD YIAL

References

[1]	"Complete genomic sequence of Pasteurella multocida Pm70." May B.J., Zhang Q., Li L.L., Paustian M.L., Whittam T.S., Kapur V. Proc. Natl. Acad. Sci. U.S.A. 98:3460-3465(2001) [PubMed: 11248100] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Pm70.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE004439 Genomic DNA. Translation: AAK02343.1.
RefSeq	NP_245196.1.
3D structure databases
HSSP	HSSP built from PDB template 1CTT based on UniProtKB P13652.
ModBase	Search...
Genome annotation databases
GeneID	1243606.
GenomeReviews	Gene locus PM0259 in contig AE004439_GR.
KEGG	pmu:PM0259.
NMPDR	fig|272843.1.peg.259.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9CP11.
OMA	FSPCGHC.
Enzyme and pathway databases
BRENDA	3.5.4.5. 258935.
Family and domain databases
HAMAP	MF_01558. [Tree]
InterPro	IPR016192. APOBEC/CMP_deaminase_Zn-bd. IPR002125. CMP_dCMP_Zn_bd. IPR013171. Cyd/dCyd_deaminase_Zn_bd. IPR006263. Cyt_deam_dimer. [Graphical view]
Pfam	PF00383. dCMP_cyt_deam_1. 1 hit. PF08211. dCMP_cyt_deam_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR01355. cyt_deam_dimer. 1 hit.
PROSITE	PS00903. CYT_DCMP_DEAMINASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDD_PASMU

Accession

Primary (citable) accession number: Q9CP11

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	June 1, 2001
Last modified:	November 3, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)